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MILLS, GORDON B

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Item Type	Name
Academic Article	Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity.
Academic Article	WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome.
Academic Article	Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis.
Academic Article	Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.
Academic Article	Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer.
Academic Article	Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.
Academic Article	Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon.
Academic Article	The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis.
Academic Article	Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.
Academic Article	Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells.
Academic Article	Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor.
Academic Article	Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium.
Academic Article	Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer.
Academic Article	Exploratory analysis of the copy number alterations in glioblastoma multiforme.
Academic Article	Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer.
Concept	Transgenes
Concept	DNA, Recombinant
Concept	Genes, Reporter
Concept	Gene Expression Regulation, Enzymologic
Concept	Gene Expression Profiling
Concept	Regulatory Elements, Transcriptional
Concept	src Homology Domains
Concept	Genes, erbB-2
Concept	Gene Amplification
Concept	Gene Regulatory Networks
Concept	Multigene Family
Concept	Genes, BRCA1
Concept	Genes, Tumor Suppressor
Concept	Oncogenes
Concept	Epistasis, Genetic
Concept	Gene Expression
Concept	Genes
Concept	Amino Acid Sequence
Concept	Genes, Dominant
Concept	Catalytic Domain
Concept	Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Concept	Gene Order
Concept	Genes, p16
Concept	Genome, Human
Concept	Proto-Oncogenes
Concept	Gene Fusion
Concept	Polymorphism, Single Nucleotide
Concept	Gene Library
Concept	Genes, myc
Concept	Gene Expression Regulation, Neoplastic
Concept	Sequence Homology, Amino Acid
Concept	Sequence Homology, Nucleic Acid
Concept	Genes, BRCA2
Concept	Genome
Concept	Genes, jun
Concept	Molecular Structure
Concept	Gene Frequency
Concept	Antilymphocyte Serum
Concept	Gene Deletion
Concept	Gene Silencing
Concept	Gene Duplication
Concept	Gene Knockout Techniques
Concept	Genes, erbB-1
Concept	Base Sequence
Concept	Alleles
Concept	Gene Knockdown Techniques
Concept	Genes, Homeobox
Concept	Gene Transfer Techniques
Concept	Molecular Sequence Data
Concept	Gene Expression Regulation, Developmental
Concept	Genes, Retinoblastoma
Concept	Conserved Sequence
Concept	Genes, ras
Concept	Gene Expression Regulation
Concept	Consensus Sequence
Concept	Genes, Neoplasm
Concept	Genes, p53
Concept	Nucleic Acid Conformation
Concept	Gene Dosage
Academic Article	Comprehensive molecular characterization of clear cell renal cell carcinoma.
Academic Article	The Cancer Genome Atlas Pan-Cancer analysis project.
Academic Article	The somatic genomic landscape of glioblastoma.
Academic Article	A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes.
Academic Article	LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients.
Academic Article	Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells.
Academic Article	Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer.
Academic Article	Comprehensive molecular characterization of urothelial bladder carcinoma.
Academic Article	Integrated genomic analyses of ovarian carcinoma.
Academic Article	Molecular characterization of gallbladder cancer using somatic mutation profiling.
Academic Article	Genome-wide transcriptome profiling of homologous recombination DNA repair.
Academic Article	Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.
Academic Article	Unraveling the regulatory connections between two controllers of breast cancer cell fate.
Academic Article	Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels.
Academic Article	Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts.
Academic Article	Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer.
Academic Article	Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase.
Academic Article	Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer.
Academic Article	Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks.
Academic Article	Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers.
Academic Article	Functional consequence of the MET-T1010I polymorphism in breast cancer.
Academic Article	Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q.
Academic Article	Bead transfection: rapid and efficient gene transfer into marrow stromal and other adherent mammalian cells.
Academic Article	Human hematopoietic cell express two forms of the cytokine receptor common gamma-chain (gamma c).
Academic Article	Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis.
Academic Article	Growth suppression of human ovarian cancer cell lines by the introduction of a p16 gene via a recombinant adenovirus.
Academic Article	Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway.
Academic Article	Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells.
Academic Article	Determinants of rapamycin sensitivity in breast cancer cells.
Academic Article	Analysis of molecular aberrations in ovarian cancer allows novel target identification.
Academic Article	The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers.
Academic Article	Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers.
Academic Article	Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signaling.
Academic Article	A module of negative feedback regulators defines growth factor signaling.
Academic Article	Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
Academic Article	Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
Academic Article	The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells.
Academic Article	Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity.
Academic Article	Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer.
Academic Article	Gene and protein expression markers of response to combined antiangiogenic and epidermal growth factor targeted therapy in renal cell carcinoma.
