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RONALD A DEPINHO

TitleProfessor
InstitutionMD Anderson
DepartmentCancer Biology
Address1400 Pressler St
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LaBella KA, Hsu WH, Li J, Qi Y, Liu Y, Liu J, Wu CC, Liu Y, Song Z, Lin Y, Blecher JM, Jiang S, Shang X, Han J, Spring DJ, Zhang J, Xia Y, DePinho RA. Telomere dysfunction alters intestinal stem cell dynamics to promote cancer. Dev Cell. 2024 Mar 28. PMID: 38574731.
      Citations:    Fields:    
    2. Hsu WH, LaBella KA, Lin Y, Xu P, Lee R, Hsieh CE, Yang L, Zhou A, Blecher JM, Wu CJ, Lin K, Shang X, Jiang S, Spring DJ, Xia Y, Chen P, Shen JP, Kopetz S, DePinho RA, Hsu WH, LaBella KA, Lin Y, Xu P, Lee R, Hsieh CE, Yang L, Zhou A, Blecher JM, Wu CJ, Lin K, Shang X, Jiang S, Spring DJ, Xia Y, Chen P, Shen JP, Kopetz S, DePinho RA. Oncogenic KRAS Drives Lipofibrogenesis to Promote Angiogenesis and Colon Cancer Progression. Cancer Discov. 2023 12 12; 13(12):2652-2673. PMID: 37768068; PMCID: PMC10807546.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    3. Khadka S, Lin YH, Ackroyd J, Sheng Y, Qian W, Guo S, Chen Y, Behr E, Barekatain Y, Arthur K, Yan V, Hsu WH, Poral A, Tran T, Chaurasia S, Georgiou DK, Asara JM, Millward SW, DePinho RA, Muller FL, Chen YA, Uddin N, Chang Q, Barthel FP. Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism. bioRxiv. 2023 Oct 19. PMID: 37214825; PMCID: PMC10197573.
      Citations:    
    4. DePinho R, Massagu? J, Manji G, Rustgi AK, Izar B. Filippo Giancotti (1958-2023). Nat Cancer. 2023 Oct; 4(10):1401-1402. PMID: 37770653.
      Citations:    Fields:    
    5. Wei Y, Liu M, Yen EY, Yao J, Nguyen PT, Wang X, Yang Z, Yousef A, Pan D, Jin Y, Theady MS, Park J, Cai Y, Takeda M, Vasquez M, Zhou Y, Zhao H, Viale A, Wang H, Zhao D, DePinho RA, Yao W, Ying H. KRAS inhibition activates an actionable CD24 'don't eat me' signal in pancreas cancer. bioRxiv. 2023 Sep 23. PMID: 37790498; PMCID: PMC10542501.
      Citations:    
    6. Li J, DePinho RA. The Y of cancer sex differences. Clin Transl Med. 2023 09; 13(9):e1402. PMID: 37679889; PMCID: PMC10485334.
      Citations:    Fields:    Translation:Humans
    7. Han J, Xu J, Liu Y, Liang S, LaBella KA, Chakravarti D, Spring DJ, Xia Y, DePinho RA. Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer. Genes Dev. 2023 09 01; 37(17-18):818-828. PMID: 37775182; PMCID: PMC10621596.
      Citations:    Fields:    Translation:HumansAnimals
    8. Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Sthanam LK, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T?cells. Dev Cell. 2023 09 11; 58(17):1562-1577.e8. PMID: 37625403; PMCID: PMC10810082.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Li J, Lan Z, Liao W, Horner JW, Xu X, Liu J, Yoshihama Y, Jiang S, Shim HS, Slotnik M, LaBella KA, Wu CJ, Dunner K, Hsu WH, Lee R, Khanduri I, Terranova C, Akdemir K, Chakravarti D, Shang X, Spring DJ, Wang YA, DePinho RA. Histone demethylase KDM5D upregulation drives sex differences in colon cancer. Nature. 2023 Jul; 619(7970):632-639. PMID: 37344599; PMCID: PMC10529424.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Gulhati P, Schalck A, Jiang S, Shang X, Wu CJ, Hou P, Ruiz SH, Soto LS, Parra E, Ying H, Han J, Dey P, Li J, Deng P, Sei E, Maeda DY, Zebala JA, Spring DJ, Kim M, Wang H, Maitra A, Moore D, Clise-Dwyer K, Wang YA, Navin NE, DePinho RA. Targeting T cell checkpoints 41BB and LAG3 and myeloid cell CXCR1/CXCR2 results in antitumor immunity and durable response in pancreatic cancer. Nat Cancer. 2023 01; 4(1):62-80. PMID: 36585453; PMCID: PMC9925045.
      Citations: 11     Fields:    Translation:HumansCells
    11. Kang Y, Deng J, Ling J, Li X, Chiang YJ, Koay EJ, Wang H, Burks JK, Chiao PJ, Hurd MW, Bhutani MS, Lee JH, Weston BR, Maitra A, Ikoma N, Tzeng CD, Lee JE, DePinho RA, Wolff RA, Pant S, McAllister F, Katz MH, Fleming JB, Kim MP. 3D imaging analysis on an organoid-based platform guides personalized treatment in pancreatic ductal adenocarcinoma. J Clin Invest. 2022 12 15; 132(24). PMID: 36282600; PMCID: PMC9753992.
      Citations: 2     Fields:    Translation:Humans
    12. Zhang J, Chen SR, Zhou MH, Jin D, Chen H, Wang L, DePinho RA, Pan HL. HDAC2 in Primary Sensory Neurons Constitutively Restrains Chronic Pain by Repressing a2d-1 Expression and Associated NMDA Receptor Activity. J Neurosci. 2022 11 30; 42(48):8918-8935. PMID: 36257688; PMCID: PMC9732832.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Lee R, Li J, Li J, Wu CJ, Jiang S, Hsu WH, Chakravarti D, Chen P, LaBella KA, Li J, Spring DJ, Zhao D, Wang YA, DePinho RA. Synthetic Essentiality of Tryptophan 2,3-Dioxygenase 2 in APC-Mutated Colorectal Cancer. Cancer Discov. 2022 07 06; 12(7):1702-1717. PMID: 35537038; PMCID: PMC9262860.
      Citations: 2     Fields:    Translation:HumansCells
    14. Davidson SM, Schmidt DR, Heyman JE, O'Brien JP, Liu AC, Israelsen WJ, Dayton TL, Sehgal R, Bronson RT, Freinkman E, Mak HH, Malstrom S, Bellinger G, Carracedo A, Pandolfi PP, Courtney KD, Jha A, DePinho RA, Horner JW, Thomas CJ, Cantley LC, Loda M, Vander Heiden MG, Fanelli GN. Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma. Cancer Res. 2022 07 05; 82(13):2403-2416. PMID: 35584006; PMCID: PMC9256808.
      Citations:    Fields:    Translation:Humans
    15. Hsieh RC, Krishnan S, Wu RC, Boda AR, Liu A, Winkler M, Hsu WH, Lin SH, Hung MC, Chan LC, Bhanu KR, Srinivasamani A, De Azevedo RA, Chou YC, DePinho RA, Gubin M, Vilar E, Chen CH, Slay R, Jayaprakash P, Hegde SM, Hartley G, Lea ST, Prasad R, Morrow B, Couillault CA, Steiner M, Wang CC, Venkatesulu BP, Taniguchi C, Kim YSB, Chen J, Rudqvist NP, Curran MA. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol. 2022 06 10; 7(72):eabl9330. PMID: 35687697; PMCID: PMC9373855.
      Citations:    Fields:    Translation:HumansAnimalsCells
    16. Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S, Li J, Turowski SG, Sexton S, Sait SJ, Singh PK, Wang J, Maitra A, Kalinski P, DePinho RA, Wang H, Liao W, Abrams SI, Segal BH, Dey P. Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell. 2022 02 14; 40(2):153-167.e11. PMID: 35120601; PMCID: PMC8847236.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    17. Shim HS, Horner JW, Wu CJ, Li J, Lan ZD, Jiang S, Xu X, Hsu WH, Zal T, Flores II, Deng P, Lin YT, Tsai LH, Wang YA, DePinho RA. Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models. Nat Aging. 2021 12; 1(12):1162-1174. PMID: 35036927; PMCID: PMC8759755.
      Citations:    
    18. Masetti M, Carriero R, Portale F, Marelli G, Pandini M, Iovino M, Partini B, Erreni M, Ponzetta A, Magrini E, Colombo P, Elefante G, Colombo FS, den Haan JMM, Peano C, Cibella J, Termanini A, Kunderfranco P, Brummelman J, Chung MWH, Lazzeri M, Hurle R, Casale P, Lugli E, DePinho RA, Mukhopadhyay S, Gordon S, Di Mitri D, Morina N. Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer. J Exp Med. 2022 02 07; 219(2). PMID: 34919143; PMCID: PMC8932635.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    19. Criss ZK, Bhasin N, Di Rienzi SC, Rajan A, Deans-Fielder K, Swaminathan G, Kamyabi N, Zeng XL, Doddapaneni H, Menon VK, Chakravarti D, Estrella C, Yu X, Patil K, Petrosino JF, Fleet JC, Verzi MP, Christakos S, Helmrath MA, Arimura S, DePinho RA, Britton RA, Maresso AW, Grande-Allen KJ, Blutt SE, Crawford SE, Estes MK, Ramani S, Shroyer NF. Drivers of transcriptional variance in human intestinal epithelial organoids. Physiol Genomics. 2021 11 01; 53(11):486-508. PMID: 34612061; PMCID: PMC8616596.
      Citations: 3     Fields:    Translation:HumansCells
    20. Hou P, Ma X, Yang Z, Zhang Q, Wu CJ, Li J, Tan L, Yao W, Yan L, Zhou X, Kimmelman AC, Lorenzi PL, Zhang J, Jiang S, Spring D, Wang YA, DePinho RA. USP21 deubiquitinase elevates macropinocytosis to enable oncogenic KRAS bypass in pancreatic cancer. Genes Dev. 2021 10 01; 35(19-20):1327-1332. PMID: 34531315; PMCID: PMC8494209.
      Citations: 3     Fields:    Translation:AnimalsCells
    21. Yoshihama Y, LaBella KA, Kim E, Bertolet L, Colic M, Li J, Shang X, Wu CJ, Spring DJ, Wang YA, Hart T, DePinho RA. AR-negative prostate cancer is vulnerable to loss of JMJD1C demethylase. Proc Natl Acad Sci U S A. 2021 09 07; 118(36). PMID: 34475205; PMCID: PMC8433584.
      Citations: 1     Fields:    Translation:HumansCells
    22. Chakravarti D, Lee R, Multani AS, Santoni A, Keith Z, Hsu WH, Chang K, Reyes L, Rashid A, Wu CJ, Li J, Zhang J, Shim HS, Chandra K, Deng P, Spring DJ, Nielsen OH, Riis LB, Mayigegowda KK, Blutt SE, Zhang J, Younes M, DuPont A, Thirumurthi S, Vilar E, Estes MK, Colla S, Shroyer NF, DePinho RA. Telomere dysfunction instigates inflammation in inflammatory bowel disease. Proc Natl Acad Sci U S A. 2021 07 20; 118(29). PMID: 34253611; PMCID: PMC8307535.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    23. Dayde D, Gunther J, Hirayama Y, Weksberg DC, Boutin A, Parhy G, Aguilar-Bonavides C, Wang H, Katayama H, Abe Y, Do KA, Hara K, Kinoshita T, Komori K, Shimizu Y, Tajika M, Niwa Y, Wang YA, DePinho R, Hanash S, Krishnan S, Taguchi A. Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer. Cancers (Basel). 2021 Jul 20; 13(14). PMID: 34298853; PMCID: PMC8306983.
      Citations: 2     
    24. Han J, DePinho RA, Maitra A. Single-cell RNA sequencing in pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2021 07; 18(7):451-452. PMID: 34040169; PMCID: PMC8819738.
      Citations: 3     Fields:    Translation:HumansAnimals
    25. Li J, Ma X, Chakravarti D, Shalapour S, DePinho RA. Genetic and biological hallmarks of colorectal cancer. Genes Dev. 2021 06; 35(11-12):787-820. PMID: 34074695; PMCID: PMC8168558.
      Citations: 8     Fields:    Translation:Humans
    26. Chuntova P, Chow F, Watchmaker PB, Galvez M, Heimberger AB, Newell EW, Diaz A, DePinho RA, Li MO, Wherry EJ, Mitchell D, Terabe M, Wainwright DA, Berzofsky JA, Herold-Mende C, Heath JR, Lim M, Margolin KA, Chiocca EA, Kasahara N, Ellingson BM, Brown CE, Chen Y, Fecci PE, Reardon DA, Dunn GP, Liau LM, Costello JF, Wick W, Cloughesy T, Timmer WC, Wen PY, Prins RM, Platten M, Okada H. Unique challenges for glioblastoma immunotherapy-discussions across neuro-oncology and non-neuro-oncology experts in cancer immunology. Meeting Report from the 2019 SNO Immuno-Oncology Think Tank. Neuro Oncol. 2021 03 25; 23(3):356-375. PMID: 33367885; PMCID: PMC7992879.
      Citations: 22     Fields:    Translation:Humans
    27. Chakravarti D, DePinho RA. Telomere Dysfunction as an Initiator of Inflammation: Clues to an Age-Old Mystery. J Inflamm Bowel Dis Disord. 2021; 6(2). PMID: 34661200; PMCID: PMC8516314.
      Citations:    
    28. Weeks KL, Tham YK, Yildiz SG, Alexander Y, Donner DG, Kiriazis H, Harmawan CA, Hsu A, Bernardo BC, Matsumoto A, DePinho RA, Abel ED, Woodcock EA, McMullen JR. FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K. Am J Physiol Heart Circ Physiol. 2021 04 01; 320(4):H1470-H1485. PMID: 33577435.
      Citations: 2     Fields:    Translation:AnimalsCells
    29. Dey P, Kimmelman AC, DePinho RA. Metabolic Codependencies in the Tumor Microenvironment. Cancer Discov. 2021 05; 11(5):1067-1081. PMID: 33504580; PMCID: PMC8102306.
      Citations: 20     Fields:    Translation:Humans
    30. Chakravarti D, LaBella KA, DePinho RA. Telomeres: history, health, and hallmarks of aging. Cell. 2021 01 21; 184(2):306-322. PMID: 33450206; PMCID: PMC8081271.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    31. Chen P, Hsu WH, Han J, Xia Y, DePinho RA. Cancer Stemness Meets Immunity: From Mechanism to Therapy. Cell Rep. 2021 01 05; 34(1):108597. PMID: 33406434; PMCID: PMC7839836.
      Citations: 16     Fields:    Translation:HumansCells
    32. Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2021 Jan; 3(1):122. PMID: 33340032.
      Citations:    Fields:    
    33. Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2020 12; 2(12):1413-1426. PMID: 33230295; PMCID: PMC7744354.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    34. Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020 09 21; 11(1):4766. PMID: 32958778; PMCID: PMC7505960.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    35. Zhao D, Cai L, Lu X, Liang X, Li J, Chen P, Ittmann M, Shang X, Jiang S, Li H, Meng C, Flores I, Song JH, Horner JW, Lan Z, Wu CJ, Li J, Chang Q, Chen KC, Wang G, Deng P, Spring DJ, Wang YA, DePinho RA. Chromatin Regulator CHD1 Remodels the Immunosuppressive Tumor Microenvironment in PTEN-Deficient Prostate Cancer. Cancer Discov. 2020 09; 10(9):1374-1387. PMID: 32385075; PMCID: PMC7483306.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    36. Huang T, Cheng X, Chahoud J, Sarhan A, Tamboli P, Rao P, Guo M, Manyam G, Zhang L, Xiang Y, Han L, Shang X, Deng P, Luo Y, Lu X, Feng S, Ferrer MM, Alan Wang Y, DePinho RA, Pettaway CA, Lu X. Effective combinatorial immunotherapy for penile squamous cell carcinoma. Nat Commun. 2020 05 01; 11(1):2124. PMID: 32358507; PMCID: PMC7195486.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    37. Hou P, Kapoor A, Zhang Q, Li J, Wu CJ, Li J, Lan Z, Tang M, Ma X, Ackroyd JJ, Kalluri R, Zhang J, Jiang S, Spring DJ, Wang YA, DePinho RA. Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer. Cancer Discov. 2020 07; 10(7):1058-1077. PMID: 32341020; PMCID: PMC7334087.
