"Chromosome Fragile Sites" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Specific loci that show up during KARYOTYPING as a gap (an uncondensed stretch in closer views) on a CHROMATID arm after culturing cells under specific conditions. These sites are associated with an increase in CHROMOSOME FRAGILITY. They are classified as common or rare, and by the specific culture conditions under which they develop. Fragile site loci are named by the letters "FRA" followed by a designation for the specific chromosome, and a letter which refers to which fragile site of that chromosome (e.g. FRAXA refers to fragile site A on the X chromosome. It is a rare, folic acid-sensitive fragile site associated with FRAGILE X SYNDROME.)
| Descriptor ID |
D043283
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| MeSH Number(s) |
G05.360.340.024.189.610
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| Concept/Terms |
Chromosome Fragile Sites- Chromosome Fragile Sites
- Chromosome Fragile Site
- Fragile Site, Chromosome
- Site, Chromosome Fragile
- Sites, Chromosome Fragile
- Fragile Sites, Chromosome
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Fragile Sites".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Fragile Sites".
This graph shows the total number of publications written about "Chromosome Fragile Sites" by people in this website by year, and whether "Chromosome Fragile Sites" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chromosome Fragile Sites" by people in Profiles.
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Biology before the SOS Response-DNA Damage Mechanisms at Chromosome Fragile Sites. Cells. 2021 09 01; 10(9).
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Signatures of mutation and selection in the cancer genome. Nature. 2010 Feb 18; 463(7283):893-8.
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Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias. Oral Oncol. 2008 Aug; 44(8):753-8.
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Association between decreased WWOX protein expression and thyroid cancer development. Thyroid. 2007 Nov; 17(11):1055-9.
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WWOX, a chromosomal fragile site gene and its role in cancer. Adv Exp Med Biol. 2006; 587:149-59.
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Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development. Biochem Biophys Res Commun. 2006 Feb 17; 340(3):887-93.
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Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR. Mol Carcinog. 2005 Nov; 44(3):174-82.
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A survey of homozygous deletions in human cancer genomes. Proc Natl Acad Sci U S A. 2005 Mar 22; 102(12):4542-7.
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Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 2004 Aug 16; 91(4):753-9.
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WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res. 2003; 100(1-4):101-10.