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GORDON B MILLS

TitleProfessor
InstitutionMD Anderson
DepartmentSystems Biology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sims Z, Mills GB, Chang YH. MIM-CyCIF: masked imaging modeling for enhancing cyclic immunofluorescence (CyCIF) with panel reduction and imputation. Commun Biol. 2024 Apr 03; 7(1):409. PMID: 38570598; PMCID: PMC10991424.
      Citations:    
    2. Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwiatkowski DJ, Liu W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WY, Robertson AG, Cancer Genome Atlas Research Network, Spellman PT, Rathmell WK, Linehan WM. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep. 2024 Apr 03; 43(4):113063. PMID: 38578829.
      Citations:    Fields:    
    3. Hu Z, Wu Z, Liu W, Ning Y, Liu J, Ding W, Fan J, Cai S, Li Q, Li W, Yang X, Dou Y, Wang W, Peng W, Lu F, Zhuang X, Qin T, Kang X, Feng C, Xu Z, Lv Q, Wang Q, Wang C, Wang X, Wang Z, Wang J, Jiang J, Wang B, Mills GB, Ma D, Gao Q, Li K, Chen G, Chen X, Sun C. Proteogenomic insights into early-onset endometrioid endometrial carcinoma: predictors for fertility-sparing therapy response. Nat Genet. 2024 Apr 02. PMID: 38565644.
      Citations:    Fields:    
    4. Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling. Cell. 2024 Mar 14; 187(6):1563-1564. PMID: 38490182.
      Citations:    Fields:    
    5. Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W. Author Correction: Stiff matrix induces exosome secretion to promote tumour growth. Nat Cell Biol. 2024 Mar; 26(3):490-491. PMID: 38347184.
      Citations:    Fields:    
    6. Evans NJ, Mills GB, Wu G, Song X, McWeeney S. Graph Structured Neural Networks for Perturbation Biology. bioRxiv. 2024 Feb 29. PMID: 38464019; PMCID: PMC10925270.
      Citations:    
    7. Mohanty V, Baran N, Huang Y, Ramage CL, Cooper LM, He S, Iqbal R, Daher M, CTD2 Research Network, Tyner JW, Mills GB, Konopleva M, Chen K, Mohanty V, Baran N, Huang Y, Ramage CL, Cooper LM, He S, Iqbal R, Daher M, Tyner JW, Mills GB, Konopleva M, Chen K. Transcriptional and phenotypic heterogeneity underpinning venetoclax resistance in AML. bioRxiv. 2024 Jan 30. PMID: 38352538; PMCID: PMC10862759.
      Citations:    
    8. Fan J, Lu F, Qin T, Peng W, Zhuang X, Li Y, Hou X, Fang Z, Yang Y, Guo E, Yang B, Li X, Fu Y, Kang X, Wu Z, Han L, Mills GB, Ma X, Li K, Wu P, Ma D, Chen G, Sun C. Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance. Nat Genet. 2023 Dec; 55(12):2175-2188. PMID: 37985817.
      Citations:    Fields:    Translation:Humans
    9. Saridogan T, Akcakanat A, Zhao M, Evans KW, Yuca E, Scott S, Kirby BP, Zheng X, Ha MJ, Chen H, Ng PKS, DiPeri TP, Mills GB, Rodon Ahnert J, Damodaran S, Meric-Bernstam F. Efficacy of futibatinib, an irreversible fibroblast growth factor receptor inhibitor, in FGFR-altered breast cancer. Sci Rep. 2023 11 18; 13(1):20223. PMID: 37980453; PMCID: PMC10657448.
      Citations:    Fields:    Translation:HumansAnimals
    10. Chadwick V, Kim M, Mills G, Tang C, Anazodo A, Dear R, Rogers R, Lavee O, Milliken S, McCaughn G, Hamad N, Chadwick V, Kim M, Mills G, Tang C, Anazodo A, Dear R, Rodgers R, Lavee O, Milliken S, McCaughan G, Hamad N. A minority of women of childbearing potential are tested for pregnancy before chemoimmunotherapy: an Australian cancer centre experience. Intern Med J. 2023 Nov 06. PMID: 37929784.
      Citations:    Fields:    
    11. Queitsch K, Moore TW, O'Connell BL, Nichols RV, Muschler JL, Keith D, Lopez C, Sears RC, Mills GB, Yardimci GG, Adey AC. Accessible high-throughput single-cell whole-genome sequencing with paired chromatin accessibility. Cell Rep Methods. 2023 Nov 20; 3(11):100625. PMID: 37918402; PMCID: PMC10694488.
      Citations:    Translation:Cells
    12. McGrail DJ, Li Y, Smith RS, Feng B, Dai H, Hu L, Dennehey B, Awasthi S, Mendillo ML, Sood AK, Mills GB, Lin SY, Yi SS, Sahni N. Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins. Cell Rep Med. 2023 11 21; 4(11):101255. PMID: 37909041; PMCID: PMC10694618.
      Citations:    Fields:    Translation:Humans
    13. Zhong W, Lu Y, Han X, Yang J, Qin Z, Zhang W, Yu Z, Wu B, Liu S, Xu W, Zheng C, Schuchter LM, Karakousis GC, Mitchell TC, Amaravadi R, Flowers AJ, Gimotty PA, Xiao M, Mills G, Herlyn M, Dong H, Mitchell MJ, Kim J, Xu X, Guo W. Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity. Cell Rep. 2023 10 31; 42(10):113224. PMID: 37805922; PMCID: PMC10697782.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    14. Tuna M, Mills GB, Amos CI. Common and distinct patterns of acquired uniparental disomy and homozygous deletions between lung squamous cell carcinomas and lung adenocarcinoma. Neoplasia. 2023 Nov; 45:100932. PMID: 37801862; PMCID: PMC10562662.
      Citations:    Fields:    Translation:Humans
    15. Lei JT, Jaehnig EJ, Smith H, Holt MV, Li X, Anurag M, Ellis MJ, Mills GB, Zhang B, Labrie M. The Breast Cancer Proteome and Precision Oncology. Cold Spring Harb Perspect Med. 2023 10 03; 13(10). PMID: 37137501; PMCID: PMC10547392.
      Citations:    Fields:    Translation:Humans
    16. Kinose Y, Xu H, Kim H, Kumar S, Shan X, George E, Wang X, Medvedev S, Ferman B, Gitto SB, Whicker M, D'Andrea K, Wubbenhorst B, Hallberg D, O'Connor M, Schwartz LE, Hwang WT, Nathanson KL, Mills GB, Velculescu VE, Wang TL, Brown EJ, Drapkin R, Simpkins F. Dual blockade of BRD4 and ATR/WEE1 pathways exploits ARID1A loss in clear cell ovarian cancer. Res Sq. 2023 Sep 27. PMID: 37841875; PMCID: PMC10571599.
      Citations:    
    17. Chang YH, Sims Z, Mills G. MIM-CyCIF: Masked Imaging Modeling for Enhancing Cyclic Immunofluorescence (CyCIF) with Panel Reduction and Imputation. Res Sq. 2023 Sep 21. PMID: 37790506; PMCID: PMC10543389.
      Citations:    
    18. Doha ZO, Wang X, Calistri NL, Eng J, Daniel CJ, Ternes L, Kim EN, Pelz C, Munks M, Betts C, Kwon S, Bucher E, Li X, Waugh T, Tatarova Z, Blumberg D, Ko A, Kirchberger N, Pietenpol JA, Sanders ME, Langer EM, Dai MS, Mills G, Chin K, Chang YH, Coussens LM, Gray JW, Heiser LM, Sears RC. MYC Deregulation and PTEN Loss Model Tumor and Stromal Heterogeneity of Aggressive Triple-Negative Breast Cancer. Nat Commun. 2023 09 13; 14(1):5665. PMID: 37704631; PMCID: PMC10499828.
      Citations: 3     Fields:    Translation:HumansAnimals
    19. Nasioudis D, Fernandez ML, Wong N, Powell DJ, Mills GB, Westin S, Fader AN, Carey MS, Simpkins F. The spectrum of MAPK-ERK pathway genomic alterations in gynecologic malignancies: Opportunities for novel therapeutic approaches. Gynecol Oncol. 2023 Oct; 177:86-94. PMID: 37657193.
      Citations:    Fields:    
    20. Kim HJ, Rames MJ, Goncalves F, Kirschbaum CW, Roskams-Hieter B, Spiliotopoulos E, Briand J, Doe A, Estabrook J, Wagner JT, Demir E, Mills G, Ngo TTM. Selective enrichment of plasma cell-free messenger RNA in cancer-associated extracellular vesicles. Commun Biol. 2023 08 29; 6(1):885. PMID: 37644220; PMCID: PMC10465482.
      Citations: 1     Translation:HumansCells
    21. Park SY, Jeong KJ, Poire A, Zhang D, Tsang YH, Blucher AS, Mills GB. Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer. Cell Death Dis. 2023 08 18; 14(8):532. PMID: 37596261; PMCID: PMC10439209.
      Citations: 3     Fields:    Translation:HumansCells
    22. Lenz L, Neff C, Solimeno C, Cogan ES, Abramson VG, Boughey JC, Falkson C, Goetz MP, Ford JM, Gradishar WJ, Jankowitz RC, Kaklamani VG, Marcom PK, Richardson AL, Storniolo AM, Tung NM, Vinayak S, Hodgson DR, Lai Z, Dearden S, Hennessy BT, Mayer EL, Mills GB, Slavin TP, Gutin A, Connolly RM, Telli ML, Stearns V, Lanchbury JS, Timms KM. Identifying homologous recombination deficiency in breast cancer: genomic instability score distributions differ among breast cancer subtypes. Breast Cancer Res Treat. 2023 Nov; 202(1):191-201. PMID: 37589839; PMCID: PMC10504389.
      Citations: 2     Fields:    Translation:Humans
    23. Sims Z, Mills GB, Chang YH. MIM-CyCIF: Masked Imaging Modeling for Enhancing Cyclic Immunofluorescence (CyCIF) with Panel Reduction and Imputation. bioRxiv. 2023 Aug 16. PMID: 37645765; PMCID: PMC10461912.
      Citations:    
    24. Li X, Poire A, Jeong KJ, Zhang D, Chen G, Sun C, Mills GB. Single-cell trajectory analysis reveals a CD9 positive state to contribute to exit from stem cell-like and embryonic diapause states and transit to drug-resistant states. Cell Death Discov. 2023 Aug 04; 9(1):285. PMID: 37542044; PMCID: PMC10403509.
      Citations: 2     
    25. Johnson A, Ng PK, Kahle M, Castillo J, Amador B, Wang Y, Zeng J, Holla V, Vu T, Su F, Kim SH, Conway T, Jiang X, Chen K, Shaw KRM, Yap TA, Rodon J, Mills GB, Meric-Bernstam F. Actionability classification of variants of unknown significance correlates with functional effect. NPJ Precis Oncol. 2023 Jul 15; 7(1):67. PMID: 37454202; PMCID: PMC10349825.
      Citations:    
    26. Tagore S, Tsang S, Mills GB, Califano A. Systematic Pan-cancer Functional Inference and Validation of Hyper, Hypo and Neomorphic Mutations. bioRxiv. 2023 May 02. PMID: 37205498; PMCID: PMC10187182.
      Citations:    
    27. Pantel AR, Gitto SB, Makvandi M, Kim H, Medvedv S, Weeks JK, Torigian DA, Hsieh CJ, Ferman B, Latif NA, Tanyi JL, Martin LP, Lanzo SM, Liu F, Cao Q, Mills GB, Doot RK, Mankoff DA, Mach RH, Lin LL, Simpkins F. [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study. Clin Cancer Res. 2023 04 14; 29(8):1515-1527. PMID: 36441795.
      Citations: 3     Fields:    Translation:Humans
    28. Zieseniss A, Katschinski DM, Sertel SM, Rizzoli SO, Sch?n MP, Stejerean-Todoran I, Gimotty PA, Watters A, Brafford P, Krepler C, Godok T, Li H, Bonilla Del Rio Z, Garman B, Nathanson KL, Xu X, Chen Q, Oswald JH, Lotem M, Mills GB, Davies MA, Bogeski I, Herlyn M, Vultur A. A distinct pattern of growth and RAC1 signaling in melanoma brain metastasis cells. Neuro Oncol. 2023 04 06; 25(4):674-686. PMID: 36054930; PMCID: PMC10076948.
      Citations:    
    29. Fu Y, Yang B, Cui Y, Hu X, Li X, Lu F, Qin T, Zhang L, Hu Z, Guo E, Fan J, Xiao R, Li W, Qin X, Hu D, Peng W, Liu J, Wang B, Mills GB, Chen G, Sun C. BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors. J Immunother Cancer. 2023 04; 11(4). PMID: 37072347; PMCID: PMC10124306.
      Citations:    Fields:    Translation:HumansCells
    30. Ren T, Chen C, Danilov AV, Liu S, Guan X, Du S, Wu X, Sherman MH, Spellman PT, Coussens LM, Adey AC, Mills GB, Wu LY, Xia Z. Supervised learning of high-confidence phenotypic subpopulations from single-cell data. bioRxiv. 2023 Mar 25. PMID: 36993424; PMCID: PMC10055361.
      Citations:    
    31. Yu K, Kong K, Lozzi B, Luna-Figueroa E, Cervantes A, Curry R, Mohila CA, Rao G, Jalali A, Mills GB, Scott KL, Deneen B. In vivo functional characterization of EGFR variants identifies novel drivers of glioblastoma. Neuro Oncol. 2023 03 14; 25(3):471-481. PMID: 36044040; PMCID: PMC10013639.
      Citations:    
    32. Chagani S, De Macedo MP, Carapeto F, Wang F, Marzese DM, Wani K, Haydu LE, Peng W, Ong GT, Warren SE, Beechem JM, Hoon DSB, Mills GB, Tetzlaff MT, Lazar AJ, Kwong LN, Davies MA. Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma. J Invest Dermatol. 2023 09; 143(9):1779-1787.e1. PMID: 36871660; PMCID: PMC10475489.
      Citations:    Fields:    Translation:Humans
    33. Wu B, Liu DA, Guan L, Myint PK, Chin L, Dang H, Xu Y, Ren J, Li T, Yu Z, Jabban S, Mills GB, Nukpezah J, Chen YH, Furth EE, Gimotty PA, Wells RG, Weaver VM, Radhakrishnan R, Wang XW, Guo W. Stiff matrix induces exosome secretion to promote tumour growth. Nat Cell Biol. 2023 03; 25(3):415-424. PMID: 36797475; PMCID: PMC10351222.
      Citations: 2     Fields:    Translation:HumansCells
    34. Park KC, Kim JM, Kim SY, Kim SM, Lim JH, Kim MK, Fang S, Kim Y, Mills GB, Noh SH, Cheong JH. PMCA inhibition reverses drug resistance in clinically refractory cancer patient-derived models. BMC Med. 2023 02 01; 21(1):38. PMID: 36726166; PMCID: PMC9893610.
      Citations: 1     Fields:    Translation:HumansAnimals
    35. Tatarova Z, Blumberg DC, Bensen A, Mills GB, Jonas O. Panobinostat Induced Spatial In Situ Biomarkers Predictive of Anti-PD-1 Efficacy in Mouse Mammary Carcinoma. Cells. 2023 01 13; 12(2). PMID: 36672243; PMCID: PMC9856407.
      Citations: 1     Fields:    Translation:HumansAnimals
    36. Fan J, Fu Y, Peng W, Li X, Shen Y, Guo E, Lu F, Zhou S, Liu S, Yang B, Qin X, Hu D, Xiao R, Li X, Yang S, Yuan C, Shu Y, Huang H, Wan T, Pi Y, Wang S, Chen W, Wang H, Zhong L, Yuan L, Wen B, Kong B, Mills GB, Zou D, Xia B, Song K, Chen G, Ma D, Sun C. Multi-omics characterization of silent and productive HPV integration in cervical cancer. Cell Genom. 2023 Jan 11; 3(1):100211. PMID: 36777180; PMCID: PMC9903858.
      Citations: 1     
    37. Hua X, Li Y, Pentaparthi SR, McGrail DJ, Zou R, Guo L, Shrawat A, Cirillo KM, Li Q, Bhat A, Xu M, Qi D, Singh A, McGrath F, Andrews S, Aung KL, Das J, Zhou Y, Lodi A, Mills GB, Eckhardt SG, Mendillo ML, Tiziani S, Wu E, Huang JH, Sahni N, Yi SS. Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer. Cancer Res. 2023 01 04; 83(1):59-73. PMID: 36265133; PMCID: PMC9811166.
      Citations: 1     Fields:    Translation:Humans
    38. Yang B, Li X, Zhang W, Fan J, Zhou Y, Li W, Yin J, Yang X, Guo E, Li X, Fu Y, Liu S, Hu D, Qin X, Dou Y, Xiao R, Lu F, Wang Z, Qin T, Wang W, Zhang Q, Li S, Ma D, Mills GB, Chen G, Sun C. Spatial heterogeneity of infiltrating T?cells in high-grade serous ovarian cancer revealed by multi-omics analysis. Cell Rep Med. 2022 Dec 20; 3(12):100856. PMID: 36543113.
      Citations: 4     Fields:    
    39. Doberstein K, Spivak R, Reavis HD, Hooda J, Feng Y, Kroeger PT, Stuckelberger S, Mills GB, Devins KM, Schwartz LE, Iwanicki MP, Fogel M, Altevogt P, Drapkin R. L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary. Commun Biol. 2022 Dec 12; 5(1):1362. PMID: 36509990.
      Citations: 2     
    40. Shehwana H, Kumar SV, Melott JM, Rohrdanz MA, Wakefield C, Ju Z, Siwak DR, Lu Y, Broom BM, Weinstein JN, Mills GB, Akbani R. RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data. Bioinformatics. 2022 11 15; 38(22):5131-5133. PMID: 36205581; PMCID: PMC9665860.
      Citations:    Fields:    
    41. Aguilar-Arevalo AA, Brown BC, Conrad JM, Dharmapalan R, Diaz A, Djurcic Z, Finley DA, Ford R, Garvey GT, Gollapinni S, Hourlier A, Huang EC, Kamp NW, Karagiorgi G, Katori T, Kobilarcik T, Lin K, Louis WC, Mariani C, Marsh W, Mills GB, Mirabal-Martinez J, Moore CD, Nelson RH, Nowak J, Pavlovic Z, Ray H, Roe BP, Russell AD, Schneider A, Shaevitz MH, Spitz J, Stancu I, Tayloe R, Thornton RT, Tzanov M, Van de Water RG, White DH, Zimmerman ED, MiniBooNE Collaboration. MiniBooNE and MicroBooNE Combined Fit to a 3+1 Sterile Neutrino Scenario. Phys Rev Lett. 2022 Nov 11; 129(20):201801. PMID: 36461983.
      Citations:    Fields:    
    42. Fujita M, Chen MM, Siwak DR, Sasagawa S, Oosawa-Tatsuguchi A, Arihiro K, Ono A, Miura R, Maejima K, Aikata H, Ueno M, Hayami S, Yamaue H, Chayama K, Lee JS, Lu Y, Mills GB, Liang H, Nishizuka SS, Nakagawa H. Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets. Nat Commun. 2022 10 29; 13(1):6481. PMID: 36309506; PMCID: PMC9617926.
      Citations: 1     Fields:    Translation:Humans
    43. Serra V, Wang AT, Castroviejo-Bermejo M, Polanska UM, Palafox M, Herencia-Ropero A, Jones GN, Lai Z, Armenia J, Michopoulos F, Llop-Guevara A, Brough R, Gulati A, Pettitt SJ, Bulusu KC, Nikkil? J, Wilson Z, Hughes A, Wijnhoven PWG, Ahmed A, Bruna A, Gris-Oliver A, Guzman M, Rodr?guez O, Grueso J, Arribas J, Cort?s J, Saura C, Lau A, Critchlow S, Dougherty B, Caldas C, Mills GB, Barrett JC, Forment JV, Cadogan E, Lord CJ, Cruz C, Balma?a J, O'Connor MJ. Identification of a Molecularly-Defined Subset of Breast and Ovarian Cancer Models that Respond to WEE1 or ATR Inhibition, Overcoming PARP Inhibitor Resistance. Clin Cancer Res. 2022 10 14; 28(20):4536-4550. PMID: 35921524; PMCID: PMC9561606.
      Citations:    
    44. Gross SM, Dane MA, Smith RL, Devlin KL, McLean IC, Derrick DS, Mills CE, Subramanian K, London AB, Torre D, Evangelista JE, Clarke DJB, Xie Z, Erdem C, Lyons N, Natoli T, Pessa S, Lu X, Mullahoo J, Li J, Adam M, Wassie B, Liu M, Kilburn DF, Liby TA, Bucher E, Sanchez-Aguila C, Daily K, Omberg L, Wang Y, Jacobson C, Yapp C, Chung M, Vidovic D, Lu Y, Schurer S, Lee A, Pillai A, Subramanian A, Papanastasiou M, Fraenkel E, Feiler HS, Mills GB, Jaffe JD, Ma'ayan A, Birtwistle MR, Sorger PK, Korkola JE, Gray JW, Heiser LM. A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses. Commun Biol. 2022 10 07; 5(1):1066. PMID: 36207580; PMCID: PMC9546880.
      Citations: 2     
    45. Jeong BY, Cho KH, Jeong KJ, Cho SJ, Won M, Kim SH, Cho NH, Hur GM, Yoon SH, Park HW, Mills GB, Lee HY. Lysophosphatidic acid-induced amphiregulin secretion by cancer-associated fibroblasts augments cancer cell invasion. Cancer Lett. 2022 Dec 28; 551:215946. PMID: 36209972.
      Citations:    Fields:    
    46. Kuhn M, Zhang Y, Favate J, Morita M, Blucher A, Das S, Liang S, Preet R, Parham LR, Williams KN, Molugu S, Armstrong RJ, Zhang W, Yang J, Hamilton KE, Dixon DA, Mills G, Morgan TK, Shah P, Andres SF. IMP1/IGF2BP1 in human colorectal cancer extracellular vesicles. Am J Physiol Gastrointest Liver Physiol. 2022 12 01; 323(6):G571-G585. PMID: 36194131; PMCID: PMC9678429.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    47. Yan G, Luna A, Wang H, Bozorgui B, Li X, Sanchez M, Dereli Z, Kahraman N, Kara G, Chen X, Zheng C, McGrail D, Sahni N, Lu Y, Babur O, Cokol M, Lim B, Ozpolat B, Sander C, Mills GB, Korkut A. BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer. Cell Rep. 2022 09 13; 40(11):111304. PMID: 36103824; PMCID: PMC9523722.
      Citations:    
    48. Chakravarty AK, McGrail DJ, Lozanoski TM, Dunn BS, Shih DJH, Cirillo KM, Cetinkaya SH, Zheng WJ, Mills GB, Yi SS, Jarosz DF, Sahni N. Biomolecular Condensation: A New Phase in Cancer Research. Cancer Discov. 2022 09 02; 12(9):2031-2043. PMID: 35852417; PMCID: PMC9437557.
      Citations:    Fields:    
    49. Reda M, Ngamcherdtrakul W, Nelson MA, Siriwon N, Wang R, Zaidan HY, Bejan DS, Reda S, Hoang NH, Crumrine NA, Rehwaldt JPC, Bindal A, Mills GB, Gray JW, Yantasee W. Development of a nanoparticle-based immunotherapy targeting PD-L1 and PLK1 for lung cancer treatment. Nat Commun. 2022 07 23; 13(1):4261. PMID: 35871223; PMCID: PMC9308817.
      Citations:    Fields:    Translation:Humans
    50. Guan L, Wu B, Li T, Beer LA, Sharma G, Li M, Lee CN, Liu S, Yang C, Huang L, Frederick DT, Boland GM, Shao G, Svitkina TM, Cai KQ, Chen F, Dong MQ, Mills GB, Schuchter LM, Karakousis GC, Mitchell TC, Flaherty KT, Speicher DW, Chen YH, Herlyn M, Amaravadi RK, Xu X, Guo W. HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8+ T-cell infiltration into tumors. Nat Commun. 2022 07 14; 13(1):4078. PMID: 35835783; PMCID: PMC9283393.
      Citations:    Fields:    Translation:HumansAnimalsCells
    51. Tatarova Z, Blumberg DC, Korkola JE, Heiser LM, Muschler JL, Schedin PJ, Ahn SW, Mills GB, Coussens LM, Jonas O, Gray JW. A multiplex implantable microdevice assay identifies synergistic combinations of cancer immunotherapies and conventional drugs. Nat Biotechnol. 2022 12; 40(12):1823-1833. PMID: 35788566; PMCID: PMC9750874.
      Citations:    Fields:    
    52. Kurnit KC, Fellman BM, Mills GB, Bowser JL, Xie S, Broaddus RR. Adjuvant treatment in early-stage endometrial cancer: context-dependent impact of somatic CTNNB1 mutation on recurrence-free survival. Int J Gynecol Cancer. 2022 07 04; 32(7):869-874. PMID: 35483739; PMCID: PMC10811601.
      Citations:    Fields:    
    53. Pejovic T, Fitch K, Mills G. Ovarian cancer recurrence: "is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?" Cancer Drug Resist. 2022; 5(2):451-458. PMID: 35800377; PMCID: PMC9255235.
      Citations:    
    54. Xiao R, You L, Zhang L, Guo X, Guo E, Zhao F, Yang B, Li X, Fu Y, Lu F, Wang Z, Liu C, Peng W, Li W, Yang X, Dou Y, Liu J, Wang W, Qin T, Cui Y, Zhang X, Li F, Jin Y, Zeng Q, Wang B, Mills GB, Chen G, Sheng X, Sun C. Inhibiting the IRE1a Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer. Adv Sci (Weinh). 2022 07; 9(21):e2105469. PMID: 35619328; PMCID: PMC9313493.
      Citations: 1     Fields:    Translation:HumansCells
    55. Curtiss BM, VanCampen J, Macaraeg J, Kong GL, Taherinasab A, Tsuchiya M, Yashar WM, Tsang YH, Horton W, Coleman DJ, Estabrook J, Lusardi TA, Mills GB, Druker BJ, Maxson JE, Braun TP. PU.1 and MYC transcriptional network defines synergistic drug responses to KIT and LSD1 inhibition in acute myeloid leukemia. Leukemia. 2022 07; 36(7):1781-1793. PMID: 35590033; PMCID: PMC9256806.
      Citations:    Fields:    Translation:HumansCells
    56. Wei S, Yin D, Yu S, Lin X, Savani MR, Du K, Ku Y, Wu D, Li S, Liu H, Tian M, Chen Y, Bowie M, Hariharan S, Waitkus M, Keir ST, Sugarman ET, Deek RA, Labrie M, Khasraw M, Lu Y, Mills GB, Herlyn M, Wu K, Liu L, Wei Z, Flaherty KT, Abdullah K, Zhang G, Ashley DM. Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas. Clin Cancer Res. 2022 05 13; 28(10):2180-2195. PMID: 35247901.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    57. Liu X, Ge Z, Yang F, Contreras A, Lee S, White JB, Lu Y, Labrie M, Arun BK, Moulder SL, Mills GB, Piwnica-Worms H, Litton JK, Chang JT. Identification of biomarkers of response to preoperative talazoparib monotherapy in treatment na?ve gBRCA+ breast cancers. NPJ Breast Cancer. 2022 May 10; 8(1):64. PMID: 35538088; PMCID: PMC9090765.
      Citations:    
    58. Mo X, Niu Q, Ivanov AA, Tsang YH, Tang C, Shu C, Li Q, Qian K, Wahafu A, Doyle SP, Cicka D, Yang X, Fan D, Reyna MA, Cooper LAD, Moreno CS, Zhou W, Owonikoko TK, Lonial S, Khuri FR, Du Y, Ramalingam SS, Mills GB, Fu H. Systematic discovery of mutation-directed neo-protein-protein interactions in cancer. Cell. 2022 05 26; 185(11):1974-1985.e12. PMID: 35512704; PMCID: PMC9597701.
      Citations:    Fields:    Translation:Humans
    59. Cathcart AM, Smith H, Labrie M, Mills GB. Characterization of anticancer drug resistance by reverse-phase protein array: new targets and strategies. Expert Rev Proteomics. 2022 02; 19(2):115-129. PMID: 35466854; PMCID: PMC9215307.
      Citations:    Fields:    Translation:Humans
    60. Le X, Gleber-Netto FO, Rubin ML, Qing Y, Du R, Kies M, Blumenschein G, Lu C, Johnson FM, Bell D, Lewis J, Zhang J, Feng L, Wilson K, Marcelo-Lewis K, Ginsberg L, Gillison M, Lee JJ, Meric-Bernstam F, Mills GB, William WN, Myers JN, Pickering CR, Wang J. Induction chemotherapy with or without erlotinib in patients with head and neck squamous cell carcinoma amenable for surgical resection. Clin Cancer Res. 2022 Apr 20. PMID: 35443062.
      Citations:    Fields:    
    61. Stover EH, Xiong N, Myers AP, Tayob N, Engvold V, Polak M, Broaddus RR, Makker V, Drapkin R, Liu JF, Horowitz NS, Meric-Bernstam F, Aghajanian C, Coleman RL, Mills GB, Cantley LC, Matulonis UA, Westin SN, Konstantinopoulos PA. A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma. Gynecol Oncol Rep. 2022 Apr; 40:100974. PMID: 35434236; PMCID: PMC9011027.
      Citations:    
    62. Ternes L, Dane M, Gross S, Labrie M, Mills G, Gray J, Heiser L, Chang YH. A multi-encoder variational autoencoder controls multiple transformational features in single-cell image analysis. Commun Biol. 2022 03 23; 5(1):255. PMID: 35322205; PMCID: PMC8943013.
      Citations: 2     
    63. Labrie M, Brugge JS, Mills GB, Zervantonakis IK. Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer. Nat Rev Cancer. 2022 06; 22(6):323-339. PMID: 35264777; PMCID: PMC9149051.
      Citations: 1     Fields:    Translation:Humans
    64. Kalli M, Li R, Mills GB, Stylianopoulos T, Zervantonakis IK. Mechanical Stress Signaling in Pancreatic Cancer Cells Triggers p38 MAPK- and JNK-Dependent Cytoskeleton Remodeling and Promotes Cell Migration via Rac1/cdc42/Myosin II. Mol Cancer Res. 2022 Mar 01; 20(3):485-497. PMID: 34782370; PMCID: PMC8898300.
      Citations: 3     Fields:    Translation:HumansCells
    65. Johnson BE, Creason AL, Stommel JM, Keck JM, Parmar S, Betts CB, Blucher A, Boniface C, Bucher E, Burlingame E, Camp T, Chin K, Eng J, Estabrook J, Feiler HS, Heskett MB, Hu Z, Kolodzie A, Kong BL, Labrie M, Lee J, Leyshock P, Mitri S, Patterson J, Riesterer JL, Sivagnanam S, Somers J, Sudar D, Thibault G, Weeder BR, Zheng C, Nan X, Thompson RF, Heiser LM, Spellman PT, Thomas G, Demir E, Chang YH, Coussens LM, Guimaraes AR, Corless C, Goecks J, Bergan R, Mitri Z, Mills GB, Gray JW. An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancer. Cell Rep Med. 2022 02 15; 3(2):100525. PMID: 35243422; PMCID: PMC8861971.
      Citations: 1     Fields:    Translation:Humans
    66. Li J, Lu H, Ng PK, Pantazi A, Ip CKM, Jeong KJ, Amador B, Tran R, Tsang YH, Yang L, Song X, Dogruluk T, Ren X, Hadjipanayis A, Bristow CA, Lee S, Kucherlapati M, Parfenov M, Tang J, Seth S, Mahadeshwar HS, Mojumdar K, Zeng D, Zhang J, Protopopov A, Seidman JG, Creighton CJ, Lu Y, Sahni N, Shaw KR, Meric-Bernstam F, Futreal A, Chin L, Scott KL, Kucherlapati R, Mills GB, Liang H. A functional genomic approach to actionable gene fusions for precision oncology. Sci Adv. 2022 02 11; 8(6):eabm2382. PMID: 35138907; PMCID: PMC8827659.
      Citations:    Fields:    Translation:Humans
    67. Tuna M, Amos CI, Mills GB. Whole-chromosome arm acquired uniparental disomy in cancer development is a consequence of isochromosome formation. Neoplasia. 2022 03; 25:9-17. PMID: 35065533; PMCID: PMC8788198.
      Citations: 1     Fields:    Translation:HumansCells
    68. Somers J, Georgiades M, Su MP, Bagi J, Alampounti A, Mills G, Ntabaliba W, Moore SJ, Spaccapelo R, Albert JT, Andr?s M. Hitting the right note at the right time: Circadian control of audibility in Anopheles mosquito mating swarms is mediated by flight tones. Sci Adv. 2022 Jan 14; 8(2):eabl4844. PMID: 35020428; PMCID: PMC8754303.
      Citations: 1     Fields:    
    69. Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim JA, Dustin D, Lo HC, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans WF, Fuqua SAW, And? S. Correction to: Hormonal modulation of ESR1 mutant metastasis. Oncogene. 2022 Jan; 41(3):460. PMID: 34782721.
      Citations:    Fields:    
    70. Rathod KS, Comer K, Casey-Gillman O, Moore L, Mills G, Ferguson G, Antoniou S, Patel R, Fhadil S, Damani T, Wright P, Ozkor M, Das D, Guttmann OP, Baumbach A, Archbold RA, Wragg A, Jain AK, Choudry FA, Mathur A, Jones DA. Early Hospital Discharge Following PCI for Patients With STEMI. J Am Coll Cardiol. 2021 12 21; 78(25):2550-2560. PMID: 34915986.
      Citations:    Fields:    Translation:Humans
    71. Ye Y, Zhang Y, Yang N, Gao Q, Ding X, Kuang X, Bao R, Zhang Z, Sun C, Zhou B, Wang L, Hu Q, Lin C, Gao J, Lou Y, Lin SH, Diao L, Liu H, Chen X, Mills GB, Han L. Profiling of immune features to predict immunotherapy efficacy. Innovation (Camb). 2022 Jan 25; 3(1):100194. PMID: 34977836; PMCID: PMC8688727.
      Citations: 4     
    72. Wang H, Chen H, Liu S, Zhang J, Lu H, Somasundaram R, Choi R, Zhang G, Ou L, Scholler J, Tian S, Dong L, Yeye G, Huang L, Connelly T, Li L, Huang A, Mitchell TC, Fan Y, June CH, Mills GB, Guo W, Herlyn M, Xu X. Costimulation of ?dTCR and TLR7/8 promotes Vd2 T-cell antitumor activity by modulating mTOR pathway and APC function. J Immunother Cancer. 2021 12; 9(12). PMID: 34937742; PMCID: PMC8705233.
      Citations: 5     Fields:    Translation:HumansAnimals
    73. Guo E, Xiao R, Wu Y, Lu F, Liu C, Yang B, Li X, Fu Y, Wang Z, Li Y, Huang Y, Li F, Wu X, You L, Qin T, Lu Y, Huang X, Ma D, Mills GB, Sun C, Chen G. WEE1 inhibition induces anti-tumor immunity by activating ERV and the dsRNA pathway. J Exp Med. 2022 01 03; 219(1). PMID: 34825915; PMCID: PMC8628262.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    74. Jin N, Keam B, Cho J, Lee MJ, Kim HR, Torosyan H, Jura N, Ng PK, Mills GB, Li H, Zeng Y, Barbash Z, Tarcic G, Kang H, Bauman JE, Kim MO, VanLandingham NK, Swaney DL, Krogan NJ, Johnson DE, Grandis JR. Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma. J Clin Invest. 2021 11 15; 131(22). PMID: 34779417; PMCID: PMC8592538.
      Citations:    Fields:    Translation:HumansAnimalsCells
    75. Bouhaddou M, Lee RH, Li H, Bhola NE, O'Keefe RA, Naser M, Zhu TR, Nwachuku K, Duvvuri U, Olshen AB, Roy R, Hechmer A, Bolen J, Keysar SB, Jimeno A, Mills GB, Vandenberg S, Swaney DL, Johnson DE, Krogan NJ, Grandis JR. Caveolin-1 and Sox-2 are predictive biomarkers of cetuximab response in head and neck cancer. JCI Insight. 2021 10 22; 6(20). PMID: 34546978; PMCID: PMC8564908.
      Citations:    Fields:    Translation:HumansAnimals
    76. Jing Y, Liu Y, Li Q, Ye Y, Diao L, Huang Y, Zhou Y, Green MR, Mills GB, Han L. Expression of chimeric antigen receptor therapy targets detected by single-cell sequencing of normal cells may contribute to off-tumor toxicity. Cancer Cell. 2021 12 13; 39(12):1558-1559. PMID: 34678153.
      Citations: 1     Fields:    Translation:Humans
    77. Labrie M, Li A, Creason A, Betts C, Keck J, Johnson B, Sivagnanam S, Boniface C, Ma H, Blucher A, Chang YH, Chin K, Vuky J, Guimaraes AR, Downey M, Lim JY, Gao L, Siex K, Parmar S, Kolodzie A, Spellman PT, Goecks J, Coussens LM, Corless CL, Bergan R, Gray JW, Mills GB, Mitri ZI. Multiomics analysis of serial PARP inhibitor treated metastatic TNBC inform on rational combination therapies. NPJ Precis Oncol. 2021 Oct 19; 5(1):92. PMID: 34667258; PMCID: PMC8526613.
      Citations: 4     
    78. Martino R, Fitch MI, Fuller CD, Hope A, Krisciunas G, Langmore SE, Lazarus C, Macdonald CL, McCulloch T, Mills G, Palma DA, Pytynia K, Ringash J, Sultanem K, Theurer J, Thorpe KE, Hutcheson K. The PRO-ACTIVE trial protocol: a randomized study comparing the effectiveness of PROphylACTic swallow InterVEntion for patients receiving radiotherapy for head and neck cancer. BMC Cancer. 2021 Oct 13; 21(1):1100. PMID: 34645411; PMCID: PMC8513207.
      Citations: 1     Fields:    Translation:HumansPHPublic HealthCTClinical Trials
    79. Zhang X, Bustos MA, Gross R, Ramos RI, Takeshima TL, Mills GB, Yu Q, Hoon DSB. Interleukin enhancer-binding factor 2 promotes cell proliferation and DNA damage response in metastatic melanoma. Clin Transl Med. 2021 10; 11(10):e608. PMID: 34709752; PMCID: PMC8516365.