      Citations: 33     Fields:    Translation:Humans
    38. Li X, Qian X, Wang B, Xia Y, Zheng Y, Du L, Xu D, Xing D, DePinho RA, Lu Z. Programmable base editing of mutated TERT promoter inhibits brain tumour growth. Nat Cell Biol. 2020 03; 22(3):282-288. PMID: 32066906.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    39. Dey P, Li J, Zhang J, Chaurasiya S, Strom A, Wang H, Liao WT, Cavallaro F, Denz P, Bernard V, Yen EY, Genovese G, Gulhati P, Liu J, Chakravarti D, Deng P, Zhang T, Carbone F, Chang Q, Ying H, Shang X, Spring DJ, Ghosh B, Putluri N, Maitra A, Wang YA, DePinho RA. Oncogenic KRAS-Driven Metabolic Reprogramming in Pancreatic Cancer Cells Utilizes Cytokines from the Tumor Microenvironment. Cancer Discov. 2020 04; 10(4):608-625. PMID: 32046984; PMCID: PMC7125035.
      Citations: 48     Fields:    Translation:HumansAnimals
    40. Chen P, Hsu WH, Chang A, Tan Z, Lan Z, Zhou A, Spring DJ, Lang FF, Wang YA, DePinho RA. Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment. Cancer Discov. 2020 03; 10(3):371-381. PMID: 31919052; PMCID: PMC7058515.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    41. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer. Cell. 2019 Nov 14; 179(5):1239. PMID: 31730860; PMCID: PMC6941747.
      Citations: 9     Fields:    
    42. Hou P, Ma X, Zhang Q, Wu CJ, Liao W, Li J, Wang H, Zhao J, Zhou X, Guan C, Ackroyd J, Jiang S, Zhang J, Spring DJ, Wang YA, DePinho RA. USP21 deubiquitinase promotes pancreas cancer cell stemness via Wnt pathway activation. Genes Dev. 2019 10 01; 33(19-20):1361-1366. PMID: 31488580; PMCID: PMC6771391.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    43. Chen P, Zhao D, Li J, Liang X, Li J, Chang A, Henry VK, Lan Z, Spring DJ, Rao G, Wang YA, DePinho RA. Symbiotic Macrophage-Glioma Cell Interactions Reveal Synthetic Lethality in PTEN-Null Glioma. Cancer Cell. 2019 06 10; 35(6):868-884.e6. PMID: 31185211; PMCID: PMC6561349.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    44. Frenquelli M, Caridi N, Antonini E, Storti F, Gaviraghi M, Occhionorelli M, Bianchessi S, Bongiovanni L, Spinelli A, Marcatti M, Belloni D, Ferrero E, Karki S, Brambilla P, Martinelli-Boneschi F, Colla S, Ponzoni M, DePinho RA, Tonon G, Vigan? V. The WNT receptor ROR2 drives the interaction of multiple myeloma cells with the microenvironment through AKT activation. Leukemia. 2020 01; 34(1):257-270. PMID: 31148590.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    45. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2019 04 01; 33(7-8):477. PMID: 30936192; PMCID: PMC6446545.
      Citations:    Fields:    
    46. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019 04; 568(7752):410-414. PMID: 30918400; PMCID: PMC6661074.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    47. Liao W, Overman MJ, Boutin AT, Shang X, Zhao D, Dey P, Li J, Wang G, Lan Z, Li J, Tang M, Jiang S, Ma X, Chen P, Katkhuda R, Korphaisarn K, Chakravarti D, Chang A, Spring DJ, Chang Q, Zhang J, Maru DM, Maeda DY, Zebala JA, Kopetz S, Wang YA, DePinho RA. KRAS-IRF2 Axis Drives Immune Suppression and Immune Therapy Resistance in Colorectal Cancer. Cancer Cell. 2019 04 15; 35(4):559-572.e7. PMID: 30905761; PMCID: PMC6467776.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    48. Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5. PMID: 30625329.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    49. Son DH, Doan KV, Yang DJ, Sun JS, Kim SK, Kang N, Kang JY, Paik JH, DePinho RA, Choi YH, Shin DM, Kim KW. FoxO1 regulates leptin-induced mood behavior by targeting tyrosine hydroxylase. Metabolism. 2019 02; 91:43-52. PMID: 30500562.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Singh AK, Khare P, Obaid A, Conlon KP, Basrur V, DePinho RA, Venuprasad K. SUMOylation of ROR-?t inhibits IL-17 expression and inflammation via HDAC2. Nat Commun. 2018 10 30; 9(1):4515. PMID: 30375383; PMCID: PMC6207785.
      Citations: 25     Fields:    Translation:AnimalsCells
    51. Moreira D, Adamus T, Zhao X, Su YL, Zhang Z, White SV, Swiderski P, Lu X, DePinho RA, Pal SK, Kortylewski M. STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers. Clin Cancer Res. 2018 12 01; 24(23):5948-5962. PMID: 30337279; PMCID: PMC6279477.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    52. Webb AE, DePinho RA, Paik J, Sch?ffner I, Minakaki G, Khan MA, Balta EA, Schl?tzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Wurst W, Klucken J, Lie DC. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. 2018 09 19; 99(6):1188-1203.e6. PMID: 30197237; PMCID: PMC6186958.
      Citations: 43     Fields:    Translation:AnimalsCells
    53. Wang G, Zhao D, Spring DJ, DePinho RA. Genetics and biology of prostate cancer. Genes Dev. 2018 09 01; 32(17-18):1105-1140. PMID: 30181359; PMCID: PMC6120714.
      Citations: 142     Fields:    Translation:HumansAnimals
    54. Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 07; 24(7):1036-1046. PMID: 29892070.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    55. Lu X, Pan X, Wu CJ, Zhao D, Feng S, Zang Y, Lee R, Khadka S, Amin SB, Jin EJ, Shang X, Deng P, Luo Y, Morgenlander WR, Weinrich J, Lu X, Jiang S, Chang Q, Navone NM, Troncoso P, DePinho RA, Wang YA. An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. Cancer Res. 2018 07 15; 78(14):3823-3833. PMID: 29769196; PMCID: PMC6381393.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    56. Al-Tamari HM, Dabral S, Schmall A, Sarvari P, Ruppert C, Paik J, DePinho RA, Grimminger F, Guenther A, Seeger W, Savai R, Pullamsetti SS, Eickelberg O. FoxO3 an important player in fibrogenesis and therapeutic target for idiopathic pulmonary fibrosis. EMBO Mol Med. 2018 02; 10(2):276-293. PMID: 29217661; PMCID: PMC5801513.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    57. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW, Gabriel Sauv? CE. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2018 01 08; 33(1):152. PMID: 29316430; PMCID: PMC5892424.
      Citations: 78     Fields:    
    58. Lu X, Jin EJ, Cheng X, Feng S, Shang X, Deng P, Jiang S, Chang Q, Rahmy S, Chaudhary S, Lu X, Zhao R, Wang YA, DePinho RA. Opposing roles of TGF? and BMP signaling in prostate cancer development. Genes Dev. 2017 12 01; 31(23-24):2337-2342. PMID: 29352019; PMCID: PMC5795781.
      Citations: 18     Fields:    Translation:AnimalsCells
    59. Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A. Future cancer research priorities in the USA: a Lancet Oncology Commission. Lancet Oncol. 2017 11; 18(11):e653-e706. PMID: 29208398; PMCID: PMC6178838.
      Citations: 52     Fields:    Translation:Humans
    60. Ong DST, Hu B, Ho YW, Bristow CA, Wang Q, Multani AS, Chen P, Nezi L, Jiang S, Gorman CE, Monasterio MM, Koul D, Marchesini M, Colla S, Jin EJ, Sulman EP, Spring DJ, Yung WA, Verhaak RGW, Chin L, Wang YA, DePinho RA, Sauv? CG. PAF promotes stemness and radioresistance of glioma stem cells. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9086-E9095. PMID: 29073105; PMCID: PMC5664518.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    61. Yang Y, Blee AM, Wang D, An J, Pan Y, Yan Y, Ma T, He Y, Dugdale J, Hou X, Zhang J, Weroha SJ, Zhu WG, Wang YA, DePinho RA, Xu W, Huang H. Loss of FOXO1 Cooperates with TMPRSS2-ERG Overexpression to Promote Prostate Tumorigenesis and Cell Invasion. Cancer Res. 2017 12 01; 77(23):6524-6537. PMID: 28986382; PMCID: PMC5712249.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    62. Wang Q, Hu B, Hu X, Kim H, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW, Squatrito M, Sauv? CG. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 07 10; 32(1):42-56.e6. PMID: 28697342; PMCID: PMC5599156.
      Citations: 549     Fields:    Translation:HumansCells
    63. Zhao D, DePinho RA. Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer. Bioessays. 2017 08; 39(8). PMID: 28675450; PMCID: PMC8610080.
      Citations: 15     Fields:    Translation:HumansCells
    64. Marchesini M, Ogoti Y, Fiorini E, Aktas Samur A, Nezi L, D'Anca M, Storti P, Samur MK, Ganan-Gomez I, Fulciniti MT, Mistry N, Jiang S, Bao N, Marchica V, Neri A, Bueso-Ramos C, Wu CJ, Zhang L, Liang H, Peng X, Giuliani N, Draetta G, Clise-Dwyer K, Kantarjian H, Munshi N, Orlowski R, Garcia-Manero G, DePinho RA, Colla S. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017 07 10; 32(1):88-100.e6. PMID: 28669490; PMCID: PMC5593798.
      Citations: 51     Fields:    Translation:HumansCells
    65. Sarkar S, Bristow CA, Dey P, Rai K, Perets R, Ramirez-Cardenas A, Malasi S, Huang-Hobbs E, Haemmerle M, Wu SY, McGuire M, Protopopov A, Jiang S, Liu JF, Hirsch MS, Chang Q, Lazar AJ, Sood AK, Drapkin R, DePinho R, Draetta G, Chin L. PRKCI promotes immune suppression in ovarian cancer. Genes Dev. 2017 06 01; 31(11):1109-1121. PMID: 28698296; PMCID: PMC5538434.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    66. Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, Jiang S, Chang Q, Spring DJ, Sharma P, Zebala JA, Maeda DY, Wang YA, DePinho RA. Erratum: Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017 05 03; 545(7652):116. PMID: 28470201.
      Citations: 5     Fields:    
    67. Lu X, Horner JW, Paul E, Shang X, Troncoso P, Deng P, Jiang S, Chang Q, Spring DJ, Sharma P, Zebala JA, Maeda DY, Wang YA, DePinho RA. Effective combinatorial immunotherapy for castration-resistant prostate cancer. Nature. 2017 03 30; 543(7647):728-732. PMID: 28321130; PMCID: PMC5374023.
      Citations: 182     Fields:    Translation:HumansAnimalsCells
    68. Chen CT, Chen YC, Du Y, Han Z, Ying H, Bouchard RR, Hsu JL, Hsu JM, Mitcham TM, Chen MK, Sun HL, Chang SS, Li D, Chang P, DePinho RA, Hung MC. A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. Am J Cancer Res. 2017; 7(3):657-672. PMID: 28401019; PMCID: PMC5385650.
      Citations: 3     
    69. Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, DePinho RA, Huang P, Xu RH, Chiao PJ. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun. 2017 02 24; 8:14437. PMID: 28232723; PMCID: PMC5333128.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    70. Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, Wang YA, Kwong LN, DePinho RA. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev. 2017 02 15; 31(4):370-382. PMID: 28289141; PMCID: PMC5358757.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    71. Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L, Sgambato A. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017 02 16; 542(7641):362-366. PMID: 28178232; PMCID: PMC7609022.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    72. Zhao D, Lu X, Wang G, Lan Z, Liao W, Li J, Liang X, Chen JR, Shah S, Shang X, Tang M, Deng P, Dey P, Chakravarti D, Chen P, Spring DJ, Navone NM, Troncoso P, Zhang J, Wang YA, DePinho RA. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature. 2017 02 23; 542(7642):484-488. PMID: 28166537; PMCID: PMC5448706.
      Citations: 84     Fields:    Translation:HumansCells
    73. Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017 02 02; 542(7639):119-123. PMID: 28099419; PMCID: PMC5398413.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    74. Hu B, Wang Q, Wang YA, Hua S, Ong D, Lan ZD, Chang Q, Ho YW, Monasterio MM, Lu X, Zhong Y, Zhang J, Deng P, Tan Z, Wang G, Liao WT, Corley LJ, Yan H, Zhang J, You Y, Liu N, Cai L, Finocchiaro G, Phillips JJ, Berger MS, Spring DJ, Hu J, Sulman EP, Fuller GN, Chin L, Verhaak RGW, DePinho RA, Sauv? CG. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 2016 11 17; 167(5):1281-1295.e18. PMID: 27863244; PMCID: PMC5320931.
      Citations: 110     Fields:    Translation:HumansCells
    75. Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec; 12(12):1053-1058. PMID: 27723749; PMCID: PMC5110371.
      Citations: 37     Fields:    Translation:HumansCells
    76. Doan KV, Kinyua AW, Yang DJ, Ko CM, Moh SH, Shong KE, Kim H, Park SK, Kim DH, Kim I, Paik JH, DePinho RA, Yoon SG, Kim IY, Seong JK, Choi YH, Kim KW. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016 Sep 29; 7:12733. PMID: 27681312; PMCID: PMC5056402.
      Citations: 19     Fields:    
    77. Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. In?Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep. 2016 06 28; 16(1):133-147. PMID: 27320920.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    78. Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A, DePinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2016 Feb 15; 30(4):355-85. PMID: 26883357; PMCID: PMC4762423.
      Citations: 208     Fields:    Translation:HumansCells
    79. Wang G, Lu X, Dey P, Deng P, Wu CC, Jiang S, Fang Z, Zhao K, Konaparthi R, Hua S, Zhang J, Li-Ning-Tapia EM, Kapoor A, Wu CJ, Patel NB, Guo Z, Ramamoorthy V, Tieu TN, Heffernan T, Zhao D, Shang X, Khadka S, Hou P, Hu B, Jin EJ, Yao W, Pan X, Ding Z, Shi Y, Li L, Chang Q, Troncoso P, Logothetis CJ, McArthur MJ, Chin L, Wang YA, DePinho RA. Targeting YAP-Dependent MDSC Infiltration Impairs Tumor Progression. Cancer Discov. 2016 Jan; 6(1):80-95. PMID: 26701088; PMCID: PMC4707102.
      Citations: 203     Fields:    Translation:HumansAnimalsCells
    80. Muller FL, Aquilanti EA, DePinho RA. Collateral Lethality: A new therapeutic strategy in oncology. Trends Cancer. 2015 Nov 01; 1(3):161-173. PMID: 26870836; PMCID: PMC4746004.
      Citations: 50     Fields:    
    81. Taguchi A, Rho JH, Yan Q, Zhang Y, Zhao Y, Xu H, Tripathi SC, Wang H, Brenner DE, Kucherlapati M, Kucherlapati R, Boutin AT, Wang YA, DePinho RA, Feng Z, Lampe PD, Hanash SM. MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas. Cancer Prev Res (Phila). 2015 Nov; 8(11):1112-9. PMID: 26342024; PMCID: PMC4633385.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    82. Eelen G, Verlinden L, Maes C, Beullens I, Gysemans C, Paik JH, DePinho RA, Bouillon R, Carmeliet G, Verstuyf A. Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation. J Steroid Biochem Mol Biol. 2016 11; 164:337-343. PMID: 26232637.
      Citations: 9     Fields:    Translation:AnimalsCells
    83. O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG. Erratum: FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nat Commun. 2015 Jul 24; 6:7861. PMID: 26206703.
      Citations: 5     Fields:    
    84. Muller F, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee M, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2015 Sep 10; 525(7568):278. PMID: 26153864.
      Citations:    Fields:    
    85. O-Sullivan I, Zhang W, Wasserman DH, Liew CW, Liu J, Paik J, DePinho RA, Stolz DB, Kahn CR, Schwartz MW, Unterman TG. FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nat Commun. 2015 May 12; 6:7079. PMID: 25963540; PMCID: PMC4755301.
      Citations: 90     Fields:    Translation:AnimalsCells
    86. Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 2015 May 11; 27(5):644-57. PMID: 25965571; PMCID: PMC4596059.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    87. Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, Blaauw B, DePinho RA, Sandri M. Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 2015 Apr 10; 6:6670. PMID: 25858807; PMCID: PMC4403316.
