"Centrosome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The cell center, consisting of a pair of CENTRIOLES surrounded by a cloud of amorphous material called the pericentriolar region. During interphase, the centrosome nucleates microtubule outgrowth. The centrosome duplicates and, during mitosis, separates to form the two poles of the mitotic spindle (MITOTIC SPINDLE APPARATUS).
| Descriptor ID |
D018385
|
| MeSH Number(s) |
A11.284.430.214.190.750.585.160 A11.284.430.214.190.750.820.500.500
|
| Concept/Terms |
Pericentriolar Region- Pericentriolar Region
- Pericentriolar Regions
- Region, Pericentriolar
- Regions, Pericentriolar
|
Below are MeSH descriptors whose meaning is more general than "Centrosome".
Below are MeSH descriptors whose meaning is more specific than "Centrosome".
This graph shows the total number of publications written about "Centrosome" by people in this website by year, and whether "Centrosome" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1998 | 3 | 2 | 5 |
| 2000 | 3 | 3 | 6 |
| 2001 | 2 | 0 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 4 | 0 | 4 |
| 2004 | 2 | 1 | 3 |
| 2005 | 2 | 4 | 6 |
| 2006 | 1 | 0 | 1 |
| 2007 | 1 | 4 | 5 |
| 2008 | 3 | 1 | 4 |
| 2009 | 1 | 1 | 2 |
| 2010 | 3 | 2 | 5 |
| 2011 | 1 | 4 | 5 |
| 2012 | 0 | 5 | 5 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 2 | 2 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2023 | 1 | 1 | 2 |
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Below are the most recent publications written about "Centrosome" by people in Profiles.
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CDK2 inhibition disorders centrosome stoichiometry and alters cellular outcomes in aneuploid cancer cells. Cancer Biol Ther. 2023 12 31; 24(1):2279241.
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Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells. Cancer Med. 2023 04; 12(7):8499-8509.
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Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy. Mol Cancer Ther. 2019 10; 18(10):1775-1786.
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Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. PLoS One. 2019; 14(7):e0218111.
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Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1913-1918.
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Precocious centriole disengagement and centrosome fragmentation induced by mitotic delay. Nat Commun. 2017 06 13; 8:15803.
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Next-Generation CDK2/9 Inhibitors and Anaphase Catastrophe in Lung Cancer. J Natl Cancer Inst. 2017 06 01; 109(6).
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A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel. Clin Cancer Res. 2017 04 15; 23(8):1945-1954.
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Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22; 12(4):863.
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Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown. Mol Cancer Ther. 2015 Nov; 14(11):2576-85.