      Citations: 6     Fields:    Translation:HumansCells
    80. Jing Y, Zhang Y, Wang J, Li K, Chen X, Heng J, Gao Q, Ye Y, Zhang Z, Liu Y, Lou Y, Lin SH, Diao L, Liu H, Chen X, Mills GB, Han L. Association Between Sex and Immune-Related Adverse Events During Immune Checkpoint Inhibitor Therapy. J Natl Cancer Inst. 2021 10 01; 113(10):1396-1404. PMID: 33705549.
      Citations: 13     Fields:    Translation:Humans
    81. Yu S, Wei S, Savani M, Lin X, Du K, Mender I, Siteni S, Vasilopoulos T, Reitman ZJ, Ku Y, Wu D, Liu H, Tian M, Chen Y, Labrie M, Charbonneau CM, Sugarman E, Bowie M, Hariharan S, Waitkus M, Jiang W, McLendon RE, Pan E, Khasraw M, Walsh KM, Lu Y, Herlyn M, Mills G, Herbig U, Wei Z, Keir ST, Flaherty K, Liu L, Wu K, Shay JW, Abdullah K, Zhang G, Ashley DM. A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas. Clin Cancer Res. 2021 12 15; 27(24):6800-6814. PMID: 34593527; PMCID: PMC8678347.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    82. Chauhan J, Silva JRD, Carvalho LADC, Dias D, Watanabe LRM, Rebecca VW, Mills G, Lu Y, Herlyn M, Possik PA, Goding CR, Maria-Engler SS, Oliveira ?A, Carvalho DG, da Silva ASF, Consolaro MEL. TOP1 modulation during melanoma progression and in adaptative resistance to BRAF and MEK inhibitors. Pharmacol Res. 2021 11; 173:105911. PMID: 34560251; PMCID: PMC8729257.
      Citations: 1     Fields:    Translation:HumansCells
    83. Xu H, George E, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F. CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med. 2021 09 21; 2(9):100394. PMID: 34622231; PMCID: PMC8484689.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    84. Westin SN, Labrie M, Litton JK, Blucher A, Fang Y, Vellano CP, Marszalek JR, Feng N, Ma X, Creason A, Fellman B, Yuan Y, Lee S, Kim TB, Liu J, Chelariu-Raicu A, Chen TH, Kabil N, Soliman PT, Frumovitz M, Schmeler KM, Jazaeri A, Lu KH, Murthy R, Meyer LA, Sun CC, Sood AK, Coleman RL, Mills GB. Phase Ib Dose Expansion and Translational Analyses of Olaparib in Combination with Capivasertib in Recurrent Endometrial, Triple-Negative Breast, and Ovarian Cancer. Clin Cancer Res. 2021 12 01; 27(23):6354-6365. PMID: 34518313; PMCID: PMC8639651.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    85. Castellanet O, Ahmad F, Vinik Y, Mills GB, Habermann B, Lev S, Lamballe F, Maina F, Borg JP. BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators. Theranostics. 2021; 11(19):9180-9197. PMID: 34646365; PMCID: PMC8490507.
      Citations:    Fields:    Translation:HumansAnimalsCells
    86. Guo L, Li Y, Cirillo KM, Marick RA, Su Z, Yin X, Hua X, Mills GB, Sahni N, Yi SS. mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity. Brief Bioinform. 2021 09 02; 22(5). PMID: 33855356; PMCID: PMC8579161.
      Citations: 4     Fields:    Translation:HumansCells
    87. Liu J, Rebecca VW, Kossenkov AV, Connelly T, Liu Q, Gutierrez A, Xiao M, Li L, Zhang G, Samarkina A, Zayasbazan D, Zhang J, Cheng C, Wei Z, Alicea GM, Fukunaga-Kalabis M, Krepler C, Aza-Blanc P, Yang CC, Delvadia B, Tong C, Huang Y, Delvadia M, Morias AS, Sproesser K, Brafford P, Wang JX, Beqiri M, Somasundaram R, Vultur A, Hristova DM, Wu LW, Lu Y, Mills GB, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Amaravadi RK, Kwong LN, Frederick DT, Boland GM, Salvino JM, Speicher DW, Flaherty KT, Ronai ZA, Herlyn M. Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance. Cancer Res. 2021 10 15; 81(20):5230-5241. PMID: 34462276; PMCID: PMC8530965.
      Citations:    Fields:    Translation:HumansAnimalsCells
    88. Feferkorn I, Badeghiesh A, Mills G, Baghlaf H, Dahan M. The effects of smoking on pregnancy risks in women with polycystic ovary syndrome: a population-based study. Hum Reprod. 2021 08 18; 36(9):2549-2557. PMID: 34164665.
      Citations:    Fields:    Translation:Humans
    89. Wang B, Zhang W, Zhang G, Kwong L, Lu H, Tan J, Sadek N, Xiao M, Zhang J, Labrie M, Randell S, Beroard A, Sugarman E, Rebecca VW, Wei Z, Lu Y, Mills GB, Field J, Villanueva J, Xu X, Herlyn M, Guo W. Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF-mutant melanoma. Oncogene. 2021 09; 40(37):5590-5599. PMID: 34304249; PMCID: PMC8445818.
      Citations: 5     Fields:    Translation:Humans
    90. Mohanty V, Wang F, Mills GB, CTD2 Research Network, Chen K. Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancers. Cell Rep Med. 2021 07 20; 2(7):100349. PMID: 34337565; PMCID: PMC8324495.
      Citations:    Fields:    Translation:Humans
    91. Dietz MS, Sutton TL, Walker BS, Gast CE, Zarour L, Sengupta SK, Swain JR, Eng J, Parappilly M, Limbach K, Sattler A, Burlingame E, Chin Y, Gower A, Mira JLM, Sapre A, Chiu YJ, Clayburgh DR, Pommier SJ, Cetnar JP, Fischer JM, Jaboin JJ, Pommier RF, Sheppard BC, Tsikitis VL, Skalet AH, Mayo SC, Lopez CD, Gray JW, Mills GB, Mitri Z, Chang YH, Chin K, Wong MH. Relevance of circulating hybrid cells as a non-invasive biomarker for myriad solid tumors. Sci Rep. 2021 07 01; 11(1):13630. PMID: 34211050; PMCID: PMC8249418.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    92. Ngamcherdtrakul W, Reda M, Nelson MA, Wang R, Zaidan HY, Bejan DS, Hoang NH, Lane RS, Luoh SW, Leachman SA, Mills GB, Gray JW, Lund AW, Yantasee W. In Situ Tumor Vaccination with Nanoparticle Co-Delivering CpG and STAT3 siRNA to Effectively Induce Whole-Body Antitumor Immune Response. Adv Mater. 2021 Aug; 33(31):e2100628. PMID: 34118167; PMCID: PMC8424660.
      Citations: 8     Fields:    Translation:AnimalsPHPublic Health
    93. Loree JM, Wang Y, Syed MA, Sorokin AV, Coker O, Xiu J, Weinberg BA, Vanderwalde AM, Tesfaye A, Raymond VM, Miron B, Tarcic G, Zelichov O, Broaddus RR, Ng PKS, Jeong KJ, Tsang YH, Mills GB, Overman MJ, Grothey A, Marshall JL, Kopetz S. Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer. Clin Cancer Res. 2021 08 15; 27(16):4587-4598. PMID: 34117033; PMCID: PMC8364867.
      Citations: 3     Fields:    Translation:Humans
    94. Blucher AS, Mills GB, Tsang YH. Precision oncology for breast cancer through clinical trials. Clin Exp Metastasis. 2022 02; 39(1):71-78. PMID: 33950412.
      Citations: 2     Fields:    Translation:Humans
    95. Mandal M, Kim S, Younes MN, Jasser SA, El-Naggar AK, Mills GB, Myers JN. Retraction Note to: The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. Br J Cancer. 2021 May; 124(10):1747. PMID: 33603199; PMCID: PMC8110797.
      Citations:    Fields:    
    96. Garcia-Soto AE, McKenzie ND, Whicker ME, Pearson JM, Jimenez EA, Portelance L, Hu JJ, Lucci JA, Qureshi R, Kossenkov A, Schwartz L, Mills GB, Maity A, Lin LL, Simpkins F. Phase 1 trial of nelfinavir added to standard cisplatin chemotherapy with concurrent pelvic radiation for locally advanced cervical cancer. Cancer. 2021 07 01; 127(13):2279-2293. PMID: 33932031; PMCID: PMC8252376.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    97. Huang KL, Scott AD, Zhou DC, Wang LB, Weerasinghe A, Elmas A, Liu R, Wu Y, Wendl MC, Wyczalkowski MA, Baral J, Sengupta S, Lai CW, Ruggles K, Payne SH, Raphael B, Chen K, Mills G, Ding L, Feny? D. Spatially interacting phosphorylation sites and mutations in cancer. Nat Commun. 2021 04 19; 12(1):2313. PMID: 33875650; PMCID: PMC8055881.
      Citations: 3     Fields:    Translation:HumansCells
    98. Georgopoulou D, Callari M, Rueda OM, Shea A, Martin A, Giovannetti A, Qosaj F, Dariush A, Chin SF, Carnevalli LS, Provenzano E, Greenwood W, Lerda G, Esmaeilishirazifard E, O'Reilly M, Serra V, Bressan D, IMAXT Consortium, Mills GB, Ali HR, Cosulich SS, Hannon GJ, Bruna A, Caldas C. Landscapes of cellular phenotypic diversity in breast cancer xenografts and their impact on drug response. Nat Commun. 2021 03 31; 12(1):1998. PMID: 33790302; PMCID: PMC8012607.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    99. Akcakanat A, Zheng X, Cruz Pico CX, Kim TB, Chen K, Korkut A, Sahin A, Holla V, Tarco E, Singh G, Damodaran S, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Genomic, Transcriptomic, and Proteomic Profiling of Metastatic Breast Cancer. Clin Cancer Res. 2021 06 01; 27(11):3243-3252. PMID: 33782032; PMCID: PMC8172429.
      Citations: 1     Fields:    Translation:HumansCells
    100. Li A, Keck JM, Parmar S, Patterson J, Labrie M, Creason AL, Johnson BE, Downey M, Thomas G, Beadling C, Heiser LM, Kolodzie A, Guimaraes AR, Corless CL, Gray JW, Mills GB, Bergan RC, Mitri ZI. Characterizing advanced breast cancer heterogeneity and treatment resistance through serial biopsies and comprehensive analytics. NPJ Precis Oncol. 2021 Mar 26; 5(1):28. PMID: 33772089; PMCID: PMC7997873.
      Citations: 4     
    101. Yaegashi M, Iwaya T, Sasaki N, Fujita M, Ju Z, Siwak D, Hachiya T, Sato K, Endo F, Kimura T, Otsuka K, Sugimoto R, Sugai T, Liotta L, Lu Y, Mills GB, Nakagawa H, Nishizuka SS. Frequent post-operative monitoring of colorectal cancer using individualised ctDNA validated by multiregional molecular profiling. Br J Cancer. 2021 04; 124(9):1556-1565. PMID: 33658639; PMCID: PMC8076308.
      Citations:    Fields:    Translation:Humans
    102. Yang B, Li X, Fu Y, Guo E, Ye Y, Li F, Liu S, Xiao R, Liu C, Lu F, Huang J, Qin T, Han L, Peng G, Mills GB, Sun C, Chen G. MEK Inhibition Remodels the Immune Landscape of Mutant KRAS Tumors to Overcome Resistance to PARP and Immune Checkpoint Inhibitors. Cancer Res. 2021 05 15; 81(10):2714-2729. PMID: 33589518; PMCID: PMC8265237.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    103. Haugen MH, Hedenfalk I, Borgen E, Loman N, Hatschek T, Mills GB, Engebraaten O, Lingj?rde OC, Garred ?, B?rresen-Dale AL, Naume B, M?landsmo GM. Protein Signature Predicts Response to Neoadjuvant Treatment With Chemotherapy and Bevacizumab in HER2-Negative Breast Cancers. JCO Precis Oncol. 2021; 5. PMID: 34036235; PMCID: PMC8140811.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    104. Wicker CA, Hunt BG, Krishnan S, Aziz K, Parajuli S, Palackdharry S, Elaban WR, Wise-Draper TM, Mills GB, Waltz SE, Takiar V. Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models. Cancer Lett. 2021 04 01; 502:180-188. PMID: 33450358; PMCID: PMC7897292.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    105. Parmar S, Keck JM, Kong B, Look R, Johnson B, Patterson J, Labrie M, Guimaraes AR, Corless CL, Beadling C, Kolodzie A, Bergan R, Gray JW, Mills GB, Mitri ZI. Exceptional Response to Trastuzumab in a Heavily Pretreated Patient With ERBB3-Mutated Metastatic Breast Cancer. JCO Precis Oncol. 2021; 5. PMID: 34250408; PMCID: PMC8232752.
      Citations: 1     Fields:    Translation:Humans
    106. Lamballe F, Ahmad F, Vinik Y, Castellanet O, Daian F, Josselin E, Charafe-Jauffret E, Mills GB, Lev S, Maina F, M?ller AK, K?hler UA, Bailly AL, Castellano R, Cayrou C, G?li V, Borg JP. Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance. Adv Sci (Weinh). 2021 Feb; 8(3):2003049. PMID: 33552868; PMCID: PMC7856896.
      Citations: 6     Fields:    
    107. Gu G, Tian L, Herzog SK, Rechoum Y, Gelsomino L, Gao M, Du L, Kim JA, Dustin D, Lo HC, Beyer AR, Edwards DG, Gonzalez T, Tsimelzon A, Huang HJ, Fernandez NM, Grimm SL, Hilsenbeck SG, Liu D, Xu J, Alaniz A, Li S, Mills GB, Janku F, Kittler R, Zhang XH, Coarfa C, Foulds CE, Symmans WF, Fuqua SAW, And? S. Hormonal modulation of ESR1 mutant metastasis. Oncogene. 2021 02; 40(5):997-1011. PMID: 33323970; PMCID: PMC8020875.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    108. Kalachand RD, Stordal B, Madden S, Chandler B, Cunningham J, Goode EL, Ignatov A, Yu H, Katsaros D, Mills GB, Lu KH, Carey MS, Timms KM, Kupryjanczyk J, Rzepecka IK, Podgorska A, McAlpine JN, Swisher EM, Bernards SS, O'Riain C, O'Toole S, O'Leary JJ, Bowtell DD, Thomas DM, Prieske K, Joosse SA, Woelber L, Chaudhry P, Runnebaum IB, Hennessy BT, Ruscito I, Braicu EI, Sehouli J, H?fner N. BRCA1 Promoter Methylation and Clinical Outcomes in Ovarian Cancer: An Individual Patient Data Meta-Analysis. J Natl Cancer Inst. 2020 12 14; 112(12):1190-1203. PMID: 32413141; PMCID: PMC7735770.
      Citations: 12     Fields:    Translation:HumansCells
    109. Tognon CE, Sears RC, Mills GB, Gray JW, Tyner JW. Ex Vivo Analysis of Primary Tumor Specimens for Evaluation of Cancer Therapeutics. Annu Rev Cancer Biol. 2021 Mar; 5:39-57. PMID: 34222745; PMCID: PMC8248658.
      Citations: 1     
    110. Naffar-Abu Amara S, Kuiken HJ, Selfors LM, Butler T, Leung ML, Leung CT, Kuhn EP, Kolarova T, Hage C, Ganesh K, Panayiotou R, Foster R, Rueda BR, Aktipis A, Spellman P, Ince TA, Xiu J, Oberley M, Gatalica Z, Navin N, Mills GB, Bronson RT, Brugge JS. Transient commensal clonal interactions can drive tumor metastasis. Nat Commun. 2020 11 16; 11(1):5799. PMID: 33199705; PMCID: PMC7669858.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    111. Zhao W, Li J, Chen MM, Luo Y, Ju Z, Nesser NK, Johnson-Camacho K, Boniface CT, Lawrence Y, Pande NT, Davies MA, Herlyn M, Muranen T, Zervantonakis IK, von Euw E, Schultz A, Kumar SV, Korkut A, Spellman PT, Akbani R, Slamon DJ, Gray JW, Brugge JS, Lu Y, Mills GB, Liang H. Large-Scale Characterization of Drug Responses of Clinically Relevant Proteins in Cancer Cell Lines. Cancer Cell. 2020 12 14; 38(6):829-843.e4. PMID: 33157050; PMCID: PMC7738392.
      Citations: 10     Fields:    Translation:HumansCells
    112. Garrido-Castro AC, Barroso-Sousa R, Guo H, Ciruelos E, Serra V, Villagrasa P, Li Y, Savoie J, Xu Z, Arteaga CL, Krop IE, Solit DB, Mills GB, Cantley LC, Winer EP, Lin NU, Saura C, Bermejo B, Gavil? J, Prat A, Par? L, C?liz P, Rodon J. Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer. Breast Cancer Res. 2020 11 02; 22(1):120. PMID: 33138866; PMCID: PMC7607628.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    113. Wang L, Yang L, Wang C, Zhao W, Ju Z, Zhang W, Shen J, Peng Y, An C, Luu YT, Song S, Yap TA, Ajani JA, Mills GB, Shen X, Peng G. Inhibition of the ATM/Chk2 axis promotes cGAS/STING signaling in ARID1A-deficient tumors. J Clin Invest. 2020 11 02; 130(11):5951-5966. PMID: 33016929; PMCID: PMC7598069.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    114. Zou J, Qin W, Yang L, Wang L, Wang Y, Shen J, Xiong W, Yu S, Song S, Ajani JA, Lin SY, Mills GB, Yuan X, Chen J, Peng G. Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer. Am J Cancer Res. 2020; 10(11):3947-3972. PMID: 33294279; PMCID: PMC7716160.
      Citations: 4     
    115. Parashar D, Nair B, Geethadevi A, George J, Nair A, Tsaih SW, Kadamberi IP, Gopinadhan Nair GK, Lu Y, Ramchandran R, Uyar DS, Rader JS, Ram PT, Mills GB, Pradeep S, Chaluvally-Raghavan P. Peritoneal Spread of Ovarian Cancer Harbors Therapeutic Vulnerabilities Regulated by FOXM1 and EGFR/ERBB2 Signaling. Cancer Res. 2020 12 15; 80(24):5554-5568. PMID: 33087324; PMCID: PMC7744365.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    116. Sasaki N, Iwaya T, Chiba T, Fujita M, Ju Z, Endo F, Yaegashi M, Hachiya T, Sugimoto R, Sugai T, Siwak DR, Liotta LA, Lu Y, Mills GB, Nakagawa H, Nishizuka SS. Analysis of mutational and proteomic heterogeneity of gastric cancer suggests an effective pipeline to monitor post-treatment tumor burden using circulating tumor DNA. PLoS One. 2020; 15(10):e0239966. PMID: 33027286; PMCID: PMC7540850.
      Citations: 2     Fields:    Translation:Humans
    117. Vinik Y, Ortega FG, Mills GB, Lu Y, Jurkowicz M, Halperin S, Aharoni M, Gutman M, Lev S. Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response. Sci Adv. 2020 10; 6(40). PMID: 33008904; PMCID: PMC7852393.
      Citations: 17     Fields:    Translation:HumansCells
    118. Jing Y, Liu J, Ye Y, Pan L, Deng H, Wang Y, Yang Y, Diao L, Lin SH, Mills GB, Zhuang G, Xue X, Han L. Multi-omics prediction of immune-related adverse events during checkpoint immunotherapy. Nat Commun. 2020 10 02; 11(1):4946. PMID: 33009409; PMCID: PMC7532211.
      Citations: 35     Fields:    Translation:Humans
    119. Adamson P, Anghel I, Aurisano A, Barr G, Blake A, Cao SV, Carroll TJ, Chen R, Childress S, Coelho JAB, De Rijck S, Evans JJ, Feldman GJ, Flanagan W, Gabrielyan M, Germani S, Graf N, Grzelak K, Habig A, Hahn SR, Hartnell J, Hatcher R, Holin A, Huang J, Koerner LW, Kordosky M, Kreymer A, Lang K, Lucas P, Mann WA, Marshak ML, Mayer N, Mehdiyev R, Meier JR, Miller WH, Mills G, Naples D, Nelson JK, Nichol RJ, O'Connor J, Pahlka RB, Pawloski G, Perch A, Phan DD, Plunkett RK, Poonthottathil N, Qiu X, Radovic A, Sail P, Sanchez MC, Schneps J, Schreckenberger A, Sharma R, Sousa A, Tagg N, Thomas J, Thomson MA, Timmons A, Todd J, Toner R, Torretta D, Vahle P, Weber A, Whitehead LH, Wojcicki SG, MINOS+ PMID: 33034464.
      Citations:    Fields:    
    120. Astanehe A, Arenillas D, Wasserman WW, Leung PCK, Dunn SE, Davies BR, Mills GB, Auersperg N. Expression of Concern: Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer. J Cell Sci. 2020 09 11; 133(17). PMID: 32917731.
      Citations:    Fields:    
    121. Li Y, Burgman B, McGrail DJ, Sun M, Qi D, Shukla SA, Wu E, Capasso A, Lin SY, Wu CJ, Eckhardt SG, Mills GB, Li B, Sahni N, Yi SS. Integrated Genomic Characterization of the Human Immunome in Cancer. Cancer Res. 2020 11 01; 80(21):4854-4867. PMID: 32855206; PMCID: PMC7642109.
      Citations: 4     Fields:    Translation:HumansCells
    122. Verma N, Vinik Y, Saroha A, Nair NU, Ruppin E, Mills G, Karn T, Dubey V, Khera L, Raj H, Maina F, Lev S. Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis. Sci Adv. 2020 08; 6(34). PMID: 32937365; PMCID: PMC7442484.
      Citations: 16     Fields:    
    123. Marusak C, Thakur V, Li Y, Freitas JT, Zmina PM, Thakur VS, Chang M, Gao M, Tan J, Xiao M, Lu Y, Mills GB, Flaherty K, Frederick DT, Miao B, Sullivan RJ, Moll T, Boland GM, Herlyn M, Zhang G, Bedogni B. Targeting Extracellular Matrix Remodeling Restores BRAF Inhibitor Sensitivity in BRAFi-resistant Melanoma. Clin Cancer Res. 2020 11 15; 26(22):6039-6050. PMID: 32820016; PMCID: PMC7669662.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    124. Tsang YH, Mills GB. The roles of MAGEA6 variants in pancreatic cancer development and their potential impact on cancer immunotherapy. Autophagy. 2020 10; 16(10):1923-1924. PMID: 32809888; PMCID: PMC8386611.
      Citations: 1     Fields:    Translation:Humans
    125. Adamson P, An FP, Anghel I, Aurisano A, Balantekin AB, Band HR, Barr G, Bishai M, Blake A, Blyth S, Cao GF, Cao J, Cao SV, Carroll TJ, Chang JF, Chang Y, Chen HS, Chen R, Chen SM, Chen Y, Chen YX, Cheng J, Cheng ZK, Cherwinka JJ, Childress S, Chu MC, Chukanov A, Coelho JAB, Cummings JP, Dash N, De Rijck S, Deng FS, Ding YY, Diwan MV, Dohnal T, Dolzhikov D, Dove J, Dwyer DA, Evans JJ, Feldman GJ, Flanagan W, Gabrielyan M, Gallo JP, Germani S, Gonchar M, Gong GH, Gong H, Graf N, Grzelak K, Gu WQ, Guo JY, Guo L, Guo XH, Guo YH, Guo Z, Habig A, Hackenburg RW, Hahn SR, Hans S, Hartnell J, Hatcher R, He M, Heeger KM, Heng YK, Higuera A, Holin A, Hor YK, Hsiung YB, Hu BZ, Hu JR, Hu T, Hu ZJ, Huang HX, Huang J, Huang XT, Huang YB, Huber P, Jaffe DE, Jen KL, Ji XL, Ji XP, Johnson RA, Jones D, Kang L, Kettell SH, Koerner LW, Kohn S, Kordosky M, Kramer M, Kreymer A, Lang K, Langford TJ, Lee J, Lee JHC, Lei RT, Leitner R, Leung JKC, Li F, Li HL, Li JJ, Li QJ, Li S, Li SC, Li SJ, Li WD, Li XN, Li XQ, Li YF, Li ZB, Liang H, Lin CJ, Lin GL, Lin S, Ling JJ, Link JM, Littenberg L, Littlejohn BR, Liu JC, Liu JL, Liu Y, Liu YH, Lu C, Lu HQ, Lu JS, Lucas P, Luk KB, Ma XB, Ma XY, Ma YQ, Mann WA, Marshak ML, Marshall C, Martinez Caicedo DA, Mayer N, McDonald KT, McKeown RD, Mehdiyev R, Meier JR, Meng Y, Miller WH, Mills G, Naples D, Napolitano J, Naumov D, Naumova E, Nelson JK, Nichol RJ, O'Connor J, Ochoa-Ricoux JP, Olshevskiy A, Pahlka RB, Pan HR, Park J, Patton S, Pawloski G, Peng JC, Perch A, Phan DD, Plunkett RK, Poonthottathil N, Pun CSJ, Qi FZ, Qi M, Qian X, Qiu X, Radovic A, Raper N, Ren J, Rosero R, Roskovec B, Ruan XC, Sail P, Sanchez MC, Schneps J, Schreckenberger A, Shaheed N, Sharma R, Sousa A, Steiner H, Sun JL, Tagg N, Thomas J, Thomson MA, Timmons A, Tmej T, Todd J, Toner R, Torretta D, Treskov K, Tse WH, Tull CE, Vahle P, Viren B, Vorobel V, Wang CH, Wang J, Wang M, Wang NY, Wang RG, Wang W, Wang W, Wang X, Wang Y, Wang YF, Wang Z, Wang Z, Wang ZM, Weber A, Wei HY, Wei LH, Wen LJ, Whisnant K, White C, Whitehead LH, Wojcicki SG, Wong HLH, Wong SCF, Worcester E, Wu DR, Wu FL, Wu Q, Wu WJ, Xia DM, Xie ZQ, Xing ZZ, Xu JL, Xu T, Xue T, Yang CG, Yang L, Yang YZ, Yao HF, Ye M, Yeh M, Young BL, Yu HZ, Yu ZY, Yue BB, Zeng S, Zeng Y, Zhan L, Zhang C, Zhang FY, Zhang HH, Zhang JW, Zhang QM, Zhang XT, Zhang YM, Zhang YX, Zhang YY, Zhang ZJ, Zhang ZP, Zhang ZY, Zhao J, Zhou L, Zhuang HL, Daya Bay Collaboration, MINOS+ PMID: 32857527.
      Citations:    Fields:    
    126. Gagliardi A, Porter VL, Zong Z, Bowlby R, Titmuss E, Namirembe C, Griner NB, Petrello H, Bowen J, Chan SK, Culibrk L, Darragh TM, Stoler MH, Wright TC, Gesuwan P, Dyer MA, Ma Y, Mungall KL, Jones SJM, Nakisige C, Novik K, Orem J, Origa M, Gastier-Foster JM, Yarchoan R, Casper C, Mills GB, Rader JS, Ojesina AI, Gerhard DS, Mungall AJ, Marra MA. Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade-specific epigenome and transcriptome landscapes. Nat Genet. 2020 08; 52(8):800-810. PMID: 32747824; PMCID: PMC7498180.
      Citations: 14     Fields:    Translation:HumansCells
    127. Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F. Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun. 2020 07 24; 11(1):3726. PMID: 32709856; PMCID: PMC7381609.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    128. Reinhold WC, Elloumi F, Varma S, Mills GB, Pommier Y, Robert J. Candidate biomarker assessment for pharmacological response. Transl Oncol. 2020 Oct; 13(10):100830. PMID: 32652468; PMCID: PMC7348063.
      Citations:    
    129. Kim SJ, Ju JS, Kang MH, Eun JW, Kim YH, Raninga PV, Khanna KK, Pack CG, Han HD, Lee HJ, Gong G, Shin Y, Mills GB, Eyun SI, Park YY, Gyorffy B. RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC. Theranostics. 2020; 10(18):7974-7992. PMID: 32724453; PMCID: PMC7381744.
      Citations: 17     Fields:    Translation:HumansCells
    130. Sun C, Fang Y, Labrie M, Li X, Mills GB. Systems approach to rational combination therapy: PARP inhibitors. Biochem Soc Trans. 2020 06 30; 48(3):1101-1108. PMID: 32379297; PMCID: PMC7329579.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    131. Zervantonakis IK, Poskus MD, Scott AL, Selfors LM, Lin JR, Dillon DA, Pathania S, Sorger PK, Mills GB, Brugge JS. Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways. Proc Natl Acad Sci U S A. 2020 07 14; 117(28):16500-16508. PMID: 32601199; PMCID: PMC7368275.
      Citations: 9     Fields:    Translation:HumansCells
    132. Ramos RI, Bustos MA, Wu J, Jones P, Chang SC, Kiyohara E, Tran K, Zhang X, Stern SL, Izraely S, Sagi-Assif O, Witz IP, Davies MA, Mills GB, Kelly DF, Irie RF, Hoon DSB. Upregulation of cell surface GD3 ganglioside phenotype is associated with human melanoma brain metastasis. Mol Oncol. 2020 08; 14(8):1760-1778. PMID: 32358995; PMCID: PMC7400791.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    133. Merritt CR, Ong GT, Church SE, Barker K, Danaher P, Geiss G, Hoang M, Jung J, Liang Y, McKay-Fleisch J, Nguyen K, Norgaard Z, Sorg K, Sprague I, Warren C, Warren S, Webster PJ, Zhou Z, Zollinger DR, Dunaway DL, Mills GB, Beechem JM. Multiplex digital spatial profiling of proteins and RNA in fixed tissue. Nat Biotechnol. 2020 05; 38(5):586-599. PMID: 32393914.
      Citations: 113     Fields:    Translation:Humans
    134. Rao L, Mak VCY, Zhou Y, Zhang D, Li X, Fung CCY, Sharma R, Gu C, Lu Y, Tipoe GL, Cheung ANY, Mills GB, Cheung LWT. p85? regulates autophagic degradation of AXL to activate oncogenic signaling. Nat Commun. 2020 05 08; 11(1):2291. PMID: 32385243; PMCID: PMC7210311.
      Citations: 7     Fields:    Translation:HumansCells
    135. Ngan HL, Liu Y, Fong AY, Poon PHY, Yeung CK, Chan SSM, Lau A, Piao W, Li H, Tse JSW, Lo KW, Chan SM, Su YX, Chan JYK, Lau CW, Mills GB, Grandis JR, Lui VWY. MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling. Life Sci Alliance. 2020 06; 3(6). PMID: 32381551; PMCID: PMC7219112.
      Citations: 13     Fields:    Translation:HumansCells
    136. Wang X, Bustos MA, Zhang X, Ramos RI, Tan C, Iida Y, Chang SC, Salomon MP, Tran K, Gentry R, Kravtsova-Ivantsiv Y, Kelly DF, Mills GB, Ciechanover A, Mao Y, Hoon DSB. Downregulation of the Ubiquitin-E3 Ligase RNF123 Promotes Upregulation of the NF-?B1 Target SerpinE1 in Aggressive Glioblastoma Tumors. Cancers (Basel). 2020 Apr 27; 12(5). PMID: 32349217; PMCID: PMC7281601.
      Citations: 10     
    137. Blucher AS, Mills GB, Tsang YH. Which path to follow? Utilizing proteomics to improve therapy choices for breast cancer patients. Expert Rev Proteomics. 2020 03; 17(3):187-190. PMID: 32306787.
      Citations:    Fields:    Translation:Humans
    138. Ye Y, Jing Y, Li L, Mills GB, Diao L, Liu H, Han L. Sex-associated molecular differences for cancer immunotherapy. Nat Commun. 2020 04 14; 11(1):1779. PMID: 32286310; PMCID: PMC7156379.
      Citations: 53     Fields:    Translation:Humans
    139. Lee S, Zhao L, Rojas C, Bateman NW, Yao H, Lara OD, Celestino J, Morgan MB, Nguyen TV, Conrads KA, Rangel KM, Dood RL, Hajek RA, Fawcett GL, Chu RA, Wilson K, Loffredo JL, Viollet C, Jazaeri AA, Dalgard CL, Mao X, Song X, Zhou M, Hood BL, Banskota N, Wilkerson MD, Te J, Soltis AR, Roman K, Dunn A, Cordover D, Eterovic AK, Liu J, Burks JK, Baggerly KA, Fleming ND, Lu KH, Westin SN, Coleman RL, Mills GB, Casablanca Y, Zhang J, Conrads TP, Maxwell GL, Futreal PA, Sood AK. Molecular Analysis of Clinically Defined Subsets of High-Grade Serous Ovarian Cancer. Cell Rep. 2020 04 14; 31(2):107502. PMID: 32294438; PMCID: PMC7234854.
      Citations: 26     Fields:    Translation:Humans
    140. Tsang YH, Wang Y, Kong K, Grzeskowiak C, Zagorodna O, Dogruluk T, Lu H, Villafane N, Bhavana VH, Moreno D, Elsea SH, Liang H, Mills GB, Scott KL. Differential expression of MAGEA6 toggles autophagy to promote pancreatic cancer progression. Elife. 2020 04 09; 9. PMID: 32270762; PMCID: PMC7164953.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    141. Liang J, Wang L, Wang C, Shen J, Su B, Marisetty AL, Fang D, Kassab C, Jeong KJ, Zhao W, Lu Y, Jain AK, Zhou Z, Liang H, Sun SC, Lu C, Xu ZX, Yu Q, Shao S, Chen X, Gao M, Claret FX, Ding Z, Chen J, Chen P, Barton MC, Peng G, Mills GB, Heimberger AB. Verteporfin Inhibits PD-L1 through Autophagy and the STAT1-IRF1-TRIM28 Signaling Axis, Exerting Antitumor Efficacy. Cancer Immunol Res. 2020 07; 8(7):952-965. PMID: 32265228; PMCID: PMC8204534.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    142. Chen MM, Li J, Mills GB, Liang H. Predicting Cancer Cell Line Dependencies From the Protein Expression Data of Reverse-Phase Protein Arrays. JCO Clin Cancer Inform. 2020 04; 4:357-366. PMID: 32330068; PMCID: PMC7259880.
      Citations: 4     Fields:    Translation:HumansCells
    143. Hazim A, Mills G, Prasad V, Haslam A, Chen EY. Relationship Between Response and Dose in Published, Contemporary Phase I Oncology Trials. J Natl Compr Canc Netw. 2020 04; 18(4):428-433. PMID: 32259790.
      Citations: 3     Fields:    Translation:Humans
    144. Gris-Oliver A, Palafox M, Monserrat L, Ibrahim YH, Villacampa G, Grueso J, Bruna A, Hirst CS, Barnicle A, de Bruin EC, Reddy A, Schiavon G, Mills GB, Caldas C, Dienstmann R, Prat A, Nuciforo P, Razavi P, Scaltriti M, Turner NC, Davies BR, Serra V, Bras?-Maristany F, ?dena A, S?nchez-Guix? M, Par?s M, Guzm?n M, Rodr?guez O, Arribas J, Saura C, Oliveira M. Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts. Clin Cancer Res. 2020 07 15; 26(14):3720-3731. PMID: 32220884; PMCID: PMC7814659.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    145. Krishnamurthy S, Sabir S, Ban K, Wu Y, Sheth R, Tam A, Meric-Bernstam F, Shaw K, Mills G, Bassett R, Hamilton S, Hicks M, Gupta S. Comparison of Real-Time Fluorescence Confocal Digital Microscopy With Hematoxylin-Eosin-Stained Sections of Core-Needle Biopsy Specimens. JAMA Netw Open. 2020 03 02; 3(3):e200476. PMID: 32134465; PMCID: PMC7059022.
      Citations: 7     Fields:    Translation:Humans
    146. Kreisberg JF, Ideker T, Meric-Bernstam F, Mills G. Prospecting whole cancer genomes. Nat Cancer. 2020 03; 1(3):273-275. PMID: 35122032.
      Citations:    Translation:Humans
    147. McGrail DJ, Garnett J, Yin J, Dai H, Shih DJH, Lam TNA, Li Y, Sun C, Li Y, Schmandt R, Wu JY, Hu L, Liang Y, Peng G, Jonasch E, Menter D, Yates MS, Kopetz S, Lu KH, Broaddus R, Mills GB, Sahni N, Lin SY. Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer. Cancer Cell. 2020 03 16; 37(3):371-386.e12. PMID: 32109374; PMCID: PMC7337255.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    148. Wu CC, Beird HC, Andrew Livingston J, Advani S, Mitra A, Cao S, Reuben A, Ingram D, Wang WL, Ju Z, Hong Leung C, Lin H, Zheng Y, Roszik J, Wang W, Patel S, Benjamin RS, Somaiah N, Conley AP, Mills GB, Hwu P, Gorlick R, Lazar A, Daw NC, Lewis V, Futreal PA. Immuno-genomic landscape of osteosarcoma. Nat Commun. 2020 02 21; 11(1):1008. PMID: 32081846; PMCID: PMC7035358.
      Citations: 59     Fields:    Translation:Humans
    149. Chen H, Li J, Wang Y, Ng PK, Tsang YH, Shaw KR, Mills GB, Liang H. Comprehensive assessment of computational algorithms in predicting cancer driver mutations. Genome Biol. 2020 02 20; 21(1):43. PMID: 32079540; PMCID: PMC7033911.
      Citations: 19     Fields:    Translation:Humans
    150. Berg HF, Ju Z, Myrvold M, Fasmer KE, Halle MK, Hoivik EA, Westin SN, Trovik J, Haldorsen IS, Mills GB, Krakstad C, Werner HMJ. Development of prediction models for lymph node metastasis in endometrioid endometrial carcinoma. Br J Cancer. 2020 03; 122(7):1014-1022. PMID: 32037399; PMCID: PMC7109044.
      Citations: 2     Fields:    Translation:Humans
    151. Lee EK, Tan-Wasielewski Z, Aghajanian C, Coleman RL, Curtis J, Hirsch MS, Matulonis UA, Cantley LC, Mills GB, Doyle LA, Liu JF. Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035). Gynecol Oncol Rep. 2020 May; 32:100546. PMID: 32083163; PMCID: PMC7021536.