      Citations: 253     Fields:    Translation:AnimalsCells
    88. Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res. 2015 Mar 15; 75(6):1091-101. PMID: 25736685; PMCID: PMC4446709.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    89. Lee JH, Anver M, Kost-Alimova M, Protopopov A, DePinho RA, Rane SG. Telomere dysfunction suppresses multiple endocrine neoplasia in mice. Genes Cancer. 2014 Sep; 5(9-10):306-19. PMID: 25352948; PMCID: PMC4209601.
      Citations: 1     
    90. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF, S?nchez N. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014 Oct 30; 514(7524):628-32. PMID: 25119024; PMCID: PMC4376130.
      Citations: 549     Fields:    Translation:AnimalsCells
    91. Ying H, DePinho RA. Cancer signaling: when phosphorylation meets methylation. Cell Res. 2014 Nov; 24(11):1282-3. PMID: 25104733; PMCID: PMC4220151.
      Citations: 3     Fields:    Translation:HumansAnimals
    92. Bardeesy N, DePinho RA, Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 Jul 14; 26(1):14-5. PMID: 25026209; PMCID: PMC4381566.
      Citations: 82     Fields:    Translation:Animals
    93. Zheng X, Zhai B, Koivunen P, Shin SJ, Lu G, Liu J, Geisen C, Chakraborty AA, Moslehi JJ, Smalley DM, Wei X, Chen X, Chen Z, Beres JM, Zhang J, Tsao JL, Brenner MC, Zhang Y, Fan C, DePinho RA, Paik J, Gygi SP, Kaelin WG, Zhang Q. Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev. 2014 Jul 01; 28(13):1429-44. PMID: 24990963; PMCID: PMC4083087.
      Citations: 63     Fields:    Translation:AnimalsCells
    94. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell. 2014 Jul 03; 158(1):185-197. PMID: 24954535; PMCID: PMC4109295.
      Citations: 303     Fields:    Translation:HumansAnimalsCells
    95. Tang H, Inoki K, Lee M, Wright E, Khuong A, Khuong A, Sugiarto S, Garner M, Paik J, DePinho RA, Goldman D, Guan KL, Shrager JB. mTORC1 promotes denervation-induced muscle atrophy through a mechanism involving the activation of FoxO and E3 ubiquitin ligases. Sci Signal. 2014 Feb 25; 7(314):ra18. PMID: 24570486.
      Citations: 53     Fields:    Translation:Animals
    96. Stopczynski RE, Normolle DP, Hartman DJ, Ying H, DeBerry JJ, Bielefeldt K, Rhim AD, DePinho RA, Albers KM, Davis BM. Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Res. 2014 Mar 15; 74(6):1718-27. PMID: 24448244; PMCID: PMC4036226.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    97. Jun S, Lee S, Kim HC, Ng C, Schneider AM, Ji H, Ying H, Wang H, DePinho RA, Park JI. PAF-mediated MAPK signaling hyperactivation via LAMTOR3 induces pancreatic tumorigenesis. Cell Rep. 2013 Oct 31; 5(2):314-22. PMID: 24209743; PMCID: PMC4157353.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    98. Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 2013 Oct 10; 155(2):397-409. PMID: 24120138; PMCID: PMC3850755.
      Citations: 245     Fields:    Translation:HumansAnimalsCells
    99. Hua Y, White-Gilbertson S, Kellner J, Rachidi S, Usmani SZ, Chiosis G, Depinho R, Li Z, Liu B. Molecular chaperone gp96 is a novel therapeutic target of multiple myeloma. Clin Cancer Res. 2013 Nov 15; 19(22):6242-51. PMID: 24077352; PMCID: PMC3851294.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    100. Xiong X, Tao R, DePinho RA, Dong XC. Deletion of hepatic FoxO1/3/4 genes in mice significantly impacts on glucose metabolism through downregulation of gluconeogenesis and upregulation of glycolysis. PLoS One. 2013; 8(8):e74340. PMID: 24015318; PMCID: PMC3755981.
      Citations: 50     Fields:    Translation:AnimalsCells
    101. Tao R, Xiong X, DePinho RA, Deng CX, Dong XC. FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression. J Biol Chem. 2013 Oct 11; 288(41):29252-9. PMID: 23974119; PMCID: PMC3795227.
      Citations: 72     Fields:    Translation:AnimalsCells
    102. Hu J, Ho AL, Yuan L, Hu B, Hua S, Hwang SS, Zhang J, Hu T, Zheng H, Gan B, Wu G, Wang YA, Chin L, DePinho RA. From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14520-7. PMID: 23918370; PMCID: PMC3767545.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    103. Tao R, Xiong X, DePinho RA, Deng CX, Dong XC. Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6. J Lipid Res. 2013 Oct; 54(10):2745-53. PMID: 23881913; PMCID: PMC3770087.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    104. DePinho R. QnAs with Ronald DePinho. Interview by Prashant Nair. Proc Natl Acad Sci U S A. 2013 Sep 03; 110(36):14508-9. PMID: 23868851; PMCID: PMC3767552.
      Citations:    Fields:    Translation:Humans
    105. Mourkioti F, Kustan J, Kraft P, Day JW, Zhao MM, Kost-Alimova M, Protopopov A, DePinho RA, Bernstein D, Meeker AK, Blau HM. Role of telomere dysfunction in cardiac failure in Duchenne muscular dystrophy. Nat Cell Biol. 2013 Aug; 15(8):895-904. PMID: 23831727; PMCID: PMC3774175.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    106. Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R. Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia. 2013 Jul; 15(7):684-93. PMID: 23814481; PMCID: PMC3689232.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    107. Zhang Y, Shin SJ, Liu D, Ivanova E, Foerster F, Ying H, Zheng H, Xiao Y, Chen Z, Protopopov A, Depinho RA, Paik JH. ZNF365 promotes stability of fragile sites and telomeres. Cancer Discov. 2013 Jul; 3(7):798-811. PMID: 23776040; PMCID: PMC3710545.
      Citations: 9     Fields:    Translation:HumansCells
    108. Roudier E, Milkiewicz M, Birot O, Slopack D, Montelius A, Gustafsson T, Paik JH, DePinho RA, Casale GP, Pipinos II, Haas TL. Endothelial FoxO1 is an intrinsic regulator of thrombospondin 1 expression that restrains angiogenesis in ischemic muscle. Angiogenesis. 2013 Oct; 16(4):759-72. PMID: 23677673; PMCID: PMC3822003.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    109. Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B, Clarke CJ, Hannun YA, DePinho RA, Guo XE, Mann JJ, Karsenty G. Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab. 2013 Jun 04; 17(6):901-915. PMID: 23684624; PMCID: PMC3679303.
      Citations: 102     Fields:    Translation:AnimalsCells
    110. Keniry M, Pires MM, Mense S, Lefebvre C, Gan B, Justiano K, Lau YK, Hopkins B, Hodakoski C, Koujak S, Toole J, Fenton F, Calahan A, Califano A, DePinho RA, Maurer M, Parsons R. Survival factor NFIL3 restricts FOXO-induced gene expression in cancer. Genes Dev. 2013 Apr 15; 27(8):916-27. PMID: 23630076; PMCID: PMC3650228.
      Citations: 25     Fields:    Translation:HumansCells
    111. Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013 Apr 04; 496(7443):101-5. PMID: 23535601; PMCID: PMC3656466.
      Citations: 819     Fields:    Translation:HumansCells
    112. Rosborough BR, Matta BM, Lee K, Gan B, DePinho RA, Hackstein H, Boothby M, Turnquist HR, Thomson AW, Ra?ch-Regu? D. Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction. Blood. 2013 May 02; 121(18):3619-30. PMID: 23444404; PMCID: PMC3643762.
      Citations: 30     Fields:    Translation:AnimalsCells
    113. Kopycinska J, Kempinska-Podhorodecka A, Haas T, Elias E, DePinho RA, Paik J, Milkiewicz P, Milkiewicz M. Activation of FoxO3a/Bim axis in patients with Primary Biliary Cirrhosis. Liver Int. 2013 Feb; 33(2):231-8. PMID: 23295054.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    114. Gallagher SJ, Kofman AE, Huszar JM, Dannenberg JH, DePinho RA, Braun RE, Payne CJ. Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia. Dev Biol. 2013 Jan 01; 373(1):83-94. PMID: 23085237; PMCID: PMC3508146.
      Citations: 12     Fields:    Translation:AnimalsCells
    115. Xiong X, Tao R, DePinho RA, Dong XC. The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism. J Biol Chem. 2012 Nov 09; 287(46):39107-14. PMID: 22992773; PMCID: PMC3493951.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    116. Shi X, Wallis AM, Gerard RD, Voelker KA, Grange RW, DePinho RA, Garry MG, Garry DJ. Foxk1 promotes cell proliferation and represses myogenic differentiation by regulating Foxo4 and Mef2. J Cell Sci. 2012 Nov 15; 125(Pt 22):5329-37. PMID: 22956541; PMCID: PMC3561855.
      Citations: 33     Fields:    Translation:AnimalsCells
    117. Kode A, Mosialou I, Silva BC, Rached MT, Zhou B, Wang J, Townes TM, Hen R, DePinho RA, Guo XE, Kousteni S. FOXO1 orchestrates the bone-suppressing function of gut-derived serotonin. J Clin Invest. 2012 Oct; 122(10):3490-503. PMID: 22945629; PMCID: PMC3461930.
      Citations: 28     Fields:    Translation:AnimalsCells
    118. Lu X, Agasti SS, Vinegoni C, Waterman P, DePinho RA, Weissleder R. Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjug Chem. 2012 Sep 19; 23(9):1945-51. PMID: 22917215; PMCID: PMC3775343.
      Citations: 17     Fields:    Translation:Animals
    119. Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012 Aug 16; 488(7411):337-42. PMID: 22895339; PMCID: PMC3712624.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    120. Fenton TR, Nathanson D, Ponte de Albuquerque C, Kuga D, Iwanami A, Dang J, Yang H, Tanaka K, Oba-Shinjo SM, Uno M, Inda MM, Wykosky J, Bachoo RM, James CD, DePinho RA, Vandenberg SR, Zhou H, Marie SK, Mischel PS, Cavenee WK, Furnari FB. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14164-9. PMID: 22891331; PMCID: PMC3435194.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    121. Chen AJ, Paik JH, Zhang H, Shukla SA, Mortensen R, Hu J, Ying H, Hu B, Hurt J, Farny N, Dong C, Xiao Y, Wang YA, Silver PA, Chin L, Vasudevan S, Depinho RA. STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev. 2012 Jul 01; 26(13):1459-72. PMID: 22751500; PMCID: PMC3403014.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    122. Kim KW, Donato J, Berglund ED, Choi YH, Kohno D, Elias CF, Depinho RA, Elmquist JK. FOXO1 in the ventromedial hypothalamus regulates energy balance. J Clin Invest. 2012 Jul; 122(7):2578-89. PMID: 22653058; PMCID: PMC3386826.
      Citations: 60     Fields:    Translation:AnimalsCells
    123. DePinho RA, Sahin E. Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol. 2012 May 16; 13(6):397-404. PMID: 22588366; PMCID: PMC3718675.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    124. Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG, White MF. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metab. 2012 May 02; 15(5):703-12. PMID: 22560222; PMCID: PMC3361909.
      Citations: 31     Fields:    Translation:AnimalsCells
    125. Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 2012 Apr 27; 149(3):656-70. PMID: 22541435; PMCID: PMC3472002.
      Citations: 843     Fields:    Translation:HumansAnimalsCells
    126. Moslehi J, DePinho RA, Sahin E. Telomeres and mitochondria in the aging heart. Circ Res. 2012 Apr 27; 110(9):1226-37. PMID: 22539756; PMCID: PMC3718635.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    127. Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, Dunn IF, Agarwalla PK, Chheda MG, Campos B, Wang A, Brennan C, Ligon KL, Furnari F, Cavenee WK, Depinho RA, Chin L, Hahn WC. Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev. 2012 Apr 15; 26(8):756-84. PMID: 22508724; PMCID: PMC3337451.
      Citations: 276     Fields:    Translation:HumansCells
    128. Talchai C, Xuan S, Kitamura T, DePinho RA, Accili D. Generation of functional insulin-producing cells in the gut by Foxo1 ablation. Nat Genet. 2012 Mar 11; 44(4):406-12, S1. PMID: 22406641; PMCID: PMC3315609.
      Citations: 88     Fields:    Translation:AnimalsCells
    129. Tsuchiya K, Tanaka J, Shuiqing Y, Welch CL, DePinho RA, Tabas I, Tall AR, Goldberg IJ, Accili D. FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis. Cell Metab. 2012 Mar 07; 15(3):372-81. PMID: 22405072; PMCID: PMC3315846.
      Citations: 84     Fields:    Translation:AnimalsCells
    130. Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RA. Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17; 148(4):651-63. PMID: 22341440; PMCID: PMC3286017.
      Citations: 143     Fields:    Translation:HumansAnimalsCells
    131. Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA. Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell. 2012 Mar 02; 148(5):896-907. PMID: 22341455; PMCID: PMC3629723.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    132. Sharma R, Garcia MD, Wada AM, Nolte MJ, Udan RS, Paik JH, DePinho RA, Bartlett JD, Dickinson ME, Poch? RA. Transcription factor FoxO1 is essential for enamel biomineralization. PLoS One. 2012; 7(1):e30357. PMID: 22291941; PMCID: PMC3265481.
      Citations: 8     Fields:    Translation:Animals
    133. DePinho R. Straight talk with... Ronald DePinho. Interview by Rebecca Hersher. Nat Med. 2012 Jan 06; 18(1):9. PMID: 22227654.
      Citations:    Fields:    Translation:Humans
    134. Zhang K, Li L, Qi Y, Zhu X, Gan B, DePinho RA, Averitt T, Guo S. Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice. Endocrinology. 2012 Feb; 153(2):631-46. PMID: 22147007; PMCID: PMC5393302.
      Citations: 73     Fields:    Translation:AnimalsCells
    135. Martin NE, Mucci LA, Loda M, Depinho RA. Prognostic determinants in prostate cancer. Cancer J. 2011 Nov-Dec; 17(6):429-37. PMID: 22157287; PMCID: PMC3240856.
      Citations: 23     Fields:    Translation:HumansAnimals
    136. Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM, Fa?a VM. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 2011 Sep 13; 20(3):289-99. PMID: 21907921; PMCID: PMC3406925.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    137. Bass AJ, Lawrence MS, Brace LE, Ramos AH, Drier Y, Cibulskis K, Sougnez C, Voet D, Saksena G, Sivachenko A, Jing R, Parkin M, Pugh T, Verhaak RG, Stransky N, Boutin AT, Barretina J, Solit DB, Vakiani E, Shao W, Mishina Y, Warmuth M, Jimenez J, Chiang DY, Signoretti S, Kaelin WG, Spardy N, Hahn WC, Hoshida Y, Ogino S, DePinho RA, Chin L, Garraway LA, Fuchs CS, Baselga J, Tabernero J, Gabriel S, Lander ES, Getz G, Meyerson M. Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion. Nat Genet. 2011 Sep 04; 43(10):964-968. PMID: 21892161; PMCID: PMC3802528.
      Citations: 172     Fields:    Translation:HumansCells
    138. Sykes SM, Lane SW, Bullinger L, Kalaitzidis D, Yusuf R, Saez B, Ferraro F, Mercier F, Singh H, Brumme KM, Acharya SS, Scholl C, Tothova Z, Attar EC, DePinho RA, Armstrong SA, Gilliland DG, Scadden DT, Sch?ll C, Fr?hling S. AKT/FOXO signaling enforces reversible differentiation blockade in myeloid leukemias. Cell. 2011 Sep 02; 146(5):697-708. PMID: 21884932; PMCID: PMC3826540.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    139. Draetta GF, Depinho RA. Cancer drug discovery faces the FACT. Sci Transl Med. 2011 Aug 10; 3(95):95ps34. PMID: 21832237.
      Citations: 4     Fields:    Translation:HumansAnimals
    140. Scott KL, Nogueira C, Heffernan TP, van Doorn R, Dhakal S, Hanna JA, Min C, Jaskelioff M, Xiao Y, Wu CJ, Cameron LA, Perry SR, Zeid R, Feinberg T, Kim M, Vande Woude G, Granter SR, Bosenberg M, Chu GC, DePinho RA, Rimm DL, Chin L. Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell. 2011 Jul 12; 20(1):92-103. PMID: 21741599; PMCID: PMC3176328.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    141. Cornejo MG, Mabialah V, Sykes SM, Khandan T, Lo Celso C, Rameau P, Tothova Z, Aster JC, DePinho RA, Scadden DT, Gilliland DG, Mercher T, Lopez CK, Rivera-Mu?oz P. Crosstalk between NOTCH and AKT signaling during murine megakaryocyte lineage specification. Blood. 2011 Aug 04; 118(5):1264-73. PMID: 21653327; PMCID: PMC3152494.
