"Genes, erbB-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The proto-oncogene c-erbB-1 codes for the epidermal growth factor receptor. Its name originates from the viral homolog v-erbB which was isolated from an avian erythroblastosis virus (AEV) where it was contained as a fragment of the chicken c-ErbB-1 gene lacking the amino-terminal ligand-binding domain. Overexpression of erbB-1 genes occurs in a wide range of tumors, commonly squamous carcinomas of various sites and less commonly adenocarcinomas. The human c-erbB-1 gene is located in the chromosomal region 7p14 and 7p12.
| Descriptor ID |
D018773
|
| MeSH Number(s) |
G05.360.340.024.340.375.500.791.295.300
|
| Concept/Terms |
Genes, erbB-1- Genes, erbB-1
- Genes, erbB1
- Gene, erbB1
- erbB1 Gene
- erbB1 Genes
- erbB-1 Genes
- erbB 1 Genes
- erbB-1 Gene
v-erbB Genes- v-erbB Genes
- v erbB Genes
- v-erbB Gene
- v-erbB Oncogenes
- v erbB Oncogenes
- v-erbB Oncogene
c-erbB-1 Genes- c-erbB-1 Genes
- c erbB 1 Genes
- c-erbB-1 Gene
- EGFR Genes
- Epidermal Growth Factor Receptor Genes
- c-erbB-1 Proto-Oncogenes
- c erbB 1 Proto Oncogenes
- c-erbB-1 Proto-Oncogene
- Genes, EGFR
- EGFR Gene
|
Below are MeSH descriptors whose meaning is more general than "Genes, erbB-1".
Below are MeSH descriptors whose meaning is more specific than "Genes, erbB-1".
This graph shows the total number of publications written about "Genes, erbB-1" by people in this website by year, and whether "Genes, erbB-1" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Genes, erbB-1" by people in Profiles.
-
Progression of EGFR-Mutant Lung Adenocarcinoma is Driven By Alveolar Macrophages. Clin Cancer Res. 2017 Feb 01; 23(3):778-788.
-
Prognostic and Predictive Biomarkers in Colorectal Cancer: Implications for the Clinical Surgeon. Ann Surg Oncol. 2015 Oct; 22(11):3433-50.
-
Clinical and biomarker outcomes of the phase II vandetanib study from the BATTLE trial. J Thorac Oncol. 2013 May; 8(5):658-61.
-
Somatic deletions of the polyA tract in the 3' untranslated region of epidermal growth factor receptor are common in microsatellite instability-high endometrial and colorectal carcinomas. Arch Pathol Lab Med. 2012 May; 136(5):510-6.
-
Immunophenotype and molecular characterisation of adenocarcinoma of the small intestine. Br J Cancer. 2010 Jan 05; 102(1):144-50.
-
Oncolytic adenovirus retargeted to Delta-EGFR induces selective antiglioma activity. Cancer Gene Ther. 2009 Mar; 16(3):256-65.
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008 Oct 23; 455(7216):1061-8.
-
Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas. Cancer Prev Res (Phila). 2008 Aug; 1(3):192-200.
-
Molecular analysis-based treatment strategies for non-small cell lung cancer. Cancer Control. 2008 Apr; 15(2):130-9.
-
EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity. Cancer Res. 2007 May 15; 67(10):4665-70.