      Citations: 3     
    152. Yu K, Lin CJ, Hatcher A, Lozzi B, Kong K, Huang-Hobbs E, Cheng YT, Beechar VB, Zhu W, Zhang Y, Chen F, Mills GB, Mohila CA, Creighton CJ, Noebels JL, Scott KL, Deneen B. PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis. Nature. 2020 02; 578(7793):166-171. PMID: 31996845; PMCID: PMC7577741.
      Citations: 38     Fields:    Translation:Animals
    153. Verma N, Kothari C, Panayotopoulou E, Kedan A, Selitrennik M, Mills GB, Nguyen LK, Shin S, Karn T, Holtrich U, Lev S, M?ller AK. Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. Cancer Res. 2020 Jan 15; 80(2):362. PMID: 31941679.
      Citations:    Fields:    
    154. Bollu LR, Shepherd J, Zhao D, Ma Y, Tahaney W, Speers C, Mazumdar A, Mills GB, Brown PH. Mutant P53 induces MELK expression by release of wild-type P53-dependent suppression of FOXM1. NPJ Breast Cancer. 2020; 6:2. PMID: 31909186; PMCID: PMC6941974.
      Citations: 7     
    155. Parashar D, Geethadevi A, Aure MR, Mishra J, George J, Chen C, Mishra MK, Zhao W, Nair B, Lu Y, Mangala LS, Rodriguez-Aguayo C, Lopez-Berestein G, Camara AKS, Liang M, Rader JS, Ramchandran R, You M, Sood AK, Mills GB, Pradeep S, Chaluvally-Raghavan P, Tahiri A, Kristensen VN. miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer. Cell Rep. 2019 12 24; 29(13):4389-4406.e10. PMID: 31875548; PMCID: PMC7380555.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    156. Myers AP, Konstantinopoulos PA, Barry WT, Luo W, Broaddus RR, Makker V, Drapkin R, Liu J, Doyle A, Horowitz NS, Meric-Bernstam F, Birrer M, Aghajanian C, Coleman RL, Mills GB, Cantley LC, Matulonis UA, Westin SN. Phase II, 2-stage, 2-arm, PIK3CA mutation stratified trial of MK-2206 in recurrent endometrial cancer. Int J Cancer. 2020 07 15; 147(2):413-422. PMID: 31714586; PMCID: PMC7214201.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    157. Xu X, Wang Y, Mojumdar K, Zhou Z, Jeong KJ, Mangala LS, Yu S, Tsang YH, Rodriguez-Aguayo C, Lu Y, Lopez-Berestein G, Sood AK, Mills GB, Liang H. A-to-I-edited miRNA-379-5p inhibits cancer cell proliferation through CD97-induced apoptosis. J Clin Invest. 2019 12 02; 129(12):5343-5356. PMID: 31682236; PMCID: PMC6877318.
      Citations: 24     Fields:    Translation:AnimalsCells
    158. Tuna M, Ju Z, Yoshihara K, Amos CI, Tanyi JL, Mills GB. Clinical relevance of TP53 hotspot mutations in high-grade serous ovarian cancers. Br J Cancer. 2020 02; 122(3):405-412. PMID: 31780779; PMCID: PMC7000721.
      Citations: 18     Fields:    Translation:Humans
    159. Tuna M, Liu W, Amos CI, Mills GB. Genome-Wide Profiling of Acquired Uniparental Disomy Reveals Prognostic Factors in Head and Neck Squamous Cell Carcinoma. Neoplasia. 2019 11; 21(11):1102-1109. PMID: 31734631; PMCID: PMC6889229.
      Citations: 1     Fields:    Translation:Humans
    160. Sun C, Li X, Guo E, Li N, Zhou B, Lu H, Huang J, Xia M, Shan W, Wang B, Li K, Weng D, Xu X, Gao Q, Wang S, Hu J, Lu Y, Mills GB, Chen G. MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis. Oncogene. 2020 02; 39(8):1681-1695. PMID: 31705064; PMCID: PMC8290627.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    161. Westin SN, Sill MW, Coleman RL, Waggoner S, Moore KN, Mathews CA, Martin LP, Modesitt SC, Lee S, Ju Z, Mills GB, Schilder RJ, Fracasso PM, Birrer MJ, Aghajanian C. Safety lead-in of the MEK inhibitor trametinib in combination with GSK2141795, an AKT inhibitor, in patients with recurrent endometrial cancer: An NRG Oncology/GOG study. Gynecol Oncol. 2019 12; 155(3):420-428. PMID: 31623857; PMCID: PMC6922584.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    162. Zhang Z, Lee JH, Ruan H, Ye Y, Krakowiak J, Hu Q, Xiang Y, Gong J, Zhou B, Wang L, Lin C, Diao L, Mills GB, Li W, Han L. Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer. Nat Commun. 2019 10 08; 10(1):4562. PMID: 31594934; PMCID: PMC6783481.
      Citations: 71     Fields:    Translation:HumansCells
    163. Labrie M, Kendsersky ND, Ma H, Campbell L, Eng J, Chin K, Mills GB. Proteomics advances for precision therapy in ovarian cancer. Expert Rev Proteomics. 2019 10; 16(10):841-850. PMID: 31512530; PMCID: PMC6814571.
      Citations: 2     Fields:    Translation:Humans
    164. Eterovic AK, Zheng X, Liu S, Chen K, Mills GB, Meric-Bernstam F, Lluch A, Gonz?lez-Angulo AM, Casadevall D, Mart?nez de Due?as E, Guerrero-Zotano ?, P?rez R, Chac?n JI, Antol?n S, Blancas I, L?pez-Serra P, Carrasco E, Caballero R, Prat A, Rojo F, Gonzalez-Perez A, Albanell J. Dynamic clonal remodelling in breast cancer metastases is associated with subtype conversion. Eur J Cancer. 2019 10; 120:54-64. PMID: 31491604.
      Citations: 8     Fields:    Translation:Humans
    165. Rader JS, Pan A, Corbin B, Iden M, Lu Y, Vellano CP, Akbani R, Mills GB, Simpson P. Identification and validation of a prognostic proteomic signature for cervical cancer. Gynecol Oncol. 2019 11; 155(2):324-330. PMID: 31477280; PMCID: PMC6825895.
      Citations: 3     Fields:    Translation:Humans
    166. Arango NP, Brusco L, Shaw KRM, Chen K, Eterovic AK, Holla V, Johnson A, Litzenburger B, Khotskaya YB, Sanchez N, Bailey A, Zheng X, Horombe C, Kopetz S, Farhangfar CJ, Routbort M, Broaddus R, Bernstam EV, Mendelsohn J, Mills GB, Meric-Bernstam F. Correction: A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory. Oncotarget. 2019 Aug 27; 10(50):5254. PMID: 31497255; PMCID: PMC6718259.
      Citations:    Fields:    
    167. Fan XJ, Huang Y, Wu PH, Yin XK, Yu XH, Fu XH, Feng LL, Wang YL, Yi HJ, Chen ZT, Yin JX, Zhang DL, Feng WX, Bai SM, Kim T, Mills GB, Lu YL, Wan XB, Wang L. Impact of Cold Ischemic Time and Freeze-Thaw Cycles on RNA, DNA and Protein Quality in Colorectal Cancer Tissues Biobanking. J Cancer. 2019; 10(20):4978-4988. PMID: 31598170; PMCID: PMC6775519.
      Citations: 1     
    168. Ruan H, Xiang Y, Ko J, Li S, Jing Y, Zhu X, Ye Y, Zhang Z, Mills T, Feng J, Liu CJ, Jing J, Cao J, Zhou B, Wang L, Zhou Y, Lin C, Guo AY, Chen X, Diao L, Li W, Chen Z, He X, Mills GB, Blackburn MR, Han L. Comprehensive characterization of circular RNAs in ~?1000 human cancer cell lines. Genome Med. 2019 08 26; 11(1):55. PMID: 31446897; PMCID: PMC6709551.
      Citations: 50     Fields:    Translation:HumansCells
    169. Buj R, Chen CW, Dahl ES, Leon KE, Kuskovsky R, Maglakelidze N, Navaratnarajah M, Zhang G, Doan MT, Jiang H, Zaleski M, Kutzler L, Lacko H, Lu Y, Mills GB, Gowda R, Robertson GP, Warrick JI, Herlyn M, Imamura Y, Kimball SR, DeGraff DJ, Snyder NW, Aird KM. Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming. Cell Rep. 2019 08 20; 28(8):1971-1980.e8. PMID: 31433975; PMCID: PMC6716532.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    170. Liu ZB, Ezzedine NE, Eterovic AK, Ensor JE, Huang HJ, Choi DS, Liu Y, Wong H, Shao ZM, Darcourt JG, Mills GB, Dave B, Chang JC, Albanell J, Lluch A, Rojo F, Mart?nez-Due?as E, Guerrero-Zotano ?. Detection of breast cancer stem cell gene mutations in circulating free DNA during the evolution of metastases. Breast Cancer Res Treat. 2019 Nov; 178(2):251-261. PMID: 31388936; PMCID: PMC8272952.
      Citations: 7     Fields:    Translation:HumansCells
    171. Mazumdar A, Tahaney WM, Reddy Bollu L, Poage G, Hill J, Zhang Y, Mills GB, Brown PH. The phosphatase PPM1A inhibits triple negative breast cancer growth by blocking cell cycle progression. NPJ Breast Cancer. 2019; 5:22. PMID: 31372497; PMCID: PMC6659706.
      Citations: 7     
    172. Bhandari B, Bian J, Bilton K, Callahan C, Chaves J, Chen H, Cline D, Cooper RL, Danielson D, Danielson J, Dokania N, Elliott S, Fernandes S, Gardiner S, Garvey G, Gehman V, Giuliani F, Glavin S, Gold M, Grant C, Guardincerri E, Haines T, Higuera A, Ji JY, Kadel R, Kamp N, Karlin A, Ketchum W, Koerner LW, Lee D, Lee K, Liu Q, Locke S, Louis WC, Manalaysay A, Maricic J, Martin E, Martinez MJ, Martynenko S, Mauger C, McGrew C, Medina J, Medina PJ, Mills A, Mills G, Mirabal-Martinez J, Olivier A, Pantic E, Philipbar B, Pitcher C, Radeka V, Ramsey J, Rielage K, Rosen M, Sanchez AR, Shin J, Sinnis G, Smy M, Sondheim W, Stancu I, Sterbenz C, Sun Y, Svoboda R, Taylor C, Teymourian A, Thorn C, Tull CE, Tzanov M, Van de Water RG, Walker D, Walsh N, Wang H, Wang Y, Yanagisawa C, Yarritu A, Yoo J, CAPTAIN Collaboration. First Measurement of the Total Neutron Cross Section on Argon between 100 and 800?MeV. Phys Rev Lett. 2019 Jul 26; 123(4):042502. PMID: 31491269.
      Citations:    Fields:    
    173. Lindemann A, Patel AA, Silver NL, Tang L, Liu Z, Wang L, Tanaka N, Rao X, Takahashi H, Maduka NK, Zhao M, Chen TC, Liu W, Gao M, Wang J, Frank SJ, Hittelman WN, Mills GB, Myers JN, Osman AA. COTI-2, A Novel Thiosemicarbazone Derivative, Exhibits Antitumor Activity in HNSCC through p53-dependent and -independent Mechanisms. Clin Cancer Res. 2019 09 15; 25(18):5650-5662. PMID: 31308060; PMCID: PMC6759991.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    174. Albayrak I, Mamyan V, Christy ME, Ahmidouch A, Arrington J, Asaturyan A, Bodek A, Bosted P, Bradford R, Brash E, Bruell A, Butuceanu C, Coleman SJ, Commisso M, Connell SH, Dalton MM, Danagoulian S, Daniel A, Day DB, Dhamija S, Dunne J, Dutta D, Ent R, Gaskell D, Gasparian A, Gran R, Horn T, Huang L, Huber GM, Jayalath C, Johnson M, Jones MK, Kalantarians N, Liyanage A, Keppel CE, Kinney E, Li Y, Malace S, Manly S, Markowitz P, Maxwell J, Mbianda NN, McFarland KS, Meziane M, Meziani ZE, Mills GB, Mkrtchyan H, Mkrtchyan A, Mulholland J, Nelson J, Niculescu G, Niculescu I, Pentchev L, Puckett A, Punjabi V, Qattan IA, Reimer PE, Reinhold J, Rodriguez VM, Rondon-Aramayo O, Sakuda M, Sakumoto WK, Segbefia E, Seva T, Sick I, Slifer K, Smith GR, Steinman J, Solvignon P, Tadevosyan V, Tajima S, Tvaskis V, Vulcan WF, Walton T, Wesselmann FR, Wood SA, Ye Z, E06-009 Collaboration. Measurements of Nonsinglet Moments of the Nucleon Structure Functions and Comparison to Predictions from Lattice QCD for Q^{2}=4??GeV^{2}. Phys Rev Lett. 2019 Jul 12; 123(2):022501. PMID: 31386522.
      Citations:    Fields:    
    175. Xing Y, Lin NU, Maurer MA, Chen H, Mahvash A, Sahin A, Akcakanat A, Li Y, Abramson V, Litton J, Chavez-MacGregor M, Valero V, Piha-Paul SA, Hong D, Do KA, Tarco E, Riall D, Eterovic AK, Wulf GM, Cantley LC, Mills GB, Doyle LA, Winer E, Hortobagyi GN, Gonzalez-Angulo AM, Meric-Bernstam F. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Res. 2019 07 05; 21(1):78. PMID: 31277699; PMCID: PMC6612080.
      Citations: 52     Fields:    Translation:HumansCTClinical Trials
    176. Chen MM, Li J, Wang Y, Akbani R, Lu Y, Mills GB, Liang H. TCPA v3.0: An Integrative Platform to Explore the Pan-Cancer Analysis of Functional Proteomic Data. Mol Cell Proteomics. 2019 08 09; 18(8 suppl 1):S15-S25. PMID: 31201206; PMCID: PMC6692772.
      Citations: 18     Fields:    Translation:Humans
    177. Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy. Cancer Cell. 2019 06 10; 35(6):851-867.e7. PMID: 31185210; PMCID: PMC6642675.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    178. Yin Y, Liu W, Shen Q, Zhang P, Wang L, Tao R, Li H, Ma X, Zeng X, Cheong JH, Song S, Ajani JA, Mills GB, Tao K, Peng G. The DNA Endonuclease Mus81 Regulates ZEB1 Expression and Serves as a Target of BET4 Inhibitors in Gastric Cancer. Mol Cancer Ther. 2019 08; 18(8):1439-1450. PMID: 31142662; PMCID: PMC8345820.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    179. Labrie M, Kim TB, Ju Z, Lee S, Zhao W, Fang Y, Lu Y, Chen K, Ramirez P, Frumovitz M, Meyer L, Fleming ND, Sood AK, Coleman RL, Mills GB, Westin SN. Adaptive responses in a PARP inhibitor window of opportunity trial illustrate limited functional interlesional heterogeneity and potential combination therapy options. Oncotarget. 2019 May 28; 10(37):3533-3546. PMID: 31191824; PMCID: PMC6544405.
      Citations: 10     Fields:    
    180. Beaver JA, Coleman RL, Arend RC, Armstrong DK, Bala S, Mills GB, Sood AK, Herzog TJ. Advancing Drug Development in Gynecologic Malignancies. Clin Cancer Res. 2019 08 15; 25(16):4874-4880. PMID: 31126961; PMCID: PMC6697564.
      Citations: 8     Fields:    Translation:Humans
    181. Ghandi M, Huang FW, Kryukov GV, Lo CC, McDonald ER, Barretina J, Gelfand ET, Bielski CM, Li H, Hu K, Andreev-Drakhlin AY, Kim J, Hess JM, Haas BJ, Weir BA, Rothberg MV, Paolella BR, Lawrence MS, Akbani R, Lu Y, Tiv HL, Gokhale PC, de Weck A, Mansour AA, Oh C, Shih J, Hadi K, Rosen Y, Bistline J, Venkatesan K, Reddy A, Sonkin D, Liu M, Lehar J, Korn JM, Porter DA, Jones MD, Golji J, Caponigro G, Taylor JE, Dunning CM, Creech AL, Warren AC, McFarland JM, Zamanighomi M, Kauffmann A, Stransky N, Imielinski M, Maruvka YE, Cherniack AD, Tsherniak A, Vazquez F, Jaffe JD, Lane AA, Weinstock DM, Johannessen CM, Morrissey MP, Stegmeier F, Schlegel R, Hahn WC, Getz G, Mills GB, Boehm JS, Golub TR, Garraway LA, Sellers WR, Jan?-Valbuena J, Aguet F. Next-generation characterization of the Cancer Cell Line Encyclopedia. Nature. 2019 05; 569(7757):503-508. PMID: 31068700; PMCID: PMC6697103.
      Citations: 746     Fields:    Translation:HumansCells
    182. Hwang MH, Cho KH, Jeong KJ, Park YY, Kim JM, Yu SL, Park CG, Mills GB, Lee HY. Correction: RCP induces Slug expression and cancer cell invasion by stabilizing ?1 integrin. Oncogene. 2019 May; 38(20):3970-3971. PMID: 30679788.
      Citations:    Fields:    
    183. Kang MH, Jeong KJ, Kim WY, Lee HJ, Gong G, Suh N, Kim S, Jeong SY, Mills GB, Park YY, Gyorffy B. Correction: Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer. Oncogene. 2019 May; 38(22):4427-4428. PMID: 30718918.
      Citations:    Fields:    
    184. Wang F, Zhang S, Kim TB, Lin YY, Iqbal R, Wang Z, Mohanty V, Sircar K, Karam JA, Wendl MC, Meric-Bernstam F, Weinstein JN, Ding L, Mills GB, Chen K. Integrated transcriptomic-genomic tool Texomer profiles cancer tissues. Nat Methods. 2019 05; 16(5):401-404. PMID: 30988467; PMCID: PMC7337246.
      Citations: 4     Fields:    Translation:HumansCells
    185. Dumbrava EI, Brusco L, Daniels M, Wathoo C, Shaw K, Lu K, Zheng X, Strong L, Litton J, Arun B, Eterovic AK, Routbort M, Patel K, Qi Y, Piha-Paul S, Subbiah V, Hong D, Rodon J, Kopetz S, Mendelsohn J, Mills GB, Chen K, Meric-Bernstam F. Expanded analysis of secondary germline findings from matched tumor/normal sequencing identifies additional clinically significant mutations. JCO Precis Oncol. 2019; 3. PMID: 31517177; PMCID: PMC6741435.
      Citations: 4     Fields:    
    186. Johansson HJ, Socciarelli F, Vacanti NM, Haugen MH, Zhu Y, Siavelis I, Fernandez-Woodbridge A, Aure MR, Sennblad B, Vesterlund M, Branca RM, Orre LM, Huss M, Fredlund E, Beraki E, Boekel J, Zhao W, Nord S, Jans DC, Brismar H, Haukaas TH, Bathen TF, Schlichting E, Consortia Oslo Breast Cancer Research Consortium (OSBREAC), Luders T, Borgen E, Kristensen VN, Russnes HG, Mills GB, Sahlberg KK, Garred ?, Sauer T, H?glander EK, Naume B, Lingj?rde OC, B?rresen-Dale AL, Lehti? J. Breast cancer quantitative proteome and proteogenomic landscape. Nat Commun. 2019 04 08; 10(1):1600. PMID: 30962452; PMCID: PMC6453966.
      Citations: 56     Fields:    Translation:Humans
    187. Li BT, Janku F, Jung B, Hou C, Madwani K, Alden R, Razavi P, Reis-Filho JS, Shen R, Isbell JM, Blocker AW, Eattock N, Gnerre S, Satya RV, Xu H, Zhao C, Hall MP, Hu Y, Sehnert AJ, Brown D, Ladanyi M, Rudin CM, Hunkapiller N, Feeney N, Mills GB, Paweletz CP, Janne PA, Solit DB, Riely GJ, Aravanis A, Oxnard GR. Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium. Ann Oncol. 2019 04 01; 30(4):597-603. PMID: 30891595; PMCID: PMC6503621.
      Citations: 57     Fields:    Translation:Humans
    188. Zheng S, Alfaro-Munoz K, Wei W, Wang X, Wang F, Eterovic AK, Shaw KRM, Meric-Bernstam F, Fuller GN, Chen K, Verhaak RG, Mills GB, Yung WKA, Weathers SP, de Groot JF. Prospective Clinical Sequencing of Adult Glioma. Mol Cancer Ther. 2019 05; 18(5):991-1000. PMID: 30926639; PMCID: PMC6497568.
      Citations: 5     Fields:    Translation:HumansCells
    189. Siwak DR, Mills GB, Maric G, Annis MG, MacDonald PA, Russo C, Perkins D, Siegel PM. GPNMB augments Wnt-1 mediated breast tumor initiation and growth by enhancing PI3K/AKT/mTOR pathway signaling and ?-catenin activity. Oncogene. 2019 06; 38(26):5294-5307. PMID: 30914799.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    190. Rozanov D, Cheltsov A, Nilsen A, Boniface C, Forquer I, Korkola J, Gray J, Tyner J, Tognon CE, Mills GB, Spellman P. Targeting mitochondria in cancer therapy could provide a basis for the selective anti-cancer activity. PLoS One. 2019; 14(3):e0205623. PMID: 30908483; PMCID: PMC6433232.
      Citations: 9     Fields:    Translation:HumansCells
    191. Baffi TR, Van AN, Zhao W, Mills GB, Newton AC. Protein Kinase C Quality Control by Phosphatase PHLPP1?Unveils Loss-of-Function Mechanism in Cancer. Mol Cell. 2019 04 18; 74(2):378-392.e5. PMID: 30904392; PMCID: PMC6504549.
      Citations: 17     Fields:    Translation:HumansCells
    192. Heiser LM, Mills GB, Gray JW. Therapeutic Clues from an Integrated Omic Assessment of East Asian Triple Negative Breast Cancers. Cancer Cell. 2019 03 18; 35(3):341-343. PMID: 30889376; PMCID: PMC6499473.
      Citations: 1     Fields:    Translation:HumansCells
    193. Ye Y, Hu Q, Chen H, Liang K, Yuan Y, Xiang Y, Ruan H, Zhang Z, Song A, Zhang H, Liu L, Diao L, Lou Y, Zhou B, Wang L, Zhou S, Gao J, Jonasch E, Lin SH, Xia Y, Lin C, Yang L, Mills GB, Liang H, Han L. Characterization of Hypoxia-associated Molecular Features to Aid Hypoxia-Targeted Therapy. Nat Metab. 2019 04; 1(4):431-444. PMID: 31984309; PMCID: PMC6980239.
      Citations: 50     Fields:    Translation:HumansCells
    194. Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, Buss MK, Aghajanian C, Mills GB, Palakurthi S, Kirschmeier P, Liu J, Cantley LC, Kaufmann SH, Swisher EM, D'Andrea AD, Winer E, Wulf GM, Matulonis UA. Olaparib and a-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. Lancet Oncol. 2019 04; 20(4):570-580. PMID: 30880072; PMCID: PMC7025391.
      Citations: 69     Fields:    Translation:HumansCTClinical Trials
    195. Tuna M, Amos CI, Mills GB. Molecular mechanisms and pathobiology of oncogenic fusion transcripts in epithelial tumors. Oncotarget. 2019 Mar 12; 10(21):2095-2111. PMID: 31007851; PMCID: PMC6459343.
      Citations: 10     Fields:    
    196. Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X. Author Correction: Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2019 03 11; 10(1):1211. PMID: 30858377; PMCID: PMC6411891.
      Citations:    Fields:    
    197. Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L. Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer. 2019 06 15; 125(12):1963-1972. PMID: 30835824; PMCID: PMC6557260.
      Citations: 17     Fields:    Translation:Humans
    198. Li X, Mak VCY, Zhou Y, Wang C, Wong ESY, Sharma R, Lu Y, Cheung ANY, Mills GB, Cheung LWT. Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer. Nat Commun. 2019 02 12; 10(1):716. PMID: 30755611; PMCID: PMC6372715.
      Citations: 14     Fields:    Translation:HumansCells
    199. Wang Z, Sun K, Xiao Y, Feng B, Mikule K, Ma X, Feng N, Vellano CP, Federico L, Marszalek JR, Mills GB, Hanke J, Ramaswamy S, Wang J. Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models. Sci Rep. 2019 02 12; 9(1):1853. PMID: 30755715; PMCID: PMC6372650.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    200. Tang C, Mills GB, Yap TA, Pili? PG. State-of-the-art strategies for targeting the DNA damage response in cancer. Nat Rev Clin Oncol. 2019 02; 16(2):81-104. PMID: 30356138; PMCID: PMC8327299.
      Citations: 286     Fields:    Translation:HumansCells
    201. Hedberg ML, Peyser ND, Bauman JE, Gooding WE, Li H, Bhola NE, Zhu TR, Zeng Y, Brand TM, Kim MO, Jordan RCK, VandenBerg S, Olivas V, Bivona TG, Chiosea SI, Wang L, Mills GB, Johnson JT, Duvvuri U, Ferris RL, Ha P, Johnson DE, Grandis JR. Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer. J Exp Med. 2019 02 04; 216(2):419-427. PMID: 30683736; PMCID: PMC6363423.
      Citations: 24     Fields:    Translation:HumansAnimalsCTClinical Trials
    202. Iavarone C, Zervantonakis IK, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis UA, Hallberg D, Velculescu VE, Leverson JD, Sampath D, Mills GB, Brugge JS. Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness. Mol Cancer Ther. 2019 03; 18(3):642-655. PMID: 30679390; PMCID: PMC6399746.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    203. Li Y, McGrail DJ, Xu J, Li J, Liu NN, Sun M, Lin R, Pancsa R, Zhang J, Lee JS, Wang H, Mills GB, Li X, Yi S, Sahni N. MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology. Hepatology. 2019 08; 70(2):532-546. PMID: 30153342; PMCID: PMC6538468.
      Citations: 18     Fields:    Translation:Humans
    204. Tuna M, Amos CI, Mills GB. Genome-Wide Analysis of Head and Neck Squamous Cell Carcinomas Reveals HPV, TP53, Smoking and Alcohol-Related Allele-Based Acquired Uniparental Disomy Genomic Alterations. Neoplasia. 2019 02; 21(2):197-205. PMID: 30616092; PMCID: PMC6321975.
      Citations: 11     Fields:    Translation:Humans
    205. Lu H, Liu S, Zhang G, Wu B, Zhu Y, Frederick DT, Hu Y, Zhong W, Randell S, Sadek N, Zhang W, Chen G, Cheng C, Zeng J, Wu LW, Zhang J, Liu X, Xu W, Krepler C, Sproesser K, Xiao M, Miao B, Liu J, Song CD, Liu JY, Karakousis GC, Schuchter LM, Lu Y, Mills G, Cong Y, Chernoff J, Guo J, Boland GM, Sullivan RJ, Wei Z, Field J, Amaravadi RK, Flaherty KT, Herlyn M, Xu X, Guo W. Author Correction: PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature. 2019 01; 565(7738):E4. PMID: 30532003.
      Citations: 1     Fields:    
    206. Labrie M, Fang Y, Kendsersky ND, Li J, Liang H, Westin SN, Mitri Z, Mills GB. Using Reverse Phase Protein Array (RPPA) to Identify and Target Adaptive Resistance. Adv Exp Med Biol. 2019; 1188:251-266. PMID: 31820393; PMCID: PMC7382818.
      Citations: 7     Fields:    Translation:Humans
    207. Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Gao Y, Song D, Ecker BL, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Sun L, Zhang L, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X. Loss of Phd2 cooperates with BRAFV600E to drive melanomagenesis. Nat Commun. 2018 12 21; 9(1):5426. PMID: 30575721; PMCID: PMC6303344.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    208. Mitri ZI, Parmar S, Johnson B, Kolodzie A, Keck JM, Morris M, Guimaraes AR, Beckett BR, Borate U, Lopez CD, Kemmer KA, Alumkal JJ, Beer TM, Corless CL, Mills GB, Gray JW, Bergan RC. Implementing a comprehensive translational oncology platform: from molecular testing to actionability. J Transl Med. 2018 12 14; 16(1):358. PMID: 30551737; PMCID: PMC6295039.
      Citations: 14     Fields:    Translation:Humans
    209. Liu S, Li S, Wang B, Liu W, Gagea M, Chen H, Sohn J, Parinyanitikul N, Primeau T, Do KA, Vande Woude GF, Mendelsohn J, Ueno NT, Mills GB, Tripathy D, Gonzalez-Angulo AM. Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer. Mol Cancer Ther. 2019 02; 18(2):399-412. PMID: 30518672; PMCID: PMC7357548.
      Citations: 5     Fields:    Translation:HumansCells
    210. Brown BC, Bugel L, Cheng G, Conrad JM, Cooper RL, Dharmapalan R, Diaz A, Djurcic Z, Finley DA, Ford R, Garcia FG, Garvey GT, Grange J, Huang EC, Huelsnitz W, Ignarra C, Johnson RA, Karagiorgi G, Katori T, Kobilarcik T, Louis WC, Mariani C, Marsh W, Mills GB, Mirabal J, Monroe J, Moore CD, Mousseau J, Nienaber P, Nowak J, Osmanov B, Pavlovic Z, Perevalov D, Ray H, Roe BP, Russell AD, Shaevitz MH, Spitz J, Stancu I, Tayloe R, Thornton RT, Tzanov M, Van de Water RG, White DH, Wickremasinghe DA, Zimmerman ED, MiniBooNE Collaboration, Aguilar-Arevalo AA. Significant Excess of Electronlike Events in the MiniBooNE Short-Baseline Neutrino Experiment. Phys Rev Lett. 2018 Nov 30; 121(22):221801. PMID: 30547637.
      Citations: 1     Fields:    
    211. Shen J, Zhao W, Ju Z, Wang L, Peng Y, Labrie M, Yap TA, Mills GB, Peng G. PARPi Triggers the STING-Dependent Immune Response and Enhances the Therapeutic Efficacy of Immune Checkpoint Blockade Independent of BRCAness. Cancer Res. 2019 01 15; 79(2):311-319. PMID: 30482774; PMCID: PMC6588002.
      Citations: 152     Fields:    Translation:HumansAnimalsCells
    212. Holst F, Werner HMJ, Hoivik EA, Kusonmano K, Wik E, Berg A, Birkeland E, Gibson WJ, Halle MK, Trovik J, Cherniack AD, Kalland KH, Mills GB, Singer CF, Krakstad C, Beroukhim R, Salvesen HB, Mj?s S. PIK3CA Amplification Associates with Aggressive Phenotype but Not Markers of AKT-MTOR Signaling in Endometrial Carcinoma. Clin Cancer Res. 2019 01 01; 25(1):334-345. PMID: 30442683; PMCID: PMC6384094.
      Citations: 7     Fields:    Translation:HumansCells
    213. Ip CKM, Ng PKS, Jeong KJ, Shao SH, Ju Z, Leonard PG, Hua X, Vellano CP, Woessner R, Sahni N, Scott KL, Mills GB. Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies. Nat Commun. 2018 11 02; 9(1):4583. PMID: 30389923; PMCID: PMC6214970.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    214. Krishnamurthy S, Ban K, Shaw K, Mills G, Sheth R, Tam A, Gupta S, Sabir S. Confocal Fluorescence Microscopy Platform Suitable for Rapid Evaluation of Small Fragments of Tissue in Surgical Pathology Practice. Arch Pathol Lab Med. 2019 03; 143(3):305-313. PMID: 30376375.
      Citations: 7     Fields:    Translation:Humans
    215. Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK, Jeong KJ, Tsang YH, Moreno D, Bhavana VH, Peng X, Ge Z, Chen H, Li J, Chen Z, Zhang H, Han L, Du D, Creighton CJ, Mills GB, Cancer Genome Atlas Research Network, Camargo F, Liang H. Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer. Cell Rep. 2018 10 30; 25(5):1304-1317.e5. PMID: 30380420; PMCID: PMC6326181.
      Citations: 115     Fields:    Translation:HumansCells
    216. Keene KS, King T, Hwang ES, Peng B, McGuire KP, Tapia C, Zhang H, Bae S, Nakhlis F, Klauber-Demore N, Meszoely I, Sabel MS, Willey SC, Eterovic AK, Hudis C, Wolff AC, De Los Santos J, Thompson A, Mills GB, Meric-Bernstam F. Molecular determinants of post-mastectomy breast cancer recurrence. NPJ Breast Cancer. 2018; 4:34. PMID: 30345349; PMCID: PMC6185974.
      Citations: 3     
    217. Ha MJ, Banerjee S, Akbani R, Liang H, Mills GB, Do KA, Baladandayuthapani V. Personalized Integrated Network Modeling of the Cancer Proteome Atlas. Sci Rep. 2018 10 08; 8(1):14924. PMID: 30297783; PMCID: PMC6175854.
      Citations: 3     Fields:    Translation:HumansCells
    218. Hsieh HJ, Zhang W, Lin SH, Yang WH, Wang JZ, Shen J, Zhang Y, Lu Y, Wang H, Yu J, Mills GB, Peng G. Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery. Nat Commun. 2018 09 28; 9(1):3982. PMID: 30266942; PMCID: PMC6162282.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    219. Mach J, Atkins M, Gajewski KM, Mottier-Pavie V, Sansores-Garcia L, Xie J, Mills RA, Kowalczyk W, Van Huffel L, Mills GB, Halder G. Modulation of the Hippo pathway and organ growth by RNA processing proteins. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):10684-10689. PMID: 30257938; PMCID: PMC6196505.
      Citations: 6     Fields:    Translation:AnimalsCells
    220. Zhang M, Roszik J, Williams LJ, Peng X, Chiu Y, Tsou CC, Talukder A, Forget MA, Haymaker C, Bernatchez C, Han L, Tsang YH, Kong K, Xu X, Scott KL, Lizee G, Liang H, Mills GB, Hwu P, Fritsche J, Hoffgaard F, Goldfinger V, Schoor O, Singh-Jasuja H, Weinschenk T. RNA editing derived epitopes function as cancer antigens to elicit immune responses. Nat Commun. 2018 09 25; 9(1):3919. PMID: 30254248; PMCID: PMC6156571.
      Citations: 43     Fields:    Translation:HumansCells
    221. Jeong BY, Cho KH, Jeong KJ, Park YY, Kim JM, Rha SY, Park CG, Mills GB, Cheong JH, Lee HY. Author Correction: Rab25 augments cancer cell invasiveness through a ?1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin. Exp Mol Med. 2018 09 19; 50(9):1-2. PMID: 30232331; PMCID: PMC6145867.
      Citations:    Fields:    
    222. Ileana Dumbrava EE, Mills GB, Yap TA. Targeting gamma secretase: has progress moved up a Notch? Ann Oncol. 2018 09 01; 29(9):1889-1891. PMID: 30084907.
      Citations: 3     Fields:    Translation:HumansCells
    223. Kang MH, Choi H, Oshima M, Cheong JH, Kim S, Lee JH, Park YS, Choi HS, Kweon MN, Pack CG, Lee JS, Mills GB, Myung SJ, Park YY. Author Correction: Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun. 2018 08 31; 9(1):3599. PMID: 30171186; PMCID: PMC6119198.
      Citations:    Fields:    
    224. Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Castro MAA, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, de Sa Carvalho B, Chagas VS, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ, TCGA Research Network, Weinstein JN, Kwiatkowski DJ, Lerner SP. Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2018 08 09; 174(4):1033. PMID: 30096301; PMCID: PMC6297116.
      Citations: 111     Fields:    
    225. Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Colaprico A, Wendl MC, Kim J, Reardon B, Kwok-Shing Ng P, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H, MC3 Working Group, Cancer Genome Atlas Research Network, Lawrence MS, Godzik A, Lopez-Bigas N, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L, Cort?s-Ciriano I. Comprehensive Characterization of Cancer Driver Genes and Mutations. Cell. 2018 08 09; 174(4):1034-1035. PMID: 30096302; PMCID: PMC8045146.
      Citations: 173     Fields:    
    226. Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R, Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Mitchell TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X, Guo W. Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response. Nature. 2018 08; 560(7718):382-386. PMID: 30089911; PMCID: PMC6095740.
      Citations: 742     Fields:    Translation:HumansAnimalsCells
    227. Rhyasen GW, Yao Y, Zhang J, Dulak A, Castriotta L, Jacques K, Zhao W, Gharahdaghi F, Hattersley MM, Lyne PD, Clark E, Zinda M, Fawell SE, Mills GB, Chen H. BRD4 amplification facilitates an oncogenic gene expression program in high-grade serous ovarian cancer and confers sensitivity to BET inhibitors. PLoS One. 2018; 13(7):e0200826. PMID: 30036377; PMCID: PMC6056044.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    228. Wang J, Zhao W, Guo H, Fang Y, Stockman SE, Bai S, Ng PK, Li Y, Yu Q, Lu Y, Jeong KJ, Chen X, Gao M, Liang J, Li W, Tian X, Jonasch E, Mills GB, Ding Z. AKT isoform-specific expression and activation across cancer lineages. BMC Cancer. 2018 Jul 16; 18(1):742. PMID: 30012111; PMCID: PMC6048698.
      Citations: 15     Fields:    Translation:HumansCells
    229. Grzeskowiak CL, Kundu ST, Mo X, Ivanov AA, Zagorodna O, Lu H, Chapple RH, Tsang YH, Moreno D, Mosqueda M, Eterovic K, Fradette JJ, Ahmad S, Chen F, Chong Z, Chen K, Creighton CJ, Fu H, Mills GB, Gibbons DL, Scott KL. In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer. Nat Commun. 2018 07 16; 9(1):2732. PMID: 30013058; PMCID: PMC6048166.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    230. Simpkins F, Jang K, Yoon H, Hew KE, Kim M, Azzam DJ, Sun J, Zhao D, Ince TA, Liu W, Guo W, Wei Z, Zhang G, Mills GB, Slingerland JM. Dual Src and MEK Inhibition Decreases Ovarian Cancer Growth and Targets Tumor Initiating Stem-Like Cells. Clin Cancer Res. 2018 10 01; 24(19):4874-4886. PMID: 29959144; PMCID: PMC6557165.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    231. Li Y, McGrail DJ, Xu J, Mills GB, Sahni N, Yi S. Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation. Trends Biochem Sci. 2018 08; 43(8):576-592. PMID: 29941230; PMCID: PMC6215597.