      Citations: 36     Fields:    Translation:AnimalsCells
    142. Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA. PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-?B-cytokine network. Cancer Discov. 2011 Jul; 1(2):158-69. PMID: 21984975; PMCID: PMC3186945.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    143. Tao R, Wei D, Gao H, Liu Y, DePinho RA, Dong XC. Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene. J Biol Chem. 2011 Apr 22; 286(16):14681-90. PMID: 21388966; PMCID: PMC3077665.
      Citations: 69     Fields:    Translation:HumansAnimals
    144. Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, Maser RS, Zhai B, Wan L, Gutierrez A, Lau AW, Xiao Y, Christie AL, Aster J, Settleman J, Gygi SP, Kung AL, Look T, Nakayama KI, DePinho RA, Wei W. SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature. 2011 Mar 03; 471(7336):104-9. PMID: 21368833; PMCID: PMC3076007.
      Citations: 337     Fields:    Translation:HumansAnimalsCells
    145. Colla S, Liesa M, Moslehi J, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA, Sahin E, M?ller FL. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65. PMID: 21307849; PMCID: PMC3741661.
      Citations: 555     Fields:    Translation:AnimalsCells
    146. Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR, Shahinian A, Lang PA, Lang KS, Morre M, Assouline B, Lahl K, Sparwasser T, Tedder TF, Paik JH, DePinho RA, Basta S, Ohashi PS, Mak TW. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell. 2011 Feb 18; 144(4):601-13. PMID: 21295337.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    147. Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 2011 Feb 10; 470(7333):269-73. PMID: 21289624; PMCID: PMC3753179.
      Citations: 276     Fields:    Translation:HumansAnimals
    148. Stegh AH, DePinho RA. Beyond effector caspase inhibition: Bcl2L12 neutralizes p53 signaling in glioblastoma. Cell Cycle. 2011 Jan 01; 10(1):33-8. PMID: 21200141; PMCID: PMC3048071.
      Citations: 31     Fields:    Translation:HumansAnimals
    149. Sengupta A, Molkentin JD, Paik JH, DePinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem. 2011 Mar 04; 286(9):7468-78. PMID: 21159781; PMCID: PMC3045002.
      Citations: 144     Fields:    Translation:AnimalsCells
    150. Jia W, Wang S, Horner JW, Wang N, Wang H, Gunther EJ, DePinho RA, Zhu J. A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. FASEB J. 2011 Mar; 25(3):979-89. PMID: 21135040; PMCID: PMC3042838.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    151. Gan B, Hu J, Jiang S, Liu Y, Zhuang L, Fletcher-Sananikone E, Colla S, Wang YA, Chin L, Depinho RA, Sahin E. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature. 2010 Dec 02; 468(7324):701-4. PMID: 21124456; PMCID: PMC3058342.
      Citations: 227     Fields:    Translation:AnimalsCells
    152. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Horner JW, Maratos-Flier E, Depinho RA, Cadi?anos J. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 06; 469(7328):102-6. PMID: 21113150; PMCID: PMC3057569.
      Citations: 309     Fields:    Translation:AnimalsCells
    153. Gan B, Lim C, Chu G, Hua S, Ding Z, Collins M, Hu J, Jiang S, Fletcher-Sananikone E, Zhuang L, Chang M, Zheng H, Wang YA, Kwiatkowski DJ, Kaelin WG, Signoretti S, DePinho RA. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell. 2010 Nov 16; 18(5):472-84. PMID: 21075312; PMCID: PMC3023886.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    154. Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res. 2010 Dec 10; 107(12):1470-82. PMID: 20947830; PMCID: PMC3011986.
      Citations: 299     Fields:    Translation:AnimalsCells
    155. Dentice M, Marsili A, Ambrosio R, Guardiola O, Sibilio A, Paik JH, Minchiotti G, DePinho RA, Fenzi G, Larsen PR, Salvatore D. The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration. J Clin Invest. 2010 Nov; 120(11):4021-30. PMID: 20978344; PMCID: PMC2964991.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    156. Stegh AH, Brennan C, Mahoney JA, Forloney KL, Jenq HT, Luciano JP, Protopopov A, Chin L, Depinho RA. Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev. 2010 Oct 01; 24(19):2194-204. PMID: 20837658; PMCID: PMC2947771.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    157. Cancer Target Discovery and Development Network, Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, Sordella R, Stein L, Trotman LC, Califano A, Dalla-Favera R, Ferrando A, Iavarone A, Pasqualucci L, Stockwell BR, Hahn WC, Chin L, DePinho RA, Boehm JS, Gopal S, Huang A, Root DE, Weir BA, Gerhard DS, Zenklusen JC, Roth MG, White MA, Minna JD, MacMillan JB, Posner BA, Silva J. Towards patient-based cancer therapeutics. Nat Biotechnol. 2010 Sep; 28(9):904-6. PMID: 20829823; PMCID: PMC2939009.
      Citations: 40     Fields:    Translation:HumansAnimals
    158. Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, Tan P, Depinho RA, Cavenee W, Furnari F. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev. 2010 Aug 15; 24(16):1731-45. PMID: 20713517; PMCID: PMC2922502.
      Citations: 258     Fields:    Translation:HumansAnimalsCells
    159. Monahan KB, Rozenberg GI, Krishnamurthy J, Johnson SM, Liu W, Bradford MK, Horner J, Depinho RA, Sharpless NE. Somatic p16(INK4a) loss accelerates melanomagenesis. Oncogene. 2010 Oct 28; 29(43):5809-17. PMID: 20697345; PMCID: PMC3007178.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    160. Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE. Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells. 2010 Aug; 28(8):1424-34. PMID: 20572009; PMCID: PMC3174062.
      Citations: 34     Fields:    Translation:AnimalsCells
    161. Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell. 2010 Jul 23; 142(2):296-308. PMID: 20655470; PMCID: PMC2910411.
      Citations: 448     Fields:    Translation:HumansAnimalsCells
    162. Wilting RH, Yanover E, Heideman MR, Jacobs H, Horner J, van der Torre J, DePinho RA, Dannenberg JH. Overlapping functions of Hdac1 and Hdac2 in cell cycle regulation and haematopoiesis. EMBO J. 2010 Aug 04; 29(15):2586-97. PMID: 20571512; PMCID: PMC2928690.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    163. Nitta M, Kozono D, Kennedy R, Stommel J, Ng K, Zinn PO, Kushwaha D, Kesari S, Inda MM, Wykosky J, Furnari F, Hoadley KA, Chin L, DePinho RA, Cavenee WK, D'Andrea A, Chen CC. Targeting EGFR induced oxidative stress by PARP1 inhibition in glioblastoma therapy. PLoS One. 2010 May 24; 5(5):e10767. PMID: 20532243; PMCID: PMC2879424.
      Citations: 37     Fields:    Translation:HumansCells
    164. Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RA. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 2010 May 18; 17(5):497-509. PMID: 20478531; PMCID: PMC2900858.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    165. Ouyang W, Beckett O, Ma Q, Paik JH, DePinho RA, Li MO. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat Immunol. 2010 Jul; 11(7):618-27. PMID: 20467422.
      Citations: 249     Fields:    Translation:AnimalsCells
    166. Harada Y, Harada Y, Elly C, Ying G, Paik JH, DePinho RA, Liu YC. Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells. J Exp Med. 2010 Jul 05; 207(7):1381-91. PMID: 20439537; PMCID: PMC2901074.
      Citations: 148     Fields:    Translation:HumansAnimalsCells
    167. International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, Barker AD, Bell C, Bhan MK, Calvo F, Eerola I, Gerhard DS, Guttmacher A, Guyer M, Hemsley FM, Jennings JL, Kerr D, Klatt P, Kolar P, Kusada J, Lane DP, Laplace F, Youyong L, Nettekoven G, Ozenberger B, Peterson J, Rao TS, Remacle J, Schafer AJ, Shibata T, Stratton MR, Vockley JG, Watanabe K, Yang H, Yuen MM, Knoppers BM, Bobrow M, Cambon-Thomsen A, Dressler LG, Dyke SO, Joly Y, Kato K, Kennedy KL, Parker MJ, Rial-Sebbag E, Romeo-Casabona CM, Shaw KM, Wallace S, Wiesner GL, Zeps N, Lichter P, Biankin AV, Chabannon C, Chin L, de Alava E, Ferguson ML, Geary P, Hayes DN, Johns AL, Kasprzyk A, Nakagawa H, Penny R, Piris MA, Sarin R, Scarpa A, van de Vijver M, Futreal PA, Aburatani H, Botwell DD, Campbell PJ, Estivill X, Grimmond SM, Gut I, Hirst M, Majumder P, Marra M, McPherson JD, Ning Z, Puente XS, Ruan Y, Stunnenberg HG, Swerdlow H, Velculescu VE, Wilson RK, Xue HH, Yang L, Spellman PT, Bader GD, Boutros PC, Flicek P, Getz G, Guo G, Haussler D, Heath S, Hubbard TJ, Jiang T, Jones SM, Li Q, Luo R, Muthuswamy L, Ouellette BF, Pearson JV, Quesada V, Raphael BJ, Sander C, Speed TP, Stein LD, Stuart JM, Teague JW, Totoki Y, Tsunoda T, Valencia A, Wheeler DA, Wu H, Zhao S, Zhou G, Lathrop M, Thomas G, Yoshida T, Axton M, Gunter C, Miller LJ, Zhang J, Haider SA, Wang J, Yung CK, Cros A, Cross A, Liang Y, Gnaneshan S, Guberman J, Hsu J, Chalmers DR, Hasel KW, Kaan TS, Lowrance WW, Masui T, Rodriguez LL, Vergely C, Bowtell DD, Cloonan N, deFazio A, Eshleman JR, Etemadmoghadam D, Gardiner BB, Gardiner BA, Kench JG, Sutherland RL, Tempero MA, Waddell NJ, Wilson PJ, Gallinger S, Tsao MS, Shaw PA, Petersen GM, Mukhopadhyay D, DePinho RA, Thayer S, Shazand K, Beck T, Sam M, Timms L, Ballin V, Lu Y, Ji J, Zhang X, Chen F, Hu X, Yang Q, Tian G, Zhang L, Xing X, Li X, Zhu Z, Yu Y, Yu J, Brennan P, Holcatova I, Zaridze D, Brazma A, Egevard L, Prokhortchouk E, Banks RE, Viksna J, Ponten F, Skryabin K, Birney E, Borg A, Caldas C, Foekens JA, Martin S, Reis-Filho JS, Richardson AL, Sotiriou C, Thoms G, van't Veer L, Birnbaum D, Boucher P, Boyault S, Masson-Jacquemier JD, Pivot X, Vincent-Salomon A, Tabone E, Theillet C, Treilleux I, Bioulac-Sage P, Decaens T, Franco D, Gut M, Samuel D, Zucman-Rossi J, Eils R, Brors B, Korbel JO, Korshunov A, Landgraf P, Lehrach H, Pfister S, Radlwimmer B, Reifenberger G, Taylor MD, von Kalle C, Majumder PP, Pederzoli P, Lawlor RA, Delledonne M, Bardelli A, Gress T, Klimstra D, Zamboni G, Nakamura Y, Miyano S, Fujimoto A, Campo E, Montserrat E, Jares P, Himmelbauer H, Himmelbaue H, Bea S, Aparicio S, Easton DF, Collins FS, Compton CC, Lander ES, Burke W, Green AR, Hamilton SR, Kallioniemi OP, Ley TJ, Liu ET, Wainwright BJ, Bernab? RR, Nicol?s P, Cl?ment B, Degos F, Bay?s M, L?pez-Ot?n C, Guig? R, L?pez-Bigas N, Tost J, Uhl?n M, B?rresen-Dale AL, Blanche H, Pauport? I, de Sanjos? S, Gonz?lez-D?az M. International network of cancer genome projects. Nature. 2010 Apr 15; 464(7291):993-8. PMID: 20393554; PMCID: PMC2902243.
      Citations: 1005     Fields:    Translation:HumansCells
    168. Ying H, Zheng H, Scott K, Wiedemeyer R, Yan H, Lim C, Huang J, Dhakal S, Ivanova E, Xiao Y, Zhang H, Hu J, Stommel JM, Lee MA, Chen AJ, Paik JH, Segatto O, Brennan C, Elferink LA, Wang YA, Chin L, DePinho RA. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A. 2010 Apr 13; 107(15):6912-7. PMID: 20351267; PMCID: PMC2872443.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    169. Depinho RA, Sahin E. Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature. 2010 Mar 25; 464(7288):520-8. PMID: 20336134; PMCID: PMC3733214.
      Citations: 293     Fields:    Translation:HumansAnimalsCells
    170. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21. PMID: 20351400; PMCID: PMC2871240.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    171. Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010 Feb 03; 11(2):136-46. PMID: 20142101; PMCID: PMC2819984.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    172. Rached MT, Kode A, Xu L, Yoshikawa Y, Paik JH, Depinho RA, Kousteni S. FoxO1 is a positive regulator of bone formation by favoring protein synthesis and resistance to oxidative stress in osteoblasts. Cell Metab. 2010 Feb 03; 11(2):147-60. PMID: 20142102; PMCID: PMC2820405.
      Citations: 144     Fields:    Translation:AnimalsCells
    173. Zhou Y, Rideout WM, Zi T, Bressel A, Reddypalli S, Rancourt R, Woo JK, Horner JW, Chin L, Chiu MI, Bosenberg M, Jacks T, Clark SC, Depinho RA, Robinson MO, Heyer J. Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nat Biotechnol. 2010 Jan; 28(1):71-8. PMID: 20023657.
      Citations: 31     Fields:    Translation:AnimalsCells
    174. Rached MT, Kode A, Silva BC, Jung DY, Gray S, Ong H, Paik JH, DePinho RA, Kim JK, Karsenty G, Kousteni S. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice. J Clin Invest. 2010 Jan; 120(1):357-68. PMID: 20038793; PMCID: PMC2798687.
      Citations: 104     Fields:    Translation:AnimalsCells
    175. Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell. 2009 Nov 06; 16(5):379-89. PMID: 19878870; PMCID: PMC3048064.
      Citations: 166     Fields:    Translation:HumansAnimalsCells
    176. Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 06; 5(5):540-53. PMID: 19896444; PMCID: PMC3285492.
      Citations: 222     Fields:    Translation:AnimalsCells
    177. Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis. 2010 Jan; 31(1):9-18. PMID: 19887512; PMCID: PMC3003493.
      Citations: 300     Fields:    Translation:HumansAnimalsCells
    178. Srinivasan L, Sasaki Y, Calado DP, Zhang B, Paik JH, DePinho RA, Kutok JL, Kearney JF, Otipoby KL, Rajewsky K. PI3 kinase signals BCR-dependent mature B cell survival. Cell. 2009 Oct 30; 139(3):573-86. PMID: 19879843; PMCID: PMC2787092.
      Citations: 333     Fields:    Translation:AnimalsCells
    179. Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nat Med. 2009 Nov; 15(11):1307-11. PMID: 19838201; PMCID: PMC3994712.
      Citations: 144     Fields:    Translation:AnimalsCells
    180. Plum L, Lin HV, Dutia R, Tanaka J, Aizawa KS, Matsumoto M, Kim AJ, Cawley NX, Paik JH, Loh YP, DePinho RA, Wardlaw SL, Accili D. The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake. Nat Med. 2009 Oct; 15(10):1195-201. PMID: 19767734; PMCID: PMC2777744.
      Citations: 80     Fields:    Translation:AnimalsCells
    181. Maher EA, Mietz J, Arteaga CL, DePinho RA, Mohla S. Brain metastasis: opportunities in basic and translational research. Cancer Res. 2009 Aug 01; 69(15):6015-20. PMID: 19638593.
      Citations: 46     Fields:    Translation:HumansAnimals
    182. Tanaka J, Qiang L, Banks AS, Welch CL, Matsumoto M, Kitamura T, Ido-Kitamura Y, DePinho RA, Accili D. Foxo1 links hyperglycemia to LDL oxidation and endothelial nitric oxide synthase dysfunction in vascular endothelial cells. Diabetes. 2009 Oct; 58(10):2344-54. PMID: 19584310; PMCID: PMC2750207.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    183. Zhou W, Cao Q, Peng Y, Zhang QJ, Castrillon DH, DePinho RA, Liu ZP. FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation. Gastroenterology. 2009 Oct; 137(4):1403-14. PMID: 19560465; PMCID: PMC2764529.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    184. Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D. Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. Mol Cell Biol. 2009 Aug; 29(16):4417-30. PMID: 19506018; PMCID: PMC2725741.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    185. Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature. 2009 May 07; 459(7243):55-60. PMID: 19424149; PMCID: PMC3498958.
