Minichromosome Maintenance Proteins
"Minichromosome Maintenance Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that were originally identified in SACCHAROMYCES CEREVISIAE as being essential for maintaining the structure of minichromosomes00. They form into a protein complex that has helicase activity and is involved in a variety of DNA-related functions including replication elongation, RNA transcription, chromatin remodeling, and genome stability.
| Descriptor ID |
D064110
|
| MeSH Number(s) |
D08.811.277.040.025.159.186 D08.811.399.340.186 D12.776.167.409 D12.776.660.235.500 D12.776.664.235.750
|
| Concept/Terms |
MCM Protein Complex- MCM Protein Complex
- MCM2-7 Helicase
- Helicase, MCM2-7
- MCM2 7 Helicase
- MCM2-7 Complex
- MCM2 7 Complex
|
Below are MeSH descriptors whose meaning is more general than "Minichromosome Maintenance Proteins".
Below are MeSH descriptors whose meaning is more specific than "Minichromosome Maintenance Proteins".
This graph shows the total number of publications written about "Minichromosome Maintenance Proteins" by people in this website by year, and whether "Minichromosome Maintenance Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Minichromosome Maintenance Proteins" by people in Profiles.
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Human NK cell deficiency as a result of biallelic mutations in MCM10. J Clin Invest. 2020 10 01; 130(10):5272-5286.
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Exome Sequencing of a Primary Ovarian Insufficiency Cohort Reveals Common Molecular Etiologies for a Spectrum of Disease. J Clin Endocrinol Metab. 2019 08 01; 104(8):3049-3067.
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Minichromosome Maintenance Proteins Cooperate with LANA during the G1/S Phase of the Cell Cycle To Support Viral DNA Replication. J Virol. 2019 04 01; 93(7).
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Gene variants identified by whole-exome sequencing in 33 French women with premature ovarian insufficiency. J Assist Reprod Genet. 2019 Jan; 36(1):39-45.
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Kaposi's Sarcoma-Associated Herpesvirus Deregulates Host Cellular Replication during Lytic Reactivation by Disrupting the MCM Complex through ORF59. J Virol. 2018 11 15; 92(22).
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SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer. Oncogene. 2018 02 15; 37(7):912-923.
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MCM8 and MCM9 Nucleotide Variants in Women With Primary Ovarian Insufficiency. J Clin Endocrinol Metab. 2017 02 01; 102(2):576-582.
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Reproductive aging and MCM8/9. Oncotarget. 2015 Jun 30; 6(18):15750-1.
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MCM9 mutations are associated with ovarian failure, short stature, and chromosomal instability. Am J Hum Genet. 2014 Dec 04; 95(6):754-62.
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Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability. J Clin Invest. 2015 Jan; 125(1):258-62.