      Citations: 8     Fields:    Translation:HumansCells
    232. Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwiatkowski DJ, Lui W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WY, Robertson AG, Cancer Genome Atlas Research Network, Spellman PT, Rathmell WK, Linehan WM. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep. 2018 Jun 19; 23(12):3698. PMID: 29925010.
      Citations: 82     Fields:    
    233. Antony J, Zanini E, Kelly Z, Tan TZ, Karali E, Alomary M, Jung Y, Nixon K, Cunnea P, Fotopoulou C, Paterson A, Roy-Nawathe S, Mills GB, Huang RY, Thiery JP, Gabra H, Recchi C. The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer. EMBO Rep. 2018 08; 19(8). PMID: 29907679; PMCID: PMC6073217.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    234. Lee H, Kim N, Yoo YJ, Kim H, Jeong E, Choi S, Moon SU, Oh SH, Mills GB, Yoon S, Kim WY. ?-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer. Oncogene. 2018 10; 37(40):5466-5475. PMID: 29895971.
      Citations: 5     Fields:    Translation:HumansCells
    235. Kuppa SS, Jia W, Liu S, Nguyen H, Smyth SS, Mills GB, Dobbin KK, Hardman WJ, Murph MM. Autotaxin exacerbates tumor progression by enhancing MEK1 and overriding the function of miR-489-3p. Cancer Lett. 2018 09 28; 432:84-92. PMID: 29859298; PMCID: PMC6075675.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    236. Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell. 2018 06 11; 33(6):985-1003.e7. PMID: 29805077; PMCID: PMC6100788.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    237. Kang MH, Choi H, Oshima M, Cheong JH, Kim S, Lee JH, Park YS, Choi HS, Kweon MN, Pack CG, Lee JS, Mills GB, Myung SJ, Park YY. Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun. 2018 05 15; 9(1):1920. PMID: 29765046; PMCID: PMC5954140.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    238. McGrail DJ, Lin CC, Dai H, Mo W, Li Y, Stephan C, Davies P, Lu Z, Mills GB, Lee JS, Lin SY. Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype. Cell Rep. 2018 05 15; 23(7):2095-2106. PMID: 29768207.
      Citations: 16     Fields:    Translation:HumansCells
    239. Parekh A, Das S, Parida S, Das CK, Dutta D, Mallick SK, Wu PH, Kumar BNP, Bharti R, Dey G, Banerjee K, Rajput S, Bharadwaj D, Pal I, Dey KK, Rajesh Y, Jena BC, Biswas A, Banik P, Pradhan AK, Das SK, Das AK, Dhara S, Fisher PB, Wirtz D, Mills GB, Mandal M. Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo. Oncogene. 2018 08; 37(33):4546-4561. PMID: 29743594.
      Citations: 22     Fields:    Translation:HumansCells
    240. Wang Z, Ng KS, Chen T, Kim TB, Wang F, Shaw K, Scott KL, Meric-Bernstam F, Mills GB, Chen K. Cancer driver mutation prediction through Bayesian integration of multi-omic data. PLoS One. 2018; 13(5):e0196939. PMID: 29738578; PMCID: PMC5940219.
      Citations: 7     Fields:    Translation:Humans
    241. Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G. ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nat Med. 2018 05; 24(5):556-562. PMID: 29736026; PMCID: PMC6076433.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    242. Oh SC, Sohn BH, Cheong JH, Kim SB, Lee JE, Park KC, Lee SH, Park JL, Park YY, Lee HS, Jang HJ, Park ES, Kim SC, Heo J, Chu IS, Jang YJ, Mok YJ, Jung W, Kim BH, Kim A, Cho JY, Lim JY, Hayashi Y, Song S, Elimova E, Estralla JS, Lee JH, Bhutani MS, Lu Y, Liu W, Lee J, Kang WK, Kim S, Noh SH, Mills GB, Kim SY, Ajani JA, Lee JS. Clinical and genomic landscape of gastric cancer with a mesenchymal phenotype. Nat Commun. 2018 05 03; 9(1):1777. PMID: 29725014; PMCID: PMC5934392.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    243. Reyes-Uribe PI, Guterres AN, Yin X, Kossenkov AV, Liu Q, Zhang G, Krepler C, Cheng C, Wei Z, Somasundaram R, Karakousis G, Xu W, Morrissette JJ, Lu Y, Mills GB, Sullivan RJ, Benchun M, Frederick DT, Boland G, Flaherty KT, Weeraratna AT, Herlyn M, Amaravadi R, Schuchter LM, Burd CE, Aplin AE, Xu X, Villanueva J, Echevarr?a-Vargas IM. Co-targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor-resistant melanoma. EMBO Mol Med. 2018 05; 10(5). PMID: 29650805; PMCID: PMC5938620.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    244. Zhao W, Li J, Akbani R, Liang H, Mills GB. Credentialing Individual Samples for Proteogenomic Analysis. Mol Cell Proteomics. 2018 08; 17(8):1515-1530. PMID: 29716986; PMCID: PMC6072548.
      Citations: 3     Fields:    Translation:Humans
    245. Peng X, Xu X, Wang Y, Hawke DH, Yu S, Han L, Zhou Z, Mojumdar K, Jeong KJ, Labrie M, Tsang YH, Zhang M, Lu Y, Hwu P, Scott KL, Liang H, Mills GB. A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer. Cancer Cell. 2018 05 14; 33(5):817-828.e7. PMID: 29706454; PMCID: PMC5953833.
      Citations: 67     Fields:    Translation:HumansCells
    246. Meric-Bernstam F, Zheng X, Shariati M, Damodaran S, Wathoo C, Brusco L, Demirhan ME, Tapia C, Eterovic AK, Basho RK, Ueno NT, Janku F, Sahin A, Rodon J, Broaddus R, Kim TB, Mendelsohn J, Mills Shaw KR, Tripathy D, Mills GB, Chen K. Survival Outcomes by TP53 Mutation Status in Metastatic Breast Cancer. JCO Precis Oncol. 2018; 2018. PMID: 30035249; PMCID: PMC6050977.
      Citations: 19     Fields:    
    247. Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z. EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Mol Cell. 2018 04 19; 70(2):197-210.e7. PMID: 29677490; PMCID: PMC6114939.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    248. Du D, Ma W, Yates MS, Chen T, Lu KH, Lu Y, Weinstein JN, Broaddus RR, Mills GB, Liu Y. Predicting high-risk endometrioid carcinomas using proteins. Oncotarget. 2018 Apr 13; 9(28):19704-19715. PMID: 29731976; PMCID: PMC5929419.
      Citations: 4     Fields:    
    249. Zhang J, Dulak AM, Hattersley MM, Willis BS, Wang A, Lau A, Reimer C, Zinda M, Fawell SE, Mills GB, Chen H, Nikkil? J. BRD4 facilitates replication stress-induced DNA damage response. Oncogene. 2018 07; 37(28):3763-3777. PMID: 29636547; PMCID: PMC6101970.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    250. Brown BC, Bugel L, Cheng G, Church ED, Conrad JM, Cooper RL, Dharmapalan R, Djurcic Z, Finley DA, Fitzpatrick RS, Ford R, Garcia FG, Garvey GT, Grange J, Huelsnitz W, Ignarra C, Imlay R, Johnson RA, Jordan JR, Karagiorgi G, Katori T, Kobilarcik T, Louis WC, Mahn K, Mariani C, Marsh W, Mills GB, Mirabal J, Moore CD, Mousseau J, Nienaber P, Osmanov B, Pavlovic Z, Perevalov D, Ray H, Roe BP, Russell AD, Shaevitz MH, Spitz J, Stancu I, Tayloe R, Thornton RT, Van de Water RG, Wascko MO, White DH, Wickremasinghe DA, Zeller GP, Zimmerman ED, MiniBooNE Collaboration, Aguilar-Arevalo AA. First Measurement of Monoenergetic Muon Neutrino Charged Current Interactions. Phys Rev Lett. 2018 Apr 06; 120(14):141802. PMID: 29694148.
      Citations:    Fields:    
    251. Ding L, Bailey MH, Porta-Pardo E, Thorsson V, Bertrand D, Gibbs DL, Weerasinghe A, Huang KL, Tokheim C, Jayasinghe R, Chen F, Yu L, Sun S, Kim J, Taylor AM, Cherniack AD, Akbani R, Suphavilai C, Nagarajan N, Stuart JM, Mills GB, Wyczalkowski MA, Vincent BG, Hutter CM, Zenklusen JC, Hoadley KA, Wendl MC, Shmulevich L, Lazar AJ, Wheeler DA, Getz G, Cancer Genome Atlas Research Network, Colaprico A, Cort?s-Ciriano I, Olsen C. Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics. Cell. 2018 04 05; 173(2):305-320.e10. PMID: 29625049; PMCID: PMC5916814.
      Citations: 118     Fields:    Translation:HumansCells
    252. Bailey MH, Tokheim C, Porta-Pardo E, Sengupta S, Bertrand D, Weerasinghe A, Wendl MC, Kim J, Reardon B, Ng PK, Jeong KJ, Cao S, Wang Z, Gao J, Gao Q, Wang F, Liu EM, Mularoni L, Rubio-Perez C, Nagarajan N, Zhou DC, Liang WW, Hess JM, Yellapantula VD, Tamborero D, Gonzalez-Perez A, Suphavilai C, Ko JY, Khurana E, Park PJ, Van Allen EM, Liang H, MC3 Working Group, Cancer Genome Atlas Research Network, Lawrence MS, Godzik A, Stuart J, Wheeler D, Getz G, Chen K, Lazar AJ, Mills GB, Karchin R, Ding L, Colaprico A, Cort?s-Ciriano I, Lopez-Bigas N. Comprehensive Characterization of Cancer Driver Genes and Mutations. Cell. 2018 04 05; 173(2):371-385.e18. PMID: 29625053; PMCID: PMC6029450.
      Citations: 625     Fields:    Translation:Humans
    253. Knijnenburg TA, Wang L, Zimmermann MT, Chambwe N, Gao GF, Cherniack AD, Fan H, Shen H, Way GP, Greene CS, Liu Y, Akbani R, Feng B, Donehower LA, Miller C, Shen Y, Karimi M, Chen H, Kim P, Jia P, Shinbrot E, Zhang S, Liu J, Hu H, Bailey MH, Yau C, Wolf D, Zhao Z, Weinstein JN, Li L, Ding L, Mills GB, Laird PW, Wheeler DA, Shmulevich I, Cancer Genome Atlas Research Network, Monnat RJ, Xiao Y, Wang C. Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas. Cell Rep. 2018 04 03; 23(1):239-254.e6. PMID: 29617664; PMCID: PMC5961503.
      Citations: 310     Fields:    Translation:HumansCells
    254. Ricketts CJ, De Cubas AA, Fan H, Smith CC, Lang M, Reznik E, Bowlby R, Gibb EA, Akbani R, Beroukhim R, Bottaro DP, Choueiri TK, Gibbs RA, Godwin AK, Haake S, Hakimi AA, Henske EP, Hsieh JJ, Ho TH, Kanchi RS, Krishnan B, Kwiatkowski DJ, Lui W, Merino MJ, Mills GB, Myers J, Nickerson ML, Reuter VE, Schmidt LS, Shelley CS, Shen H, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Vincent BG, Vocke CD, Wheeler DA, Yang L, Kim WY, Robertson AG, Cancer Genome Atlas Research Network, Spellman PT, Rathmell WK, Linehan WM, Liu W. The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma. Cell Rep. 2018 04 03; 23(1):313-326.e5. PMID: 29617669; PMCID: PMC6075733.
      Citations: 204     Fields:    Translation:Humans
    255. McGrail DJ, Federico L, Li Y, Dai H, Lu Y, Mills GB, Yi S, Lin SY, Sahni N. Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. Nat Commun. 2018 04 03; 9(1):1317. PMID: 29615613; PMCID: PMC5882811.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    256. Berger AC, Korkut A, Kanchi RS, Hegde AM, Lenoir W, Liu W, Liu Y, Fan H, Shen H, Ravikumar V, Rao A, Schultz A, Li X, Sumazin P, Mestdagh P, Gunaratne PH, Yau C, Bowlby R, Robertson AG, Wang C, Cherniack AD, Godwin AK, Kuderer NM, Rader JS, Zuna RE, Sood AK, Lazar AJ, Ojesina AI, Adebamowo C, Adebamowo SN, Baggerly KA, Chen TW, Chiu HS, Lefever S, Liu L, MacKenzie K, Orsulic S, Roszik J, Shelley CS, Song Q, Vellano CP, Wentzensen N, Cancer Genome Atlas Research Network, Weinstein JN, Mills GB, Levine DA, Akbani R, Williams C, Tiezzi DG. A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers. Cancer Cell. 2018 04 09; 33(4):690-705.e9. PMID: 29622464; PMCID: PMC5959730.
      Citations: 207     Fields:    Translation:Humans
    257. Xiang Y, Ye Y, Lou Y, Yang Y, Cai C, Zhang Z, Mills T, Chen NY, Kim Y, Muge Ozguc F, Diao L, Karmouty-Quintana H, Xia Y, Kellems RE, Chen Z, Blackburn MR, Yoo SH, Shyu AB, Mills GB, Han L. Comprehensive Characterization of Alternative Polyadenylation in Human Cancer. J Natl Cancer Inst. 2018 04 01; 110(4):379-389. PMID: 29106591; PMCID: PMC6059203.
      Citations: 47     Fields:    Translation:HumansCells
    258. Zhang G, Wu LW, Mender I, Barzily-Rokni M, Hammond MR, Ope O, Cheng C, Vasilopoulos T, Randell S, Sadek N, Beroard A, Xiao M, Tian T, Tan J, Saeed U, Sugarman E, Krepler C, Brafford P, Sproesser K, Murugan S, Somasundaram R, Garman B, Wubbenhorst B, Woo J, Yin X, Liu Q, Frederick DT, Miao B, Xu W, Karakousis GC, Xu X, Schuchter LM, Mitchell TC, Kwong LN, Amaravadi RK, Lu Y, Boland GM, Wei Z, Nathanson K, Herbig U, Mills GB, Flaherty KT, Herlyn M, Shay JW. Induction of Telomere Dysfunction Prolongs Disease Control of Therapy-Resistant Melanoma. Clin Cancer Res. 2018 10 01; 24(19):4771-4784. PMID: 29563139; PMCID: PMC6150856.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    259. Watson SS, Dane M, Chin K, Tatarova Z, Liu M, Liby T, Thompson W, Smith R, Nederlof M, Bucher E, Kilburn D, Whitman M, Sudar D, Mills GB, Heiser LM, Jonas O, Gray JW, Korkola JE. Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. Cell Syst. 2018 Mar 28; 6(3):329-342.e6. PMID: 29550255; PMCID: PMC5927625.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    260. Lee J, Geiss GK, Demirkan G, Vellano CP, Filanoski B, Lu Y, Ju Z, Yu S, Guo H, Bogatzki LY, Carter W, Meredith RK, Krishnamurthy S, Ding Z, Beechem JM, Mills GB. Implementation of a Multiplex and Quantitative Proteomics Platform for Assessing Protein Lysates Using DNA-Barcoded Antibodies. Mol Cell Proteomics. 2018 06; 17(6):1245-1258. PMID: 29531020; PMCID: PMC5986246.
      Citations: 8     Fields:    Translation:HumansCells
    261. Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB. BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell. 2018 03 12; 33(3):401-416.e8. PMID: 29533782; PMCID: PMC5944839.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    262. Ng PK, Li J, Jeong KJ, Shao S, Chen H, Tsang YH, Sengupta S, Wang Z, Bhavana VH, Tran R, Soewito S, Minussi DC, Moreno D, Kong K, Dogruluk T, Lu H, Tokheim C, Zhou DC, Johnson AM, Zeng J, Ip CKM, Ju Z, Wester M, Yu S, Li Y, Vellano CP, Karchin R, Ding L, Lu Y, Cheung LWT, Chen K, Shaw KR, Meric-Bernstam F, Scott KL, Yi S, Sahni N, Liang H, Mills GB, Gao J, Schultz N. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018 03 12; 33(3):450-462.e10. PMID: 29533785; PMCID: PMC5926201.
      Citations: 78     Fields:    Translation:Humans
    263. Ye Y, Xiang Y, Ozguc FM, Kim Y, Liu CJ, Park PK, Hu Q, Diao L, Lou Y, Lin C, Guo AY, Zhou B, Wang L, Chen Z, Takahashi JS, Mills GB, Yoo SH, Han L. The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy. Cell Syst. 2018 Mar 28; 6(3):314-328.e2. PMID: 29525205; PMCID: PMC6056007.
      Citations: 65     Fields:    Translation:Humans
    264. Aslan O, Cremona M, Morgan C, Cheung LW, Mills GB, Hennessy BT. Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro. BMC Cancer. 2018 02 09; 18(1):168. PMID: 29426295; PMCID: PMC5807759.
      Citations: 10     Fields:    Translation:HumansCells
    265. Kurnit KC, Dumbrava EEI, Litzenburger B, Khotskaya YB, Johnson AM, Yap TA, Rodon J, Zeng J, Shufean MA, Bailey AM, Holla V, Mendelsohn J, Shaw KM, Bernstam EV, Mills GB, Meric-Bernstam F, S?nchez NS. Precision Oncology Decision Support: Current Approaches and Strategies for the Future. Clin Cancer Res. 2018 06 15; 24(12):2719-2731. PMID: 29420224; PMCID: PMC6004235.
      Citations: 23     Fields:    Translation:Humans
    266. Acciarri R, Adams C, An R, Anthony J, Asaadi J, Bagby L, Balasubramanian S, Baller B, Barnes C, Barr G, Bass M, Bay F, Bishai M, Blake A, Bolton T, Camilleri L, Caratelli D, Carls B, Castillo Fernandez R, Cavanna F, Chen H, Church E, Cianci D, Cohen E, Collin GH, Conrad JM, Convery M, Del Tutto M, Devitt D, Dytman S, Eberly B, Escudero Sanchez L, Esquivel J, Fadeeva AA, Fleming BT, Foreman W, Furmanski AP, Garcia-Gamez D, Garvey GT, Genty V, Gollapinni S, Graf N, Gramellini E, Greenlee H, Grosso R, Guenette R, Hackenburg A, Hamilton P, Hen O, Hewes J, Hill C, Ho J, Horton-Smith G, Hourlier A, Huang EC, James C, Jan de Vries J, Jen CM, Jiang L, Johnson RA, Joshi J, Jostlein H, Kaleko D, Karagiorgi G, Ketchum W, Kirby B, Kirby M, Kobilarcik T, Laube A, Li Y, Lister A, Littlejohn BR, Lockwitz S, Louis WC, Lundberg B, Luo X, Marchionni A, Mariani C, Marshall J, Martinez Caicedo DA, Meddage V, Miceli T, Mills GB, Moon J, Mooney M, Moore CD, Mousseau J, Murrells R, Naples D, Nienaber P, Nowak J, Palamara O, Paolone V, Papavassiliou V, Pate SF, Pavlovic Z, Piasetzky E, Porzio D, Pulliam G, Qian X, Raaf JL, Rafique A, Rochester L, Russell B, Schmitz DW, Schukraft A, Seligman W, Shaevitz MH, Smith A, Snider EL, Soderberg M, Soleti SR, Spentzouris P, Spitz J, St John J, Strauss T, Szelc AM, Tagg N, Terao K, Thomson M, Toups M, Tsai YT, Tufanli S, Usher T, Van De Pontseele W, Van de Water RG, Viren B, Wickremasinghe DA, Wolbers S, Wongjirad T, Woodruff K, Yang T, Yates L, Zeller GP, Zennamo J, Zhang C, Auger M, Crespo-Anad?n JI, Ereditato A, Goeldi D, Kreslo I, Lorca D, Luethi M, Rudolf von Rohr C, Sinclair J, S?ldner-Rembold S, Weber M. The Pandora multi-algorithm approach to automated pattern recognition of cosmic-ray muon and neutrino events in the MicroBooNE detector. Eur Phys J C Part Fields. 2018; 78(1):82. PMID: 31258394; PMCID: PMC6566216.
      Citations: 1     
    267. Jeong BY, Cho KH, Jeong KJ, Park YY, Kim JM, Rha SY, Park CG, Mills GB, Cheong JH, Lee HY. Rab25 augments cancer cell invasiveness through a ?1 integrin/EGFR/VEGF-A/Snail signaling axis and expression of fascin. Exp Mol Med. 2018 01 26; 50(1):e435. PMID: 29371698; PMCID: PMC5799805.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    268. Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Walter V, Danilova L, Lichtenberg TM, Kucherlapati M, Kimes PK, Tang M, Penson A, Babur O, Akbani R, Bristow CA, Hoadley KA, Iype L, Chang MT, TCGA Research Network, Cherniack AD, Benz C, Mills GB, Verhaak RGW, Griewank KG, Felau I, Zenklusen JC, Gershenwald JE, Schoenfield L, Lazar AJ, Abdel-Rahman MH, Roman-Roman S, Stern MH, Cebulla CM, Williams MD, Jager MJ, Coupland SE, Esmaeli B, Kandoth C, Woodman SE. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. Cancer Cell. 2018 01 08; 33(1):151. PMID: 29316429.
      Citations: 41     Fields:    
    269. Sabir SH, Krishnamurthy S, Gupta S, Mills GB, Wei W, Cortes AC, Mills Shaw KR, Luthra R, Wallace MJ. Characteristics of percutaneous core biopsies adequate for next generation genomic sequencing. PLoS One. 2017; 12(12):e0189651. PMID: 29281680; PMCID: PMC5744968.
      Citations: 9     Fields:    Translation:Humans
    270. Park KC, Kim SW, Jeon JY, Jo AR, Choi HJ, Kim J, Lee HG, Kim Y, Mills GB, Noh SH, Lee MG, Park ES, Cheong JH. Survival of Cancer Stem-Like Cells Under Metabolic Stress via CaMK2a-mediated Upregulation of Sarco/Endoplasmic Reticulum Calcium ATPase Expression. Clin Cancer Res. 2018 04 01; 24(7):1677-1690. PMID: 29279319.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    271. Emran AA, Marzese DM, Menon DR, Stark MS, Torrano J, Hammerlindl H, Zhang G, Brafford P, Salomon MP, Nelson N, Hammerlindl S, Gupta D, Mills GB, Lu Y, Sturm RA, Flaherty K, Hoon DSB, Gabrielli B, Herlyn M, Schaider H. Distinct histone modifications denote early stress-induced drug tolerance in cancer. Oncotarget. 2018 Feb 02; 9(9):8206-8222. PMID: 29492189; PMCID: PMC5823586.
      Citations: 33     Fields:    
    272. Krishnamurthy S, Cortes A, Lopez M, Wallace M, Sabir S, Shaw K, Mills G. Ex Vivo Confocal Fluorescence Microscopy for Rapid Evaluation of Tissues in Surgical Pathology Practice. Arch Pathol Lab Med. 2018 Mar; 142(3):396-401. PMID: 29266968.
      Citations: 13     Fields:    Translation:Humans
    273. Litton JK, Scoggins M, Ramirez DL, Murthy RK, Whitman GJ, Hess KR, Adrada BE, Moulder SL, Barcenas CH, Valero V, Gomez JS, Mittendorf EA, Thompson A, Helgason T, Mills GB, Piwnica-Worms H, Arun BK. A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity. NPJ Breast Cancer. 2017; 3:49. PMID: 29238749; PMCID: PMC5719044.
      Citations: 24     
    274. Huo D, Hu H, Rhie SK, Gamazon ER, Cherniack AD, Liu J, Yoshimatsu TF, Pitt JJ, Hoadley KA, Troester M, Ru Y, Sturtz LA, Shelley CS, Benz CC, Mills GB, Laird PW, Shriver CD, Perou CM, Olopade OI, Lichtenberg T. Comparison of Breast Cancer Molecular Features and Survival by African and European Ancestry in The Cancer Genome Atlas. JAMA Oncol. 2017 12 01; 3(12):1654-1662. PMID: 28472234; PMCID: PMC5671371.
      Citations: 109     Fields:    Translation:Humans
    275. Peng G, Mills GB. Surviving Ovarian Cancer: An Affair between Defective DNA Repair and RB1. Clin Cancer Res. 2018 02 01; 24(3):508-510. PMID: 29191971; PMCID: PMC5905329.
      Citations: 8     Fields:    Translation:HumansCells
    276. Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A, Sch?rer SC. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018 01 24; 6(1):13-24. PMID: 29199020; PMCID: PMC5799026.
      Citations: 145     Fields:    Translation:HumansCells
    277. Brusco LL, Wathoo C, Mills Shaw KR, Holla VR, Bailey AM, Johnson AM, Khotskaya YB, Litzenburger BC, Sanchez NS, Zeng J, Bernstam EV, Eng C, Kee BK, Amaria RN, Routbort MJ, Mills GB, Mendelsohn J, Meric-Bernstam F. Physician interpretation of genomic test results and treatment selection. Cancer. 2018 03 01; 124(5):966-972. PMID: 29165790; PMCID: PMC5821595.
      Citations: 4     Fields:    Translation:Humans
    278. Krepler C, Sproesser K, Brafford P, Beqiri M, Garman B, Xiao M, Shannan B, Watters A, Perego M, Zhang G, Vultur A, Yin X, Liu Q, Anastopoulos IN, Wubbenhorst B, Wilson MA, Xu W, Karakousis G, Feldman M, Xu X, Amaravadi R, Gangadhar TC, Elder DE, Haydu LE, Wargo JA, Davies MA, Lu Y, Mills GB, Frederick DT, Barzily-Rokni M, Flaherty KT, Hoon DS, Guarino M, Bennett JJ, Ryan RW, Petrelli NJ, Shields CL, Terai M, Sato T, Aplin AE, Roesch A, Darr D, Angus S, Kumar R, Halilovic E, Caponigro G, Jeay S, Wuerthner J, Walter A, Ocker M, Boxer MB, Schuchter L, Nathanson KL, Herlyn M. A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma. Cell Rep. 2017 Nov 14; 21(7):1953-1967. PMID: 29141225; PMCID: PMC5726788.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    279. Li J, Akbani R, Zhao W, Lu Y, Weinstein JN, Mills GB, Liang H. Explore, Visualize, and Analyze Functional Cancer Proteomic Data Using the Cancer Proteome Atlas. Cancer Res. 2017 11 01; 77(21):e51-e54. PMID: 29092939; PMCID: PMC5679242.
      Citations: 44     Fields:    Translation:Humans
    280. Kurnit KC, Bailey AM, Zeng J, Johnson AM, Shufean MA, Brusco L, Litzenburger BC, Khotskaya YB, Holla V, Simpson A, Mills GB, Mendelsohn J, Bernstam E, Shaw K, Meric-Bernstam F, S?nchez NS. "Personalized Cancer Therapy": A Publicly Available Precision Oncology Resource. Cancer Res. 2017 11 01; 77(21):e123-e126. PMID: 29092956; PMCID: PMC5774617.
      Citations: 13     Fields:    Translation:Humans
    281. Evans KW, Yuca E, Akcakanat A, Scott SM, Arango NP, Zheng X, Chen K, Tapia C, Tarco E, Eterovic AK, Black DM, Litton JK, Yap TA, Tripathy D, Mills GB, Meric-Bernstam F. A Population of Heterogeneous Breast Cancer Patient-Derived Xenografts Demonstrate Broad Activity of PARP Inhibitor in BRCA1/2 Wild-Type Tumors. Clin Cancer Res. 2017 Nov 01; 23(21):6468-6477. PMID: 29093017; PMCID: PMC5679124.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    282. Mauland KK, Ju Z, Berg A, Kalland KH, Westin SN, Krakstad C, Trovik J, Mills GB, Hoivik EA, Johanna Werner HM, Tangen IL, ?yan AM, Bj?rge L. Proteomic profiling of endometrioid endometrial cancer reveals differential expression of hormone receptors and MAPK signaling proteins in obese versus non-obese patients. Oncotarget. 2017 Dec 05; 8(63):106989-107001. PMID: 29291005; PMCID: PMC5739790.
      Citations: 3     Fields:    
    283. Daniels M, Wathoo C, Brusco L, Lu KH, Shaw K, Dumbrava EEI, Arun B, Strong L, Litton JK, Eterovic K, Aytac U, Mendelsohn J, Mills GB, Chen K, Meric-Bernstam F. Active Disclosure of Secondary Germline Findings to Deceased Research Participants' Personal Representatives: Process and Outcomes. JCO Precis Oncol. 2017; 1. PMID: 31552380; PMCID: PMC6759057.
      Citations: 1     Fields:    
    284. Mills GB, Mills Shaw KR, S?nchez NS. Precision oncology: neither a silver bullet nor a dream. Pharmacogenomics. 2017 Nov; 18(16):1525-1539. PMID: 29061079.
      Citations: 11     Fields:    Translation:Humans
    285. Korkola JE, Collisson EA, Heiser LM, Oates C, Bayani N, Itani S, Esch A, Thompson W, Griffith OL, Wang NJ, Kuo WL, Cooper B, Billig J, Ziyad S, Hung JL, Jakkula L, Feiler H, Lu Y, Mills GB, Spellman PT, Tomlin C, Mukherjee S, Gray JW. Correction: Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer. PLoS One. 2017; 12(10):e0186551. PMID: 29020035; PMCID: PMC5636161.
      Citations:    Fields:    
    286. Robertson AG, Kim J, Al-Ahmadie H, Bellmunt J, Guo G, Cherniack AD, Hinoue T, Laird PW, Hoadley KA, Akbani R, Gibb EA, Kanchi RS, Gordenin DA, Shukla SA, Sanchez-Vega F, Hansel DE, Czerniak BA, Reuter VE, Su X, Mungall KL, Sadeghi S, Pedamallu CS, Lu Y, Klimczak LJ, Zhang J, Choo C, Ojesina AI, Bullman S, Leraas KM, Lichtenberg TM, Wu CJ, Schultz N, Getz G, Meyerson M, Mills GB, McConkey DJ, TCGA Research Network, Kwiatkowski DJ, Lerner SP, Castro MAA, de Sa Carvalho B, Chagas VS, Weinstein JN. Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer. Cell. 2017 Oct 19; 171(3):540-556.e25. PMID: 28988769; PMCID: PMC5687509.
      Citations: 661     Fields:    Translation:HumansCells
    287. Han G, Zhao W, Song X, Kwok-Shing Ng P, Karam JA, Jonasch E, Mills GB, Zhao Z, Ding Z, Jia P. Unique protein expression signatures of survival time in kidney renal clear cell carcinoma through a pan-cancer screening. BMC Genomics. 2017 Oct 03; 18(Suppl 6):678. PMID: 28984208; PMCID: PMC5629613.
      Citations: 15     Fields:    Translation:HumansPHPublic Health
    288. Lu H, Liu S, Zhang G, Zhu Y, Frederick DT, Hu Y, Zhong W, Randell S, Sadek N, Zhang W, Chen G, Cheng C, Zeng J, Wu LW, Zhang J, Liu X, Xu W, Krepler C, Sproesser K, Xiao M, Miao B, Liu J, Song CD, Liu JY, Karakousis GC, Schuchter LM, Lu Y, Mills G, Cong Y, Chernoff J, Guo J, Boland GM, Sullivan RJ, Wei Z, Field J, Amaravadi RK, Flaherty KT, Herlyn M, Xu X, Guo W. PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas. Nature. 2017 10 05; 550(7674):133-136. PMID: 28953887; PMCID: PMC5891348.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    289. Mitra S, Montgomery JE, Kolar MJ, Li G, Jeong KJ, Peng B, Verdine GL, Mills GB, Moellering RE. Stapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer. Nat Commun. 2017 09 22; 8(1):660. PMID: 28939823; PMCID: PMC5610242.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    290. Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS. Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo. NPJ Breast Cancer. 2017; 3:38. PMID: 28948214; PMCID: PMC5610185.
      Citations:    
    291. Clarke CN, Lee MS, Wei W, Manyam G, Jiang ZQ, Lu Y, Morris J, Broom B, Menter D, Vilar-Sanchez E, Raghav K, Eng C, Chang GJ, Simon I, Bernards R, Overman M, Mills GB, Maru D, Kopetz S. Proteomic Features of Colorectal Cancer Identify Tumor Subtypes Independent of Oncogenic Mutations and Independently Predict Relapse-Free Survival. Ann Surg Oncol. 2017 Dec; 24(13):4051-4058. PMID: 28936799; PMCID: PMC6063735.
      Citations: 14     Fields:    Translation:Humans
    292. Dondelinger F, Hill SM, Akbani R, Lu Y, Mills GB, Mukherjee S, St?dler N. Molecular heterogeneity at the network level: high-dimensional testing, clustering and a TCGA case study. Bioinformatics. 2017 Sep 15; 33(18):2890-2896. PMID: 28535188; PMCID: PMC5590725.
      Citations: 5     Fields:    Translation:HumansCells
    293. Johnson A, Khotskaya YB, Brusco L, Zeng J, Holla V, Bailey AM, Litzenburger BC, Sanchez N, Shufean MA, Piha-Paul S, Subbiah V, Hong D, Routbort M, Broaddus R, Mills Shaw KR, Mills GB, Mendelsohn J, Meric-Bernstam F. Clinical Use of Precision Oncology Decision Support. JCO Precis Oncol. 2017; 2017. PMID: 30320296; PMCID: PMC6179148.
      Citations: 12     Fields:    
    294. Rebecca VW, Nicastri MC, McLaughlin N, Fennelly C, McAfee Q, Ronghe A, Nofal M, Lim CY, Witze E, Chude CI, Zhang G, Alicea GM, Piao S, Murugan S, Ojha R, Levi SM, Wei Z, Barber-Rotenberg JS, Murphy ME, Mills GB, Lu Y, Rabinowitz J, Marmorstein R, Liu Q, Liu S, Xu X, Herlyn M, Zoncu R, Brady DC, Speicher DW, Winkler JD, Amaravadi RK. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 11; 7(11):1266-1283. PMID: 28899863; PMCID: PMC5833978.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    295. Ndoye A, Budina-Kolomets A, Kugel CH, Webster MR, Kaur A, Behera R, Rebecca VW, Li L, Brafford PA, Liu Q, Gopal YNV, Davies MA, Mills GB, Xu X, Wu H, Herlyn M, Nicastri MC, Winkler JD, Soengas MS, Amaravadi RK, Murphy ME, Weeraratna AT. ATG5 Mediates a Positive Feedback Loop between Wnt Signaling and Autophagy in Melanoma. Cancer Res. 2017 11 01; 77(21):5873-5885. PMID: 28887323; PMCID: PMC5718045.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    296. Mjos S, Werner HMJ, Birkeland E, Holst F, Berg A, Halle MK, Tangen IL, Kusonmano K, Mauland KK, Oyan AM, Kalland KH, Mills GB, Krakstad C, Trovik J, Salvesen HB, Hoivik EA, Lewis AE. PIK3CA exon9 mutations associate with reduced survival, and are highly concordant between matching primary tumors and metastases in endometrial cancer. Sci Rep. 2017 08 31; 7(1):10240. PMID: 28860563; PMCID: PMC5578954.
      Citations: 10     Fields:    Translation:HumansCells
    297. Zervantonakis IK, Iavarone C, Chen HY, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis U, Leverson JD, Sampath D, Mills GB, Brugge JS. Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. Nat Commun. 2017 08 28; 8(1):365. PMID: 28848242; PMCID: PMC5573720.
      Citations: 25     Fields:    Translation:Humans
    298. Robertson AG, Shih J, Yau C, Gibb EA, Oba J, Mungall KL, Hess JM, Uzunangelov V, Danilova L, Lichtenberg TM, Kucherlapati M, Kimes PK, Tang M, Babur O, Akbani R, Bristow CA, Hoadley KA, Iype L, Chang MT, TCGA Research Network, Cherniack AD, Benz C, Mills GB, Verhaak RGW, Griewank KG, Felau I, Zenklusen JC, Gershenwald JE, Schoenfield L, Lazar AJ, Abdel-Rahman MH, Roman-Roman S, Stern MH, Cebulla CM, Williams MD, Jager MJ, Coupland SE, Esmaeli B, Woodman SE, Walter V, Penson A, Kandoth C. Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma. Cancer Cell. 2017 08 14; 32(2):204-220.e15. PMID: 28810145; PMCID: PMC5619925.
      Citations: 275     Fields:    Translation:HumansCells
    299. Wang Z, Kim TB, Peng B, Karam J, Creighton C, Joon A, Kawakami F, Trevisan P, Jonasch E, Chow CW, Canales JR, Tamboli P, Tannir N, Wood C, Monzon F, Baggerly K, Varella-Garcia M, Czerniak B, Wistuba I, Mills G, Shaw K, Chen K, Sircar K. Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape. Clin Cancer Res. 2017 Nov 01; 23(21):6686-6696. PMID: 28710314; PMCID: PMC5683086.
      Citations: 26     Fields:    Translation:Humans
    300. Arango NP, Brusco L, Mills Shaw KR, Chen K, Eterovic AK, Holla V, Johnson A, Litzenburger B, Khotskaya YB, Sanchez N, Bailey A, Zheng X, Horombe C, Kopetz S, Farhangfar CJ, Routbort M, Broaddus R, Bernstam EV, Mendelsohn J, Mills GB, Meric-Bernstam F. A feasibility study of returning clinically actionable somatic genomic alterations identified in a research laboratory. Oncotarget. 2017 Jun 27; 8(26):41806-41814. PMID: 28415679; PMCID: PMC5522029.
      Citations: 10     Fields:    Translation:Humans
    301. Zhao W, Li J, Mills GB. Functional proteomic characterization of cancer cell lines. Oncoscience. 2017 May; 4(5-6):41-42. PMID: 28781984; PMCID: PMC5538845.
      Citations: 1     
    302. Korphaisarn K, Loree JM, Nguyen V, Coulson R, Holla V, Litzenburger BC, Chen K, Mills GB, Maru DM, Meric-Bernstan F, Shaw KRM, Kopetz S. Genomic analysis of exceptional responder to regorafenib in treatment-refractory metastatic rectal cancer: a case report and review of the literature. Oncotarget. 2017 Aug 22; 8(34):57882-57888. PMID: 28915719; PMCID: PMC5593691.