      Citations: 712     Fields:    Translation:AnimalsCells
    186. Wu M, Jung L, Cooper AB, Fleet C, Chen L, Breault L, Clark K, Cai Z, Vincent S, Bottega S, Shen Q, Richardson A, Bosenburg M, Naber SP, DePinho RA, Kuperwasser C, Robinson MO. Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7022-7. PMID: 19369208; PMCID: PMC2669443.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    187. Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nat Immunol. 2009 May; 10(5):504-13. PMID: 19363483; PMCID: PMC2712214.
      Citations: 120     Fields:    Translation:AnimalsCells
    188. Gan B, DePinho RA. mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle. 2009 Apr 01; 8(7):1003-6. PMID: 19270523; PMCID: PMC2743144.
      Citations: 60     Fields:    Translation:AnimalsCells
    189. van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O'Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009 May; 41(5):521-3. PMID: 19330029; PMCID: PMC2873835.
      Citations: 371     Fields:    Translation:Humans
    190. Dankort D, Curley DP, Cartlidge RA, Nelson B, Karnezis AN, Damsky WE, You MJ, DePinho RA, McMahon M, Bosenberg M. Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet. 2009 May; 41(5):544-52. PMID: 19282848; PMCID: PMC2705918.
      Citations: 542     Fields:    Translation:AnimalsCells
    191. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA. Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma. Cold Spring Harb Symp Quant Biol. 2008; 73:427-37. PMID: 19150964.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    192. Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nat Immunol. 2009 Feb; 10(2):176-84. PMID: 19136962; PMCID: PMC2856471.
      Citations: 285     Fields:    Translation:AnimalsCells
    193. Menon R, Zhang Q, Zhang Y, Fermin D, Bardeesy N, DePinho RA, Lu C, Hanash SM, Omenn GS, States DJ. Identification of novel alternative splice isoforms of circulating proteins in a mouse model of human pancreatic cancer. Cancer Res. 2009 Jan 01; 69(1):300-9. PMID: 19118015; PMCID: PMC2613545.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    194. Gan B, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA, Sahin E. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19384-9. PMID: 19052232; PMCID: PMC2593615.
      Citations: 123     Fields:    Translation:AnimalsCells
    195. Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19372-7. PMID: 19050074; PMCID: PMC2614768.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    196. Dengler HS, Baracho GV, Omori SA, Bruckner S, Arden KC, Castrillon DH, DePinho RA, Rickert RC. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol. 2008 Dec; 9(12):1388-98. PMID: 18978794; PMCID: PMC2679692.
      Citations: 175     Fields:    Translation:AnimalsCells
    197. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008 Oct 23; 455(7216):1129-33. PMID: 18948956; PMCID: PMC4051433.
      Citations: 368     Fields:    Translation:HumansAnimalsCells
    198. Hu P, Geles KG, Paik JH, DePinho RA, Tjian R. Codependent activators direct myoblast-specific MyoD transcription. Dev Cell. 2008 Oct; 15(4):534-46. PMID: 18854138; PMCID: PMC2614327.
      Citations: 63     Fields:    Translation:AnimalsCells
    199. Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, Li X. Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. Biol Psychiatry. 2009 Jan 15; 65(2):150-9. PMID: 18823877; PMCID: PMC2630515.
      Citations: 52     Fields:    Translation:AnimalsCells
    200. Stegh AH, Chin L, Louis DN, DePinho RA. What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator. Cell Cycle. 2008 Sep 15; 7(18):2833-9. PMID: 18769159.
      Citations: 28     Fields:    Translation:HumansCells
    201. Senokuchi T, Liang CP, Seimon TA, Han S, Matsumoto M, Banks AS, Paik JH, DePinho RA, Accili D, Tabas I, Tall AR. Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress. Diabetes. 2008 Nov; 57(11):2967-76. PMID: 18728232; PMCID: PMC2570393.
      Citations: 41     Fields:    Translation:AnimalsCells
    202. Jeon HM, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev. 2008 Aug 01; 22(15):2028-33. PMID: 18676808; PMCID: PMC2492750.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    203. Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, Louis DN, Chin L, DePinho RA. Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10703-8. PMID: 18669646; PMCID: PMC2504776.
      Citations: 66     Fields:    Translation:HumansCells
    204. Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metab. 2008 Jul; 8(1):65-76. PMID: 18590693; PMCID: PMC2929667.
      Citations: 207     Fields:    Translation:AnimalsCells
    205. Faca VM, Song KS, Wang H, Zhang Q, Krasnoselsky AL, Newcomb LF, Plentz RR, Gurumurthy S, Redston MS, Pitteri SJ, Pereira-Faca SR, Ireton RC, Katayama H, Glukhova V, Phanstiel D, Brenner DE, Anderson MA, Misek D, Scholler N, Urban ND, Barnett MJ, Edelstein C, Goodman GE, Thornquist MD, McIntosh MW, DePinho RA, Bardeesy N, Hanash SM. A mouse to human search for plasma proteome changes associated with pancreatic tumor development. PLoS Med. 2008 Jun 10; 5(6):e123. PMID: 18547137; PMCID: PMC2504036.
      Citations: 108     Fields:    Translation:HumansAnimals
    206. Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS, States DJ, Hanash SM. A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol. 2008; 9(6):R93. PMID: 18522751; PMCID: PMC2481425.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    207. Herzog S, Hug E, Meixlsperger S, Paik JH, DePinho RA, Reth M, Jumaa H. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat Immunol. 2008 Jun; 9(6):623-31. PMID: 18488031.
      Citations: 86     Fields:    Translation:HumansCells
    208. Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R. Targeted nanoparticles for imaging incipient pancreatic ductal adenocarcinoma. PLoS Med. 2008 Apr 15; 5(4):e85. PMID: 18416599; PMCID: PMC2292750.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    209. Aghi M, Visted T, Depinho RA, Chiocca EA. Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16. Oncogene. 2008 Jul 10; 27(30):4249-54. PMID: 18345032; PMCID: PMC7100519.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    210. David G, Grandinetti KB, Finnerty PM, Simpson N, Chu GC, Depinho RA. Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4168-72. PMID: 18332431; PMCID: PMC2393767.
      Citations: 72     Fields:    Translation:AnimalsCells
    211. Katajisto P, Vaahtomeri K, Ekman N, Bardeesy N, Feil R, DePinho RA, Ventel? E, Ristim?ki A, M?kel? TP. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet. 2008 Apr; 40(4):455-9. PMID: 18311138.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    212. Perera SA, Maser RS, Xia H, McNamara K, Protopopov A, Chen L, Hezel AF, Kim CF, Bronson RT, Castrillon DH, Chin L, Bardeesy N, Depinho RA, Wong KK. Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer. Carcinogenesis. 2008 Apr; 29(4):747-53. PMID: 18283039.
      Citations: 26     Fields:    Translation:AnimalsCells
    213. Konopka G, Puram SV, Chan JA, Bachoo RM, You MJ, Levy DE, Depinho RA, Bonni A, de la Iglesia N. Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway. Genes Dev. 2008 Feb 15; 22(4):449-62. PMID: 18258752; PMCID: PMC2238667.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    214. Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA. Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol. 2008 Apr; 28(7):2414-25. PMID: 18227155; PMCID: PMC2268441.
      Citations: 80     Fields:    Translation:AnimalsCells
    215. O'Neil J, Tchinda J, Gutierrez A, Moreau L, Maser RS, Wong KK, Li W, McKenna K, Liu XS, Feng B, Neuberg D, Silverman L, DeAngelo DJ, Kutok JL, Rothstein R, DePinho RA, Chin L, Lee C, Look AT. Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med. 2007 Dec 24; 204(13):3059-66. PMID: 18070937; PMCID: PMC2150982.
      Citations: 44     Fields:    Translation:HumansCells
    216. Kim TK, Lee JS, Oh SY, Jin X, Choi YJ, Lee TH, Lee Eh, Choi YK, You S, Chung YG, Lee JB, DePinho RA, Chin L, Kim H. Direct transcriptional activation of promyelocytic leukemia protein by IFN regulatory factor 3 induces the p53-dependent growth inhibition of cancer cells. Cancer Res. 2007 Dec 01; 67(23):11133-40. PMID: 18056437.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    217. Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K, Kucherlapati R, Bailey G, Redston M, Chin L, DePinho RA. Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res. 2007 Nov 15; 67(22):10736-43. PMID: 18006816.
      Citations: 39     Fields:    Translation:HumansCells
    218. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev. 2007 Nov 01; 21(21):2683-710. PMID: 17974913.
      Citations: 1044     Fields:    Translation:HumansAnimals
    219. Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C, Chin L, DePinho RA. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science. 2007 Oct 12; 318(5848):287-90. PMID: 17872411.
      Citations: 449     Fields:    Translation:HumansCells
    220. Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007 Sep; 8(9):703-13. PMID: 17717515.
      Citations: 366     Fields:    Translation:HumansAnimalsCells
    221. Matsumoto M, Pocai A, Rossetti L, Depinho RA, Accili D. Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor Foxo1 in liver. Cell Metab. 2007 Sep; 6(3):208-16. PMID: 17767907.
      Citations: 302     Fields:    Translation:AnimalsCells
    222. Kitamura T, Kitamura YI, Funahashi Y, Shawber CJ, Castrillon DH, Kollipara R, DePinho RA, Kitajewski J, Accili D. A Foxo/Notch pathway controls myogenic differentiation and fiber type specification. J Clin Invest. 2007 Sep; 117(9):2477-85. PMID: 17717603; PMCID: PMC1950461.
      Citations: 144     Fields:    Translation:AnimalsCells
    223. Chu GC, Kimmelman AC, Hezel AF, DePinho RA. Stromal biology of pancreatic cancer. J Cell Biochem. 2007 Jul 01; 101(4):887-907. PMID: 17266048.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    224. Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10968-73. PMID: 17576930; PMCID: PMC1904138.
      Citations: 55     Fields:    Translation:AnimalsCells
    225. Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I, Lin E, Mani V, Jiang S, McNamara K, Zaghlul S, Edkins S, Stevens C, Brennan C, Martin ES, Wiedemeyer R, Kabbarah O, Nogueira C, Histen G, Aster J, Mansour M, Duke V, Foroni L, Fielding AK, Goldstone AH, Rowe JM, Wang YA, Look AT, Stratton MR, Chin L, Futreal PA, DePinho RA. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007 Jun 21; 447(7147):966-71. PMID: 17515920; PMCID: PMC2714968.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    226. Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS, Munshi N, Horner J, Ivanova EV, Protopopov A, Anderson KC, Tonon G, DePinho RA. The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell. 2007 Apr; 11(4):349-60. PMID: 17418411; PMCID: PMC1885943.
      Citations: 196     Fields:    Translation:HumansAnimalsCells
    227. Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, Depinho RA. Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):3931-6. PMID: 17360455; PMCID: PMC1820686.
      Citations: 27     Fields:    Translation:AnimalsCells
    228. Podar K, Raab MS, Tonon G, Sattler M, Zhang J, Tai YT, Yasui H, Raje N, DePinho RA, Hideshima T, Chauhan D, Anderson KC, Baril? D. Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma. Cancer Res. 2007 Feb 15; 67(4):1680-8. PMID: 17308109.
      Citations: 35     Fields:    Translation:HumansCells
    229. Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007 Feb 15; 53(4):503-17. PMID: 17296553; PMCID: PMC1810344.
      Citations: 256     Fields:    Translation:AnimalsCells
    230. Sharpless NE, DePinho RA. Cancer biology: gone but not forgotten. Nature. 2007 Feb 08; 445(7128):606-7. PMID: 17251931.
      Citations: 14     Fields:    Translation:HumansAnimals
    231. Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR, Jiang S, Gilliland DG, Chin L, Wong WH, Castrillon DH, DePinho RA. FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell. 2007 Jan 26; 128(2):309-23. PMID: 17254969; PMCID: PMC1855089.
      Citations: 535     Fields:    Translation:AnimalsCells
    232. Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, Armstrong SA, DePinho RA, Gilliland DG, Passegu? E. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell. 2007 Jan 26; 128(2):325-39. PMID: 17254970.
      Citations: 766     Fields:    Translation:AnimalsCells
    233. Li H, Liang J, Castrillon DH, DePinho RA, Olson EN, Liu ZP. FoxO4 regulates tumor necrosis factor alpha-directed smooth muscle cell migration by activating matrix metalloproteinase 9 gene transcription. Mol Cell Biol. 2007 Apr; 27(7):2676-86. PMID: 17242183; PMCID: PMC1899894.
      Citations: 51     Fields:    Translation:AnimalsCells
    234. Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN, DePinho RA, Chin L. Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev. 2007 Jan 01; 21(1):98-111. PMID: 17210792; PMCID: PMC1759904.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    235. Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA. DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol. 2007 Mar; 27(6):2253-65. PMID: 17145779; PMCID: PMC1820500.
      Citations: 42     Fields:    Translation:AnimalsCells
    236. Maher EA, Brennan C, Wen PY, Durso L, Ligon KL, Richardson A, Khatry D, Feng B, Sinha R, Louis DN, Quackenbush J, Black PM, Chin L, DePinho RA. Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res. 2006 Dec 01; 66(23):11502-13. PMID: 17114236.
      Citations: 81     Fields:    Translation:HumansCells
    237. Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 2006 Nov 15; 20(22):3130-46. PMID: 17114584; PMCID: PMC1635148.
      Citations: 314     Fields:    Translation:AnimalsCells
    238. Liu F, Park PJ, Lai W, Maher E, Chakravarti A, Durso L, Jiang X, Yu Y, Brosius A, Thomas M, Chin L, Brennan C, DePinho RA, Kohane I, Carroll RS, Black PM, Johnson MD. A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res. 2006 Nov 15; 66(22):10815-23. PMID: 17090523.
      Citations: 55     Fields:    Translation:HumansCells
    239. Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S, Welsh R, DePinho RA. Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres. Oncogene. 2007 May 03; 26(20):2815-21. PMID: 17072335.
      Citations: 4     Fields:    Translation:AnimalsCells
    240. Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006 Sep 28; 443(7110):421-6. PMID: 16957735.
      Citations: 485     Fields:    Translation:AnimalsCells
    241. Sharpless NE, Depinho RA. The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov. 2006 Sep; 5(9):741-54. PMID: 16915232.
      Citations: 258     Fields:    Translation:HumansAnimals
    242. Okumura K, Mendoza M, Bachoo RM, DePinho RA, Cavenee WK, Furnari FB. PCAF modulates PTEN activity. J Biol Chem. 2006 Sep 08; 281(36):26562-8. PMID: 16829519.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    243. Farazi PA, Zeisberg M, Glickman J, Zhang Y, Kalluri R, DePinho RA. Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice. Cancer Res. 2006 Jul 01; 66(13):6622-7. PMID: 16818635.
      Citations: 43     Fields:    Translation:AnimalsCells
    244. Dickie R, Bachoo RM, Rupnick MA, Dallabrida SM, Deloid GM, Lai J, Depinho RA, Rogers RA. Three-dimensional visualization of microvessel architecture of whole-mount tissue by confocal microscopy. Microvasc Res. 2006 Jul-Sep; 72(1-2):20-6. PMID: 16806289.
      Citations: 35     Fields:    Translation:AnimalsCells
    245. David G, Dannenberg JH, Simpson N, Finnerty PM, Miao L, Turner GM, Ding Z, Carrasco R, Depinho RA. Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53. Oncogene. 2006 Nov 30; 25(56):7354-60. PMID: 16767157.
      Citations: 6     Fields:    Translation:AnimalsCells
    246. Hezel AF, Kimmelman AC, Stanger BZ, Bardeesy N, Depinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2006 May 15; 20(10):1218-49. PMID: 16702400.
      Citations: 528     Fields:    Translation:HumansAnimals
    247. Farazi PA, Glickman J, Horner J, Depinho RA. Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. Cancer Res. 2006 May 01; 66(9):4766-73. PMID: 16651430.