Academic Article	Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.
Academic Article	ERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer.
Academic Article	Androgen regulation of 5a-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention.
Academic Article	An emerging toolkit for targeted cancer therapies.
Academic Article	Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance.
Academic Article	Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo.
Academic Article	Mechanistic basis for overcoming platinum resistance using copper chelating agents.
Academic Article	Functional proteomics characterization of residual breast cancer after neoadjuvant systemic chemotherapy.
Academic Article	Rab25 in cancer: a brief update.
Academic Article	Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia.
Academic Article	Favorable modulation of benign breast tissue and serum risk biomarkers is associated with > 10 % weight loss in postmenopausal women.
Academic Article	Modeling precision treatment of breast cancer.
Academic Article	Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes.
Academic Article	Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma.
Academic Article	Expression of TTK, a novel human protein kinase, is associated with cell proliferation.
Academic Article	Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.
Academic Article	Expression of ras oncogene leads to down-regulation of protein kinase C.
Academic Article	Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine.
Academic Article	The cell biology of ras-induced transformation: insights from studies utilizing an inducible hybrid oncogene system.
Academic Article	Comparison of phorbol ester/calcium ionophore and phytohemagglutinin-induced signaling in human T lymphocytes. Demonstration of interleukin 2-independent transferrin receptor gene expression.
Academic Article	pp60c-src expression is induced by activation of normal human T lymphocytes.
Academic Article	HLA-G expression during preimplantation human embryo development.
Academic Article	Expression of p16 induces transcriptional downregulation of the RB gene.
Academic Article	p202 prevents apoptosis in murine AKR-2B fibroblasts.
Academic Article	Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Academic Article	NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas.
Academic Article	Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer.
Academic Article	Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer.
Academic Article	Genetic analysis of early- versus late-stage ovarian tumors.
Academic Article	Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells.
Academic Article	ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.
Academic Article	Overexpression of kallikrein 10 in epithelial ovarian carcinomas.
Academic Article	Molecular therapeutics: promise and challenges.
Academic Article	Stem cell-ness: a "magic marker" for cancer.
Academic Article	Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells.
Academic Article	International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers.
Academic Article	Bayesian models based on test statistics for multiple hypothesis testing problems.
Academic Article	Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
Academic Article	A sequence-based survey of the complex structural organization of tumor genomes.
Academic Article	Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha.
Academic Article	Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance.
Academic Article	Rak functions as a tumor suppressor by regulating PTEN protein stability and function.
Academic Article	Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis.
Academic Article	Genomic amplicons target vesicle recycling in breast cancer.
Academic Article	miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells.
Academic Article	Ras-superfamily GTP-ases in ovarian cancer.
Academic Article	Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer.
Academic Article	Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation.
Academic Article	Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy.
Academic Article	MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells.
Academic Article	HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.
Academic Article	Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.
Academic Article	Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer.
Academic Article	Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival.
Academic Article	Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing.
Academic Article	Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis.
Academic Article	Integrated genomic characterization of endometrial carcinoma.
Academic Article	Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer.
Academic Article	PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells.
Academic Article	An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation.
Academic Article	Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer.
Academic Article	Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer.
Academic Article	Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.
Academic Article	Comprehensive molecular profiling of lung adenocarcinoma.
Academic Article	T-lymphocyte proliferation: tyrosine kinases in interleukin 2 signal transduction.
Academic Article	Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells.
Academic Article	Activation of the Na+/H+ antiport is not required for epidermal growth factor-dependent gene expression, growth inhibition or proliferation in human breast cancer cells.
Academic Article	Induction of competence and progression signals in human T lymphocytes by phorbol esters and calcium ionophores.
Academic Article	Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma.
Academic Article	Genomic components of carcinogenesis.
Academic Article	Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation.
Academic Article	Cell cycle dependent regulation of the protein kinase TTK.
Academic Article	Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity.
Academic Article	Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status.
Academic Article	Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells.
Academic Article	Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase.
Academic Article	Human telomerase reverse transcriptase promoter regulation in normal and malignant human ovarian epithelial cells.
Academic Article	Future for ovarian cancer screening: novel markers from emerging technologies of transcriptional profiling and proteomics.
Academic Article	The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy.
Academic Article	Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity.
Academic Article	Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors.
Academic Article	Expression of endogenous granzyme B in a subset of human primary breast carcinomas.
Academic Article	Current research and treatment for epithelial ovarian cancer. A Position Paper from the Helene Harris Memorial Trust.
Academic Article	A genetically defined model for human ovarian cancer.
Academic Article	ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction.
Academic Article	BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer.
Academic Article	Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer.