      Citations: 5     Fields:    
    303. Backfish M, Bashyal A, Batell B, Brown BC, Carr R, Chatterjee A, Cooper RL, deNiverville P, Dharmapalan R, Djurcic Z, Ford R, Garcia FG, Garvey GT, Grange J, Green JA, Huelsnitz W, Karagiorgi G, Katori T, Ketchum W, Kobilarcik T, Liu Q, Louis WC, Marsh W, Moore CD, Mills GB, Mirabal J, Nienaber P, Pavlovic Z, Perevalov D, Ray H, Roe BP, Shaevitz MH, Shahsavarani S, Stancu I, Tayloe R, Taylor C, Thornton RT, Van de Water R, Wester W, White DH, Yu J, MiniBooNE-DM Collaboration, Aguilar-Arevalo AA, de Icaza Astiz IL. Dark Matter Search in a Proton Beam Dump with MiniBooNE. Phys Rev Lett. 2017 Jun 02; 118(22):221803. PMID: 28621993.
      Citations: 1     Fields:    
    304. Sun C, Fang Y, Yin J, Chen J, Ju Z, Zhang D, Chen X, Vellano CP, Jeong KJ, Ng PK, Eterovic AKB, Bhola NH, Lu Y, Westin SN, Grandis JR, Lin SY, Scott KL, Peng G, Brugge J, Mills GB. Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566428; PMCID: PMC5919217.
      Citations: 80     Fields:    Translation:AnimalsCells
    305. Janku F, Zhang S, Waters J, Liu L, Huang HJ, Subbiah V, Hong DS, Karp DD, Fu S, Cai X, Ramzanali NM, Madwani K, Cabrilo G, Andrews DL, Zhao Y, Javle M, Kopetz ES, Luthra R, Kim HJ, Gnerre S, Satya RV, Chuang HY, Kruglyak KM, Toung J, Zhao C, Shen R, Heymach JV, Meric-Bernstam F, Mills GB, Fan JB, Salathia NS. Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer. Clin Cancer Res. 2017 Sep 15; 23(18):5648-5656. PMID: 28536309; PMCID: PMC5600825.
      Citations: 27     Fields:    Translation:Humans
    306. Zhang Y, Kwok-Shing Ng P, Kucherlapati M, Chen F, Liu Y, Tsang YH, de Velasco G, Jeong KJ, Akbani R, Hadjipanayis A, Pantazi A, Bristow CA, Lee E, Mahadeshwar HS, Tang J, Zhang J, Yang L, Seth S, Lee S, Ren X, Song X, Sun H, Seidman J, Luquette LJ, Xi R, Chin L, Protopopov A, Westbrook TF, Shelley CS, Choueiri TK, Ittmann M, Van Waes C, Weinstein JN, Liang H, Henske EP, Godwin AK, Park PJ, Kucherlapati R, Scott KL, Mills GB, Kwiatkowski DJ, Creighton CJ. A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations. Cancer Cell. 2017 06 12; 31(6):820-832.e3. PMID: 28528867; PMCID: PMC5502825.
      Citations: 189     Fields:    Translation:HumansCells
    307. Lu H, Villafane N, Dogruluk T, Grzeskowiak CL, Kong K, Tsang YH, Zagorodna O, Pantazi A, Yang L, Neill NJ, Kim YW, Creighton CJ, Verhaak RG, Mills GB, Park PJ, Kucherlapati R, Scott KL. Engineering and Functional Characterization of Fusion Genes Identifies Novel Oncogenic Drivers of Cancer. Cancer Res. 2017 07 01; 77(13):3502-3512. PMID: 28512244; PMCID: PMC5568774.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    308. Zhang D, Zhang G, Hu X, Wu L, Feng Y, He S, Zhang Y, Hu Z, Yang L, Tian T, Xu W, Wei Z, Lu Y, Flaherty KT, Zhong X, Mills GB, Gimotty PA, Xu X, Herlyn M, Zhang L. Oncogenic RAS Regulates Long Noncoding RNA Orilnc1 in Human Cancer. Cancer Res. 2017 07 15; 77(14):3745-3757. PMID: 28473531; PMCID: PMC5511552.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    309. Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS. Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo. NPJ Breast Cancer. 2017; 3:18. PMID: 28649658; PMCID: PMC5460247.
      Citations: 13     
    310. Federico L, Chong Z, Zhang D, McGrail DJ, Zhao W, Jeong KJ, Vellano CP, Ju Z, Gagea M, Liu S, Mitra S, Dennison JB, Lorenzi PL, Cardnell R, Diao L, Wang J, Lu Y, Byers LA, Perou CM, Lin SY, Mills GB. A murine preclinical syngeneic transplantation model for breast cancer precision medicine. Sci Adv. 2017 Apr; 3(4):e1600957. PMID: 28439535; PMCID: PMC5397135.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    311. Wang Y, Xu X, Yu S, Jeong KJ, Zhou Z, Han L, Tsang YH, Li J, Chen H, Mangala LS, Yuan Y, Eterovic AK, Lu Y, Sood AK, Scott KL, Mills GB, Liang H. Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers. Genome Res. 2017 07; 27(7):1112-1125. PMID: 28411194; PMCID: PMC5495064.
      Citations: 69     Fields:    Translation:HumansCells
    312. Iida Y, Ciechanover A, Marzese DM, Hata K, Bustos M, Ono S, Wang J, Salomon MP, Tran K, Lam S, Hsu S, Nelson N, Kravtsova-Ivantsiv Y, Mills GB, Davies MA, Hoon DSB. Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-?B Pathway in Melanoma. Clin Cancer Res. 2017 Aug 15; 23(16):4831-4842. PMID: 28389511; PMCID: PMC5559338.
      Citations: 18     Fields:    Translation:HumansCells
    313. Aure MR, Vitelli V, Kumar S, Krohn M, Due EU, Haukaas TH, Leivonen SK, Vollan HK, Vaske CJ, Zhao W, Nord S, Bathen TF, Caldas C, Tramm T, Alsner J, Overgaard J, Bukholm IR, Schlichting E, Sauer T, Mills GB, Frigessi A, Kristensen VN, Sahlberg KK, OSBREAC, Jernstr?m S, L?ders T, R?dland E, M?ller EK, Giske?deg?rd GF, Geisler J, Naume B, K?resen R, M?landsmo GM, Lingj?rde OC, B?rresen-Dale AL. Integrative clustering reveals a novel split in the luminal A subtype of breast cancer with impact on outcome. Breast Cancer Res. 2017 03 29; 19(1):44. PMID: 28356166; PMCID: PMC5372339.
      Citations: 39     Fields:    Translation:Humans
    314. Yi S, Lin S, Li Y, Zhao W, Mills GB, Sahni N. Functional variomics and network perturbation: connecting genotype to phenotype in cancer. Nat Rev Genet. 2017 07; 18(7):395-410. PMID: 28344341; PMCID: PMC6020840.
      Citations: 40     Fields:    Translation:Humans
    315. Bauman JE, Duvvuri U, Gooding WE, Rath TJ, Gross ND, Song J, Jimeno A, Yarbrough WG, Johnson FM, Wang L, Chiosea S, Sen M, Kass J, Johnson JT, Ferris RL, Kim S, Hirsch FR, Ellison K, Flaherty JT, Mills GB, Grandis JR. Randomized, placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer. JCI Insight. 2017 03 23; 2(6):e90449. PMID: 28352657; PMCID: PMC5358497.
      Citations: 24     Fields:    Translation:HumansCells
    316. Cherniack AD, Shen H, Walter V, Stewart C, Murray BA, Bowlby R, Hu X, Ling S, Soslow RA, Broaddus RR, Zuna RE, Robertson G, Laird PW, Kucherlapati R, Mills GB, Cancer Genome Atlas Research Network, Weinstein JN, Zhang J, Akbani R, Levine DA. Integrated Molecular Characterization of Uterine Carcinosarcoma. Cancer Cell. 2017 03 13; 31(3):411-423. PMID: 28292439; PMCID: PMC5599133.
      Citations: 137     Fields:    Translation:Humans
    317. Kurnit KC, Kim GN, Fellman BM, Urbauer DL, Mills GB, Zhang W, Broaddus RR. CTNNB1 (beta-catenin) mutation identifies low grade, early stage endometrial cancer patients at increased risk of recurrence. Mod Pathol. 2017 07; 30(7):1032-1041. PMID: 28281553; PMCID: PMC5493522.
      Citations: 78     Fields:    Translation:Humans
    318. McGrail DJ, Lin CC, Garnett J, Liu Q, Mo W, Dai H, Lu Y, Yu Q, Ju Z, Yin J, Vellano CP, Hennessy B, Mills GB, Lin SY. Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm. NPJ Syst Biol Appl. 2017; 3:8. PMID: 28649435; PMCID: PMC5445594.
      Citations: 29     Fields:    
    319. Yin Y, Shen Q, Zhang P, Tao R, Chang W, Li R, Xie G, Liu W, Zhang L, Kapoor P, Song S, Ajani J, Mills GB, Chen J, Tao K, Peng G. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017; 7(3):473-483. PMID: 28401005; PMCID: PMC5385637.
      Citations: 24     
    320. Fitzgibbon M, Bergan L, Clegg N, Crispin D, Mills GB, McIntosh M, Zhao W. Identifying Abundant Immunotherapy and Other Targets in Solid Tumors: Integrating RNA-seq and Mass Spectrometry Proteomics Data Sets. Cancer J. 2017 Mar/Apr; 23(2):108-114. PMID: 28410298; PMCID: PMC5839124.
      Citations: 2     Fields:    Translation:Humans
    321. Matulonis UA, Wulf GM, Barry WT, Birrer M, Westin SN, Farooq S, Bell-McGuinn KM, Obermayer E, Whalen C, Spagnoletti T, Luo W, Liu H, Hok RC, Aghajanian C, Solit DB, Mills GB, Taylor BS, Won H, Berger MF, Palakurthi S, Liu J, Cantley LC, Winer E. Phase I dose escalation study of the PI3kinase pathway inhibitor BKM120 and the oral poly (ADP ribose) polymerase (PARP) inhibitor olaparib for the treatment of high-grade serous ovarian and breast cancer. Ann Oncol. 2017 03 01; 28(3):512-518. PMID: 27993796; PMCID: PMC5834157.
      Citations: 74     Fields:    Translation:HumansCTClinical Trials
    322. Wang C, Gu C, Jeong KJ, Zhang D, Guo W, Lu Y, Ju Z, Panupinthu N, Yang JY, Gagea MM, Ng PK, Zhang F, Mills GB. YAP/TAZ-Mediated Upregulation of GAB2 Leads to Increased Sensitivity to Growth Factor-Induced Activation of the PI3K Pathway. Cancer Res. 2017 04 01; 77(7):1637-1648. PMID: 28202507; PMCID: PMC6026015.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    323. Li J, Zhao W, Akbani R, Liu W, Ju Z, Ling S, Vellano CP, Roebuck P, Yu Q, Eterovic AK, Byers LA, Davies MA, Deng W, Gopal YN, Chen G, von Euw EM, Slamon D, Conklin D, Heymach JV, Gazdar AF, Minna JD, Myers JN, Lu Y, Mills GB, Liang H. Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays. Cancer Cell. 2017 02 13; 31(2):225-239. PMID: 28196595; PMCID: PMC5501076.
      Citations: 96     Fields:    Translation:HumansCells
    324. George E, Kim H, Krepler C, Wenz B, Makvandi M, Tanyi JL, Brown E, Zhang R, Brafford P, Jean S, Mach RH, Lu Y, Mills GB, Herlyn M, Morgan M, Zhang X, Soslow R, Drapkin R, Johnson N, Zheng Y, Cotsarelis G, Nathanson KL, Simpkins F. A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. JCI Insight. 2017 01 12; 2(1):e89760. PMID: 28097235; PMCID: PMC5214535.
      Citations: 33     Fields:    Translation:HumansAnimals
    325. Holla VR, Elamin YY, Bailey AM, Johnson AM, Litzenburger BC, Khotskaya YB, Sanchez NS, Zeng J, Shufean MA, Shaw KR, Mendelsohn J, Mills GB, Meric-Bernstam F, Simon GR. ALK: a tyrosine kinase target for cancer therapy. Cold Spring Harb Mol Case Stud. 2017 Jan; 3(1):a001115. PMID: 28050598; PMCID: PMC5171696.
      Citations: 49     Fields:    
    326. Dave B, Gonzalez DD, Liu ZB, Li X, Wong H, Granados S, Ezzedine NE, Sieglaff DH, Ensor JE, Miller KD, Radovich M, KarinaEtrovic A, Gross SS, Elemento O, Mills GB, Gilcrease MZ, Chang JC. Role of RPL39 in Metaplastic Breast Cancer. J Natl Cancer Inst. 2017 06; 109(6). PMID: 28040796; PMCID: PMC6245334.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    327. Hill SM, Nesser NK, Johnson-Camacho K, Jeffress M, Johnson A, Boniface C, Spencer SE, Lu Y, Heiser LM, Lawrence Y, Pande NT, Korkola JE, Gray JW, Mills GB, Mukherjee S, Spellman PT. Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling. Cell Syst. 2017 01 25; 4(1):73-83.e10. PMID: 28017544; PMCID: PMC5279869.
      Citations: 18     Fields:    Translation:HumansCells
    328. Previs RA, Sood AK, Mills GB, Westin SN. The rise of genomic profiling in ovarian cancer. Expert Rev Mol Diagn. 2016 12; 16(12):1337-1351. PMID: 27828713; PMCID: PMC5659206.
      Citations: 11     Fields:    Translation:HumansCells
    329. Basho RK, de Melo Gagliato D, Ueno NT, Wathoo C, Chen H, Shariati M, Wei C, Alvarez RH, Moulder SL, Sahin AA, Roy-Chowdhuri S, Chavez-MacGregor M, Litton JK, Valero V, Luthra R, Zeng J, Shaw KR, Mendelsohn J, Mills GB, Tripathy D, Meric-Bernstam F. Clinical outcomes based on multigene profiling in metastatic breast cancer patients. Oncotarget. 2016 Nov 22; 7(47):76362-76373. PMID: 27806348; PMCID: PMC5363515.
      Citations: 12     Fields:    Translation:Humans
    330. Takiar V, Ip CK, Gao M, Mills GB, Cheung LW. Neomorphic mutations create therapeutic challenges in cancer. Oncogene. 2017 03 23; 36(12):1607-1618. PMID: 27841866; PMCID: PMC6609160.
      Citations: 14     Fields:    Translation:HumansAnimals
    331. Khotskaya YB, Mills GB, Mills Shaw KR. Next-Generation Sequencing and Result Interpretation in Clinical Oncology: Challenges of Personalized Cancer Therapy. Annu Rev Med. 2017 01 14; 68:113-125. PMID: 27813876.
      Citations: 16     Fields:    Translation:Humans
    332. Verma N, Kothari C, Panayotopoulou E, Kedan A, Selitrennik M, Mills GB, Nguyen LK, Shin S, Karn T, Holtrich U, Lev S, M?ller AK. Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. Cancer Res. 2017 01 01; 77(1):86-99. PMID: 27793840.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    333. Roszik J, Haydu LE, Hess KR, Oba J, Joon AY, Siroy AE, Karpinets TV, Stingo FC, Baladandayuthapani V, Tetzlaff MT, Wargo JA, Chen K, Haymaker CL, Chen JQ, Meric-Bernstam F, Eterovic AK, Shaw KR, Mills GB, Gershenwald JE, Radvanyi LG, Hwu P, Futreal PA, Gibbons DL, Lazar AJ, Bernatchez C, Davies MA, Woodman SE, Forget MA. Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set. BMC Med. 2016 10 25; 14(1):168. PMID: 27776519; PMCID: PMC5078889.
      Citations: 64     Fields:    Translation:HumansCells
    334. Chen F, Zhang Y, Parra E, Rodriguez J, Behrens C, Akbani R, Lu Y, Kurie JM, Gibbons DL, Mills GB, Wistuba II, Creighton CJ. Multiplatform-based molecular subtypes of non-small-cell lung cancer. Oncogene. 2017 03; 36(10):1384-1393. PMID: 27775076; PMCID: PMC5344748.
      Citations: 56     Fields:    Translation:HumansCells
    335. Song M, Lee H, Nam MH, Jeong E, Kim S, Hong Y, Kim N, Yim HY, Yoo YJ, Kim JS, Kim JS, Cho YY, Mills GB, Kim WY, Yoon S. Loss-of-function screens of druggable targetome against cancer stem-like cells. FASEB J. 2017 02; 31(2):625-635. PMID: 27811063; PMCID: PMC5240669.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    336. Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS. ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP. Cancer Res. 2016 12 15; 76(24):7168-7180. PMID: 27913436; PMCID: PMC5161652.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    337. Lisanti S, Garlick DS, Bryant KG, Tavecchio M, Mills GB, Lu Y, Kossenkov AV, Showe LC, Languino LR, Altieri DC. Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development. J Biol Chem. 2016 Nov 25; 291(48):25247-25254. PMID: 27754870; PMCID: PMC5122790.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    338. Seviour EG, Sehgal V, Mishra D, Rupaimoole R, Rodriguez-Aguayo C, Lopez-Berestein G, Lee JS, Sood AK, Kim MP, Mills GB, Ram PT. Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p. Oncogene. 2017 03; 36(10):1339-1350. PMID: 27669434; PMCID: PMC5344721.
      Citations: 24     Fields:    Translation:HumansCells
    339. Kang MH, Jeong KJ, Kim WY, Lee HJ, Gong G, Suh N, Kim S, Jeong SY, Mills GB, Park YY, Gyorffy B. Musashi RNA-binding protein 2 regulates estrogen receptor 1 function in breast cancer. Oncogene. 2017 03 23; 36(12):1745-1752. PMID: 27593929.
      Citations: 32     Fields:    Translation:HumansCells
    340. Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R. Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics. Clin Cancer Res. 2017 Mar 01; 23(5):1263-1273. PMID: 27573169; PMCID: PMC5332350.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    341. Rhyasen GW, Hattersley MM, Yao Y, Dulak A, Wang W, Petteruti P, Dale IL, Boiko S, Cheung T, Zhang J, Wen S, Castriotta L, Lawson D, Collins M, Bao L, Ahdesmaki MJ, Walker G, O'Connor G, Yeh TC, Rabow AA, Dry JR, Reimer C, Lyne P, Mills GB, Fawell SE, Waring MJ, Zinda M, Clark E, Chen H. AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies. Mol Cancer Ther. 2016 11; 15(11):2563-2574. PMID: 27573426.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    342. Hwang MH, Cho KH, Jeong KJ, Park YY, Kim JM, Yu SL, Park CG, Mills GB, Lee HY. RCP induces Slug expression and cancer cell invasion by stabilizing ?1 integrin. Oncogene. 2017 02 23; 36(8):1102-1111. PMID: 27524413.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    343. Witkiewicz AK, Balaji U, Eslinger C, McMillan E, Conway W, Posner B, Mills GB, O'Reilly EM, Knudsen ES. Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer. Cell Rep. 2016 08 16; 16(7):2017-31. PMID: 27498862; PMCID: PMC5287055.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    344. Kim N, Yim HY, He N, Lee CJ, Kim JH, Choi JS, Lee HS, Kim S, Jeong E, Song M, Jeon SM, Kim WY, Mills GB, Cho YY, Yoon S. Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. Sci Rep. 2016 07 19; 6:29721. PMID: 27431571; PMCID: PMC4949473.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    345. Mazumdar A, Poage GM, Shepherd J, Tsimelzon A, Hartman ZC, Den Hollander P, Hill J, Zhang Y, Chang J, Hilsenbeck SG, Fuqua S, Kent Osborne C, Mills GB, Brown PH. Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. Breast Cancer Res Treat. 2016 08; 158(3):441-54. PMID: 27393618; PMCID: PMC4963453.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    346. Mitra S, Federico L, Zhao W, Dennison J, Sarkar TR, Zhang F, Takiar V, Cheng KW, Mani S, Lee JS, Mills GB. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget. 2016 Jun 28; 7(26):40252-40265. PMID: 27259233; PMCID: PMC5130006.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    347. Haukaas TH, Euceda LR, Krohn M, Aure MR, Due EU, Mills GB, Sahlberg KK, Bathen TF, Oslo Breast Cancer Consortium (OSBREAC), Giske?deg?rd GF, Lamichhane S, Jernstr?m S, Lingj?rde OC, Schlichting E, Garred ?, B?rresen-Dale AL. Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes. Cancer Metab. 2016; 4:12. PMID: 27350877; PMCID: PMC4922058.
      Citations: 30     
    348. Chen T, Wang Z, Zhou W, Chong Z, Meric-Bernstam F, Mills GB, Chen K. Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types. BMC Genomics. 2016 06 23; 17 Suppl 2:394. PMID: 27356755; PMCID: PMC4928158.
      Citations: 18     Fields:    Translation:HumansCells
    349. Lu Y, Ling S, Hegde AM, Byers LA, Coombes K, Mills GB, Akbani R. Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer. Semin Oncol. 2016 08; 43(4):476-83. PMID: 27663479; PMCID: PMC5111873.
      Citations: 24     Fields:    Translation:Humans
    350. Jeong AL, Han S, Lee S, Su Park J, Lu Y, Yu S, Li J, Chun KH, Mills GB, Yang Y. Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway. Sci Rep. 2016 06 07; 6:27391. PMID: 27272709; PMCID: PMC4895347.
      Citations: 16     Fields:    Translation:HumansCells
    351. Meyer L, Suidan R, Sun C, Westin S, Coleman RL, Mills GB. The management of malignant ascites and impact on quality of life outcomes in women with ovarian cancer. Expert Rev Qual Life Cancer Care. 2016; 1(3):231-238. PMID: 30906877; PMCID: PMC6425954.
      Citations: 6     
    352. Janku F, Huang HJ, Claes B, Falchook GS, Fu S, Hong D, Ramzanali NM, Nitti G, Cabrilo G, Tsimberidou AM, Naing A, Piha-Paul SA, Wheler JJ, Karp DD, Holley VR, Zinner RG, Subbiah V, Luthra R, Kopetz S, Overman MJ, Kee BK, Patel S, Devogelaere B, Sablon E, Maertens G, Mills GB, Kurzrock R, Meric-Bernstam F. BRAF Mutation Testing in Cell-Free DNA from the Plasma of Patients with Advanced Cancers Using a Rapid, Automated Molecular Diagnostics System. Mol Cancer Ther. 2016 06; 15(6):1397-404. PMID: 27207774.
      Citations: 43     Fields:    Translation:HumansCells
    353. Dennison JB, Shahmoradgoli M, Liu W, Ju Z, Meric-Bernstam F, Perou CM, Sahin AA, Welm A, Oesterreich S, Sikora MJ, Brown RE, Mills GB. High Intratumoral Stromal Content Defines Reactive Breast Cancer as a Low-risk Breast Cancer Subtype. Clin Cancer Res. 2016 Oct 15; 22(20):5068-5078. PMID: 27172895; PMCID: PMC5103285.
      Citations: 18     Fields:    Translation:HumansCells
    354. Berns K, Sonnenblick A, Gennissen A, Hijmans EM, Evers B, Fumagalli D, Desmedt C, Loibl S, Neven P, Guo W, Zhang F, Knijnenburg TA, Bosse T, van der Heijden MS, Hindriksen S, Nijkamp W, Wessels LF, Joensuu H, Mills GB, Beijersbergen RL, Sotiriou C, Broh?e S, Denkert C, Bernards R. Loss of ARID1A Activates ANXA1, which Serves as a Predictive Biomarker for Trastuzumab Resistance. Clin Cancer Res. 2016 Nov 01; 22(21):5238-5248. PMID: 27172896.
      Citations: 27     Fields:    Translation:HumansCells
    355. Ledgerwood LG, Kumar D, Eterovic AK, Wick J, Chen K, Zhao H, Tazi L, Manna P, Kerley S, Joshi R, Wang L, Chiosea SI, Garnett JD, Tsue TT, Chien J, Mills GB, Grandis JR, Thomas SM. The degree of intratumor mutational heterogeneity varies by primary tumor sub-site. Oncotarget. 2016 May 10; 7(19):27185-98. PMID: 27034009; PMCID: PMC5053641.
      Citations: 21     Fields:    Translation:Humans
    356. Turpin J, Ling C, Crosby EJ, Hartman ZC, Simond AM, Chodosh LA, Rennhack JP, Andrechek ER, Ozcelik J, Hallett M, Mills GB, Cardiff RD, Gray JW, Griffith OL, Muller WJ. The ErbB2?Ex16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment. Oncogene. 2016 11 24; 35(47):6053-6064. PMID: 27157621; PMCID: PMC5102823.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    357. Yuan Y, Liu L, Chen H, Wang Y, Xu Y, Mao H, Li J, Mills GB, Shu Y, Li L, Liang H. Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients. Cancer Cell. 2016 05 09; 29(5):711-722. PMID: 27165743; PMCID: PMC4864951.
      Citations: 100     Fields:    Translation:HumansCells
    358. Chaluvally-Raghavan P, Jeong KJ, Pradeep S, Silva AM, Yu S, Liu W, Moss T, Rodriguez-Aguayo C, Zhang D, Ram P, Liu J, Lu Y, Lopez-Berestein G, Calin GA, Sood AK, Mills GB. Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer. Cell Rep. 2016 05 17; 15(7):1493-1504. PMID: 27160903; PMCID: PMC4914391.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    359. Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Huang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, Bissig KD, L?pez-Terrada D. Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. J Hepatol. 2016 08; 65(2):325-33. PMID: 27117591; PMCID: PMC5668139.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    360. Zhang G, Frederick DT, Wu L, Wei Z, Krepler C, Srinivasan S, Chae YC, Xu X, Choi H, Dimwamwa E, Ope O, Shannan B, Basu D, Zhang D, Guha M, Xiao M, Randell S, Sproesser K, Xu W, Liu J, Karakousis GC, Schuchter LM, Gangadhar TC, Amaravadi RK, Gu M, Xu C, Ghosh A, Xu W, Tian T, Zhang J, Zha S, Liu Q, Brafford P, Weeraratna A, Davies MA, Wargo JA, Avadhani NG, Lu Y, Mills GB, Altieri DC, Flaherty KT, Herlyn M. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. J Clin Invest. 2016 05 02; 126(5):1834-56. PMID: 27043285; PMCID: PMC4855947.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    361. Budina-Kolomets A, Webster MR, Leu JI, Jennis M, Krepler C, Guerrini A, Kossenkov AV, Xu W, Karakousis G, Schuchter L, Amaravadi RK, Wu H, Yin X, Liu Q, Lu Y, Mills GB, Xu X, George DL, Weeraratna AT, Murphy ME. HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors. Cancer Res. 2016 05 01; 76(9):2720-30. PMID: 26984758; PMCID: PMC4939897.
      Citations: 19     Fields:    Translation:HumansAnimals
    362. German P, Bai S, Liu XD, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott KL, Mills GB, Jonasch E, Ding Z. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene. 2016 09 22; 35(38):4973-80. PMID: 26973240; PMCID: PMC5086402.
      Citations: 7     Fields:    Translation:HumansCells
    363. McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Correction: Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS One. 2016; 11(3):e0151121. PMID: 26953790; PMCID: PMC4782992.
      Citations: 2     Fields:    
    364. Telli ML, Timms KM, Reid J, Hennessy B, Mills GB, Jensen KC, Szallasi Z, Barry WT, Winer EP, Tung NM, Isakoff SJ, Ryan PD, Greene-Colozzi A, Gutin A, Sangale Z, Iliev D, Neff C, Abkevich V, Jones JT, Lanchbury JS, Hartman AR, Garber JE, Ford JM, Silver DP, Richardson AL. Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer. Clin Cancer Res. 2016 08 01; 22(15):3764-73. PMID: 26957554; PMCID: PMC6773427.
      Citations: 268     Fields:    Translation:HumansCellsCTClinical Trials
    365. Chen F, Zhang Y, Senbabaoglu Y, Ciriello G, Yang L, Reznik E, Shuch B, Micevic G, De Velasco G, Shinbrot E, Noble MS, Lu Y, Covington KR, Xi L, Drummond JA, Muzny D, Kang H, Lee J, Tamboli P, Reuter V, Shelley CS, Kaipparettu BA, Bottaro DP, Godwin AK, Gibbs RA, Getz G, Kucherlapati R, Park PJ, Sander C, Henske EP, Zhou JH, Kwiatkowski DJ, Ho TH, Choueiri TK, Hsieh JJ, Akbani R, Mills GB, Hakimi AA, Wheeler DA, Creighton CJ. Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Rep. 2016 Mar 15; 14(10):2476-89. PMID: 26947078; PMCID: PMC4794376.
      Citations: 166     Fields:    Translation:HumansCells
    366. Mitchell L, Mitra S, Mills GB, Chodosh L, Strathdee D, Norman JC, Boulay PL, Turpin J, Huot-Marchand J?, Lavoie C, Sanguin-Gendreau V, Jones L, Livingstone JM, Campbell S, Hallett M, Park M, Muller WJ. Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression. Cancer Res. 2016 05 01; 76(9):2662-74. PMID: 26933086; PMCID: PMC5070470.
      Citations: 19     Fields:    Translation:HumansAnimals
    367. Lucenay KS, Doostan I, Karakas C, Bui T, Ding Z, Mills GB, Hunt KK, Keyomarsi K. Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells. Cancer Res. 2016 04 15; 76(8):2406-18. PMID: 26928812; PMCID: PMC4873469.
      Citations: 30     Fields:    Translation:HumansCells
    368. den Hollander P, Rawls K, Tsimelzon A, Shepherd J, Mazumdar A, Hill J, Fuqua SA, Chang JC, Osborne CK, Hilsenbeck SG, Mills GB, Brown PH. Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival. Cancer Res. 2016 04 01; 76(7):1942-53. PMID: 26921331; PMCID: PMC4873402.
      Citations: 39     Fields:    Translation:HumansCells
    369. Hill SM, Heiser LM, Cokelaer T, Unger M, Nesser NK, Carlin DE, Zhang Y, Sokolov A, Paull EO, Wong CK, Graim K, Bivol A, Wang H, Zhu F, Afsari B, Danilova LV, Favorov AV, Lee WS, Taylor D, Hu CW, Long BL, Noren DP, Bisberg AJ, HPN-DREAM Consortium, Mills GB, Gray JW, Kellen M, Norman T, Friend S, Qutub AA, Fertig EJ, Guan Y, Song M, Stuart JM, Spellman PT, Koeppl H, Stolovitzky G, Saez-Rodriguez J, Mukherjee S. Inferring causal molecular networks: empirical assessment through a community-based effort. Nat Methods. 2016 Apr; 13(4):310-8. PMID: 26901648; PMCID: PMC4854847.
      Citations: 84     Fields:    Translation:HumansCells
    370. Overman MJ, Morris V, Kee B, Fogelman D, Xiao L, Eng C, Dasari A, Shroff R, Mazard T, Shaw K, Vilar E, Raghav K, Shureiqi I, Liang L, Mills GB, Wolff RA, Hamilton S, Meric-Bernstam F, Abbruzzese J, Morris J, Maru D, Kopetz S. Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials. Ann Oncol. 2016 06; 27(6):1068-1074. PMID: 27045102; PMCID: PMC6276928.
      Citations: 13     Fields:    Translation:HumansCellsCTClinical Trials
    371. Seviour EG, Sehgal V, Lu Y, Luo Z, Moss T, Zhang F, Hill SM, Liu W, Maiti SN, Cooper L, Azencot R, Lopez-Berestein G, Rodriguez-Aguayo C, Roopaimoole R, Pecot CV, Sood AK, Mukherjee S, Gray JW, Mills GB, Ram PT. Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer. Oncogene. 2016 Feb 11; 35(6):801. PMID: 26865225; PMCID: PMC7608397.
      Citations: 11     Fields:    
    372. Jinesh GG, Molina JR, Huang L, Laing NM, Mills GB, Bar-Eli M, Kamat AM. Mitochondrial oligomers boost glycolysis in cancer stem cells to facilitate blebbishield-mediated transformation after apoptosis. Cell Death Discov. 2016; 2:16003. PMID: 27551498; PMCID: PMC4979437.
      Citations: 13     
    373. Cheung LW, Mills GB. Targeting therapeutic liabilities engendered by PIK3R1 mutations for cancer treatment. Pharmacogenomics. 2016 Feb; 17(3):297-307. PMID: 26807692; PMCID: PMC5558511.
      Citations: 18     Fields:    Translation:HumansCells
    374. Tsang YH, Dogruluk T, Tedeschi PM, Wardwell-Ozgo J, Lu H, Espitia M, Nair N, Minelli R, Chong Z, Chen F, Chang QE, Dennison JB, Dogruluk A, Li M, Ying H, Bertino JR, Gingras MC, Ittmann M, Kerrigan J, Chen K, Creighton CJ, Eterovic K, Mills GB, Scott KL. Functional annotation of rare gene aberration drivers of pancreatic cancer. Nat Commun. 2016 Jan 25; 7:10500. PMID: 26806015; PMCID: PMC4737758.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    375. Meric-Bernstam F, Brusco L, Daniels M, Wathoo C, Bailey AM, Strong L, Shaw K, Lu K, Qi Y, Zhao H, Lara-Guerra H, Litton J, Arun B, Eterovic AK, Aytac U, Routbort M, Subbiah V, Janku F, Davies MA, Kopetz S, Mendelsohn J, Mills GB, Chen K. Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol. Ann Oncol. 2016 05; 27(5):795-800. PMID: 26787237; PMCID: PMC4843184.
      Citations: 57     Fields:    Translation:Humans
    376. Marcotte R, Sayad A, Brown KR, Sanchez-Garcia F, Haider M, Virtanen C, Bradner JE, Bader GD, Mills GB, Pe'er D, Moffat J, Neel BG, Reimand J. Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance. Cell. 2016 Jan 14; 164(1-2):293-309. PMID: 26771497; PMCID: PMC4724865.
      Citations: 181     Fields:    Translation:HumansCells
    377. Meric-Bernstam F, Shaw K, Mendelsohn J, Mills GB. Reply to M.P. Decatris et al. J Clin Oncol. 2016 Mar 10; 34(8):886. PMID: 26755522.
      Citations: 1     Fields:    Translation:Humans
    378. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Akematsu T, Akporiaye ET, Al-Rubeai M, Albanese C, Albani D, Albert ML, Aldudo J, Alirezaei M, Alloza I, Almasan A, Alnemri ES, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bao H, Barrachina MD, Barreiro E, Bartel B, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beck GR, Beckham JD, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernassola F, Bertolotti A, Bess AS, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bingol B, Bird SW, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Bonaldo P, Bordi M, Boulton ME, Bouret SG, Bozhkov PV, Brady N, Braga VM, Brancolini C, Brennan LA, Bresnick EH, Brest P, Bridges D, Brini M, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burke RE, Burmeister M, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Campanella M, Campbell GR, Campbell M, Campello S, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carroll B, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Cervia D, Cetrullo S, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clarke PG, Clarke R, Clementi E, Cnop M, Cocco T, Cohen EE, Colecchia D, Coletto L, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977.
      Citations: 2567     Fields:    Translation:HumansAnimals
    379. Li H, Wheeler S, Park Y, Ju Z, Thomas SM, Fichera M, Egloff AM, Lui VW, Duvvuri U, Bauman JE, Mills GB, Grandis JR. Proteomic Characterization of Head and Neck Cancer Patient-Derived Xenografts. Mol Cancer Res. 2016 Mar; 14(3):278-86. PMID: 26685214; PMCID: PMC4794346.
      Citations: 29     Fields:    Translation:HumansAnimals
    380. Nishizuka SS, Mills GB. New era of integrated cancer biomarker discovery using reverse-phase protein arrays. Drug Metab Pharmacokinet. 2016 Feb; 31(1):35-45. PMID: 26822993.
      Citations: 17     Fields:    Translation:Humans
    381. Krepler C, Xiao M, Sproesser K, Brafford PA, Shannan B, Beqiri M, Liu Q, Xu W, Garman B, Nathanson KL, Xu X, Karakousis GC, Mills GB, Lu Y, Ahmed TA, Poulikakos PI, Caponigro G, Boehm M, Peters M, Schuchter LM, Weeraratna AT, Herlyn M. Personalized Preclinical Trials in BRAF Inhibitor-Resistant Patient-Derived Xenograft Models Identify Second-Line Combination Therapies. Clin Cancer Res. 2016 Apr 01; 22(7):1592-602. PMID: 26673799; PMCID: PMC4818716.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    382. Wang C, Zhu X, Feng W, Yu Y, Jeong K, Guo W, Lu Y, Mills GB. Verteporfin inhibits YAP function through up-regulating 14-3-3s sequestering YAP in the cytoplasm. Am J Cancer Res. 2016; 6(1):27-37. PMID: 27073720; PMCID: PMC4759394.
      Citations: 96     
    383. Rupaimoole R, Lee J, Haemmerle M, Ling H, Previs RA, Pradeep S, Wu SY, Ivan C, Ferracin M, Dennison JB, Millward NMZ, Nagaraja AS, Gharpure KM, McGuire M, Sam N, Armaiz-Pena GN, Sadaoui NC, Rodriguez-Aguayo C, Calin GA, Drapkin RI, Kovacs J, Mills GB, Zhang W, Lopez-Berestein G, Bhattacharya PK, Sood AK. Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Rep. 2015 Dec 22; 13(11):2395-2402. PMID: 26686630; PMCID: PMC4691557.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    384. Cheraghchi-Bashi A, Parker CA, Curry E, Salazar JF, Gungor H, Saleem A, Cunnea P, Rama N, Salinas C, Mills GB, Morris SR, Kumar R, Gabra H, Stronach EA. A putative biomarker signature for clinically effective AKT inhibition: correlation of in vitro, in vivo and clinical data identifies the importance of modulation of the mTORC1 pathway. Oncotarget. 2015 Dec 08; 6(39):41736-49. PMID: 26497682; PMCID: PMC4747185.
      Citations: 9     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    385. Roy A, Skibo J, Kalume F, Ni J, Rankin S, Lu Y, Dobyns WB, Mills GB, Zhao JJ, Baker SJ, Millen KJ. Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy. Elife. 2015 Dec 03; 4. PMID: 26633882; PMCID: PMC4744197.