      Citations: 46     Fields:    Translation:AnimalsCells
    248. Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Divicio D, Nogueira C, Stommel J, Pinkus GS, Fletcher C, Hornick JL, Cavenee WK, Furnari FB, Depinho RA. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell. 2006 May; 9(5):379-90. PMID: 16697958.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    249. Bosenberg M, Muthusamy V, Curley DP, Wang Z, Hobbs C, Nelson B, Nogueira C, Horner JW, Depinho R, Chin L. Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis. 2006 May; 44(5):262-7. PMID: 16676322.
      Citations: 81     Fields:    Translation:AnimalsCells
    250. Heltweg B, Gatbonton T, Schuler AD, Posakony J, Li H, Goehle S, Kollipara R, Depinho RA, Gu Y, Simon JA, Bedalov A. Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes. Cancer Res. 2006 Apr 15; 66(8):4368-77. PMID: 16618762.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    251. Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA. Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):5947-52. PMID: 16585505; PMCID: PMC1458678.
      Citations: 297     Fields:    Translation:Animals
    252. Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M, Protopopov A, Sukhdeo K, Hanamura I, Stephens O, Barlogie B, Anderson KC, Chin L, Shaughnessy JD, Brennan C, Depinho RA. High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell. 2006 Apr; 9(4):313-25. PMID: 16616336.
      Citations: 175     Fields:    Translation:HumansCells
    253. Haines BB, Ryu CJ, Chang S, Protopopov A, Luch A, Kang YH, Draganov DD, Fragoso MF, Paik SG, Hong HJ, DePinho RA, Chen J. Block of T cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations. Cancer Cell. 2006 Feb; 9(2):109-20. PMID: 16473278.
      Citations: 18     Fields:    Translation:AnimalsCells
    254. Safran M, Kim WY, O'Connell F, Flippin L, Horner JW, Depinho RA, Kaelin WG, G?nzler V. Mouse model for noninvasive imaging of HIF prolyl hydroxylase activity: assessment of an oral agent that stimulates erythropoietin production. Proc Natl Acad Sci U S A. 2006 Jan 03; 103(1):105-10. PMID: 16373502; PMCID: PMC1324998.
      Citations: 140     Fields:    Translation:AnimalsCells
    255. Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005 Dec 09; 310(5754):1642-6. PMID: 16308421; PMCID: PMC3074427.
      Citations: 765     Fields:    Translation:HumansAnimalsCells
    256. Luo J, McMullen JR, Sobkiw CL, Zhang L, Dorfman AL, Sherwood MC, Logsdon MN, Horner JW, DePinho RA, Izumo S, Cantley LC. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Mol Cell Biol. 2005 Nov; 25(21):9491-502. PMID: 16227599; PMCID: PMC1265829.
      Citations: 85     Fields:    Translation:AnimalsCells
    257. Laud PR, Multani AS, Bailey SM, Wu L, Ma J, Kingsley C, Lebel M, Pathak S, DePinho RA, Chang S. Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway. Genes Dev. 2005 Nov 01; 19(21):2560-70. PMID: 16264192; PMCID: PMC1276730.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    258. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. PMID: 16169464.
      Citations: 148     Fields:    Translation:Animals
    259. Potente M, Urbich C, Sasaki K, Hofmann WK, Heeschen C, Aicher A, Kollipara R, DePinho RA, Zeiher AM, Dimmeler S. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest. 2005 Sep; 115(9):2382-92. PMID: 16100571; PMCID: PMC1184037.
      Citations: 236     Fields:    Translation:AnimalsCells
    260. Sharpless NE, DePinho RA. Cancer: crime and punishment. Nature. 2005 Aug 04; 436(7051):636-7. PMID: 16079829.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    261. Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10238-43. PMID: 16006513; PMCID: PMC1174923.
      Citations: 25     Fields:    Translation:AnimalsCells
    262. Dannenberg JH, David G, Zhong S, van der Torre J, Wong WH, Depinho RA. mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival. Genes Dev. 2005 Jul 01; 19(13):1581-95. PMID: 15998811; PMCID: PMC1172064.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    263. Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Depinho RA. High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9625-30. PMID: 15983384; PMCID: PMC1160520.
      Citations: 168     Fields:    Translation:HumansCells
    264. Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 2005 Jun 17; 121(6):837-48. PMID: 15960972.
      Citations: 210     Fields:    Translation:HumansCells
    265. Asher DR, Cerny AM, Weiler SR, Horner JW, Keeler ML, Neptune MA, Jones SN, Bronson RT, Depinho RA, Finberg RW. Coxsackievirus and adenovirus receptor is essential for cardiomyocyte development. Genesis. 2005 Jun; 42(2):77-85. PMID: 15864812.
      Citations: 30     Fields:    Translation:AnimalsCells
    266. Vergilis I, Sarkar P, DePinho RA, Sharpless NE, R?nger TM. How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle. 2005 May; 4(5):643-5. PMID: 15846097.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    267. Okumura K, Zhao M, DePinho RA, Furnari FB, Cavenee WK. PTEN: a novel anti-oncogenic function independent of phosphatase activity. Cell Cycle. 2005 Apr; 4(4):540-2. PMID: 15753657.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    268. Tonon G, Brennan C, Protopopov A, Maulik G, Feng B, Zhang Y, Khatry DB, You MJ, Aguirre AJ, Martin ES, Yang Z, Ji H, Chin L, Wong KK, Depinho RA. Common and contrasting genomic profiles among the major human lung cancer subtypes. Cold Spring Harb Symp Quant Biol. 2005; 70:11-24. PMID: 16869734.
      Citations: 10     Fields:    Translation:HumansCells
    269. Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, R?nger TM. Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. J Natl Cancer Inst. 2004 Dec 01; 96(23):1790-3. PMID: 15572761.
      Citations: 15     Fields:    Translation:AnimalsCells
    270. Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR. Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Nov 01; 18(21):2614-26. PMID: 15489287; PMCID: PMC525542.
      Citations: 153     Fields:    Translation:HumansAnimals
    271. Du X, Shen J, Kugan N, Furth EE, Lombard DB, Cheung C, Pak S, Luo G, Pignolo RJ, DePinho RA, Guarente L, Johnson FB. Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes. Mol Cell Biol. 2004 Oct; 24(19):8437-46. PMID: 15367665; PMCID: PMC516757.
      Citations: 99     Fields:    Translation:AnimalsCells
    272. Argilla D, Chin K, Singh M, Hodgson JG, Bosenberg M, Lockett S, DePinho RA, Gray J, Hanahan D, de Sol?rzano CO. Absence of telomerase and shortened telomeres have minimal effects on skin and pancreatic carcinogenesis elicited by viral oncogenes. Cancer Cell. 2004 Oct; 6(4):373-85. PMID: 15488760.
      Citations: 4     Fields:    Translation:AnimalsCells
    273. Maser RS, DePinho RA. Telomeres and the DNA damage response: why the fox is guarding the henhouse. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):979-88. PMID: 15279784.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    274. Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet. 2004 Aug; 36(8):877-82. PMID: 15235603.
      Citations: 188     Fields:    Translation:AnimalsCells
    275. Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell. 2004 Jul; 6(1):91-9. PMID: 15261145.
      Citations: 455     Fields:    Translation:AnimalsCells
    276. Corradetti MN, Inoki K, Bardeesy N, DePinho RA, Guan KL. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 2004 Jul 01; 18(13):1533-8. PMID: 15231735; PMCID: PMC443516.
      Citations: 221     Fields:    Translation:HumansAnimalsCells
    277. Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N, Cauwels C, Cordon-Cardo C, Redston MS, DePinho RA, Chin L. High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):9067-72. PMID: 15199222; PMCID: PMC428474.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    278. Bachoo RM, Kim RS, Ligon KL, Maher EA, Brennan C, Billings N, Chan S, Li C, Rowitch DH, Wong WH, DePinho RA. Molecular diversity of astrocytes with implications for neurological disorders. Proc Natl Acad Sci U S A. 2004 Jun 01; 101(22):8384-9. PMID: 15155908; PMCID: PMC420403.
      Citations: 107     Fields:    Translation:AnimalsCells
    279. Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004 Apr; 5(4):375-87. PMID: 15093544.
      Citations: 420     Fields:    Translation:AnimalsCells
    280. Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A. 2004 Mar 09; 101(10):3329-35. PMID: 14985505; PMCID: PMC373461.
      Citations: 843     Fields:    Translation:HumansAnimalsCells
    281. Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA. The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene. 2004 Jan 15; 23(2):379-85. PMID: 14724566.
      Citations: 87     Fields:    Translation:AnimalsCells
    282. Attardi LD, DePinho RA. Conquering the complexity of p53. Nat Genet. 2004 Jan; 36(1):7-8. PMID: 14702030.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    283. Sharpless NE, DePinho RA. Telomeres, stem cells, senescence, and cancer. J Clin Invest. 2004 Jan; 113(2):160-8. PMID: 14722605; PMCID: PMC311439.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    284. Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA. Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003 Dec 15; 17(24):3112-26. PMID: 14681207; PMCID: PMC305262.
      Citations: 532     Fields:    Translation:HumansAnimalsCells
    285. Hallows JL, Chen K, DePinho RA, Vincent I. Decreased cyclin-dependent kinase 5 (cdk5) activity is accompanied by redistribution of cdk5 and cytoskeletal proteins and increased cytoskeletal protein phosphorylation in p35 null mice. J Neurosci. 2003 Nov 19; 23(33):10633-44. PMID: 14627648; PMCID: PMC6740918.
      Citations: 43     Fields:    Translation:AnimalsCells
    286. Safran M, Kim WY, Kung AL, Horner JW, DePinho RA, Kaelin WG. Mouse reporter strain for noninvasive bioluminescent imaging of cells that have undergone Cre-mediated recombination. Mol Imaging. 2003 Oct; 2(4):297-302. PMID: 14717328.
      Citations: 85     Fields:    Translation:AnimalsCells
    287. David G, Turner GM, Yao Y, Protopopov A, DePinho RA. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. Genes Dev. 2003 Oct 01; 17(19):2396-405. PMID: 14522945; PMCID: PMC218077.
      Citations: 40     Fields:    Translation:AnimalsCells
    288. Ossipova O, Bardeesy N, DePinho RA, Green JB. LKB1 (XEEK1) regulates Wnt signalling in vertebrate development. Nat Cell Biol. 2003 Oct; 5(10):889-94. PMID: 12973359.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    289. Farazi PA, Glickman J, Jiang S, Yu A, Rudolph KL, DePinho RA. Differential impact of telomere dysfunction on initiation and progression of hepatocellular carcinoma. Cancer Res. 2003 Aug 15; 63(16):5021-7. PMID: 12941829.
      Citations: 50     Fields:    Translation:AnimalsCells
    290. Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA. Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 2003 Jul 11; 301(5630):215-8. PMID: 12855809.
      Citations: 358     Fields:    Translation:HumansAnimalsCells
    291. D'Amico M, Wu K, Di Vizio D, Reutens AT, Stahl M, Fu M, Albanese C, Russell RG, Muller WJ, White M, Negassa A, Lee HW, DePinho RA, Pestell RG. The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Res. 2003 Jun 15; 63(12):3395-402. PMID: 12810676.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    292. Weiss WA, Burns MJ, Hackett C, Aldape K, Hill JR, Kuriyama H, Kuriyama N, Milshteyn N, Roberts T, Wendland MF, DePinho R, Israel MA. Genetic determinants of malignancy in a mouse model for oligodendroglioma. Cancer Res. 2003 Apr 01; 63(7):1589-95. PMID: 12670909.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    293. Allsopp RC, Morin GB, Horner JW, DePinho R, Harley CB, Weissman IL. Effect of TERT over-expression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med. 2003 Apr; 9(4):369-71. PMID: 12669037.
      Citations: 42     Fields:    Translation:AnimalsCells
    294. DePinho RA, Wong KK. The age of cancer: telomeres, checkpoints, and longevity. J Clin Invest. 2003 Apr; 111(7):S9-14. PMID: 12688272.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    295. Allsopp RC, Morin GB, DePinho R, Harley CB, Weissman IL. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood. 2003 Jul 15; 102(2):517-20. PMID: 12663456.
      Citations: 121     Fields:    Translation:AnimalsCells
    296. Gibson SL, Dai CY, Lee HW, DePinho RA, Gee MS, Lee WM, Furth EE, Brensinger C, Enders GH. Inhibition of colon tumor progression and angiogenesis by the Ink4a/Arf locus. Cancer Res. 2003 Feb 15; 63(4):742-6. PMID: 12591718.
      Citations: 19     Fields:    Translation:Animals
    297. Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 2003 Feb 06; 421(6923):643-8. PMID: 12540856.
      Citations: 137     Fields:    Translation:AnimalsCells
    298. Chang S, Khoo CM, Naylor ML, Maser RS, DePinho RA. Telomere-based crisis: functional differences between telomerase activation and ALT in tumor progression. Genes Dev. 2003 Jan 01; 17(1):88-100. PMID: 12514102; PMCID: PMC195968.
      Citations: 56     Fields:    Translation:AnimalsCells
    299. Maser RS, DePinho RA. Take care of your chromosomes lest cancer take care of you. Cancer Cell. 2003 Jan; 3(1):4-6. PMID: 12559169.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    300. Chang S, DePinho RA. Telomerase extracurricular activities. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12520-2. PMID: 12271146; PMCID: PMC130491.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    301. Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12; 419(6903):162-7. PMID: 12226664.
      Citations: 211     Fields:    Translation:AnimalsCells
    302. Maser RS, DePinho RA. Connecting chromosomes, crisis, and cancer. Science. 2002 Jul 26; 297(5581):565-9. PMID: 12142527.
      Citations: 200     Fields:    Translation:HumansAnimalsCells
    303. Sharpless NE, DePinho RA. p53: good cop/bad cop. Cell. 2002 Jul 12; 110(1):9-12. PMID: 12150992.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    304. Lee CK, Raz R, Gimeno R, Gertner R, Wistinghausen B, Takeshita K, DePinho RA, Levy DE. STAT3 is a negative regulator of granulopoiesis but is not required for G-CSF-dependent differentiation. Immunity. 2002 Jul; 17(1):63-72. PMID: 12150892.
      Citations: 112     Fields:    Translation:AnimalsCells
    305. Artandi SE, Alson S, Tietze MK, Sharpless NE, Ye S, Greenberg RA, Castrillon DH, Horner JW, Weiler SR, Carrasco RD, DePinho RA. Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8191-6. PMID: 12034875; PMCID: PMC123043.
      Citations: 88     Fields:    Translation:AnimalsCells
    306. Sharpless NE, Alson S, Chan S, Silver DP, Castrillon DH, DePinho RA. p16(INK4a) and p53 deficiency cooperate in tumorigenesis. Cancer Res. 2002 May 15; 62(10):2761-5. PMID: 12019151.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    307. Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA. Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell. 2002 Apr; 1(3):269-77. PMID: 12086863.
      Citations: 293     Fields:    Translation:HumansAnimalsCells
    308. Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA. Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Mol Cell Biol. 2002 Apr; 22(8):2743-50. PMID: 11909966; PMCID: PMC133736.
      Citations: 54     Fields:    Translation:AnimalsCells
    309. Sviderskaya EV, Hill SP, Evans-Whipp TJ, Chin L, Orlow SJ, Easty DJ, Cheong SC, Beach D, DePinho RA, Bennett DC. p16(Ink4a) in melanocyte senescence and differentiation. J Natl Cancer Inst. 2002 Mar 20; 94(6):446-54. PMID: 11904317.
      Citations: 73     Fields:    Translation:AnimalsCells
    310. You MJ, Castrillon DH, Bastian BC, Bosenberg MW, Parsons R, Chin L, DePinho RA, O'Hagan RC. Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1455-60. PMID: 11818530; PMCID: PMC122212.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    311. Bardeesy N, Morgan J, Sinha M, Signoretti S, Srivastava S, Loda M, Merlino G, DePinho RA. Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia. Mol Cell Biol. 2002 Jan; 22(2):635-43. PMID: 11756558; PMCID: PMC139752.
      Citations: 23     Fields:    Translation:HumansAnimals
    312. Sharpless NE, Ferguson DO, O'Hagan RC, Castrillon DH, Lee C, Farazi PA, Alson S, Fleming J, Morton CC, Frank K, Chin L, Alt FW, DePinho RA. Impaired nonhomologous end-joining provokes soft tissue sarcomas harboring chromosomal translocations, amplifications, and deletions. Mol Cell. 2001 Dec; 8(6):1187-96. PMID: 11779495.
      Citations: 54     Fields:    Translation:AnimalsCells
    313. Yang J, Luan J, Yu Y, Li C, DePinho RA, Chin L, Richmond A. Induction of melanoma in murine macrophage inflammatory protein 2 transgenic mice heterozygous for inhibitor of kinase/alternate reading frame. Cancer Res. 2001 Nov 15; 61(22):8150-7. PMID: 11719444.
