"Chromosome Walking" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.
| Descriptor ID |
D016386
|
| MeSH Number(s) |
E05.393.183.250
|
| Concept/Terms |
Chromosome Walking- Chromosome Walking
- Chromosome Walkings
- Walking, Chromosome
- Walkings, Chromosome
|
Below are MeSH descriptors whose meaning is more general than "Chromosome Walking".
Below are MeSH descriptors whose meaning is more specific than "Chromosome Walking".
This graph shows the total number of publications written about "Chromosome Walking" by people in this website by year, and whether "Chromosome Walking" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
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Below are the most recent publications written about "Chromosome Walking" by people in Profiles.
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Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling. PLoS Genet. 2018 12; 14(12):e1007872.
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Fine mapping of the constitutional translocation t(11;22)(q23;q11). Hum Genet. 2000 May; 106(5):506-16.
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130 kb of DNA sequence reveals two new genes and a regional duplication distal to the human iduronate-2-sulfate sulfatase locus. Genome Res. 1995 Aug; 5(1):71-8.
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Genetic and phenotypic analysis of thirteen essential genes in cytological interval 22F1-2; 23B1-2 reveals novel genes required for neural development in Drosophila. Genetics. 1994 Sep; 138(1):111-23.
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A YAC-based binning strategy facilitating the rapid assembly of cosmid contigs: 1.6 Mb of overlapping cosmids in Xp22. Hum Mol Genet. 1994 Jul; 3(7):1155-61.
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Neuromusculin, a Drosophila gene expressed in peripheral neuronal precursors and muscles, encodes a cell adhesion molecule. Neuron. 1993 Oct; 11(4):673-87.
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Physical mapping of Xq24-25 around loci closely linked to the X-linked lymphoproliferative syndrome locus: an overlapping YAC map and linkage between DXS12, DXS42, and DXS37. Eur J Hum Genet. 1993; 1(1):64-71.
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The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGF beta superfamily. Cell. 1992 Oct 30; 71(3):399-410.