      Citations: 39     Fields:    Translation:HumansAnimals
    386. Dogruluk T, Tsang YH, Espitia M, Chen F, Chen T, Chong Z, Appadurai V, Dogruluk A, Eterovic AK, Bonnen PE, Creighton CJ, Chen K, Mills GB, Scott KL. Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations. Cancer Res. 2015 Dec 15; 75(24):5341-54. PMID: 26627007; PMCID: PMC4681596.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    387. Park YY, Sohn BH, Johnson RL, Kang MH, Kim SB, Shim JJ, Mangala LS, Kim JH, Yoo JE, Rodriguez-Aguayo C, Pradeep S, Hwang JE, Jang HJ, Lee HS, Rupaimoole R, Lopez-Berestein G, Jeong W, Park IS, Park YN, Sood AK, Mills GB, Lee JS. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology. 2016 Jan; 63(1):159-72. PMID: 26389641; PMCID: PMC4881866.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    388. He N, Kim N, Jeong E, Lu Y, Mills GB, Yoon S. Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines. Int J Oncol. 2016 Jan; 48(1):67-72. PMID: 26573869; PMCID: PMC4734611.
      Citations: 4     Fields:    Translation:HumansCells
    389. Mo W, Liu Q, Lin CC, Dai H, Peng Y, Liang Y, Peng G, Meric-Bernstam F, Mills GB, Li K, Lin SY. mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer. Clin Cancer Res. 2016 Apr 01; 22(7):1699-712. PMID: 26546619; PMCID: PMC4858320.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    390. Cancer Genome Atlas Research Network, Linehan WM, Spellman PT, Ricketts CJ, Creighton CJ, Fei SS, Davis C, Wheeler DA, Murray BA, Schmidt L, Vocke CD, Peto M, Al Mamun AA, Shinbrot E, Sethi A, Brooks S, Rathmell WK, Brooks AN, Hoadley KA, Robertson AG, Brooks D, Bowlby R, Sadeghi S, Shen H, Weisenberger DJ, Bootwalla M, Baylin SB, Laird PW, Cherniack AD, Saksena G, Haake S, Li J, Liang H, Lu Y, Mills GB, Akbani R, Leiserson MD, Raphael BJ, Anur P, Bottaro D, Albiges L, Barnabas N, Choueiri TK, Czerniak B, Godwin AK, Hakimi AA, Ho TH, Hsieh J, Ittmann M, Kim WY, Krishnan B, Merino MJ, Mills Shaw KR, Reuter VE, Reznik E, Shelley CS, Shuch B, Signoretti S, Srinivasan R, Tamboli P, Thomas G, Tickoo S, Burnett K, Crain D, Gardner J, Lau K, Mallery D, Morris S, Paulauskis JD, Penny RJ, Shelton C, Shelton WT, Sherman M, Thompson E, Yena P, Avedon MT, Bowen J, Gastier-Foster JM, Gerken M, Leraas KM, Lichtenberg TM, Ramirez NC, Santos T, Wise L, Zmuda E, Demchok JA, Felau I, Hutter CM, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Zhang J, Ayala B, Baboud J, Chudamani S, Liu J, Lolla L, Naresh R, Pihl T, Sun Q, Wan Y, Wu Y, Ally A, Balasundaram M, Balu S, Beroukhim R, Bodenheimer T, Buhay C, Butterfield YS, Carlsen R, Carter SL, Chao H, Chuah E, Clarke A, Covington KR, Dahdouli M, Dewal N, Dhalla N, Doddapaneni HV, Drummond JA, Gabriel SB, Gibbs RA, Guin R, Hale W, Hawes A, Hayes DN, Holt RA, Hoyle AP, Jefferys SR, Jones SJ, Jones CD, Kalra D, Kovar C, Lewis L, Li J, Ma Y, Marra MA, Mayo M, Meng S, Meyerson M, Mieczkowski PA, Moore RA, Morton D, Mose LE, Mungall AJ, Muzny D, Parker JS, Perou CM, Roach J, Schein JE, Schumacher SE, Shi Y, Simons JV, Sipahimalani P, Skelly T, Soloway MG, Sougnez C, Tam A, Tan D, Thiessen N, Veluvolu U, Wang M, Wilkerson MD, Wong T, Wu J, Xi L, Zhou J, Bedford J, Chen F, Fu Y, Gerstein M, Haussler D, Kasaian K, Lai P, Ling S, Radenbaugh A, Van Den Berg D, Weinstein JN, Zhu J, Albert M, Alexopoulou I, Andersen JJ, Auman JT, Bartlett J, Bastacky S, Bergsten J, Blute ML, Boice L, Bollag RJ, Boyd J, Castle E, Chen YB, Cheville JC, Curley E, Davies B, DeVolk A, Dhir R, Dike L, Eckman J, Engel J, Harr J, Hrebinko R, Huang M, Huelsenbeck-Dill L, Iacocca M, Jacobs B, Lobis M, Maranchie JK, McMeekin S, Myers J, Nelson J, Parfitt J, Parwani A, Petrelli N, Rabeno B, Roy S, Salner AL, Slaton J, Stanton M, Thompson RH, Thorne L, Tucker K, Weinberger PM, Winemiller C, Zach LA, Zuna R. Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med. 2016 Jan 14; 374(2):135-45. PMID: 26536169; PMCID: PMC4775252.
      Citations: 414     Fields:    Translation:HumansCells
    391. Zhou W, Chen T, Chong Z, Rohrdanz MA, Melott JM, Wakefield C, Zeng J, Weinstein JN, Meric-Bernstam F, Mills GB, Chen K. TransVar: a multilevel variant annotator for precision genomics. Nat Methods. 2015 Nov; 12(11):1002-3. PMID: 26513549; PMCID: PMC4772859.
      Citations: 31     Fields:    Translation:Humans
    392. Gray JW, Mills GB. Large-Scale Drug Screens Support Precision Medicine. Cancer Discov. 2015 Nov; 5(11):1130-2. PMID: 26526695; PMCID: PMC4633700.
      Citations: 5     Fields:    Translation:Humans
    393. Roy-Chowdhuri S, de Melo Gagliato D, Routbort MJ, Patel KP, Singh RR, Broaddus R, Lazar AJ, Sahin A, Alvarez RH, Moulder S, Wheler JJ, Janku F, Gonzalez-Angulo AM, Chavez-MacGregor M, Valero V, Ueno NT, Mills G, Mendelsohn J, Yao H, Aldape K, Luthra R, Meric-Bernstam F. Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing. Am J Clin Pathol. 2015 Nov; 144(5):713-21. PMID: 26486734.
      Citations: 13     Fields:    Translation:Humans
    394. Sehgal V, Seviour EG, Moss TJ, Mills GB, Azencott R, Ram PT. Robust Selection Algorithm (RSA) for Multi-Omic Biomarker Discovery; Integration with Functional Network Analysis to Identify miRNA Regulated Pathways in Multiple Cancers. PLoS One. 2015; 10(10):e0140072. PMID: 26505200; PMCID: PMC4623517.
      Citations: 6     Fields:    Translation:Humans
    395. Hew KE, Miller PC, El-Ashry D, Sun J, Besser AH, Ince TA, Gu M, Wei Z, Zhang G, Brafford P, Gao W, Lu Y, Mills GB, Slingerland JM, Simpkins F. MAPK Activation Predicts Poor Outcome and the MEK Inhibitor, Selumetinib, Reverses Antiestrogen Resistance in ER-Positive High-Grade Serous Ovarian Cancer. Clin Cancer Res. 2016 Feb 15; 22(4):935-47. PMID: 26482043; PMCID: PMC4755805.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    396. Yan X, Hu Z, Feng Y, Hu X, Yuan J, Zhao SD, Zhang Y, Yang L, Shan W, He Q, Fan L, Kandalaft LE, Tanyi JL, Li C, Yuan CX, Zhang D, Yuan H, Hua K, Lu Y, Katsaros D, Huang Q, Montone K, Fan Y, Coukos G, Boyd J, Sood AK, Rebbeck T, Mills GB, Dang CV, Zhang L. Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell. 2015 Oct 12; 28(4):529-540. PMID: 26461095; PMCID: PMC4777353.
      Citations: 328     Fields:    Translation:HumansCells
    397. Ciriello G, Gatza ML, Beck AH, Wilkerson MD, Rhie SK, Pastore A, Zhang H, McLellan M, Yau C, Kandoth C, Bowlby R, Shen H, Hayat S, Fieldhouse R, Lester SC, Tse GM, Factor RE, Collins LC, Allison KH, Chen YY, Jensen K, Johnson NB, Oesterreich S, Mills GB, Cherniack AD, Robertson G, Benz C, Sander C, Laird PW, Hoadley KA, King TA, TCGA Research Network, Perou CM. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. 2015 Oct 08; 163(2):506-19. PMID: 26451490; PMCID: PMC4603750.
      Citations: 764     Fields:    Translation:HumansCells
    398. Fabian CJ, Kimler BF, Phillips TA, Box JA, Kreutzjans AL, Carlson SE, Hidaka BH, Metheny T, Zalles CM, Mills GB, Powers KR, Sullivan DK, Petroff BK, Hensing WL, Fridley BL, Hursting SD. Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Premenopausal Women. Cancer Prev Res (Phila). 2015 Oct; 8(10):912-21. PMID: 26438592; PMCID: PMC6053670.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    399. Han L, Diao L, Yu S, Xu X, Li J, Zhang R, Yang Y, Werner HMJ, Eterovic AK, Yuan Y, Li J, Nair N, Minelli R, Tsang YH, Cheung LWT, Jeong KJ, Roszik J, Ju Z, Woodman SE, Lu Y, Scott KL, Li JB, Mills GB, Liang H. The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers. Cancer Cell. 2015 Oct 12; 28(4):515-528. PMID: 26439496; PMCID: PMC4605878.
      Citations: 208     Fields:    Translation:HumansCells
    400. Moss TJ, Luo Z, Seviour EG, Sehgal V, Lu Y, Hill SM, Rupaimoole R, Lee JS, Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK, Azencott R, Gray JW, Mukherjee S, Mills GB, Ram PT. Genome-wide perturbations by miRNAs map onto functional cellular pathways, identifying regulators of chromatin modifiers. NPJ Syst Biol Appl. 2015; 1:15001. PMID: 28725457; PMCID: PMC5516802.
      Citations: 2     Fields:    
    401. Hewitt DK, Mills G, Hayes F, Norris D, Coyle M, Wilkinson S, Davies W. N-fixation in legumes--An assessment of the potential threat posed by ozone pollution. Environ Pollut. 2016 Jan; 208(Pt B):909-18. PMID: 26385644.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    402. McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS One. 2015; 10(9):e0136851. PMID: 26325287; PMCID: PMC4556673.
      Citations: 32     Fields:    Translation:HumansAnimals
    403. Chaluvally-Raghavan P, Mills GB. Targeting ncRNAs in the 3q26.2 amplicon. Oncoscience. 2015; 2(8):671-2. PMID: 26425652; PMCID: PMC4580054.
      Citations: 1     
    404. Boland GM, Piha-Paul SA, Subbiah V, Routbort M, Herbrich SM, Baggerly K, Patel KP, Brusco L, Horombe C, Naing A, Fu S, Hong DS, Janku F, Johnson A, Broaddus R, Luthra R, Shaw K, Mendelsohn J, Mills GB, Meric-Bernstam F. Clinical next generation sequencing to identify actionable aberrations in a phase I program. Oncotarget. 2015 Aug 21; 6(24):20099-110. PMID: 26015395; PMCID: PMC4652990.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    405. Nanos-Webb A, Bui T, Karakas C, Zhang D, Carey JP, Mills GB, Hunt KK, Keyomarsi K. PKCiota promotes ovarian tumor progression through deregulation of cyclin E. Oncogene. 2016 05 12; 35(19):2428-40. PMID: 26279297; PMCID: PMC4856585.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    406. Liang J, Xu ZX, Ding Z, Lu Y, Yu Q, Werle KD, Zhou G, Park YY, Peng G, Gambello MJ, Mills GB. Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nat Commun. 2015 Aug 14; 6:7926. PMID: 26272043.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    407. Fabian CJ, Kimler BF, Phillips TA, Nydegger JL, Kreutzjans AL, Carlson SE, Hidaka BH, Metheny T, Zalles CM, Mills GB, Powers KR, Sullivan DK, Petroff BK, Hensing WL, Fridley BL, Hursting SD. Modulation of Breast Cancer Risk Biomarkers by High-Dose Omega-3 Fatty Acids: Phase II Pilot Study in Postmenopausal Women. Cancer Prev Res (Phila). 2015 Oct; 8(10):922-31. PMID: 26276744; PMCID: PMC4596784.
      Citations: 13     Fields:    Translation:HumansCTClinical Trials
    408. Cheung LW, Walkiewicz KW, Besong TM, Guo H, Hawke DH, Arold ST, Mills GB. Regulation of the PI3K pathway through a p85a monomer-homodimer equilibrium. Elife. 2015 Jul 29; 4:e06866. PMID: 26222500; PMCID: PMC4518712.
      Citations: 36     Fields:    Translation:HumansCells
    409. Yang JY, Werner HM, Li J, Westin SN, Lu Y, Halle MK, Trovik J, Salvesen HB, Mills GB, Liang H. Integrative Protein-Based Prognostic Model for Early-Stage Endometrioid Endometrial Cancer. Clin Cancer Res. 2016 Jan 15; 22(2):513-23. PMID: 26224872; PMCID: PMC4715969.
      Citations: 12     Fields:    Translation:Humans
    410. Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. 2016 04 28; 35(17):2186-96. PMID: 26212011; PMCID: PMC4792786.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    411. Korkola JE, Collisson EA, Heiser M, Oates C, Bayani N, Itani S, Esch A, Thompson W, Griffith OL, Wang NJ, Kuo WL, Cooper B, Billig J, Ziyad S, Hung JL, Jakkula L, Feiler H, Lu Y, Mills GB, Spellman PT, Tomlin C, Mukherjee S, Gray JW. Decoupling of the PI3K Pathway via Mutation Necessitates Combinatorial Treatment in HER2+ Breast Cancer. PLoS One. 2015; 10(7):e0133219. PMID: 26181325; PMCID: PMC4504492.
      Citations: 9     Fields:    Translation:HumansCells
    412. Feng Z, Uddling J, Briolat A, Alonso R, Elvira S, Karlsson PE, Mills G, Oksanen E, Wieser G, Wilkinson M, Emberson LD, B?ker P, Braun S, Gerosa G, Le Thiec D, Marzuoli R. New flux based dose-response relationships for ozone for European forest tree species. Environ Pollut. 2015 Nov; 206:163-74. PMID: 26164201.
      Citations: 11     Fields:    Translation:Animals
    413. Johnson A, Zeng J, Bailey AM, Holla V, Litzenburger B, Lara-Guerra H, Mills GB, Mendelsohn J, Shaw KR, Meric-Bernstam F. The right drugs at the right time for the right patient: the MD Anderson precision oncology decision support platform. Drug Discov Today. 2015 Dec; 20(12):1433-8. PMID: 26148707; PMCID: PMC5648066.
      Citations: 30     Fields:    Translation:Humans
    414. Lee E, Yang J, Ku M, Kim NH, Park Y, Park CB, Suh JS, Park ES, Yook JI, Mills GB, Huh YM, Cheong JH. Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition. Cell Death Dis. 2015 Jul 02; 6:e1805. PMID: 26136078; PMCID: PMC4650724.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    415. Liu Y, Yasukawa M, Chen K, Hu L, Broaddus RR, Ding L, Mardis ER, Spellman P, Levine DA, Mills GB, Shmulevich I, Sood AK, Zhang W. Association of Somatic Mutations of ADAMTS Genes With Chemotherapy Sensitivity and Survival in High-Grade Serous Ovarian Carcinoma. JAMA Oncol. 2015 Jul; 1(4):486-94. PMID: 26181259; PMCID: PMC4608536.
      Citations: 20     Fields:    Translation:Humans
    416. Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours. Nat Commun. 2015 Jun 17; 6:7419. PMID: 26080861; PMCID: PMC4473807.
      Citations: 84     Fields:    Translation:HumansCells
    417. Zhao J, Zhao D, Poage GM, Mazumdar A, Zhang Y, Hill JL, Hartman ZC, Savage MI, Mills GB, Brown PH. Death-associated protein kinase 1 promotes growth of p53-mutant cancers. J Clin Invest. 2015 Jul 01; 125(7):2707-20. PMID: 26075823; PMCID: PMC4563671.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    418. Skoulidis F, Byers LA, Diao L, Papadimitrakopoulou VA, Tong P, Izzo J, Behrens C, Kadara H, Parra ER, Canales JR, Zhang J, Giri U, Gudikote J, Cortez MA, Yang C, Fan Y, Peyton M, Girard L, Coombes KR, Toniatti C, Heffernan TP, Choi M, Frampton GM, Miller V, Weinstein JN, Herbst RS, Wong KK, Zhang J, Sharma P, Mills GB, Hong WK, Minna JD, Allison JP, Futreal A, Wang J, Wistuba II, Heymach JV. Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities. Cancer Discov. 2015 Aug; 5(8):860-77. PMID: 26069186; PMCID: PMC4527963.
      Citations: 330     Fields:    Translation:HumansCells
    419. Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov. 2015 Jul; 5(7):752-67. PMID: 26069190; PMCID: PMC4497871.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    420. Cancer Genome Atlas Research Network, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E, Miller CR, Vitucci M, Morozova O, Robertson AG, Noushmehr H, Laird PW, Cherniack AD, Akbani R, Huse JT, Ciriello G, Poisson LM, Barnholtz-Sloan JS, Berger MS, Brennan C, Colen RR, Colman H, Flanders AE, Giannini C, Grifford M, Iavarone A, Jain R, Joseph I, Kim J, Kasaian K, Mikkelsen T, Murray BA, O'Neill BP, Pachter L, Parsons DW, Sougnez C, Sulman EP, Vandenberg SR, Van Meir EG, von Deimling A, Zhang H, Crain D, Lau K, Mallery D, Morris S, Paulauskis J, Penny R, Shelton T, Sherman M, Yena P, Black A, Bowen J, Dicostanzo K, Gastier-Foster J, Leraas KM, Lichtenberg TM, Pierson CR, Ramirez NC, Taylor C, Weaver S, Wise L, Zmuda E, Davidsen T, Demchok JA, Eley G, Ferguson ML, Hutter CM, Mills Shaw KR, Ozenberger BA, Sheth M, Sofia HJ, Tarnuzzer R, Wang Z, Yang L, Zenklusen JC, Ayala B, Baboud J, Chudamani S, Jensen MA, Liu J, Pihl T, Raman R, Wan Y, Wu Y, Ally A, Auman JT, Balasundaram M, Balu S, Baylin SB, Beroukhim R, Bootwalla MS, Bowlby R, Bristow CA, Brooks D, Butterfield Y, Carlsen R, Carter S, Chin L, Chu A, Chuah E, Cibulskis K, Clarke A, Coetzee SG, Dhalla N, Fennell T, Fisher S, Gabriel S, Getz G, Gibbs R, Guin R, Hadjipanayis A, Hayes DN, Hinoue T, Hoadley K, Holt RA, Hoyle AP, Jefferys SR, Jones S, Jones CD, Kucherlapati R, Lai PH, Lander E, Lee S, Lichtenstein L, Ma Y, Maglinte DT, Mahadeshwar HS, Marra MA, Mayo M, Meng S, Meyerson ML, Mieczkowski PA, Moore RA, Mose LE, Mungall AJ, Pantazi A, Parfenov M, Park PJ, Parker JS, Perou CM, Protopopov A, Ren X, Roach J, Schein J, Schumacher SE, Seidman JG, Seth S, Shen H, Simons JV, Sipahimalani P, Soloway MG, Song X, Sun H, Tabak B, Tam A, Tan D, Tang J, Thiessen N, Triche T, Van Den Berg DJ, Veluvolu U, Waring S, Weisenberger DJ, Wilkerson MD, Wong T, Wu J, Xi L, Xu AW, Yang L, Zack TI, Zhang J, Aksoy BA, Arachchi H, Benz C, Bernard B, Carlin D, Cho J, DiCara D, Frazer S, Fuller GN, Gao J, Gehlenborg N, Haussler D, Heiman DI, Iype L, Jacobsen A, Ju Z, Katzman S, Kim H, Knijnenburg T, Kreisberg RB, Lawrence MS, Lee W, Leinonen K, Lin P, Ling S, Liu W, Liu Y, Liu Y, Lu Y, Mills G, Ng S, Noble MS, Paull E, Rao A, Reynolds S, Saksena G, Sanborn Z, Sander C, Schultz N, Senbabaoglu Y, Shen R, Shmulevich I, Sinha R, Stuart J, Sumer SO, Sun Y, Tasman N, Taylor BS, Voet D, Weinhold N, Weinstein JN, Yang D, Yoshihara K, Zheng S, Zhang W, Zou L, Abel T, Sadeghi S, Cohen ML, Eschbacher J, Hattab EM, Raghunathan A, Schniederjan MJ, Aziz D, Barnett G, Barrett W, Bigner DD, Boice L, Brewer C, Calatozzolo C, Campos B, Carlotti CG, Chan TA, Cuppini L, Curley E, Cuzzubbo S, Devine K, DiMeco F, Duell R, Elder JB, Fehrenbach A, Finocchiaro G, Friedman W, Fulop J, Gardner J, Hermes B, Herold-Mende C, Jungk C, Kendler A, Lehman NL, Lipp E, Liu O, Mandt R, McGraw M, Mclendon R, McPherson C, Neder L, Nguyen P, Noss A, Nunziata R, Ostrom QT, Palmer C, Perin A, Pollo B, Potapov A, Potapova O, Rathmell WK, Rotin D, Scarpace L, Schilero C, Senecal K, Shimmel K, Shurkhay V, Sifri S, Singh R, Sloan AE, Smolenski K, Staugaitis SM, Steele R, Thorne L, Tirapelli DP, Unterberg A, Vallurupalli M, Wang Y, Warnick R, Williams F, Wolinsky Y, Bell S, Rosenberg M, Stewart C, Huang F, et al. Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med. 2015 Jun 25; 372(26):2481-98. PMID: 26061751; PMCID: PMC4530011.
      Citations: 1192     Fields:    Translation:HumansCells
    421. Cheung LW, Mills GB. p85a neomorphic mutants: splitting away from the canonical path. Mol Cell Oncol. 2015 Oct-Dec; 2(4):e983388. PMID: 27308516; PMCID: PMC4905360.
      Citations: 1     
    422. Meric-Bernstam F, Brusco L, Shaw K, Horombe C, Kopetz S, Davies MA, Routbort M, Piha-Paul SA, Janku F, Ueno N, Hong D, De Groot J, Ravi V, Li Y, Luthra R, Patel K, Broaddus R, Mendelsohn J, Mills GB. Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials. J Clin Oncol. 2015 Sep 01; 33(25):2753-62. PMID: 26014291; PMCID: PMC4550690.
      Citations: 203     Fields:    Translation:Humans
    423. Westin SN, Ju Z, Broaddus RR, Krakstad C, Li J, Pal N, Lu KH, Coleman RL, Hennessy BT, Klempner SJ, Werner HM, Salvesen HB, Cantley LC, Mills GB, Myers AP. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients. Mol Oncol. 2015 Oct; 9(8):1694-703. PMID: 26045339; PMCID: PMC4584169.
      Citations: 21     Fields:    Translation:HumansCells
    424. Zenali M, deKay J, Liu Z, Hamilton S, Zuo Z, Lu X, Bakkar R, Mills G, Broaddus R. Retrospective Review of MET Gene Mutations. Oncoscience. 2015; 2(5):533-41. PMID: 26097886; PMCID: PMC4468339.
      Citations: 16     
    425. Federico L, Jeong KJ, Vellano CP, Mills GB. Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression. J Lipid Res. 2016 Jan; 57(1):25-35. PMID: 25977291; PMCID: PMC4689343.
      Citations: 14     Fields:    Translation:HumansAnimals
    426. Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, Van't Veer LJ, Spellman PT, Gray JW. Erratum to: Modeling precision treatment of breast cancer. Genome Biol. 2015 May 12; 16:95. PMID: 25962591; PMCID: PMC4426644.
      Citations: 4     Fields:    
    427. Van Allen EM, Lui VW, Egloff AM, Goetz EM, Li H, Johnson JT, Duvvuri U, Bauman JE, Stransky N, Zeng Y, Gilbert BR, Pendleton KP, Wang L, Chiosea S, Sougnez C, Wagle N, Zhang F, Du Y, Close D, Johnston PA, McKenna A, Carter SL, Golub TR, Getz G, Mills GB, Garraway LA, Grandis JR. Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma. JAMA Oncol. 2015 May; 1(2):238-44. PMID: 26181029; PMCID: PMC4557203.
      Citations: 25     Fields:    Translation:HumansCells
    428. Carvalho S, Lindzen M, Lauriola M, Shirazi N, Sinha S, Abdul-Hai A, Levanon K, Korach J, Barshack I, Cohen Y, Onn A, Mills G, Yarden Y. An antibody to amphiregulin, an abundant growth factor in patients' fluids, inhibits ovarian tumors. Oncogene. 2016 Jan 28; 35(4):438-47. PMID: 25915843.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    429. Cardnell RJ, Behrens C, Diao L, Fan Y, Tang X, Tong P, Minna JD, Mills GB, Heymach JV, Wistuba II, Wang J, Byers LA. An Integrated Molecular Analysis of Lung Adenocarcinomas Identifies Potential Therapeutic Targets among TTF1-Negative Tumors, Including DNA Repair Proteins and Nrf2. Clin Cancer Res. 2015 Aug 01; 21(15):3480-91. PMID: 25878335; PMCID: PMC4526428.
      Citations: 28     Fields:    Translation:HumansCells
    430. Meric-Bernstam F, Johnson A, Holla V, Bailey AM, Brusco L, Chen K, Routbort M, Patel KP, Zeng J, Kopetz S, Davies MA, Piha-Paul SA, Hong DS, Eterovic AK, Tsimberidou AM, Broaddus R, Bernstam EV, Shaw KR, Mendelsohn J, Mills GB. A decision support framework for genomically informed investigational cancer therapy. J Natl Cancer Inst. 2015 Jul; 107(7). PMID: 25863335; PMCID: PMC4651038.
      Citations: 91     Fields:    Translation:HumansAnimals
    431. Guo H, German P, Bai S, Barnes S, Guo W, Qi X, Lou H, Liang J, Jonasch E, Mills GB, Ding Z. The PI3K/AKT Pathway and Renal Cell Carcinoma. J Genet Genomics. 2015 Jul 20; 42(7):343-53. PMID: 26233890; PMCID: PMC4624215.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    432. Zhang S, Yang C, Yang Z, Zhang D, Ma X, Mills G, Liu Z. Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. Am J Cancer Res. 2015; 5(4):1265-80. PMID: 26101696; PMCID: PMC4473309.
      Citations: 9     
    433. Jeon YJ, Khelifa S, Ratnikov B, Scott DA, Feng Y, Parisi F, Ruller C, Lau E, Kim H, Brill LM, Jiang T, Rimm DL, Cardiff RD, Mills GB, Smith JW, Osterman AL, Kluger Y, Ronai ZA. Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies. Cancer Cell. 2015 Mar 09; 27(3):354-69. PMID: 25759021; PMCID: PMC4356903.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    434. Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res. 2015 Mar 15; 75(6):1091-101. PMID: 25736685; PMCID: PMC4446709.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    435. Kwong LN, Boland GM, Frederick DT, Helms TL, Akid AT, Miller JP, Jiang S, Cooper ZA, Song X, Seth S, Kamara J, Protopopov A, Mills GB, Flaherty KT, Wargo JA, Chin L. Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma. J Clin Invest. 2015 Apr; 125(4):1459-70. PMID: 25705882; PMCID: PMC4396463.
      Citations: 66     Fields:    Translation:HumansAnimals
    436. Liu S, Meric-Bernstam F, Parinyanitikul N, Wang B, Eterovic AK, Zheng X, Gagea M, Chavez-MacGregor M, Ueno NT, Lei X, Zhou W, Nair L, Tripathy D, Brown PH, Hortobagyi GN, Chen K, Mendelsohn J, Mills GB, Gonzalez-Angulo AM. Functional consequence of the MET-T1010I polymorphism in breast cancer. Oncotarget. 2015 Feb 20; 6(5):2604-14. PMID: 25605252; PMCID: PMC4413604.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    437. Harmens H, Norris DA, Sharps K, Mills G, Alber R, Aleksiayenak Y, Blum O, Cucu-Man SM, Dam M, De Temmerman L, Ene A, Fern?ndez JA, Martinez-Abaigar J, Frontasyeva M, Godzik B, Jeran Z, Lazo P, Leblond S, Liiv S, Magn?sson SH, Mankovsk? B, Karlsson GP, Piispanen J, Poikolainen J, Santamaria JM, Skudnik M, Spiric Z, Stafilov T, Steinnes E, Stihi C, Suchara I, Th?ni L, Todoran R, Yurukova L, Zechmeister HG. Heavy metal and nitrogen concentrations in mosses are declining across Europe whilst some "hotspots" remain in 2010. Environ Pollut. 2015 May; 200:93-104. PMID: 25703579.
      Citations: 18     Fields:    Translation:AnimalsPHPublic Health
    438. Zhao D, Besser AH, Wander SA, Sun J, Zhou W, Wang B, Ince T, Durante MA, Guo W, Mills G, Theodorescu D, Slingerland J. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene. 2015 Oct; 34(43):5447-59. PMID: 25684140; PMCID: PMC4537852.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    439. Gonzalez-Angulo AM, Krop I, Akcakanat A, Chen H, Liu S, Li Y, Culotta KS, Tarco E, Piha-Paul S, Moulder-Thompson S, Velez-Bravo V, Sahin AA, Doyle LA, Do KA, Winer EP, Mills GB, Kurzrock R, Meric-Bernstam F. SU2C phase Ib study of paclitaxel and MK-2206 in advanced solid tumors and metastatic breast cancer. J Natl Cancer Inst. 2015 Mar; 107(3). PMID: 25688104; PMCID: PMC4342675.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    440. Zhang S, Yang C, Yang Z, Zhang D, Ma X, Mills G, Liu Z. Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. Am J Cancer Res. 2015; 5(3):928-44. PMID: 26045978; PMCID: PMC4449427.
      Citations: 12     
    441. Tuna M, Ju Z, Smid M, Amos CI, Mills GB. Prognostic relevance of acquired uniparental disomy in serous ovarian cancer. Mol Cancer. 2015 Feb 03; 14:29. PMID: 25644622; PMCID: PMC4320828.
      Citations: 10     Fields:    Translation:HumansCells
    442. Aure MR, Krohn M, Vollan HK, Due EU, Oslo Breast Cancer Research Consortium (OSBREAC), Ram P, Lu Y, Mills GB, Sahlberg KK, Jernstr?m S, R?dland E, K?resen R, B?rresen-Dale AL, Lingj?rde OC, Kristensen VN. Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer. Genome Med. 2015; 7(1):21. PMID: 25873999; PMCID: PMC4396592.
      Citations: 19     Fields:    
    443. Seviour EG, Sehgal V, Lu Y, Luo Z, Moss T, Zhang F, Hill SM, Liu W, Maiti SN, Cooper L, Azencot R, Lopez-Berestein G, Rodriguez-Aguayo C, Roopaimoole R, Pecot CV, Pecot C, Sood AK, Mukherjee S, Gray JW, Mills GB, Ram PT. Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer. Oncogene. 2016 Feb 11; 35(6):691-701. PMID: 25639871; PMCID: PMC4522411.
      Citations: 20     Fields:    Translation:HumansCells
    444. Akbani R, Ng PK, Werner HM, Shahmoradgoli M, Zhang F, Ju Z, Liu W, Yang JY, Yoshihara K, Li J, Ling S, Seviour EG, Ram PT, Minna JD, Diao L, Tong P, Heymach JV, Hill SM, Dondelinger F, Byers LA, Meric-Bernstam F, Weinstein JN, Broom BM, Verhaak RG, Liang H, Mukherjee S, Lu Y, Mills GB, St?dler N. Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun. 2015 Jan 28; 6:4852. PMID: 25629879.
      Citations: 4     Fields:    
    445. Chen K, Meric-Bernstam F, Zhao H, Zhang Q, Ezzeddine N, Tang LY, Qi Y, Mao Y, Chen T, Chong Z, Zhou W, Zheng X, Johnson A, Aldape KD, Routbort MJ, Luthra R, Kopetz S, Davies MA, de Groot J, Moulder S, Vinod R, Farhangfar CJ, Shaw KM, Mendelsohn J, Mills GB, Eterovic AK. Clinical actionability enhanced through deep targeted sequencing of solid tumors. Clin Chem. 2015 Mar; 61(3):544-53. PMID: 25626406; PMCID: PMC4511273.
      Citations: 61     Fields:    Translation:Humans
    446. Berg A, Hoivik EA, Holst F, Werner HM, Tangen IL, Taylor-Weiner A, Gibson WJ, Kusonmano K, Wik E, Trovik J, Halle MK, Kalland KH, Cherniack AD, Beroukhim R, Stefansson I, Mills GB, Krakstad C, Salvesen HB, Mj?s S, ?yan AM. Molecular profiling of endometrial carcinoma precursor, primary and metastatic lesions suggests different targets for treatment in obese compared to non-obese patients. Oncotarget. 2015 Jan 20; 6(2):1327-39. PMID: 25415225; PMCID: PMC4359236.
      Citations: 21     Fields:    Translation:Humans
    447. Mitra S, Molina J, Mills GB, Dennison JB. Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance. Methods Mol Biol. 2015; 1298:195-205. PMID: 25800844.
      Citations: 2     Fields:    Translation:HumansCells
    448. Gong L, Govan JM, Evans EB, Dai H, Wang E, Lee SW, Lin HK, Lazar AJ, Mills GB, Lin SY. Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure. Cell Cycle. 2015; 14(14):2323-32. PMID: 25946202; PMCID: PMC4614552.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    449. Grubbs EG, Ng PK, Bui J, Busaidy NL, Chen K, Lee JE, Lu X, Lu H, Meric-Bernstam F, Mills GB, Palmer G, Perrier ND, Scott KL, Shaw KR, Waguespack SG, Williams MD, Yelensky R, Cote GJ. RET fusion as a novel driver of medullary thyroid carcinoma. J Clin Endocrinol Metab. 2015 Mar; 100(3):788-93. PMID: 25546157; PMCID: PMC4333032.
      Citations: 34     Fields:    Translation:Humans
    450. Churi CR, Shroff R, Wang Y, Rashid A, Kang HC, Weatherly J, Zuo M, Zinner R, Hong D, Meric-Bernstam F, Janku F, Crane CH, Mishra L, Vauthey JN, Wolff RA, Mills G, Javle M. Mutation profiling in cholangiocarcinoma: prognostic and therapeutic implications. PLoS One. 2014; 9(12):e115383. PMID: 25536104; PMCID: PMC4275227.
      Citations: 170     Fields:    Translation:HumansCells
    451. Kaushik P, Molinelli EJ, Miller ML, Wang W, Korkut A, Liu W, Ju Z, Lu Y, Mills G, Sander C. Spatial normalization of reverse phase protein array data. PLoS One. 2014; 9(12):e97213. PMID: 25501559; PMCID: PMC4264691.
      Citations: 9     Fields:    Translation:HumansCells
    452. Boggs AE, Vitolo MI, Whipple RA, Charpentier MS, Goloubeva OG, Ioffe OB, Tuttle KC, Slovic J, Lu Y, Mills GB, Martin SS. a-Tubulin acetylation elevated in metastatic and basal-like breast cancer cells promotes microtentacle formation, adhesion, and invasive migration. Cancer Res. 2015 Jan 01; 75(1):203-15. PMID: 25503560; PMCID: PMC4350791.
      Citations: 79     Fields:    Translation:HumansCells
    453. Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton MP, Zhao X, Rupaimoole R, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han HD, Zhang D, Venkatanarayan A, Krohn M, Kristensen VN, Gagea M, Ram P, Liu W, Lopez-Berestein G, Lorenzi PL, Chin K, Gray J, Dusetti NJ, McGuire SE, Flores ER, Sood AK, Mills GB, B?rresen-Dale AL. Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. Cancer Cell. 2014 Dec 08; 26(6):863-879. PMID: 25490449; PMCID: PMC4261159.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    454. Schwarz LJ, Fox EM, Balko JM, Garrett JT, Mills GB, Red-Brewer M, Mayer IA, Abramson V, Rizzo M, Kelley MC, Meszoely IM, Arteaga CL, Kuba MG, Estrada MV, Gonz?lez-Angulo AM. LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer. J Clin Invest. 2014 Dec; 124(12):5490-502. PMID: 25401474; PMCID: PMC4348968.
      Citations: 15     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    455. Kotlyar M, Pastrello C, Pivetta F, Lo Sardo A, Cumbaa C, Li H, Naranian T, Niu Y, Ding Z, Vafaee F, Broackes-Carter F, Petschnigg J, Mills GB, Jurisicova A, Stagljar I, Maestro R, Jurisica I. In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan; 12(1):79-84. PMID: 25402006.
      Citations: 55     Fields:    Translation:Humans
    456. Ju Z, Liu W, Roebuck PL, Siwak DR, Zhang N, Lu Y, Davies MA, Akbani R, Weinstein JN, Mills GB, Coombes KR. Development of a robust classifier for quality control of reverse-phase protein arrays. Bioinformatics. 2015 Mar 15; 31(6):912-8. PMID: 25380958; PMCID: PMC4375399.
      Citations: 24     Fields:    
    457. Kim TH, Yoo JY, Kim HI, Gilbert J, Ku BJ, Li J, Mills GB, Broaddus RR, Lydon JP, Lim JM, Yoon HG, Jeong JW. Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation. Cancer Res. 2014 Dec 15; 74(24):7371-82. PMID: 25377472; PMCID: PMC4268053.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    458. Chiu HS, Llobet-Navas D, Yang X, Chung WJ, Ambesi-Impiombato A, Iyer A, Kim HR, Seviour EG, Luo Z, Sehgal V, Moss T, Lu Y, Ram P, Mills GB, Califano A, Sumazin P, Silva J. Cupid: simultaneous reconstruction of microRNA-target and ceRNA networks. Genome Res. 2015 Feb; 25(2):257-67. PMID: 25378249; PMCID: PMC4315299.
      Citations: 51     Fields:    Translation:HumansCells
    459. Madden SF, Clarke C, Stordal B, Carey MS, Broaddus R, Gallagher WM, Crown J, Mills GB, Hennessy BT. OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets. Mol Cancer. 2014 Oct 24; 13:241. PMID: 25344116; PMCID: PMC4219121.