      Citations: 18     Fields:    Translation:HumansAnimals
    314. Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature. 2001 Sep 06; 413(6851):86-91. PMID: 11544531.
      Citations: 319     Fields:    Translation:AnimalsCells
    315. Hemann MT, Rudolph KL, Strong MA, DePinho RA, Chin L, Greider CW. Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol Biol Cell. 2001 Jul; 12(7):2023-30. PMID: 11452000; PMCID: PMC55650.
      Citations: 65     Fields:    Translation:AnimalsCells
    316. Ranganathan V, Heine WF, Ciccone DN, Rudolph KL, Wu X, Chang S, Hai H, Ahearn IM, Livingston DM, Resnick I, Rosen F, Seemanova E, Jarolim P, DePinho RA, Weaver DT. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires NBS and telomerase catalytic subunit. Curr Biol. 2001 Jun 26; 11(12):962-6. PMID: 11448772.
      Citations: 28     Fields:    Translation:HumansCells
    317. Martelli F, Hamilton T, Silver DP, Sharpless NE, Bardeesy N, Rokas M, DePinho RA, Livingston DM, Grossman SR. p19ARF targets certain E2F species for degradation. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4455-60. PMID: 11274364; PMCID: PMC31856.
      Citations: 54     Fields:    Translation:HumansCells
    318. Lee KH, Rudolph KL, Ju YJ, Greenberg RA, Cannizzaro L, Chin L, Weiler SR, DePinho RA. Telomere dysfunction alters the chemotherapeutic profile of transformed cells. Proc Natl Acad Sci U S A. 2001 Mar 13; 98(6):3381-6. PMID: 11248087; PMCID: PMC30662.
      Citations: 18     Fields:    Translation:AnimalsCells
    319. Bardeesy N, Bastian BC, Hezel A, Pinkel D, DePinho RA, Chin L. Dual inactivation of RB and p53 pathways in RAS-induced melanomas. Mol Cell Biol. 2001 Mar; 21(6):2144-53. PMID: 11238948; PMCID: PMC86838.
      Citations: 60     Fields:    Translation:AnimalsCells
    320. Zhang SL, DuBois W, Ramsay ES, Bliskovski V, Morse HC, Taddesse-Heath L, Vass WC, DePinho RA, Mock BA. Efficiency alleles of the Pctr1 modifier locus for plasmacytoma susceptibility. Mol Cell Biol. 2001 Jan; 21(1):310-8. PMID: 11113205; PMCID: PMC88804.
      Citations: 24     Fields:    Translation:AnimalsCells
    321. Castrillon DH, DePinho RA. Modeling prostate cancer in the mouse. Adv Cancer Res. 2001; 82:187-204. PMID: 11447763.
      Citations: 1     Fields:    Translation:HumansAnimals
    322. Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A. DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol. 2001 Jan; 3(1):1-7. PMID: 11146619.
      Citations: 92     Fields:    Translation:AnimalsCells
    323. de Alboran IM, O'Hagan RC, Malynn B, Davidson L, Rickert R, Rajewsky K, DePinho RA, Alt FW, G?rtner F. Analysis of C-MYC function in normal cells via conditional gene-targeted mutation. Immunity. 2001 Jan; 14(1):45-55. PMID: 11163229.
      Citations: 194     Fields:    Translation:AnimalsCells
    324. Chang MA, Horner JW, Conklin BR, DePinho RA, Bok D, Zack DJ. Tetracycline-inducible system for photoreceptor-specific gene expression. Invest Ophthalmol Vis Sci. 2000 Dec; 41(13):4281-7. PMID: 11095627.
      Citations: 14     Fields:    Translation:AnimalsCells
    325. DePinho RA. The age of cancer. Nature. 2000 Nov 09; 408(6809):248-54. PMID: 11089982.
      Citations: 265     Fields:    Translation:HumansAnimalsCells
    326. O'Hagan RC, Ohh M, David G, de Alboran IM, Alt FW, Kaelin WG, DePinho RA. Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression. Genes Dev. 2000 Sep 01; 14(17):2185-91. PMID: 10970882; PMCID: PMC316894.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    327. Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet. 2000 Sep; 26(1):85-8. PMID: 10973255.
      Citations: 93     Fields:    Translation:AnimalsCells
    328. Sherr CJ, DePinho RA. Cellular senescence: mitotic clock or culture shock? Cell. 2000 Aug 18; 102(4):407-10. PMID: 10966103.
      Citations: 239     Fields:    Translation:HumansAnimalsCells
    329. Artandi SE, Chang S, Lee SL, Alson S, Gottlieb GJ, Chin L, DePinho RA. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 2000 Aug 10; 406(6796):641-5. PMID: 10949306.
      Citations: 387     Fields:    Translation:HumansAnimalsCells
    330. Artandi SE, DePinho RA. Mice without telomerase: what can they teach us about human cancer? Nat Med. 2000 Aug; 6(8):852-5. PMID: 10932211.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    331. Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6630-3. PMID: 10823907; PMCID: PMC18682.
      Citations: 123     Fields:    Translation:AnimalsCells
    332. Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell. 2000 Jun; 5(6):993-1002. PMID: 10911993.
      Citations: 215     Fields:    Translation:AnimalsCells
    333. Malynn BA, de Alboran IM, O'Hagan RC, Bronson R, Davidson L, DePinho RA, Alt FW. N-myc can functionally replace c-myc in murine development, cellular growth, and differentiation. Genes Dev. 2000 Jun 01; 14(11):1390-9. PMID: 10837031; PMCID: PMC316670.
      Citations: 165     Fields:    Translation:AnimalsCells
    334. Albanese C, Reutens AT, Bouzahzah B, Fu M, D'Amico M, Link T, Nicholson R, Depinho RA, Pestell RG. Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice. FASEB J. 2000 May; 14(7):877-84. PMID: 10783141.
      Citations: 13     Fields:    Translation:Animals
    335. Gao Y, Ferguson DO, Xie W, Manis JP, Sekiguchi J, Frank KM, Chaudhuri J, Horner J, DePinho RA, Alt FW. Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development. Nature. 2000 Apr 20; 404(6780):897-900. PMID: 10786799.
      Citations: 211     Fields:    Translation:AnimalsCells
    336. Gagandeep S, Sokhi R, Slehria S, Gorla GR, Furgiuele J, DePinho RA, Gupta S. Hepatocyte transplantation improves survival in mice with liver toxicity induced by hepatic overexpression of Mad1 transcription factor. Mol Ther. 2000 Apr; 1(4):358-65. PMID: 10933954.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    337. Chin L, DePinho RA. Flipping the oncogene switch: illumination of tumor maintenance and regression. Trends Genet. 2000 Apr; 16(4):147-50. PMID: 10729826.
      Citations: 5     Fields:    Translation:HumansAnimals
    338. Gagandeep S, Ott M, Nisen PD, DePinho RA, Gupta S. Overexpression of Mad transcription factor inhibits proliferation of cultured human hepatocellular carcinoma cells along with tumor formation in immunodeficient animals. J Gene Med. 2000 Mar-Apr; 2(2):117-27. PMID: 10809145.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    339. Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science. 2000 Feb 18; 287(5456):1253-8. PMID: 10678830.
      Citations: 126     Fields:    Translation:AnimalsCells
    340. Artandi SE, DePinho RA. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev. 2000 Feb; 10(1):39-46. PMID: 10679392.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    341. O'Hagan RC, Schreiber-Agus N, Chen K, David G, Engelman JA, Schwab R, Alland L, Thomson C, Ronning DR, Sacchettini JC, Meltzer P, DePinho RA. Gene-target recognition among members of the myc superfamily and implications for oncogenesis. Nat Genet. 2000 Feb; 24(2):113-9. PMID: 10655054.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    342. Bardeesy N, Wong KK, DePinho RA, Chin L. Animal models of melanoma: recent advances and future prospects. Adv Cancer Res. 2000; 79:123-56. PMID: 10818679.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    343. Shen-Li H, O'Hagan RC, Hou H, Horner JW, Lee HW, DePinho RA. Essential role for Max in early embryonic growth and development. Genes Dev. 2000 Jan 01; 14(1):17-22. PMID: 10640271; PMCID: PMC316346.
      Citations: 33     Fields:    Translation:AnimalsCells
    344. Gopalkrishnan RV, Christiansen KA, Goldstein NI, DePinho RA, Fisher PB. Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells. Nucleic Acids Res. 1999 Dec 15; 27(24):4775-82. PMID: 10572178; PMCID: PMC148778.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    345. DePinho RA, Jacks T. A bumper crop of cancer genes. Nat Genet. 1999 Nov; 23(3):253-4. PMID: 10545932.
      Citations: 1     Fields:    Translation:AnimalsCells
    346. Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H, Horner JW, Cordon-Cardo C, Yancopoulos GD, DePinho RA. Essential role for oncogenic Ras in tumour maintenance. Nature. 1999 Jul 29; 400(6743):468-72. PMID: 10440378.
      Citations: 281     Fields:    Translation:AnimalsCells
    347. Ghiani CA, Yuan X, Eisen AM, Knutson PL, DePinho RA, McBain CJ, Gallo V. Voltage-activated K+ channels and membrane depolarization regulate accumulation of the cyclin-dependent kinase inhibitors p27(Kip1) and p21(CIP1) in glial progenitor cells. J Neurosci. 1999 Jul 01; 19(13):5380-92. PMID: 10377348; PMCID: PMC6782320.
      Citations: 58     Fields:    Translation:AnimalsCells
    348. Orlow I, Rabbani F, Chin L, Pomerantz J, Ligeois N, Dudas M, Depinho R, Cord?n-Card? C. Involvement of the Ink4a gene (p16 and p19arf) in murine tumorigenesis. Int J Oncol. 1999 Jul; 15(1):17-24. PMID: 10375589.
      Citations: 2     Fields:    Translation:Animals
    349. Greenberg RA, Chin L, Femino A, Lee KH, Gottlieb GJ, Singer RH, Greider CW, DePinho RA. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell. 1999 May 14; 97(4):515-25. PMID: 10338215.
      Citations: 112     Fields:    Translation:AnimalsCells
    350. Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 1999 May 14; 97(4):527-38. PMID: 10338216.
      Citations: 334     Fields:    Translation:AnimalsCells
    351. FitzGerald MJ, Arsura M, Bellas RE, Yang W, Wu M, Chin L, Mann KK, DePinho RA, Sonenshein GE. Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc. Oncogene. 1999 Apr 15; 18(15):2489-98. PMID: 10229200.
      Citations: 5     Fields:    Translation:AnimalsCells
    352. Kipling D, Wynford-Thomas D, Jones CJ, Akbar A, Aspinall R, Bacchetti S, Blasco MA, Broccoli D, DePinho RA, Edwards DR, Effros RB, Harley CB, Lansdorp PM, Linskens MH, Prowse KR, Newbold RF, Olovnikov AM, Parkinson EK, Pawelec G, Shall S, Zijlmans M, Faragher RG, Pont?n J. Telomere-dependent senescence. Nat Biotechnol. 1999 Apr; 17(4):313-4. PMID: 10207859.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    353. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell. 1999 Mar 05; 96(5):701-12. PMID: 10089885.
      Citations: 422     Fields:    Translation:AnimalsCells
    354. de Lange T, DePinho RA. Unlimited mileage from telomerase? Science. 1999 Feb 12; 283(5404):947-9. PMID: 10075559.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    355. Greenberg RA, O'Hagan RC, Deng H, Xiao Q, Hann SR, Adams RR, Lichtsteiner S, Chin L, Morin GB, DePinho RA. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene. 1999 Feb 04; 18(5):1219-26. PMID: 10022128.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    356. Sharpless NE, DePinho RA. The INK4A/ARF locus and its two gene products. Curr Opin Genet Dev. 1999 Feb; 9(1):22-30. PMID: 10072356.
      Citations: 148     Fields:    Translation:HumansCells
    357. Ghiani CA, Eisen AM, Yuan X, DePinho RA, McBain CJ, Gallo V. Neurotransmitter receptor activation triggers p27(Kip1 )and p21(CIP1) accumulation and G1 cell cycle arrest in oligodendrocyte progenitors. Development. 1999 Feb; 126(5):1077-90. PMID: 9927607.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    358. Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature. 1999 Jan 14; 397(6715):164-8. PMID: 9923679.
      Citations: 645     Fields:    Translation:HumansAnimalsCells
    359. Liegeois NJ, Zhang P, Engelman JA, Horner J, Silverman A, Burde R, Roussel MF, Sherr CJ, Elledge SJ, DePinho RA, G?mez Lahoz E. Cyclin D- and E-dependent kinases and the p57(KIP2) inhibitor: cooperative interactions in vivo. Mol Cell Biol. 1999 Jan; 19(1):353-63. PMID: 9858559; PMCID: PMC83893.
      Citations: 12     Fields:    Translation:AnimalsCells
    360. Auer KL, Park JS, Seth P, Coffey RJ, Darlington G, Abo A, McMahon M, Depinho RA, Fisher PB, Dent P. Prolonged activation of the mitogen-activated protein kinase pathway promotes DNA synthesis in primary hepatocytes from p21Cip-1/WAF1-null mice, but not in hepatocytes from p16INK4a-null mice. Biochem J. 1998 Dec 15; 336 ( Pt 3):551-60. PMID: 9841865; PMCID: PMC1219904.
      Citations: 14     Fields:    Translation:AnimalsCells
    361. Holland EC, Hively WP, DePinho RA, Varmus HE. A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 1998 Dec 01; 12(23):3675-85. PMID: 9851974; PMCID: PMC317252.
      Citations: 202     Fields:    Translation:Animals
    362. Chin L, Merlino G, DePinho RA. Malignant melanoma: modern black plague and genetic black box. Genes Dev. 1998 Nov 15; 12(22):3467-81. PMID: 9832500.
      Citations: 37     Fields:    Translation:HumansCells
    363. Radfar A, Unnikrishnan I, Lee HW, DePinho RA, Rosenberg N. p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13194-9. PMID: 9789064; PMCID: PMC23757.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    364. Zhang P, Wong C, DePinho RA, Harper JW, Elledge SJ. Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development. Genes Dev. 1998 Oct 15; 12(20):3162-7. PMID: 9784491; PMCID: PMC317217.
      Citations: 111     Fields:    Translation:Animals
    365. Schreiber-Agus N, DePinho RA. Repression by the Mad(Mxi1)-Sin3 complex. Bioessays. 1998 Oct; 20(10):808-18. PMID: 9819568.
      Citations: 35     Fields:    Translation:AnimalsCells
    366. Chin L, Pomerantz J, DePinho RA. The INK4a/ARF tumor suppressor: one gene--two products--two pathways. Trends Biochem Sci. 1998 Aug; 23(8):291-6. PMID: 9757829.
      Citations: 54     Fields:    Translation:HumansAnimals
    367. Schreiber-Agus N, Meng Y, Hoang T, Hou H, Chen K, Greenberg R, Cordon-Cardo C, Lee HW, DePinho RA. Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature. 1998 Jun 04; 393(6684):483-7. PMID: 9624006.
      Citations: 57     Fields:    Translation:Animals
    368. Alland L, Hong SH, Wong CW, DePinho RA, Dejean A, David G. Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. Oncogene. 1998 May 14; 16(19):2549-56. PMID: 9627120.
      Citations: 90     Fields:    Translation:HumansCells
    369. Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. Essential role of mouse telomerase in highly proliferative organs. Nature. 1998 Apr 09; 392(6676):569-74. PMID: 9560153.
      Citations: 431     Fields:    Translation:AnimalsCells
    370. Greenberg RA, Allsopp RC, Chin L, Morin GB, DePinho RA. Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene. 1998 Apr 02; 16(13):1723-30. PMID: 9582020.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    371. Pomerantz J, Schreiber-Agus N, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW, Cordon-Cardo C, DePinho RA, Li?geois NJ. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell. 1998 Mar 20; 92(6):713-23. PMID: 9529248.
      Citations: 411     Fields:    Translation:AnimalsCells
    372. Watanabe H, Pan ZQ, Schreiber-Agus N, DePinho RA, Hurwitz J, Xiong Y. Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen. Proc Natl Acad Sci U S A. 1998 Feb 17; 95(4):1392-7. PMID: 9465025; PMCID: PMC19016.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    373. DePinho RA. Transcriptional repression. The cancer-chromatin connection. Nature. 1998 Feb 05; 391(6667):533, 535-6. PMID: 9468130.
