"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
| Descriptor ID |
D018628
|
| MeSH Number(s) |
G05.380.350
|
| Concept/Terms |
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
|
Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in this website by year, and whether "Gene Dosage" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 3 | 3 |
| 1996 | 1 | 3 | 4 |
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 1 | 3 |
| 1999 | 2 | 0 | 2 |
| 2000 | 2 | 5 | 7 |
| 2001 | 0 | 5 | 5 |
| 2002 | 1 | 4 | 5 |
| 2003 | 0 | 5 | 5 |
| 2004 | 3 | 5 | 8 |
| 2005 | 2 | 3 | 5 |
| 2006 | 4 | 8 | 12 |
| 2007 | 3 | 11 | 14 |
| 2008 | 6 | 20 | 26 |
| 2009 | 10 | 13 | 23 |
| 2010 | 4 | 10 | 14 |
| 2011 | 4 | 10 | 14 |
| 2012 | 3 | 11 | 14 |
| 2013 | 4 | 10 | 14 |
| 2014 | 4 | 4 | 8 |
| 2015 | 3 | 10 | 13 |
| 2016 | 0 | 4 | 4 |
| 2017 | 3 | 7 | 10 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 4 | 5 |
| 2020 | 2 | 7 | 9 |
| 2021 | 1 | 4 | 5 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Dosage" by people in Profiles.
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Faslpr gene dosage tunes the extent of lymphoproliferation and T cell differentiation in lupus. Clin Immunol. 2024 01; 258:109874.
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Gene dosage changes in KCTD13 result in penile and testicular anomalies via diminished androgen receptor function. FASEB J. 2022 11; 36(11):e22567.
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Biology in balance: human diploid genome integrity, gene dosage, and genomic medicine. Trends Genet. 2022 06; 38(6):554-571.
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MET Gene High Copy Number (Amplification/Polysomy) Identified in Melanoma for Potential Targeted Therapy. Am J Clin Pathol. 2022 04 01; 157(4):502-505.
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Bacteriophage self-counting in the presence of viral replication. Proc Natl Acad Sci U S A. 2021 12 21; 118(51).
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CARD9 Expression Pattern, Gene Dosage, and Immunodeficiency Phenotype Revisited. J Clin Immunol. 2022 02; 42(2):336-349.
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CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med. 2021 09 21; 2(9):100394.
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Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell. 2021 09 16; 184(19):5031-5052.e26.
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Adrenomedullin Deficiency Potentiates Lipopolysaccharide-Induced Experimental Bronchopulmonary Dysplasia in Neonatal Mice. Am J Pathol. 2021 12; 191(12):2080-2090.
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TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 09 02; 108(9):1669-1691.