"DNA Sequence, Unstable" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A region of DNA that is highly polymorphic and is prone to strand breaks, rearrangements or other MUTATIONS because of the nature of its sequence. These regions often harbor palindromic, or repetitive sequences (REPETITIVE SEQUENCES, NUCLEIC ACID). Variability in stability of the DNA sequence is seen at CHROMOSOME FRAGILE SITES.
| Descriptor ID |
D043243
|
| MeSH Number(s) |
G05.360.340.024.189
|
| Concept/Terms |
DNA Sequence, Unstable- DNA Sequence, Unstable
- DNA Sequences, Unstable
- Sequence, Unstable DNA
- Sequences, Unstable DNA
- Unstable DNA Sequences
- Unstable DNA Sequence
|
Below are MeSH descriptors whose meaning is more general than "DNA Sequence, Unstable".
Below are MeSH descriptors whose meaning is more specific than "DNA Sequence, Unstable".
This graph shows the total number of publications written about "DNA Sequence, Unstable" by people in this website by year, and whether "DNA Sequence, Unstable" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Sequence, Unstable" by people in Profiles.
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Discordant genetic changes in ovarian and endometrial endometrioid carcinomas: a potential pitfall in molecular diagnosis. Int J Gynecol Cancer. 2006 Jan-Feb; 16(1):178-82.
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Hairpin structure-forming propensity of the (CCTG.CAGG) tetranucleotide repeats contributes to the genetic instability associated with myotonic dystrophy type 2. J Biol Chem. 2004 Oct 01; 279(40):41715-26.
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Tetranucleotide microsatellite instability in surgical margins for prediction of local recurrence of head and neck squamous cell carcinoma. Clin Cancer Res. 2004 Jun 15; 10(12 Pt 1):4022-8.
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Colorectal carcinogenesis: MSI-H versus MSI-L. Dis Markers. 2004; 20(4-5):199-206.