      Citations: 10     Fields:    Translation:Cells
    374. Browning J, Horner JW, Pettoello-Mantovani M, Raker C, Yurasov S, DePinho RA, Goldstein H. Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14637-41. PMID: 9405665; PMCID: PMC25078.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    375. Edwards MC, Liegeois N, Horecka J, DePinho RA, Sprague GF, Tyers M, Elledge SJ. Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells. Genetics. 1997 Nov; 147(3):1063-76. PMID: 9383053; PMCID: PMC1208234.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    376. Chin L, Pomerantz J, Polsky D, Jacobson M, Cohen C, Cordon-Cardo C, Horner JW, DePinho RA. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 1997 Nov 01; 11(21):2822-34. PMID: 9353252; PMCID: PMC316663.
      Citations: 120     Fields:    Translation:HumansAnimals
    377. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell. 1997 Oct 03; 91(1):25-34. PMID: 9335332.
      Citations: 707     Fields:    Translation:AnimalsCells
    378. Zhang P, Wong C, Finegold M, Hou H, Thompson JC, Silverman A, Harper JW, DePinho RA, Elledge SJ, Li?geois NJ. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature. 1997 May 08; 387(6629):151-8. PMID: 9144284.
      Citations: 240     Fields:    Translation:Animals
    379. Alland L, Muhle R, Hou H, Potes J, Chin L, Schreiber-Agus N, DePinho RA. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature. 1997 May 01; 387(6628):49-55. PMID: 9139821.
      Citations: 228     Fields:    Translation:HumansAnimalsCells
    380. Schreiber-Agus N, Stein D, Chen K, Goltz JS, Stevens L, DePinho RA. Drosophila Myc is oncogenic in mammalian cells and plays a role in the diminutive phenotype. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1235-40. PMID: 9037036; PMCID: PMC19774.
      Citations: 42     Fields:    Translation:AnimalsCells
    381. Lee HW, Rizen M, Hanahan D, DePinho R, Greider CW, Blasco MA. Mouse models for the study of telomerase. Ciba Found Symp. 1997; 211:160-70; discussion 170-6. PMID: 9524757.
      Citations: 12     Fields:    Translation:AnimalsCells
    382. Schreiber-Agus N, Alland L, Muhle R, Goltz J, Chen K, Stevens L, Stein D, DePinho RA. A biochemical and biological analysis of Myc superfamily interactions. Curr Top Microbiol Immunol. 1997; 224:159-68. PMID: 9308239.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    383. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996 Apr 05; 85(1):27-37. PMID: 8620534.
      Citations: 500     Fields:    Translation:HumansAnimalsCells
    384. Chin L, DePinho RA, Schreiber-Agus N, Li?geois N. Functional interactions among members of the Myc superfamily and potential relevance to cutaneous growth and development. J Investig Dermatol Symp Proc. 1996 Apr; 1(2):128-35. PMID: 9627706.
      Citations: 4     Fields:    Translation:HumansAnimals
    385. Hatton KS, Mahon K, Chin L, Chiu FC, Lee HW, Peng D, Morgenbesser SD, Horner J, DePinho RA. Expression and activity of L-Myc in normal mouse development. Mol Cell Biol. 1996 Apr; 16(4):1794-804. PMID: 8657155; PMCID: PMC231166.
      Citations: 47     Fields:    Translation:AnimalsCells
    386. Rao G, Alland L, Guida P, Schreiber-Agus N, Chen K, Chin L, Rochelle JM, Seldin MF, Skoultchi AI, DePinho RA. Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1. Oncogene. 1996 Mar 07; 12(5):1165-72. PMID: 8649810.
      Citations: 16     Fields:    Translation:AnimalsCells
    387. Horner JW, DePinho RA, Li?geois NJ. Lens complementation system for the genetic analysis of growth, differentiation, and apoptosis in vivo. Proc Natl Acad Sci U S A. 1996 Feb 06; 93(3):1303-7. PMID: 8577759; PMCID: PMC40075.
      Citations: 16     Fields:    Translation:AnimalsCells
    388. Xu L, Meng Y, Wallen R, DePinho RA. Loss of transcriptional attenuation in N-myc is associated with progression towards a more malignant phenotype. Oncogene. 1995 Nov 02; 11(9):1865-72. PMID: 7478616.
      Citations: 5     Fields:    Translation:AnimalsCells
    389. Bali D, Svetlanov A, Lee HW, Fusco-DeMane D, Leiser M, Li B, Barzilai N, Surana M, Hou H, Fleischer N, et al. Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem. 1995 Sep 15; 270(37):21464-7. PMID: 7665557.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    390. Katz EB, Stenbit AE, Hatton K, DePinho R, Charron MJ. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature. 1995 Sep 14; 377(6545):151-5. PMID: 7675081.
      Citations: 123     Fields:    Translation:AnimalsCells
    391. Chin L, Schreiber-Agus N, Pellicer I, Chen K, Lee HW, Dudast M, Cordon-Cardo C, DePinho RA. Contrasting roles for Myc and Mad proteins in cellular growth and differentiation. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8488-92. PMID: 7667316; PMCID: PMC41182.
      Citations: 25     Fields:    Translation:HumansAnimals
    392. Chen J, Willingham T, Margraf LR, Schreiber-Agus N, DePinho RA, Nisen PD. Effects of the MYC oncogene antagonist, MAD, on proliferation, cell cycling and the malignant phenotype of human brain tumour cells. Nat Med. 1995 Jul; 1(7):638-43. PMID: 7585143.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    393. Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, DePinho RA. An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell. 1995 Mar 10; 80(5):777-86. PMID: 7889571.
      Citations: 133     Fields:    Translation:AnimalsCells
    394. Morgenbesser SD, Schreiber-Agus N, Bidder M, Mahon KA, Overbeek PA, Horner J, DePinho RA. Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. EMBO J. 1995 Feb 15; 14(4):743-56. PMID: 7882978; PMCID: PMC398140.
      Citations: 19     Fields:    Translation:AnimalsCells
    395. Serrano M, DePinho RA, Beach D, Bar-Sagi D, G?mez-Lahoz E. Inhibition of ras-induced proliferation and cellular transformation by p16INK4. Science. 1995 Jan 13; 267(5195):249-52. PMID: 7809631.
      Citations: 91     Fields:    Translation:AnimalsCells
    396. Schreiber-Agus N, Chin L, Chen K, Torres R, Thomson CT, Sacchettini JC, DePinho RA. Evolutionary relationships and functional conservation among vertebrate Max-associated proteins: the zebra fish homolog of Mxi1. Oncogene. 1994 Nov; 9(11):3167-77. PMID: 7936639.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    397. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature. 1994 Sep 01; 371(6492):72-4. PMID: 8072529.
      Citations: 162     Fields:    Translation:Animals
    398. Lahoz EG, Xu L, Schreiber-Agus N, DePinho RA. Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5503-7. PMID: 8202517; PMCID: PMC44024.
      Citations: 37     Fields:    Translation:AnimalsCells
    399. Morgenbesser SD, DePinho RA. Use of transgenic mice to study myc family gene function in normal mammalian development and in cancer. Semin Cancer Biol. 1994 Feb; 5(1):21-36. PMID: 8186385.
      Citations: 22     Fields:    Translation:Animals
    400. Williams BO, Morgenbesser SD, DePinho RA, Jacks T. Tumorigenic and developmental effects of combined germ-line mutations in Rb and p53. Cold Spring Harb Symp Quant Biol. 1994; 59:449-57. PMID: 7587099.
      Citations: 3     Fields:    Translation:HumansAnimals
    401. Xu L, Wallen R, Patel V, DePinho RA. Role of first exon/intron sequences in the regulation of myc family oncogenic potency. Oncogene. 1993 Sep; 8(9):2547-53. PMID: 8361763.
      Citations: 8     Fields:    Translation:AnimalsCells
    402. Schreiber-Agus N, Horner J, Torres R, Chiu FC, DePinho RA. Zebra fish myc family and max genes: differential expression and oncogenic activity throughout vertebrate evolution. Mol Cell Biol. 1993 May; 13(5):2765-75. PMID: 8474440; PMCID: PMC359656.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    403. Schreiber-Agus N, Torres R, Horner J, Lau A, Jamrich M, DePinho RA. Comparative analysis of the expression and oncogenic activities of Xenopus c-, N-, and L-myc homologs. Mol Cell Biol. 1993 Apr; 13(4):2456-68. PMID: 8455622; PMCID: PMC359566.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    404. Collum RG, Fisher PE, Datta M, Mellis S, Thiele C, Huebner K, Croce CM, Israel MA, Theil T, Moroy T, et al. A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system. Nucleic Acids Res. 1992 Sep 25; 20(18):4919-25. PMID: 1357630; PMCID: PMC334251.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    405. Mukherjee B, Morgenbesser SD, DePinho RA. Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants. Genes Dev. 1992 Aug; 6(8):1480-92. PMID: 1644290.
      Citations: 56     Fields:    
    406. Torres R, Schreiber-Agus N, Morgenbesser SD, DePinho RA. Myc and Max: a putative transcriptional complex in search of a cellular target. Curr Opin Cell Biol. 1992 Jun; 4(3):468-74. PMID: 1497918.
      Citations: 19     Fields:    Translation:AnimalsCells
    407. Xu L, Morgenbesser SD, DePinho RA. Complex transcriptional regulation of myc family gene expression in the developing mouse brain and liver. Mol Cell Biol. 1991 Dec; 11(12):6007-15. PMID: 1719378; PMCID: PMC361765.
      Citations: 9     Fields:    Translation:AnimalsCells
    408. DeFranco D, Bali D, Torres R, DePinho RA, Erickson RP, Gluecksohn-Waelsch S. The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression. Proc Natl Acad Sci U S A. 1991 Jul 01; 88(13):5607-10. PMID: 2062840; PMCID: PMC51926.
      Citations: 4     Fields:    Translation:AnimalsCells
    409. Boulton TG, Nye SH, Robbins DJ, Ip NY, Radziejewska E, Morgenbesser SD, DePinho RA, Panayotatos N, Cobb MH, Yancopoulos GD. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 1991 May 17; 65(4):663-75. PMID: 2032290.
      Citations: 508     Fields:    Translation:HumansAnimalsCells
    410. Shin SU, DePinho R, Zack DJ, Rudikoff S, Scharff MD. Instability of immunoglobulin genes in S107 cell line. Somat Cell Mol Genet. 1991 May; 17(3):259-76. PMID: 1904631.
      Citations: 3     Fields:    Translation:AnimalsCells
    411. Cohen D, Piekarz RL, Hsu SI, DePinho RA, Carrasco N, Horwitz SB. Structural and functional analysis of the mouse mdr1b gene promoter. J Biol Chem. 1991 Feb 05; 266(4):2239-44. PMID: 1671222.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    412. DePinho RA, Schreiber-Agus N, Alt FW. myc family oncogenes in the development of normal and neoplastic cells. Adv Cancer Res. 1991; 57:1-46. PMID: 1950701.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    413. Fisher P, Guidos C, Ma A, Zimmerman K, Tesfaye A, DePinho R, Weissman I, Alt FW, M?r?y T. IgH enhancer deregulated expression of L-myc: abnormal T lymphocyte development and T cell lymphomagenesis. EMBO J. 1990 Nov; 9(11):3659-66. PMID: 2120050; PMCID: PMC552120.
      Citations: 14     Fields:    Translation:AnimalsCells
    414. Zimmerman K, Legouy E, Stewart V, Depinho R, Alt FW. Differential regulation of the N-myc gene in transfected cells and transgenic mice. Mol Cell Biol. 1990 May; 10(5):2096-103. PMID: 2183019; PMCID: PMC360557.
      Citations: 15     Fields:    Translation:AnimalsCells
    415. Dildrop R, Ma A, Zimmerman K, Hsu E, Tesfaye A, DePinho R, Alt FW. IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression. EMBO J. 1989 Apr; 8(4):1121-8. PMID: 2501083; PMCID: PMC400923.
      Citations: 24     Fields:    Translation:AnimalsCells
    416. Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW. Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice. Curr Top Microbiol Immunol. 1988; 141:100-9. PMID: 3215042.
      Citations: 1     Fields:    Translation:AnimalsCells
    417. DePinho RA, Hatton KS, Tesfaye A, Yancopoulos GD, Alt FW. The human myc gene family: structure and activity of L-myc and an L-myc pseudogene. Genes Dev. 1987 Dec; 1(10):1311-26. PMID: 3322939.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    418. Legouy E, DePinho R, Zimmerman K, Collum R, Yancopoulos G, Mitsock L, Kriz R, Alt FW. Structure and expression of the murine L-myc gene. EMBO J. 1987 Nov; 6(11):3359-66. PMID: 2828024; PMCID: PMC553791.
      Citations: 36     Fields:    Translation:AnimalsCells
    419. DePinho R, Mitsock L, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, et al. Myc family of cellular oncogenes. J Cell Biochem. 1987 Apr; 33(4):257-66. PMID: 3034933.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    420. Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. A functional T3 molecule associated with a novel heterodimer on the surface of immature human thymocytes. Nature. 1986 Jul 10-16; 322(6075):179-81. PMID: 3487737.
      Citations: 127     Fields:    Translation:HumansCells
    421. Depinho RA, Hatton K, Ferrier P, Zimmerman K, Legouy E, Tesfaye A, Collum R, Yancopoulos G, Nisen P, Alt F. Myc family genes: a dispersed multi-gene family. Ann Clin Res. 1986; 18(5-6):284-9. PMID: 3551773.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    422. Kohl NE, Legouy E, DePinho RA, Nisen PD, Smith RK, Gee CE, Alt FW. Human N-myc is closely related in organization and nucleotide sequence to c-myc. Nature. 1986 Jan 2-8; 319(6048):73-7. PMID: 3510398.
      Citations: 81     Fields:    Translation:HumansCells
    423. Proinvasion Metastasis Drivers in Early-Stage Melanoma Are Oncogenes. Cancer Cell. 20:277.
    424. Erratum. Nature. 525:278.
    425. FoxO1 expression in osteoblasts regulates glucose homeostasis through regulation of osteocalcin in mice (Journal of Clinical Investigation (2010) 120, 1 (357-368) (DOI. Journal of Clinical Investigation. 120:932.
    426. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nature Communications. 7.
    427. Genetics and biology of pancreatic ductal adenocarcinoma. Genes and Development. 30:355-385.
    428. Quantification of telomere length by FISH and laser scanning cytometry.
    429. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 88:9375.
    430. FoxO1 integrates direct and indirect effects of insulin on hepatic glucose production and glucose utilization. Nature Communications. 6.
    431. Erratum. Genes and Development. 21:481.
    432. Erratum. Nature Medicine. 1:1319.
    433. Erratum. Nature. 499:504.
    434. Cancer prevention in developing countries. Salud Publica de Mexico. 58:93-96.
    435. Targeting YAP-dependent MDSC infiltration impairs tumor progression. Cancer Discovery. 6:80-95.
    436. Erratum. Genes and Development. 17:541.
    437. Erratum. Cell Metabolism. 19:891.
    438. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 101:10494.
    439. Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth. Cell. 167:1281-1295.e18.
    440. Straight talk with.. Nature Medicine. 18:9.
    441. Guest editors. Oncogene. 18:5247.
    442. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Reports. 16:133-147.
    443. Collateral Lethality. Trends in Cancer. 1:161-173.
    444. Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation. Journal of Steroid Biochemistry and Molecular Biology.
    445. Erratum. Nature Medicine. 9:146.
    446. Cancer moonshot countdown. Nature Biotechnology. 34:596-599.
    447. Erratum. Nature Communications. 6.
    448. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans (DOI. Cancer Cell. 10:171.
    449. Erratum. Nature. 475:254.
    450. MAPRE1 as a plasma biomarker for early-stage colorectal cancer and adenomas. Cancer Prevention Research. 8:1112-1119.
    451. Erratum. Cell. 147:247.
    452. Telomere dysfunction suppresses multiple endocrine Neoplasia in mice. Genes and Cancer. 5:306-319.
    453. Introductory comments. Oncogene. 18:5248.
    454. Mouse model for regulation of telomerase. FASEB Journal. 11.
    455. Inhibition of C-MYC transactl vat I on by mad transcription factor interrupts cycling in hepatocellular carcinoma cells. Journal of Investigative Medicine. 44.
    456. SF2312 is a natural phosphonate inhibitor of enolase. Nature Chemical Biology.
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