      Citations: 11     Fields:    Translation:HumansCells
    460. Liu W, Ju Z, Lu Y, Mills GB, Akbani R. A comprehensive comparison of normalization methods for loading control and variance stabilization of reverse-phase protein array data. Cancer Inform. 2014; 13:109-17. PMID: 25374453; PMCID: PMC4213190.
      Citations: 14     
    461. Sohn J, Liu S, Parinyanitikul N, Lee J, Hortobagyi GN, Mills GB, Ueno NT, Gonzalez-Angulo AM. cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer. J Cancer. 2014; 5(9):745-53. PMID: 25368674; PMCID: PMC4216798.
      Citations: 21     
    462. Liu S, Meng X, Chen H, Liu W, Miller T, Murph M, Lu Y, Zhang F, Gagea M, Arteaga CL, Mills GB, Meric-Bernstam F, Gonz?lez-Angulo AM. Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer. Oncotarget. 2014 Oct 15; 5(19):9049-64. PMID: 24979294; PMCID: PMC4253418.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    463. Gopal YN, Rizos H, Chen G, Deng W, Frederick DT, Cooper ZA, Scolyer RA, Pupo G, Komurov K, Sehgal V, Zhang J, Patel L, Pereira CG, Broom BM, Mills GB, Ram P, Smith PD, Wargo JA, Long GV, Davies MA. Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation in melanoma. Cancer Res. 2014 Dec 01; 74(23):7037-47. PMID: 25297634; PMCID: PMC4347853.
      Citations: 94     Fields:    Translation:HumansCells
    464. Dillon LM, Bean JR, Yang W, Shee K, Symonds LK, Balko JM, McDonald WH, Liu S, Gonzalez-Angulo AM, Mills GB, Arteaga CL, Miller TW. P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. Oncogene. 2015 Jul 23; 34(30):3968-76. PMID: 25284585; PMCID: PMC4387124.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    465. Cheung LW, Yu S, Zhang D, Li J, Ng PK, Panupinthu N, Mitra S, Ju Z, Yu Q, Liang H, Hawke DH, Lu Y, Broaddus RR, Mills GB. Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors. Cancer Cell. 2014 Oct 13; 26(4):479-94. PMID: 25284480; PMCID: PMC4198486.
      Citations: 45     Fields:    Translation:HumansCells
    466. Hassan B, Akcakanat A, Sangai T, Evans KW, Adkins F, Eterovic AK, Zhao H, Chen K, Chen H, Do KA, Xie SM, Holder AM, Naing A, Mills GB, Meric-Bernstam F. Catalytic mTOR inhibitors can overcome intrinsic and acquired resistance to allosteric mTOR inhibitors. Oncotarget. 2014 Sep 30; 5(18):8544-57. PMID: 25261369; PMCID: PMC4226703.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    467. Werner HM, Berg A, Halle MK, Kusonmano K, Trovik J, Hoivik EA, Mills GB, Krakstad C, Salvesen HB, Tangen IL. Loss of progesterone receptor links to high proliferation and increases from primary to metastatic endometrial cancer lesions. Eur J Cancer. 2014 Nov; 50(17):3003-10. PMID: 25281525.
      Citations: 31     Fields:    Translation:Humans
    468. Fu X, Creighton CJ, Biswal NC, Kumar V, Shea M, Herrera S, Contreras A, Gutierrez C, Wang T, Nanda S, Giuliano M, Morrison G, Nardone A, Karlin KL, Westbrook TF, Heiser LM, Anur P, Spellman P, Guichard SM, Smith PD, Davies BR, Klinowska T, Lee AV, Mills GB, Rimawi MF, Hilsenbeck SG, Gray JW, Joshi A, Osborne CK, Schiff R. Overcoming endocrine resistance due to reduced PTEN levels in estrogen receptor-positive breast cancer by co-targeting mammalian target of rapamycin, protein kinase B, or mitogen-activated protein kinase kinase. Breast Cancer Res. 2014 Sep 11; 16(5):430. PMID: 25212826; PMCID: PMC4303114.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    469. Burstein MD, Tsimelzon A, Poage GM, Covington KR, Contreras A, Fuqua SA, Savage MI, Osborne CK, Hilsenbeck SG, Chang JC, Mills GB, Lau CC, Brown PH. Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clin Cancer Res. 2015 Apr 01; 21(7):1688-98. PMID: 25208879; PMCID: PMC4362882.
      Citations: 448     Fields:    Translation:HumansCells
    470. Liu Y, Patel L, Mills GB, Lu KH, Sood AK, Ding L, Kucherlapati R, Mardis ER, Levine DA, Shmulevich I, Broaddus RR, Zhang W. Clinical significance of CTNNB1 mutation and Wnt pathway activation in endometrioid endometrial carcinoma. J Natl Cancer Inst. 2014 Sep; 106(9). PMID: 25214561; PMCID: PMC4200060.
      Citations: 86     Fields:    Translation:HumansCells
    471. Hu X, Feng Y, Zhang D, Zhao SD, Hu Z, Greshock J, Zhang Y, Yang L, Zhong X, Wang LP, Jean S, Li C, Huang Q, Katsaros D, Montone KT, Tanyi JL, Lu Y, Boyd J, Nathanson KL, Li H, Mills GB, Zhang L. A functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in cancer. Cancer Cell. 2014 Sep 08; 26(3):344-357. PMID: 25203321; PMCID: PMC4159613.
      Citations: 201     Fields:    Translation:HumansAnimalsCells
    472. Mazumdar T, Byers LA, Ng PK, Mills GB, Peng S, Diao L, Fan YH, Stemke-Hale K, Heymach JV, Myers JN, Glisson BS, Johnson FM. A comprehensive evaluation of biomarkers predictive of response to PI3K inhibitors and of resistance mechanisms in head and neck squamous cell carcinoma. Mol Cancer Ther. 2014 Nov; 13(11):2738-50. PMID: 25193510; PMCID: PMC4221385.
      Citations: 44     Fields:    Translation:HumansCells
    473. Peng G, Woodman SE, Mills GB. RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy? Cancer Discov. 2014 Sep; 4(9):988-90. PMID: 25185187; PMCID: PMC4155513.
      Citations: 1     Fields:    Translation:Humans
    474. Choi MJ, Cho KH, Lee S, Bae YJ, Jeong KJ, Rha SY, Choi EJ, Park JH, Kim JM, Lee JS, Mills GB, Lee HY. hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. Oncogene. 2015 Jun; 34(26):3402-12. PMID: 25151968.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    475. Siroy AE, Boland GM, Roszik J, Frankian S, Malke J, Haydu L, Prieto VG, Tetzlaff M, Ivan D, Wang WL, Torres-Cabala C, Curry J, Roy-Chowdhuri S, Broaddus R, Rashid A, Stewart J, Gershenwald JE, Amaria RN, Patel SP, Papadopoulos NE, Bedikian A, Hwu WJ, Hwu P, Diab A, Woodman SE, Aldape KD, Luthra R, Patel KP, Shaw KR, Mills GB, Mendelsohn J, Meric-Bernstam F, Kim KB, Routbort MJ, Lazar AJ, Davies MA, Milton DR. Beyond BRAF(V600): clinical mutation panel testing by next-generation sequencing in advanced melanoma. J Invest Dermatol. 2015 Feb; 135(2):508-515. PMID: 25148578; PMCID: PMC4289407.
      Citations: 56     Fields:    Translation:Humans
    476. He N, Kim N, Song M, Park C, Kim S, Park EY, Yim HY, Kim K, Park JH, Kim KI, Zhang F, Mills GB, Yoon S. Integrated analysis of transcriptomes of cancer cell lines and patient samples reveals STK11/LKB1-driven regulation of cAMP phosphodiesterase-4D. Mol Cancer Ther. 2014 Oct; 13(10):2463-73. PMID: 25122068.
      Citations: 8     Fields:    Translation:HumansCells
    477. Lu G, Zhang Q, Huang Y, Song J, Tomaino R, Ehrenberger T, Lim E, Liu W, Bronson RT, Bowden M, Brock J, Krop IE, Dillon DA, Gygi SP, Mills GB, Richardson AL, Signoretti S, Yaffe MB, Kaelin WG. Phosphorylation of ETS1 by Src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell. 2014 Aug 11; 26(2):222-34. PMID: 25117710; PMCID: PMC4169234.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    478. Pande M, Bondy ML, Do KA, Sahin AA, Ying J, Mills GB, Thompson PA, Brewster AM. Association between germline single nucleotide polymorphisms in the PI3K-AKT-mTOR pathway, obesity, and breast cancer disease-free survival. Breast Cancer Res Treat. 2014 Sep; 147(2):381-7. PMID: 25108739; PMCID: PMC4174407.
      Citations: 10     Fields:    Translation:HumansCells
    479. Lehmann BD, Bauer JA, Schafer JM, Pendleton CS, Tang L, Johnson KC, Chen X, Balko JM, Arteaga CL, Mills GB, Sanders ME, Pietenpol JA, G?mez H. PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors. Breast Cancer Res. 2014 Aug 08; 16(4):406. PMID: 25103565; PMCID: PMC4187324.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    480. Hoadley KA, Yau C, Wolf DM, Cherniack AD, Tamborero D, Ng S, Leiserson MDM, Niu B, McLellan MD, Uzunangelov V, Zhang J, Kandoth C, Akbani R, Shen H, Omberg L, Chu A, Margolin AA, Van't Veer LJ, Laird PW, Raphael BJ, Ding L, Robertson AG, Byers LA, Mills GB, Weinstein JN, Van Waes C, Chen Z, Collisson EA, Cancer Genome Atlas Research Network, Benz CC, Perou CM, Stuart JM, Lopez-Bigas N. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell. 2014 Aug 14; 158(4):929-944. PMID: 25109877; PMCID: PMC4152462.
      Citations: 630     Fields:    Translation:HumansCells
    481. Subbiah V, Meric-Bernstam F, Mills GB, Shaw KR, Bailey AM, Rao P, Ward JF, Pagliaro LC. Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent?) a VEGFR2/PDGFR?/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial. J Hematol Oncol. 2014 Aug 01; 7:52. PMID: 25085632; PMCID: PMC4237879.
      Citations: 15     Fields:    Translation:HumansCTClinical Trials
    482. Watson IR, Li L, Cabeceiras PK, Mahdavi M, Gutschner T, Genovese G, Wang G, Fang Z, Tepper JM, Stemke-Hale K, Tsai KY, Davies MA, Mills GB, Chin L. The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF. Cancer Res. 2014 Sep 01; 74(17):4845-4852. PMID: 25056119; PMCID: PMC4167745.
      Citations: 74     Fields:    Translation:HumansCells
    483. Muranen T, Meric-Bernstam F, Mills GB. Promising rationally derived combination therapy with PI3K and CDK4/6 inhibitors. Cancer Cell. 2014 Jul 14; 26(1):7-9. PMID: 25026206.
      Citations: 3     Fields:    Translation:HumansAnimals
    484. O'Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O'Connor DP, Brennan DJ, Connor K, Li J, Gonzalez-Angulo AM, Sun HD, Pu JX, Nowis DA, Crown JP, Zagozdzon R, Gallagher WM, Pont?n F, Uhl?n M, Jirstr?m K. Peroxiredoxin-1 protects estrogen receptor a from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer. Breast Cancer Res. 2014 Jul 10; 16(4):R79. PMID: 25011585; PMCID: PMC4226972.
      Citations: 26     Fields:    Translation:HumansCells
    485. Cancer Genome Atlas Research Network. Comprehensive molecular profiling of lung adenocarcinoma. Nature. 2014 Jul 31; 511(7511):543-50. PMID: 25079552; PMCID: PMC4231481.
      Citations: 2046     Fields:    Translation:HumansCells
    486. Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, Zhang J, Bai S, German P, Hoang A, Zhou L, Jonasch D, Zhang X, Conti CJ, Efstathiou E, Tannir NM, Eissa NT, Mills GB, Walker CL, Jonasch E. Autophagy mediates HIF2a degradation and suppresses renal tumorigenesis. Oncogene. 2015 May 07; 34(19):2450-60. PMID: 24998849; PMCID: PMC4286517.
      Citations: 41     Fields:    Translation:HumansCells
    487. Joy A, Ramesh A, Smirnov I, Reiser M, Misra A, Shapiro WR, Mills GB, Kim S, Feuerstein BG. AKT pathway genes define 5 prognostic subgroups in glioblastoma. PLoS One. 2014; 9(7):e100827. PMID: 24984002; PMCID: PMC4077731.
      Citations: 8     Fields:    Translation:HumansCells
    488. Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, Sahin AA, Sood A, Mills GB, Yu D, Hortobagyi GN, Hung MC. Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res. 2014 Sep 01; 74(17):4822-35. PMID: 24970481; PMCID: PMC4154991.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    489. Yuan Y, Van Allen EM, Omberg L, Wagle N, Amin-Mansour A, Sokolov A, Byers LA, Xu Y, Hess KR, Diao L, Han L, Huang X, Lawrence MS, Weinstein JN, Stuart JM, Mills GB, Garraway LA, Margolin AA, Getz G, Liang H. Assessing the clinical utility of cancer genomic and proteomic data across tumor types. Nat Biotechnol. 2014 Jul; 32(7):644-52. PMID: 24952901; PMCID: PMC4102885.
      Citations: 124     Fields:    Translation:Humans
    490. Meric-Bernstam F, Akcakanat A, Chen H, Sahin A, Tarco E, Carkaci S, Adrada BE, Singh G, Do KA, Garces ZM, Mittendorf E, Babiera G, Bedrosian I, Hwang R, Krishnamurthy S, Symmans WF, Gonzalez-Angulo AM, Mills GB. Influence of biospecimen variables on proteomic biomarkers in breast cancer. Clin Cancer Res. 2014 Jul 15; 20(14):3870-83. PMID: 24895461; PMCID: PMC4112583.
      Citations: 25     Fields:    Translation:HumansCells
    491. Davies AH, Reipas KM, Pambid MR, Berns R, Stratford AL, Fotovati A, Firmino N, Astanehe A, Hu K, Maxwell C, Mills GB, Dunn SE. YB-1 transforms human mammary epithelial cells through chromatin remodeling leading to the development of basal-like breast cancer. Stem Cells. 2014 Jun; 32(6):1437-50. PMID: 24648416; PMCID: PMC4321723.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    492. Akbani R, Ng PK, Werner HM, Shahmoradgoli M, Zhang F, Ju Z, Liu W, Yang JY, Yoshihara K, Li J, Ling S, Seviour EG, Ram PT, Minna JD, Diao L, Tong P, Heymach JV, Hill SM, Dondelinger F, Byers LA, Meric-Bernstam F, Weinstein JN, Broom BM, Verhaak RG, Liang H, Mukherjee S, Lu Y, Mills GB, St?dler N. A pan-cancer proteomic perspective on The Cancer Genome Atlas. Nat Commun. 2014 May 29; 5:3887. PMID: 24871328; PMCID: PMC4109726.
      Citations: 248     Fields:    Translation:HumansCells
    493. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell. 2014 Jun 19; 54(6):960-974. PMID: 24857548; PMCID: PMC4067806.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    494. Lorenzi PL, Claerhout S, Mills GB, Weinstein JN. A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy. Autophagy. 2014 Jul; 10(7):1316-26. PMID: 24906121; PMCID: PMC4203555.
      Citations: 18     Fields:    Translation:HumansCells
    495. Lee J, Tiwari A, Shum V, Mills GB, Mancini MA, Igoshin OA, Bal?zsi G. Unraveling the regulatory connections between two controllers of breast cancer cell fate. Nucleic Acids Res. 2014 Jun; 42(11):6839-49. PMID: 24792166; PMCID: PMC4066784.
      Citations: 7     Fields:    Translation:HumansCells
    496. Akbani R, de Koning L, Korf U, Mills GB, Becker KF, Carragher N, Goldstein T, Liotta L, Nishizuka SS, Pawlak M, Petricoin EF, Pollard HB, Serrels B, Zhu J. Realizing the promise of reverse phase protein arrays for clinical, translational, and basic research: a workshop report: the RPPA (Reverse Phase Protein Array) society. Mol Cell Proteomics. 2014 Jul; 13(7):1625-43. PMID: 24777629; PMCID: PMC4083105.
      Citations: 64     Fields:    Translation:HumansCells
    497. Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS. Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance. J Clin Invest. 2014 Jun; 124(6):2611-25. PMID: 24762435; PMCID: PMC4038562.
      Citations: 67     Fields:    Translation:HumansCells
    498. Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun 01; 74(11):3127-36. PMID: 24755468; PMCID: PMC4047720.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    499. Yang F, Liu T, Petyuk VA, Gritsenko MA, Moore RJ, Levine DA, Olvera N, Dao F, Chan DW, Liebler D, White F, Rodland KD, Mills GB, Smith RD, Paulovich AG, Mertins P, Mani DR, Gillette MA, Clauser KR, Qiao JW, Townsend R, Erdmann-Gilmore P, Snider JE, Davies SR, Ruggles KV, Fenyo D, Kitchens RT, Li S, Rodriguez H, Ellis M, Carr SA. Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics. 2014 Jul; 13(7):1690-704. PMID: 24719451; PMCID: PMC4083109.
      Citations: 175     Fields:    Translation:HumansAnimalsCells
    500. Gonzalez-Angulo AM, Akcakanat A, Liu S, Green MC, Murray JL, Chen H, Palla SL, Koenig KB, Brewster AM, Valero V, Ibrahim NK, Moulder-Thompson S, Litton JK, Tarco E, Moore J, Flores P, Crawford D, Dryden MJ, Symmans WF, Sahin A, Giordano SH, Pusztai L, Do KA, Mills GB, Hortobagyi GN, Meric-Bernstam F. Open-label randomized clinical trial of standard neoadjuvant chemotherapy with paclitaxel followed by FEC versus the combination of paclitaxel and everolimus followed by FEC in women with triple receptor-negative breast cancer?. Ann Oncol. 2014 Jun; 25(6):1122-7. PMID: 24669015; PMCID: PMC4037860.
      Citations: 49     Fields:    Translation:HumansCellsCTClinical Trials
    501. Hewitt DK, Mills G, Hayes F, Wilkinson S, Davies W. Highlighting the threat from current and near-future ozone pollution to clover in pasture. Environ Pollut. 2014 Jun; 189:111-7. PMID: 24657604.
      Citations: 5     Fields:    Translation:Animals
    502. Dawood M, Mills GB, Ding Z. Shrewd AKT regulation to survive. Oncoscience. 2014; 1(2):113-4. PMID: 25594004; PMCID: PMC4278283.
      Citations: 5     
    503. Meric-Bernstam F, Frampton GM, Ferrer-Lozano J, Yelensky R, Wang Y, Palmer GA, Ross JS, Miller VA, Su X, Eroles P, Barrera JA, Burgues O, Lluch AM, Zheng X, Sahin A, Stephens PJ, Mills GB, Cronin MT, Gonzalez-Angulo AM, P?rez-Fidalgo JA. Concordance of genomic alterations between primary and recurrent breast cancer. Mol Cancer Ther. 2014 May; 13(5):1382-9. PMID: 24608573; PMCID: PMC4348062.
      Citations: 50     Fields:    Translation:Humans
    504. Sewell A, Brown B, Biktasova A, Mills GB, Lu Y, Tyson DR, Issaeva N, Yarbrough WG. Reverse-phase protein array profiling of oropharyngeal cancer and significance of PIK3CA mutations in HPV-associated head and neck cancer. Clin Cancer Res. 2014 May 01; 20(9):2300-11. PMID: 24599934; PMCID: PMC4027970.
      Citations: 41     Fields:    Translation:HumansCells
    505. Wiegand KC, Hennessy BT, Leung S, Wang Y, Ju Z, McGahren M, Kalloger SE, Finlayson S, Stemke-Hale K, Lu Y, Zhang F, Anglesio MS, Gilks B, Mills GB, Huntsman DG, Carey MS. A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation. BMC Cancer. 2014 Feb 22; 14:120. PMID: 24559118; PMCID: PMC3941949.
      Citations: 40     Fields:    Translation:HumansCells
    506. Werner HM, Mills GB, Ram PT. Cancer Systems Biology: a peek into the future of patient care? Nat Rev Clin Oncol. 2014 Mar; 11(3):167-76. PMID: 24492837; PMCID: PMC4321721.
      Citations: 74     Fields:    Translation:Humans
    507. Jeong W, Kim SB, Sohn BH, Park YY, Park ES, Kim SC, Kim SS, Johnson RL, Birrer M, Bowtell DSL, Mills GB, Sood A, Lee JS. Activation of YAP1 is associated with poor prognosis and response to taxanes in ovarian cancer. Anticancer Res. 2014 Feb; 34(2):811-817. PMID: 24511017; PMCID: PMC4082822.
      Citations: 35     Fields:    Translation:HumansCells
    508. Bailey AM, Mao Y, Zeng J, Holla V, Johnson A, Brusco L, Chen K, Mendelsohn J, Routbort MJ, Mills GB, Meric-Bernstam F. Implementation of biomarker-driven cancer therapy: existing tools and remaining gaps. Discov Med. 2014 Feb; 17(92):101-14. PMID: 24534473; PMCID: PMC4160907.
      Citations: 26     Fields:    Translation:Humans
    509. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014 Mar 20; 507(7492):315-22. PMID: 24476821; PMCID: PMC3962515.
      Citations: 1166     Fields:    Translation:HumansCells
    510. Labidi-Galy SI, Clauss A, Ng V, Duraisamy S, Elias KM, Piao HY, Bilal E, Davidowitz RA, Lu Y, Badalian-Very G, Kang UB, Ficarro S, Ganesan S, Mills GB, Marto JA, Drapkin R, Gy?rffy B. Elafin drives poor outcome in high-grade serous ovarian cancers and basal-like breast tumors. Oncogene. 2015 Jan 15; 34(3):373-83. PMID: 24469047; PMCID: PMC4112176.
      Citations: 22     Fields:    Translation:HumansCells
    511. Lui VW, Peyser ND, Ng PK, Hritz J, Zeng Y, Lu Y, Li H, Wang L, Gilbert BR, General IJ, Bahar I, Ju Z, Wang Z, Pendleton KP, Xiao X, Du Y, Vries JK, Hammerman PS, Garraway LA, Mills GB, Johnson DE, Grandis JR. Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1114-9. PMID: 24395800; PMCID: PMC3903220.
      Citations: 48     Fields:    Translation:HumansCells
    512. Zhou W, Chen T, Zhao H, Eterovic AK, Meric-Bernstam F, Mills GB, Chen K. Bias from removing read duplication in ultra-deep sequencing experiments. Bioinformatics. 2014 04 15; 30(8):1073-1080. PMID: 24389657; PMCID: PMC3982159.
      Citations: 15     Fields:    
    513. Mitra R, Ji Y, Zhu Y, Mills G, Lu Y, M?ller P. A Bayesian hierarchical model for inference across related reverse phase protein arrays experiments. J Appl Stat. 2014; 41(11):2483-2492. PMID: 26246652; PMCID: PMC4523276.
      Citations:    
    514. Peng G, Chun-Jen Lin C, Mo W, Dai H, Park YY, Kim SM, Peng Y, Mo Q, Siwko S, Hu R, Lee JS, Hennessy B, Hanash S, Mills GB, Lin SY. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun. 2014; 5:3361. PMID: 24553445; PMCID: PMC4017859.
      Citations: 107     Fields:    Translation:HumansCells
    515. Molinelli EJ, Korkut A, Wang W, Miller ML, Gauthier NP, Jing X, Kaushik P, He Q, Mills G, Solit DB, Pratilas CA, Braunstein A, Pagnani A, Zecchina R, Sander C, Weigt M. Perturbation biology: inferring signaling networks in cellular systems. PLoS Comput Biol. 2013; 9(12):e1003290. PMID: 24367245; PMCID: PMC3868523.
      Citations: 54     Fields:    Translation:HumansCells
    516. Cheng H, Liu P, Zhang F, Xu E, Symonds L, Ohlson CE, Bronson RT, Maira SM, Di Tomaso E, Li J, Myers AP, Cantley LC, Mills GB, Zhao JJ. A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Cancer Res. 2014 Jan 01; 74(1):15-23. PMID: 24322983; PMCID: PMC3982380.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    517. Liu Y, Zhou R, Baumbusch LO, Tsavachidis S, Brewster AM, Do KA, Sahin A, Hortobagyi GN, Taube JH, Mani SA, Mills GB, Thompson PA, Bondy ML, Aar?e J, W?rnberg F, B?rresen-Dale AL. Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer. Breast Cancer Res Treat. 2014 Jan; 143(1):189-201. PMID: 24305980; PMCID: PMC3993091.
      Citations: 5     Fields:    Translation:Humans
    518. Chavez-Macgregor M, Liu S, De Melo-Gagliato D, Chen H, Do KA, Pusztai L, Fraser Symmans W, Nair L, Hortobagyi GN, Mills GB, Meric-Bernstam F, Gonzalez-Angulo AM. Differences in gene and protein expression and the effects of race/ethnicity on breast cancer subtypes. Cancer Epidemiol Biomarkers Prev. 2014 Feb; 23(2):316-23. PMID: 24296856; PMCID: PMC3946290.
      Citations: 13     Fields:    Translation:Humans
    519. Wolf J, Flechtenmacher C, Zhang F, Shahmoradgoli M, Mills GB, Hoheisel JD, Boettcher M, M?ller-Decker K. An in vivo RNAi screen identifies SALL1 as a tumor suppressor in human breast cancer with a role in CDH1 regulation. Oncogene. 2014 Aug 14; 33(33):4273-8. PMID: 24292671; PMCID: PMC6662585.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    520. Javle M, Rashid A, Churi C, Kar S, Zuo M, Eterovic AK, Nogueras-Gonzalez GM, Janku F, Shroff RT, Aloia TA, Vauthey JN, Curley S, Mills G, Roa I. Molecular characterization of gallbladder cancer using somatic mutation profiling. Hum Pathol. 2014 Apr; 45(4):701-8. PMID: 24508317; PMCID: PMC4428571.
      Citations: 34     Fields:    Translation:Humans
    521. Krohn M, Iadevaia S, Kristian A, Mills GB, Engebraaten O, Lindholm EM, M?landsmo GM. Proteomic characterization of breast cancer xenografts identifies early and late bevacizumab-induced responses and predicts effective drug combinations. Clin Cancer Res. 2014 Jan 15; 20(2):404-12. PMID: 24192926; PMCID: PMC4326070.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    522. Mao Y, Chen H, Liang H, Meric-Bernstam F, Mills GB, Chen K. CanDrA: cancer-specific driver missense mutation annotation with optimized features. PLoS One. 2013; 8(10):e77945. PMID: 24205039; PMCID: PMC3813554.
      Citations: 48     Fields:    Translation:Humans
    523. Fabian CJ, Kimler BF, Donnelly JE, Sullivan DK, Klemp JR, Petroff BK, Phillips TA, Metheny T, Aversman S, Yeh HW, Zalles CM, Mills GB, Hursting SD. Favorable modulation of benign breast tissue and serum risk biomarkers is associated with > 10 % weight loss in postmenopausal women. Breast Cancer Res Treat. 2013 Nov; 142(1):119-32. PMID: 24141897; PMCID: PMC3921968.
      Citations: 33     Fields:    Translation:HumansCTClinical Trials
    524. Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, Zheng S, Chakravarty D, Sanborn JZ, Berman SH, Beroukhim R, Bernard B, Wu CJ, Genovese G, Shmulevich I, Barnholtz-Sloan J, Zou L, Vegesna R, Shukla SA, Ciriello G, Yung WK, Zhang W, Sougnez C, Mikkelsen T, Aldape K, Bigner DD, Van Meir EG, Prados M, Sloan A, Black KL, Eschbacher J, Finocchiaro G, Friedman W, Andrews DW, Guha A, Iacocca M, O'Neill BP, Foltz G, Myers J, Weisenberger DJ, Penny R, Kucherlapati R, Perou CM, Hayes DN, Gibbs R, Marra M, Mills GB, Lander E, Spellman P, Wilson R, Sander C, Weinstein J, Meyerson M, Gabriel S, Laird PW, Haussler D, Getz G, Chin L, TCGA Research Network. The somatic genomic landscape of glioblastoma. Cell. 2013 Oct 10; 155(2):462-77. PMID: 24120142; PMCID: PMC3910500.
      Citations: 2110     Fields:    Translation:HumansCells
    525. Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, Jacks T, Kibbey RG, Wulf GM, Di Vizio D, Mills GB, Cantley LC, Vander Heiden MG. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 2013 Oct 10; 155(2):397-409. PMID: 24120138; PMCID: PMC3850755.
      Citations: 245     Fields:    Translation:HumansAnimalsCells
    526. Cancer Genome Atlas Research Network, Weinstein JN, Collisson EA, Mills GB, Shaw KR, Ozenberger BA, Ellrott K, Shmulevich I, Sander C, Stuart JM. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet. 2013 Oct; 45(10):1113-20. PMID: 24071849; PMCID: PMC3919969.
      Citations: 2555     Fields:    Translation:Humans
    527. Cardnell RJ, Feng Y, Diao L, Fan YH, Masrorpour F, Wang J, Shen Y, Mills GB, Minna JD, Heymach JV, Byers LA. Proteomic markers of DNA repair and PI3K pathway activation predict response to the PARP inhibitor BMN 673 in small cell lung cancer. Clin Cancer Res. 2013 Nov 15; 19(22):6322-8. PMID: 24077350; PMCID: PMC3882158.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    528. Li S, Shen D, Shao J, Crowder R, Liu W, Prat A, He X, Liu S, Hoog J, Lu C, Ding L, Griffith OL, Miller C, Larson D, Fulton RS, Harrison M, Mooney T, McMichael JF, Luo J, Tao Y, Goncalves R, Schlosberg C, Hiken JF, Saied L, Sanchez C, Giuntoli T, Bumb C, Cooper C, Kitchens RT, Lin A, Phommaly C, Davies SR, Zhang J, Kavuri MS, McEachern D, Dong YY, Ma C, Pluard T, Naughton M, Bose R, Suresh R, McDowell R, Michel L, Aft R, Gillanders W, DeSchryver K, Wilson RK, Wang S, Mills GB, Gonzalez-Angulo A, Edwards JR, Maher C, Perou CM, Mardis ER, Ellis MJ. Endocrine-therapy-resistant ESR1 variants revealed by genomic characterization of breast-cancer-derived xenografts. Cell Rep. 2013 Sep 26; 4(6):1116-30. PMID: 24055055; PMCID: PMC3881975.
      Citations: 304     Fields:    Translation:HumansAnimals
    529. Li J, Lu Y, Akbani R, Ju Z, Roebuck PL, Liu W, Yang JY, Broom BM, Verhaak RG, Kane DW, Wakefield C, Weinstein JN, Mills GB, Liang H. TCPA: a resource for cancer functional proteomics data. Nat Methods. 2013 Nov; 10(11):1046-7. PMID: 24037243; PMCID: PMC4076789.
      Citations: 221     Fields:    Translation:Humans
    530. Billiard J, Dennison JB, Briand J, Annan RS, Chai D, Dodson CS, Gilbert SA, Greshock J, Jing J, Lu H, McSurdy-Freed JE, Orband-Miller LA, Mills GB, Quinn CJ, Schneck JL, Scott GF, Shaw AN, Waitt GM, Wooster RF, Duffy KJ, Col?n M. Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells. Cancer Metab. 2013 Sep 06; 1(1):19. PMID: 24280423; PMCID: PMC4178217.
      Citations: 68     
    531. Yang JY, Yoshihara K, Tanaka K, Hatae M, Masuzaki H, Itamochi H, Cancer Genome Atlas (TCGA) Research Network, Takano M, Ushijima K, Tanyi JL, Coukos G, Lu Y, Mills GB, Verhaak RG. Predicting time to ovarian carcinoma recurrence using protein markers. J Clin Invest. 2013 Sep; 123(9):3740-50. PMID: 23945238; PMCID: PMC3754259.
      Citations: 31     Fields:    Translation:HumansCells
    532. Siwak DR, Mills GB, Dupuy F, Griss T, Blagih J, Bridon G, Avizonis D, Ling C, Dong Z, Annis MG, Muller WJ, Siegel PM, Jones RG. LKB1 is a central regulator of tumor initiation and pro-growth metabolism in ErbB2-mediated breast cancer. Cancer Metab. 2013 Aug 14; 1(1):18. PMID: 24280377; PMCID: PMC4178213.
      Citations: 20     
    533. Klempner SJ, Myers AP, Mills GB, Westin SN. Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer. Expert Opin Pharmacother. 2013 Nov; 14(16):2171-82. PMID: 23937415; PMCID: PMC4103698.
      Citations: 5     Fields:    Translation:Humans
    534. Sohn J, Do KA, Liu S, Chen H, Mills GB, Hortobagyi GN, Meric-Bernstam F, Gonzalez-Angulo AM. Functional proteomics characterization of residual triple-negative breast cancer after standard neoadjuvant chemotherapy. Ann Oncol. 2013 Oct; 24(10):2522-2526. PMID: 23925999; PMCID: PMC3784335.
      Citations: 19     Fields:    Translation:HumansCells
    535. Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z. Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules. Oncogene. 2014 Jun 26; 33(26):3463-72. PMID: 23912456; PMCID: PMC3915040.
      Citations: 22     Fields:    Translation:HumansCells
    536. Irwin ME, Nelson LD, Santiago-O'Farrill JM, Knouse PD, Miller CP, Palla SL, Siwak DR, Mills GB, Estrov Z, Li S, Kornblau SM, Hughes DP, Chandra J. Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia. PLoS One. 2013; 8(8):e70608. PMID: 23936456; PMCID: PMC3731286.
      Citations: 13     Fields:    Translation:HumansCells
    537. Panupinthu N, Yu S, Zhang D, Zhang F, Gagea M, Lu Y, Grandis JR, Dunn SE, Lee HY, Mills GB. Self-reinforcing loop of amphiregulin and Y-box binding protein-1 contributes to poor outcomes in ovarian cancer. Oncogene. 2014 May 29; 33(22):2846-56. PMID: 23851501; PMCID: PMC4115609.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    538. Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature. 2013 Jul 04; 499(7456):43-9. PMID: 23792563; PMCID: PMC3771322.
      Citations: 1409     Fields:    Translation:HumansCells
    539. Zhang X, Claerhout S, Prat A, Dobrolecki LE, Petrovic I, Lai Q, Landis MD, Wiechmann L, Schiff R, Giuliano M, Wong H, Fuqua SW, Contreras A, Gutierrez C, Huang J, Mao S, Pavlick AC, Froehlich AM, Wu MF, Tsimelzon A, Hilsenbeck SG, Chen ES, Zuloaga P, Shaw CA, Rimawi MF, Perou CM, Mills GB, Chang JC, Lewis MT. A renewable tissue resource of phenotypically stable, biologically and ethnically diverse, patient-derived human breast cancer xenograft models. Cancer Res. 2013 Aug 01; 73(15):4885-97. PMID: 23737486; PMCID: PMC3732575.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    540. Dennison JB, Molina JR, Mitra S, Balko JM, Sanders ME, Pinto JA, Arteaga CL, Brown RE, Mills GB, Gonz?lez-Angulo AM, Kuba MG, G?mez HL. Lactate dehydrogenase B: a metabolic marker of response to neoadjuvant chemotherapy in breast cancer. Clin Cancer Res. 2013 Jul 01; 19(13):3703-13. PMID: 23697991; PMCID: PMC3727144.
      Citations: 52     Fields:    Translation:HumansCells
    541. Park YY, Kim SB, Han HD, Sohn BH, Kim JH, Liang J, Lu Y, Rodriguez-Aguayo C, Lopez-Berestein G, Mills GB, Sood AK, Lee JS. Tat-activating regulatory DNA-binding protein regulates glycolysis in hepatocellular carcinoma by regulating the platelet isoform of phosphofructokinase through microRNA 520. Hepatology. 2013 Jul; 58(1):182-91. PMID: 23389994; PMCID: PMC3923572.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    542. Liang J, Mills GB. AMPK: a contextual oncogene or tumor suppressor? Cancer Res. 2013 May 15; 73(10):2929-35. PMID: 23644529; PMCID: PMC3725287.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    543. Cancer Genome Atlas Research Network, Kandoth C, Schultz N, Cherniack AD, Akbani R, Liu Y, Shen H, Robertson AG, Pashtan I, Shen R, Benz CC, Yau C, Laird PW, Ding L, Zhang W, Mills GB, Kucherlapati R, Mardis ER, Levine DA. Integrated genomic characterization of endometrial carcinoma. Nature. 2013 May 02; 497(7447):67-73. PMID: 23636398; PMCID: PMC3704730.
      Citations: 1657     Fields:    Translation:HumansCells
    544. Hartman ZC, Poage GM, den Hollander P, Tsimelzon A, Hill J, Panupinthu N, Zhang Y, Mazumdar A, Hilsenbeck SG, Mills GB, Brown PH. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res. 2013 Jun 01; 73(11):3470-80. PMID: 23633491; PMCID: PMC3853111.
      Citations: 198     Fields:    Translation:HumansAnimalsCells
    545. Lui VW, Hedberg ML, Li H, Vangara BS, Pendleton K, Zeng Y, Lu Y, Zhang Q, Du Y, Gilbert BR, Freilino M, Sauerwein S, Peyser ND, Xiao D, Diergaarde B, Wang L, Chiosea S, Seethala R, Johnson JT, Kim S, Duvvuri U, Ferris RL, Romkes M, Nukui T, Kwok-Shing Ng P, Garraway LA, Hammerman PS, Mills GB, Grandis JR. Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. Cancer Discov. 2013 Jul; 3(7):761-9. PMID: 23619167; PMCID: PMC3710532.
      Citations: 270     Fields:    Translation:HumansCells
    546. Meric-Bernstam F, Farhangfar C, Mendelsohn J, Mills GB. Building a personalized medicine infrastructure at a major cancer center. J Clin Oncol. 2013 May 20; 31(15):1849-57. PMID: 23589548; PMCID: PMC4878103.