Academic Article	A new mutational AKTivation in the PI3K pathway.
Academic Article	Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.
Academic Article	A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer.
Academic Article	Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts.
Academic Article	A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
Academic Article	A systems approach to analysis of molecular complexity in breast cancer.
Academic Article	Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics.
Academic Article	3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma.
Academic Article	Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1.
Academic Article	Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase.
Academic Article	Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.
Academic Article	PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.
Academic Article	Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid.
Academic Article	Personalizing therapy for ovarian cancer: BRCAness and beyond.
Academic Article	Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer.
Academic Article	Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.
Academic Article	Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer.
Academic Article	A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance.
Academic Article	Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals.
Academic Article	Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.
Academic Article	Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.
Academic Article	EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF.
Academic Article	Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR.
Academic Article	Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer.
Academic Article	MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition.
Academic Article	Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.
Academic Article	Development and validation of a prognostic gene-expression signature for lung adenocarcinoma.
Academic Article	An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance.
Academic Article	Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes.
Academic Article	Mask is required for the activity of the Hippo pathway effector Yki/YAP.
Academic Article	EVI1 splice variants modulate functional responses in ovarian cancer cells.
Academic Article	Inferring tumour purity and stromal and immune cell admixture from expression data.
Academic Article	A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer.
Academic Article	Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression.
Academic Article	Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Academic Article	The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells.
Academic Article	Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer.
Academic Article	Specific keynote: genome copy number abnormalities in ovarian cancer.
Academic Article	Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.
Academic Article	Non-parametric quantification of protein lysate arrays.
Academic Article	Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation.
Academic Article	Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells.
Academic Article	PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth.
Academic Article	Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers.
Academic Article	A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer.
Academic Article	DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance.
Academic Article	Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.
Academic Article	Systematic analysis of genotype-specific drug responses in cancer.
Academic Article	Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice.
Academic Article	Network inference using steady-state data and Goldbeter-Koshland kinetics. [corrected].
Academic Article	Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis.
Academic Article	Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes.
Academic Article	The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin.
Academic Article	MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.
Academic Article	Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines.
Academic Article	Exploiting the PI3K/AKT pathway for cancer drug discovery.
Academic Article	Assessing BRCA carrier probabilities in extended families.
Academic Article	Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer.
Academic Article	Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis.
Academic Article	Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer.
Academic Article	AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
Academic Article	Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells.
Academic Article	Subtype and pathway specific responses to anticancer compounds in breast cancer.
Academic Article	Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins.
Academic Article	Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.
Academic Article	Alterations in oncogenes, tumor suppressor genes, and growth factors associated with epithelial ovarian cancers.
Academic Article	Regulation of mRNA expression in breast cancer - a cis-tematic trans-action.
Academic Article	Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer.
Academic Article	Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors.
Academic Article	A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.
Academic Article	Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer.
Academic Article	Concordance of genomic alterations between primary and recurrent breast cancer.
Academic Article	YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer.
Academic Article	A pan-cancer proteomic perspective on The Cancer Genome Atlas.
Academic Article	AKT pathway genes define 5 prognostic subgroups in glioblastoma.
Academic Article	PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors.
Academic Article	Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma.
Academic Article	hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness.
Academic Article	Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions.
Academic Article	Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation in melanoma.
Academic Article	OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets.
Academic Article	LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer.
Academic Article	Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients.
Academic Article	Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications.
Academic Article	Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma.
Academic Article	A decision support framework for genomically informed investigational cancer therapy.
Academic Article	An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2.
Academic Article	PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients.
Academic Article	Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities.
Academic Article	Death-associated protein kinase 1 promotes growth of p53-mutant cancers.
Academic Article	Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.
Academic Article	Retrospective Review of MET Gene Mutations.
Academic Article	Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma.
Academic Article	Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer.
Academic Article	Regulation of the PI3K pathway through a p85a monomer-homodimer equilibrium.
Academic Article	Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance.
Academic Article	Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma.
Academic Article	Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers.
Academic Article	Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers.
Academic Article	Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance.
Academic Article	mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer.
Academic Article	Functional annotation of rare gene aberration drivers of pancreatic cancer.
Academic Article	Inferring causal molecular networks: empirical assessment through a community-based effort.
Academic Article	Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.
Academic Article	Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion.
Academic Article	Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
Academic Article	Multiplatform-based molecular subtypes of non-small-cell lung cancer.
Academic Article	Functional annotation of rare gene aberration drivers of pancreatic cancer
Academic Article	Association of somatic mutations of ADAMTS genes with chemotherapy sensitivity and survival in high-grade serous ovarian carcinoma
Academic Article	Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects
Academic Article	Retrospective review of MET gene mutations
Academic Article	Messenger rna expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis
Academic Article	068 Isolation of a possible human counterpart to the murine XLR genes
Academic Article	Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set
Academic Article	Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers.
Academic Article	Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer.
Academic Article	A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.
Academic Article	Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.
Academic Article	Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape.
Academic Article	A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
Academic Article	Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.
Academic Article	Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
Academic Article	Comprehensive Characterization of Cancer Driver Genes and Mutations.
Academic Article	A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer.
Academic Article	Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype.
Academic Article	Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis.
Academic Article	An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors.
Academic Article	Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer.
Academic Article	PKCiota promotes ovarian tumor progression through deregulation of cyclin E.
Academic Article	Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer.
Academic Article	Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts.
Academic Article	Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.
Academic Article	Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies.
Academic Article	The ErbB2?Ex16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.
Academic Article	Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer.
Academic Article	Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients.
Academic Article	Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types.
Academic Article	Cardiac glycosides display selective efficacy for STK11 mutant lung cancer.
Academic Article	AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.
Academic Article	Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes.
Academic Article	HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors.
Academic Article	High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype.
Academic Article	Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT.
Academic Article	Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer.
Academic Article	Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p.
Academic Article	Clinical outcomes based on multigene profiling in metastatic breast cancer patients.
Academic Article	Loss-of-function screens of druggable targetome against cancer stem-like cells.
Academic Article	Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
Academic Article	Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome.
Academic Article	Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas.
Academic Article	Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer.
Academic Article	Functional variomics and network perturbation: connecting genotype to phenotype in cancer.
Academic Article	Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets.
Academic Article	Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm.
Academic Article	Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-?B Pathway in Melanoma.
Academic Article	PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer.
Academic Article	Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival.
Academic Article	Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer.
Academic Article	Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening.
Academic Article	Comprehensive Characterization of Alternative Polyadenylation in Human Cancer.
Academic Article	A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors.
Academic Article	Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma.
Academic Article	ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma.
Academic Article	The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.
Academic Article	Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.
Academic Article	Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers.
Academic Article	The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy.
Academic Article	Rab25 augments cancer cell invasiveness through a ?1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin.
Academic Article	Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma.
Academic Article	BRD4 facilitates replication stress-induced DNA damage response.
Academic Article	Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p.
Academic Article	The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer.
Academic Article	Modulation of the Hippo pathway and organ growth by RNA processing proteins.
Academic Article	Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.
Academic Article	?-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer.
Academic Article	BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors.
Academic Article	Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer.
Academic Article	Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation.
Academic Article	Comprehensive Characterization of Cancer Driver Genes and Mutations.
Academic Article	MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology.
Academic Article	Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.
Academic Article	PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness.
Academic Article	Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.
Academic Article	PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma.
Academic Article	Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.
Academic Article	GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and ?-catenin activity.
Academic Article	In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.
Academic Article	Breast cancer quantitative proteome and proteogenomic landscape.
Academic Article	Integrated transcriptomic-genomic tool Texomer profiles cancer tissues.
Academic Article	Next-generation characterization of the Cancer Cell Line Encyclopedia.
Concept	Gene Editing
Concept	Transcriptome
Concept	Exome
Concept	Gene Ontology
Academic Article	The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer.
Academic Article	Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling.
Academic Article	COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms.
Academic Article	Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases.
Academic Article	Comprehensive characterization of circular RNAs in ~?1000 human cancer cell lines.
Academic Article	Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming.
Academic Article	Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion.
Academic Article	Proteomics advances for precision therapy in ovarian cancer.
Academic Article	Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer.
Academic Article	MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.
Academic Article	Genome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma.
Academic Article	miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer.
Academic Article	Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer.
Academic Article	p85? regulates autophagic degradation of AXL to activate oncogenic signaling.
Academic Article	MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling.
Academic Article	Multiplex digital spatial profiling of proteins and RNA in fixed tissue.
Academic Article	Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models.
Academic Article	RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC.
Academic Article	Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma.
Academic Article	Integrated Genomic Characterization of the Human Immunome in Cancer.
Academic Article	Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling.
Academic Article	Transient commensal clonal interactions can drive tumor metastasis.
Academic Article	Hormonal modulation of ESR1 mutant metastasis.
Academic Article	Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models.
Academic Article	MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors.
Academic Article	Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer.
Academic Article	mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity.
Academic Article	Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancers.
Academic Article	Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance.
Academic Article	CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models.
Academic Article	BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators.
Academic Article	WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway.
Academic Article	A functional genomic approach to actionable gene fusions for precision oncology.
Academic Article	PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia.
Academic Article	Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer.
Academic Article	Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma.

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