      Citations: 43     Fields:    Translation:Humans
    547. Brown BC, Bugel L, Cheng G, Church ED, Conrad JM, Dharmapalan R, Djurcic Z, Finley DA, Ford R, Garcia FG, Garvey GT, Grange J, Huelsnitz W, Ignarra C, Imlay R, Johnson RA, Karagiorgi G, Katori T, Kobilarcik T, Louis WC, Mariani C, Marsh W, Mills GB, Mirabal J, Moore CD, Mousseau J, Nienaber P, Osmanov B, Pavlovic Z, Perevalov D, Polly CC, Ray H, Roe BP, Russell AD, Shaevitz MH, Spitz J, Stancu I, Tayloe R, Van de Water RG, White DH, Wickremasinghe DA, Zeller GP, Zimmerman ED, MiniBooNE Collaboration, Aguilar-Arevalo AA. Improved search for ??(?)???(e) oscillations in the MiniBooNE experiment. Phys Rev Lett. 2013 Apr 19; 110(16):161801. PMID: 23679593.
      Citations: 2     Fields:    
    548. Tabchy A, Eltonsy N, Housman DE, Mills GB. Systematic identification of combinatorial drivers and targets in cancer cell lines. PLoS One. 2013; 8(4):e60339. PMID: 23577104; PMCID: PMC3618473.
      Citations: 2     Fields:    Translation:HumansCells
    549. Myhre S, Hennessy BT, Aure MR, Carey MS, Alsner J, Tramm T, Overgaard J, Mills GB, Lingj?rde OC, B?rresen-Dale AL, S?rlie T. Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins. Mol Oncol. 2013 Jun; 7(3):704-18. PMID: 23562353; PMCID: PMC5528474.
      Citations: 38     Fields:    Translation:HumansCTClinical Trials
    550. Dutta P, Bui T, Bauckman KA, Keyomarsi K, Mills GB, Nanjundan M. EVI1 splice variants modulate functional responses in ovarian cancer cells. Mol Oncol. 2013 Jun; 7(3):647-68. PMID: 23517670; PMCID: PMC3805042.
      Citations: 21     Fields:    Translation:HumansCells
    551. Gao M, Liang J, Lu Y, Guo H, German P, Bai S, Jonasch E, Yang X, Mills GB, Ding Z. Site-specific activation of AKT protects cells from death induced by glucose deprivation. Oncogene. 2014 Feb 06; 33(6):745-55. PMID: 23396361; PMCID: PMC3874430.
      Citations: 33     Fields:    Translation:HumansCells
    552. Stordal B, Timms K, Farrelly A, Gallagher D, Busschots S, Thery J, Williams D, Potter J, Tran T, Korpanty G, Cremona M, Carey M, Li J, Li Y, Aslan O, O'Leary JJ, Mills GB, Hennessy BT, Renaud M. BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation. Mol Oncol. 2013 Jun; 7(3):567-79. PMID: 23415752; PMCID: PMC4106023.
      Citations: 73     Fields:    Translation:HumansCells
    553. Sansores-Garcia L, Atkins M, Moya IM, Shahmoradgoli M, Tao C, Mills GB, Halder G. Mask is required for the activity of the Hippo pathway effector Yki/YAP. Curr Biol. 2013 Feb 04; 23(3):229-35. PMID: 23333314; PMCID: PMC4089957.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    554. Hunt KK, Wingate H, Yokota T, Liu Y, Mills GB, Zhang F, Fang B, Su CH, Zhang M, Yi M, Keyomarsi K. Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer. Breast Cancer Res. 2013 Jan 15; 15(1):R3. PMID: 23320734; PMCID: PMC3672770.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    555. Westin SN, Mills GB, Myers AP. Repurposing the Pap smear: one step closer to gynecologic cancer screening. Sci Transl Med. 2013 Jan 09; 5(167):167ps1. PMID: 23303602; PMCID: PMC3824959.
      Citations: 1     Fields:    Translation:Humans
    556. Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Sci Signal. 2013 Jan 08; 6(257):ra2. PMID: 23300339; PMCID: PMC3748614.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    557. Daemen A, Griffith OL, Heiser LM, Wang NJ, Enache OM, Sanborn Z, Pepin F, Durinck S, Korkola JE, Griffith M, Hur JS, Huh N, Chung J, Cope L, Fackler MJ, Umbricht C, Sukumar S, Seth P, Sukhatme VP, Jakkula LR, Lu Y, Mills GB, Cho RJ, Collisson EA, van't Veer LJ, Spellman PT, Gray JW. Modeling precision treatment of breast cancer. Genome Biol. 2013; 14(10):R110. PMID: 24176112; PMCID: PMC3937590.
      Citations: 143     Fields:    Translation:HumansCells
    558. Yoshihara K, Shahmoradgoli M, Vegesna R, Kim H, Torres-Garcia W, Shen H, Laird PW, Levine DA, Carter SL, Getz G, Stemke-Hale K, Mills GB, Verhaak RG, Mart?nez E, Trevi?o V. Inferring tumour purity and stromal and immune cell admixture from expression data. Nat Commun. 2013; 4:2612. PMID: 24113773; PMCID: PMC3826632.
      Citations: 2294     Fields:    Translation:HumansCells
    559. Mao M, Tian F, Mariadason JM, Tsao CC, Lemos R, Dayyani F, Gopal YN, Jiang ZQ, Wistuba II, Tang XM, Bornman WG, Bollag G, Mills GB, Powis G, Desai J, Gallick GE, Davies MA, Kopetz S. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res. 2013 Feb 01; 19(3):657-67. PMID: 23251002; PMCID: PMC3563727.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    560. Albeck JG, Mills GB, Brugge JS. Frequency-modulated pulses of ERK activity transmit quantitative proliferation signals. Mol Cell. 2013 Jan 24; 49(2):249-61. PMID: 23219535; PMCID: PMC4151532.
      Citations: 219     Fields:    Translation:HumansCells
    561. Tuna M, Ju Z, Amos CI, Mills GB. Soft tissue sarcoma subtypes exhibit distinct patterns of acquired uniparental disomy. BMC Med Genomics. 2012 Dec 05; 5:60. PMID: 23217126; PMCID: PMC3541987.
      Citations: 4     Fields:    Translation:HumansCells
    562. Holder AM, Gonzalez-Angulo AM, Chen H, Akcakanat A, Do KA, Fraser Symmans W, Pusztai L, Hortobagyi GN, Mills GB, Meric-Bernstam F. High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients. Breast Cancer Res Treat. 2013 Jan; 137(1):319-27. PMID: 23208590; PMCID: PMC3556743.
      Citations: 44     Fields:    Translation:Humans
    563. Mitra S, Cheng KW, Mills GB. Rab25 in cancer: a brief update. Biochem Soc Trans. 2012 Dec 01; 40(6):1404-8. PMID: 23176489; PMCID: PMC3804249.
      Citations: 25     Fields:    Translation:HumansAnimals
    564. Mitra R, Mueller P, Ji Y, Mills G, Lu Y. Sparse Bayesian Graphical Models for RPPA Time Course Data. IEEE Int Workshop Genomic Signal Process Stat. 2012 Dec; 2012:113-117. PMID: 25859417; PMCID: PMC4387196.
      Citations: 1     
    565. Stemke-Hale K, Shipman K, Kitsou-Mylona I, de Castro DG, Hird V, Brown R, Flanagan J, Gabra H, Mills GB, Agarwal R, El-Bahrawy M. Frequency of mutations and polymorphisms in borderline ovarian tumors of known cancer genes. Mod Pathol. 2013 Apr; 26(4):544-52. PMID: 23174937; PMCID: PMC3856435.
      Citations: 8     Fields:    Translation:Humans
    566. Quayle SN, Lee JY, Cheung LW, Ding L, Wiedemeyer R, Dewan RW, Huang-Hobbs E, Zhuang L, Wilson RK, Ligon KL, Mills GB, Cantley LC, Chin L. Somatic mutations of PIK3R1 promote gliomagenesis. PLoS One. 2012; 7(11):e49466. PMID: 23166678; PMCID: PMC3498106.
      Citations: 32     Fields:    Translation:HumansCells
    567. Farhangfar CJ, Meric-Bernstam F, Mendelsohn J, Mills GB, Lucio-Eterovic AK. The impact of tumor heterogeneity on patient treatment decisions. Clin Chem. 2013 Jan; 59(1):38-40. PMID: 23143327.
      Citations: 4     Fields:    Translation:Humans
    568. Gonzalez-Angulo AM, Liu S, Chen H, Chavez-Macgregor M, Sahin A, Hortobagyi GN, Mills GB, Do KA, Meric-Bernstam F. Functional proteomics characterization of residual breast cancer after neoadjuvant systemic chemotherapy. Ann Oncol. 2013 Apr; 24(4):909-16. PMID: 23139263; PMCID: PMC3603436.
      Citations: 9     Fields:    Translation:Humans
    569. Kamel D, Brady B, Tabchy A, Mills GB, Hennessy B. Proteomic classification of breast cancer. Curr Drug Targets. 2012 Nov; 13(12):1495-509. PMID: 22974393.
      Citations: 11     Fields:    Translation:HumansAnimals
    570. Verhaak RG, Mills GB. Regulation of mRNA expression in breast cancer - a cis-tematic trans-action. Breast Cancer Res. 2012 Oct 29; 14(5):322. PMID: 23106814; PMCID: PMC4053097.
      Citations:    Fields:    Translation:Humans
    571. Meric-Bernstam F, Chen H, Akcakanat A, Do KA, Lluch A, Hennessy BT, Hortobagyi GN, Mills GB, Gonzalez-Angulo A. Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer. Breast Cancer Res. 2012 Oct 26; 14(5):R138. PMID: 23102376; PMCID: PMC4053117.
      Citations: 39     Fields:    Translation:HumansCells
    572. Jeong KJ, Cho KH, Panupinthu N, Kim H, Kang J, Park CG, Mills GB, Lee HY. EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol. Mol Oncol. 2013 Feb; 7(1):121-9. PMID: 23127547; PMCID: PMC5528397.
      Citations: 16     Fields:    Translation:HumansCells
    573. Byers LA, Diao L, Wang J, Saintigny P, Girard L, Peyton M, Shen L, Fan Y, Giri U, Tumula PK, Nilsson MB, Gudikote J, Tran H, Cardnell RJ, Bearss DJ, Warner SL, Foulks JM, Kanner SB, Gandhi V, Krett N, Rosen ST, Kim ES, Herbst RS, Blumenschein GR, Lee JJ, Lippman SM, Ang KK, Mills GB, Hong WK, Weinstein JN, Wistuba II, Coombes KR, Minna JD, Heymach JV. An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance. Clin Cancer Res. 2013 Jan 01; 19(1):279-90. PMID: 23091115; PMCID: PMC3567921.
      Citations: 463     Fields:    Translation:HumansAnimalsCells
    574. Abkevich V, Timms KM, Hennessy BT, Potter J, Carey MS, Meyer LA, Smith-McCune K, Broaddus R, Lu KH, Chen J, Tran TV, Williams D, Iliev D, Jammulapati S, FitzGerald LM, Krivak T, DeLoia JA, Gutin A, Mills GB, Lanchbury JS. Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer. Br J Cancer. 2012 Nov 06; 107(10):1776-82. PMID: 23047548; PMCID: PMC3493866.
      Citations: 248     Fields:    Translation:HumansCells
    575. Liang H, Cheung LW, Li J, Ju Z, Yu S, Stemke-Hale K, Dogruluk T, Lu Y, Liu X, Gu C, Guo W, Scherer SE, Carter H, Westin SN, Dyer MD, Verhaak RG, Zhang F, Karchin R, Liu CG, Lu KH, Broaddus RR, Scott KL, Hennessy BT, Mills GB. Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer. Genome Res. 2012 Nov; 22(11):2120-9. PMID: 23028188; PMCID: PMC3483541.
      Citations: 126     Fields:    Translation:HumansCells
    576. Guo H, Liu W, Ju Z, Tamboli P, Jonasch E, Mills GB, Lu Y, Hennessy BT, Tsavachidou D. An efficient procedure for protein extraction from formalin-fixed, paraffin-embedded tissues for reverse phase protein arrays. Proteome Sci. 2012 Sep 24; 10(1):56. PMID: 23006314; PMCID: PMC3561137.
      Citations: 37     
    577. Hoshino D, Jourquin J, Emmons SW, Miller T, Goldgof M, Costello K, Tyson DR, Brown B, Lu Y, Prasad NK, Zhang B, Mills GB, Yarbrough WG, Quaranta V, Seiki M, Weaver AM. Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCa invasive signaling axis. Sci Signal. 2012 Sep 11; 5(241):ra66. PMID: 22969158; PMCID: PMC3583194.
      Citations: 49     Fields:    Translation:HumansCells
    578. Park YY, Park ES, Kim SB, Kim SC, Sohn BH, Chu IS, Jeong W, Mills GB, Byers LA, Lee JS. Development and validation of a prognostic gene-expression signature for lung adenocarcinoma. PLoS One. 2012; 7(9):e44225. PMID: 22970185; PMCID: PMC3436895.
      Citations: 22     Fields:    Translation:HumansCells
    579. Byers LA, Wang J, Nilsson MB, Fujimoto J, Saintigny P, Yordy J, Giri U, Peyton M, Fan YH, Diao L, Masrorpour F, Shen L, Liu W, Duchemann B, Tumula P, Bhardwaj V, Welsh J, Weber S, Glisson BS, Kalhor N, Wistuba II, Girard L, Lippman SM, Mills GB, Coombes KR, Weinstein JN, Minna JD, Heymach JV. Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1. Cancer Discov. 2012 Sep; 2(9):798-811. PMID: 22961666; PMCID: PMC3567922.
      Citations: 217     Fields:    Translation:HumansCells
    580. Thomas F, Mills G, Howe R, Zobell J. Lithium battery fires: implications for air medical transport. Air Med J. 2012 Sep-Oct; 31(5):242-8. PMID: 22938956.
      Citations:    Fields:    Translation:Humans
    581. Sangai T, Akcakanat A, Chen H, Tarco E, Wu Y, Do KA, Miller TW, Arteaga CL, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F. Biomarkers of response to Akt inhibitor MK-2206 in breast cancer. Clin Cancer Res. 2012 Oct 15; 18(20):5816-28. PMID: 22932669; PMCID: PMC3772348.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    582. Hill SM, Lu Y, Molina J, Heiser LM, Spellman PT, Speed TP, Gray JW, Mills GB, Mukherjee S. Bayesian inference of signaling network topology in a cancer cell line. Bioinformatics. 2012 Nov 01; 28(21):2804-10. PMID: 22923301; PMCID: PMC3476330.
      Citations: 43     Fields:    Translation:HumansCells
    583. Liang ZD, Long Y, Tsai WB, Fu S, Kurzrock R, Gagea-Iurascu M, Zhang F, Chen HH, Hennessy BT, Mills GB, Savaraj N, Kuo MT. Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov; 11(11):2483-94. PMID: 22914438; PMCID: PMC3496003.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    584. Simpkins F, Hevia-Paez P, Sun J, Ullmer W, Gilbert CA, da Silva T, Pedram A, Levin ER, Reis IM, Rabinovich B, Azzam D, Xu XX, Ince TA, Yang JY, Verhaak RG, Lu Y, Mills GB, Slingerland JM. Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo. Clin Cancer Res. 2012 Nov 01; 18(21):5911-23. PMID: 22896656; PMCID: PMC3698880.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    585. Blumenschein GR, Mills GB, Gonzalez-Angulo AM. Targeting the hepatocyte growth factor-cMET axis in cancer therapy. J Clin Oncol. 2012 Sep 10; 30(26):3287-96. PMID: 22869872; PMCID: PMC3434988.
      Citations: 136     Fields:    Translation:HumansCells
    586. Yu FX, Zhao B, Panupinthu N, Jewell JL, Lian I, Wang LH, Zhao J, Yuan H, Tumaneng K, Li H, Fu XD, Mills GB, Guan KL. Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell. 2012 Aug 17; 150(4):780-91. PMID: 22863277; PMCID: PMC3433174.
      Citations: 728     Fields:    Translation:HumansAnimalsCells
    587. Meric-Bernstam F, Mills GB. Overcoming implementation challenges of personalized cancer therapy. Nat Rev Clin Oncol. 2012 Sep; 9(9):542-8. PMID: 22850751.
      Citations: 50     Fields:    Translation:Humans
    588. Oates CJ, Hennessy BT, Lu Y, Mills GB, Mukherjee S. Network inference using steady-state data and Goldbeter-Koshland kinetics. [corrected]. Bioinformatics. 2012 Sep 15; 28(18):2342-8. PMID: 22815361; PMCID: PMC3436851.
      Citations: 4     Fields:    Translation:HumansCells
    589. Marais EA, Jacob DJ, Kurosu TP, Chance K, Murphy JG, Reeves C, Mills G, Casadio S, Millet DB, Barkley MP, Paulot F, Mao J. Isoprene emissions in Africa inferred from OMI observations of formaldehyde columns. Atmos Chem Phys. 2012 Jul; 12(14):6219-6235. PMID: 33688332; PMCID: PMC7939075.
      Citations: 6     
    590. Balko JM, Cook RS, Vaught DB, Miller TW, Bhola NE, Sanders ME, Granja-Ingram NM, Smith JJ, Meszoely IM, Salter J, Dowsett M, Stemke-Hale K, Mills GB, Pinto JA, Arteaga CL, Kuba MG, Gonz?lez-Angulo AM, G?mez HL. Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance. Nat Med. 2012 Jul; 18(7):1052-9. PMID: 22683778; PMCID: PMC3693569.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    591. Gonzalez-Angulo AM, Chen H, Karuturi MS, Chavez-MacGregor M, Tsavachidis S, Meric-Bernstam F, Do KA, Hortobagyi GN, Thompson PA, Mills GB, Bondy ML, Blumenschein GR. Frequency of mesenchymal-epithelial transition factor gene (MET) and the catalytic subunit of phosphoinositide-3-kinase (PIK3CA) copy number elevation and correlation with outcome in patients with early stage breast cancer. Cancer. 2013 Jan 01; 119(1):7-15. PMID: 22736407; PMCID: PMC3461089.
      Citations: 28     Fields:    Translation:HumansCells
    592. Claerhout S, Dutta B, Bossuyt W, Zhang F, Nguyen-Charles C, Dennison JB, Yu Q, Yu S, Lu Y, Mills GB, Bal?zsi G. Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells. PLoS One. 2012; 7(6):e39400. PMID: 22745748; PMCID: PMC3383753.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    593. Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB, Lu Z. AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. EMBO Rep. 2012 Jun 01; 13(6):554-60. PMID: 22510990; PMCID: PMC3367238.
      Citations: 34     Fields:    Translation:HumansCells
    594. Carter BZ, Qiu Y, Huang X, Diao L, Zhang N, Coombes KR, Mak DH, Konopleva M, Cortes J, Kantarjian HM, Mills GB, Andreeff M, Kornblau SM. Survivin is highly expressed in CD34(+)38(-) leukemic stem/progenitor cells and predicts poor clinical outcomes in AML. Blood. 2012 Jul 05; 120(1):173-80. PMID: 22645176; PMCID: PMC3390955.
      Citations: 49     Fields:    Translation:HumansCells
    595. Gabisi V, Li X, Russe KB, Mills GB, Stemke-Hale K, Eltonsy N. Detection algorithm for the validation of human cell lines. Int J Cancer. 2012 Sep 15; 131(6):E1024-30. PMID: 22419365; PMCID: PMC3772516.
      Citations: 4     Fields:    Translation:HumansCells
    596. Nikitopoulou I, Oikonomou N, Karouzakis E, Sevastou I, Nikolaidou-Katsaridou N, Zhao Z, Mersinias V, Armaka M, Xu Y, Masu M, Mills GB, Gay S, Kollias G, Aidinis V. Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis. J Exp Med. 2012 May 07; 209(5):925-33. PMID: 22493518; PMCID: PMC3348105.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    597. Fu S, Hennessy BT, Ng CS, Ju Z, Coombes KR, Wolf JK, Sood AK, Levenback CF, Coleman RL, Kavanagh JJ, Gershenson DM, Markman M, Dice K, Howard A, Li J, Li Y, Stemke-Hale K, Dyer M, Atkinson E, Jackson E, Kundra V, Kurzrock R, Bast RC, Mills GB. Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer. Gynecol Oncol. 2012 Jul; 126(1):47-53. PMID: 22487539; PMCID: PMC3738300.
      Citations: 30     Fields:    Translation:HumansCTClinical Trials
    598. Federico L, Ren H, Mueller PA, Wu T, Liu S, Popovic J, Blalock EM, Sunkara M, Ovaa H, Albers HM, Mills GB, Morris AJ, Smyth SS. Autotaxin and its product lysophosphatidic acid suppress brown adipose differentiation and promote diet-induced obesity in mice. Mol Endocrinol. 2012 May; 26(5):786-97. PMID: 22474126; PMCID: PMC3355557.
      Citations: 33     Fields:    Translation:AnimalsCells
    599. Mu H, Calderone TL, Davies MA, Prieto VG, Wang H, Mills GB, Bar-Eli M, Gershenwald JE. Lysophosphatidic acid induces lymphangiogenesis and IL-8 production in vitro in human lymphatic endothelial cells. Am J Pathol. 2012 May; 180(5):2170-81. PMID: 22465753; PMCID: PMC3349835.
      Citations: 13     Fields:    Translation:HumansCells
    600. Kim N, He N, Kim C, Zhang F, Lu Y, Yu Q, Stemke-Hale K, Greshock J, Wooster R, Yoon S, Mills GB. Systematic analysis of genotype-specific drug responses in cancer. Int J Cancer. 2012 Nov 15; 131(10):2456-64. PMID: 22422301; PMCID: PMC4012336.
      Citations: 18     Fields:    Translation:HumansCells
    601. Duong MT, Akli S, Wei C, Wingate HF, Liu W, Lu Y, Yi M, Mills GB, Hunt KK, Keyomarsi K. LMW-E/CDK2 deregulates acinar morphogenesis, induces tumorigenesis, and associates with the activated b-Raf-ERK1/2-mTOR pathway in breast cancer patients. PLoS Genet. 2012; 8(3):e1002538. PMID: 22479189; PMCID: PMC3315462.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    602. Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV, Smyth JW, Davis SE, Yaswen P, Mills GB, Esserman LJ, Goga A. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J Exp Med. 2012 Apr 09; 209(4):679-96. PMID: 22430491; PMCID: PMC3328367.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    603. Meric-Bernstam F, Akcakanat A, Chen H, Do KA, Sangai T, Adkins F, Gonzalez-Angulo AM, Rashid A, Crosby K, Dong M, Phan AT, Wolff RA, Gupta S, Mills GB, Yao J. PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors. Clin Cancer Res. 2012 Mar 15; 18(6):1777-89. PMID: 22422409; PMCID: PMC3307149.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    604. Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG. Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci Signal. 2012 Mar 06; 5(214):ra19. PMID: 22394561; PMCID: PMC4174537.
      Citations: 36     Fields:    Translation:HumansCells
    605. Raghav KP, Wang W, Liu S, Chavez-MacGregor M, Meng X, Hortobagyi GN, Mills GB, Meric-Bernstam F, Blumenschein GR, Gonzalez-Angulo AM. cMET and phospho-cMET protein levels in breast cancers and survival outcomes. Clin Cancer Res. 2012 Apr 15; 18(8):2269-77. PMID: 22374333; PMCID: PMC3821167.
      Citations: 59     Fields:    Translation:HumansCells
    606. Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E. Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis. J Biomol Screen. 2012 Jun; 17(5):572-80. PMID: 22357874; PMCID: PMC3895461.
      Citations: 11     Fields:    Translation:HumansCells
    607. Wheeler S, Siwak DR, Chai R, LaValle C, Seethala RR, Wang L, Cieply K, Sherer C, Joy C, Mills GB, Argiris A, Siegfried JM, Grandis JR, Egloff AM. Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma. Clin Cancer Res. 2012 Apr 15; 18(8):2278-89. PMID: 22351687; PMCID: PMC3430124.
      Citations: 35     Fields:    Translation:HumansCells
    608. Ram PT, Mendelsohn J, Mills GB. Bioinformatics and systems biology. Mol Oncol. 2012 Apr; 6(2):147-54. PMID: 22377422; PMCID: PMC3345061.
      Citations: 7     Fields:    Translation:Humans
    609. Dutta B, Pusztai L, Qi Y, Lazar V, Bianchini G, Ueno N, Agarwal R, Wang B, Shiang CY, Hortobagyi GN, Mills GB, Symmans WF, Andr? F, Bal?zsi G. A network-based, integrative study to identify core biological pathways that drive breast cancer clinical subtypes. Br J Cancer. 2012 Mar 13; 106(6):1107-16. PMID: 22343619; PMCID: PMC3304402.
      Citations: 29     Fields:    Translation:HumansCells
    610. Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012 Feb 14; 21(2):227-39. PMID: 22340595; PMCID: PMC3297962.
      Citations: 212     Fields:    Translation:HumansAnimalsCells
    611. Djordjevic B, Hennessy BT, Li J, Barkoh BA, Luthra R, Mills GB, Broaddus RR. Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing. Mod Pathol. 2012 May; 25(5):699-708. PMID: 22301702; PMCID: PMC3341518.
      Citations: 56     Fields:    Translation:Humans
    612. Mills GB. An emerging toolkit for targeted cancer therapies. Genome Res. 2012 Feb; 22(2):177-82. PMID: 22301131; PMCID: PMC3266025.
      Citations: 9     Fields:    Translation:HumansCells
    613. Mitra S, Stemke-Hale K, Mills GB, Claerhout S. Interactions between tumor cells and microenvironment in breast cancer: a new opportunity for targeted therapy. Cancer Sci. 2012 Mar; 103(3):400-7. PMID: 22151725; PMCID: PMC5439106.
      Citations: 7     Fields:    Translation:HumansAnimals
    614. Cheng KW, Agarwal R, Mitra S, Lee JS, Carey M, Gray JW, Mills GB. Rab25 increases cellular ATP and glycogen stores protecting cancer cells from bioenergetic stress. EMBO Mol Med. 2012 Feb; 4(2):125-41. PMID: 22253197; PMCID: PMC3306554.
      Citations: 42     Fields:    Translation:HumansCells
    615. Astanehe A, Finkbeiner MR, Krzywinski M, Fotovati A, Dhillon J, Berquin IM, Mills GB, Marra MA, Dunn SE. MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition. Oncogene. 2012 Oct 11; 31(41):4434-46. PMID: 22249268.
      Citations: 26     Fields:    Translation:HumansCells
    616. Gubanova E, Brown B, Ivanov SV, Helleday T, Mills GB, Yarbrough WG, Issaeva N. Downregulation of SMG-1 in HPV-positive head and neck squamous cell carcinoma due to promoter hypermethylation correlates with improved survival. Clin Cancer Res. 2012 Mar 01; 18(5):1257-67. PMID: 22247495; PMCID: PMC4010255.
      Citations: 49     Fields:    Translation:HumansCells
    617. Gonzalez-Angulo AM, Iwamoto T, Liu S, Chen H, Do KA, Hortobagyi GN, Mills GB, Meric-Bernstam F, Symmans WF, Pusztai L. Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer. Clin Cancer Res. 2012 Feb 15; 18(4):1109-19. PMID: 22235097; PMCID: PMC3288822.
      Citations: 30     Fields:    Translation:HumansCells
    618. Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene. 2012 Oct 04; 31(40):4372-83. PMID: 22231447; PMCID: PMC3326223.
      Citations: 30     Fields:    Translation:HumansCells
    619. Nieto-Barajas LE, Ji Y, Lu Y, Mills GB, M?ller P. A time-series DDP for functional proteomics profiles. Biometrics. 2012 Sep; 68(3):859-68. PMID: 22221181; PMCID: PMC4091682.
      Citations: 1     Fields:    Translation:HumansCells
    620. Bast RC, Mills GB. Dissecting "PI3Kness": the complexity of personalized therapy for ovarian cancer. Cancer Discov. 2012 Jan; 2(1):16-8. PMID: 22585163; PMCID: PMC3354732.
      Citations: 17     Fields:    Translation:Humans
    621. Lee JS, Kim JH, Park YY, Mills GB. Systems biology approaches to decoding the genome of liver cancer. Cancer Res Treat. 2011 Dec; 43(4):205-11. PMID: 22247704; PMCID: PMC3253861.
      Citations: 2     Fields:    
    622. Tarcic G, Avraham R, Pines G, Amit I, Shay T, Lu Y, Zwang Y, Katz M, Ben-Chetrit N, Jacob-Hirsch J, Virgilio L, Rechavi G, Mavrothalassitis G, Mills GB, Domany E, Yarden Y. EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF. FASEB J. 2012 Apr; 26(4):1582-92. PMID: 22198386; PMCID: PMC3316897.
      Citations: 48     Fields:    Translation:HumansCells
    623. Pareja F, Ferraro DA, Rubin C, Cohen-Dvashi H, Zhang F, Aulmann S, Ben-Chetrit N, Pines G, Navon R, Crosetto N, Carvalho S, Lavi S, Schmitt F, Dikic I, Yakhini Z, Sinn P, Mills GB, Yarden Y, K?stler W. Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression. Oncogene. 2012 Oct 25; 31(43):4599-608. PMID: 22179831; PMCID: PMC3326441.
      Citations: 45     Fields:    Translation:HumansCells
    624. Park YY, Kim K, Kim SB, Hennessy BT, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo AM, Jeong W, Mills GB, Safe S, Lee JS. Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. EMBO Mol Med. 2012 Jan; 4(1):52-67. PMID: 22174013; PMCID: PMC3376834.
      Citations: 27     Fields:    Translation:HumansCells
    625. Li J, Ding Z, Wang Z, Lu JF, Maity SN, Navone NM, Logothetis CJ, Mills GB, Kim J. Androgen regulation of 5a-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention. PLoS One. 2011; 6(12):e28840. PMID: 22194926; PMCID: PMC3237548.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    626. Wang LE, Ma H, Hale KS, Yin M, Meyer LA, Liu H, Li J, Lu KH, Hennessy BT, Li X, Spitz MR, Wei Q, Mills GB. Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes. J Cancer Res Clin Oncol. 2012 Mar; 138(3):377-85. PMID: 22146979; PMCID: PMC3526101.
      Citations: 28     Fields:    Translation:HumansCells
    627. Pyle JA, Warwick NJ, Harris NR, Abas MR, Archibald AT, Ashfold MJ, Ashworth K, Barkley MP, Carver GD, Chance K, Dorsey JR, Fowler D, Gonzi S, Gostlow B, Hewitt CN, Kurosu TP, Lee JD, Langford SB, Mills G, Moller S, MacKenzie AR, Manning AJ, Misztal P, Nadzir MS, Nemitz E, Newton HM, O'Brien LM, Ong S, Oram D, Palmer PI, Peng LK, Phang SM, Pike R, Pugh TA, Rahman NA, Robinson AD, Sentian J, Samah AA, Skiba U, Ung HE, Yong SE, Young PJ. The impact of local surface changes in Borneo on atmospheric composition at wider spatial scales: coastal processes, land-use change and air quality. Philos Trans R Soc Lond B Biol Sci. 2011 Nov 27; 366(1582):3210-24. PMID: 22006963; PMCID: PMC3179638.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    628. Stronach EA, Chen M, Maginn EN, Agarwal R, Mills GB, Wasan H, Gabra H. DNA-PK mediates AKT activation and apoptosis inhibition in clinically acquired platinum resistance. Neoplasia. 2011 Nov; 13(11):1069-80. PMID: 22131882; PMCID: PMC3223610.
      Citations: 71     Fields:    Translation:HumansCells
    629. Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Yamada SD, Peter ME, Gwin K, Lengyel E, Hotamisligil GS. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 2011 Oct 30; 17(11):1498-503. PMID: 22037646; PMCID: PMC4157349.
      Citations: 890     Fields:    Translation:HumansAnimalsCells
    630. Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):24-32. PMID: 22015657; PMCID: PMC3241874.
      Citations: 19     Fields:    Translation:AnimalsCells
    631. Heiser LM, Sadanandam A, Kuo WL, Benz SC, Goldstein TC, Ng S, Gibb WJ, Wang NJ, Ziyad S, Tong F, Bayani N, Hu Z, Billig JI, Dueregger A, Lewis S, Jakkula L, Korkola JE, Durinck S, Guan Y, Purdom E, Neuvial P, Bengtsson H, Wood KW, Smith PG, Vassilev LT, Hennessy BT, Greshock J, Bachman KE, Hardwicke MA, Park JW, Marton LJ, Wolf DM, Collisson EA, Neve RM, Mills GB, Speed TP, Feiler HS, Wooster RF, Haussler D, Stuart JM, Gray JW, Spellman PT, Pepin F. Subtype and pathway specific responses to anticancer compounds in breast cancer. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2724-9. PMID: 22003129; PMCID: PMC3286973.
      Citations: 258     Fields:    Translation:HumansCells
    632. Cheong JH, Park ES, Liang J, Dennison JB, Tsavachidou D, Nguyen-Charles C, Wa Cheng K, Hall H, Zhang D, Lu Y, Ravoori M, Kundra V, Ajani J, Lee JS, Ki Hong W, Mills GB. Dual inhibition of tumor energy pathway by 2-deoxyglucose and metformin is effective against a broad spectrum of preclinical cancer models. Mol Cancer Ther. 2011 Dec; 10(12):2350-62. PMID: 21992792; PMCID: PMC3237863.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    633. Park ES, Kim SJ, Kim SW, Yoon SL, Leem SH, Kim SB, Kim SM, Park YY, Cheong JH, Woo HG, Mills GB, Fidler IJ, Lee JS. Cross-species hybridization of microarrays for studying tumor transcriptome of brain metastasis. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17456-61. PMID: 21987811; PMCID: PMC3198333.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    634. Vaughan S, Coward JI, Bast RC, Berchuck A, Berek JS, Brenton JD, Coukos G, Crum CC, Drapkin R, Etemadmoghadam D, Friedlander M, Gabra H, Kaye SB, Lord CJ, Lengyel E, Levine DA, McNeish IA, Menon U, Mills GB, Nephew KP, Oza AM, Sood AK, Stronach EA, Walczak H, Bowtell DD, Balkwill FR. Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer. 2011 Sep 23; 11(10):719-25. PMID: 21941283; PMCID: PMC3380637.
      Citations: 567     Fields:    Translation:HumansAnimals
    635. Claerhout S, Lim JY, Choi W, Park YY, Kim K, Kim SB, Lee JS, Mills GB, Cho JY. Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer. PLoS One. 2011; 6(9):e24662. PMID: 21931799; PMCID: PMC3170379.
      Citations: 55     Fields:    Translation:HumansCells
    636. Fox EM, Miller TW, Balko JM, Kuba MG, Smith RA, Liu S, Mills GB, Ye F, Shyr Y, Manning HC, Buck E, Arteaga CL, S?nchez V, Gonz?lez-Angulo AM. A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer. Cancer Res. 2011 Nov 01; 71(21):6773-84. PMID: 21908557; PMCID: PMC3206206.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    637. Hu R, Peng G, Dai H, Breuer EK, Stemke-Hale K, Li K, Gonzalez-Angulo AM, Mills GB, Lin SY. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res. 2011 Oct 15; 71(20):6524-34. PMID: 21852383; PMCID: PMC3193577.
      Citations: 17     Fields:    Translation:HumansCells
    638. Thompson PA, Brewster AM, Kim-Anh D, Baladandayuthapani V, Broom BM, Edgerton ME, Hahn KM, Murray JL, Sahin A, Tsavachidis S, Wang Y, Zhang L, Hortobagyi GN, Mills GB, Bondy ML. Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer. PLoS One. 2011; 6(8):e23543. PMID: 21858162; PMCID: PMC3155554.
      Citations: 28     Fields:    Translation:Humans
    639. Liu P, Cheng H, Santiago S, Raeder M, Zhang F, Isabella A, Yang J, Semaan DJ, Chen C, Fox EA, Gray NS, Monahan J, Schlegel R, Beroukhim R, Mills GB, Zhao JJ. Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms. Nat Med. 2011 Aug 07; 17(9):1116-20. PMID: 21822287; PMCID: PMC3169724.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    640. Brewster AM, Thompson P, Sahin AA, Do K, Edgerton M, Murray JL, Tsavachidis S, Zhou R, Liu Y, Zhang L, Mills G, Bondy M. Copy number imbalances between screen- and symptom-detected breast cancers and impact on disease-free survival. Cancer Prev Res (Phila). 2011 Oct; 4(10):1609-16. PMID: 21795423; PMCID: PMC3188338.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    641. Miller TW, Balko JM, Fox EM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, Jiang A, Smith RA, Maira SM, Manning HC, Mills GB, Higham C, Chanthaphaychith S, Kuba MG, Miller WR, Shyr Y, Arteaga CL, Gonz?lez-Angulo AM. ERa-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer. Cancer Discov. 2011 Sep; 1(4):338-51. PMID: 22049316; PMCID: PMC3204388.
      Citations: 135     Fields:    Translation:HumansAnimalsCells
    642. Pradeep CR, Lauriola M, Granit RZ, Zhang F, Jacob-Hirsch J, Rechavi G, Nair HB, Hennessy BT, Gonzalez-Angulo AM, Tekmal RR, Ben-Porath I, Mills GB, Domany E, Yarden Y, K?stler WJ. Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling. Oncogene. 2012 Feb 16; 31(7):907-17. PMID: 21743488; PMCID: PMC3193899.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    643. Gonzalez-Angulo AM, Hennessy BT, Meric-Bernstam F, Sahin A, Liu W, Ju Z, Carey MS, Myhre S, Speers C, Deng L, Broaddus R, Lluch A, Aparicio S, Brown P, Pusztai L, Symmans WF, Alsner J, Overgaard J, Borresen-Dale AL, Hortobagyi GN, Coombes KR, Mills GB. Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer. Clin Proteomics. 2011 Jul 08; 8(1):11. PMID: 21906370; PMCID: PMC3170272.
      Citations: 49     
    644. Cancer Genome Atlas Research Network. Integrated genomic analyses of ovarian carcinoma. Nature. 2011 Jun 29; 474(7353):609-15. PMID: 21720365; PMCID: PMC3163504.
      Citations: 3238     Fields:    Translation:HumansCells
    645. Lu Y, Muller M, Smith D, Dutta B, Komurov K, Iadevaia S, Ruths D, Tseng JT, Yu S, Yu Q, Nakhleh L, Balazsi G, Donnelly J, Schurdak M, Morgan-Lappe S, Fesik S, Ram PT, Mills GB. Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling. Oncogene. 2011 Nov 10; 30(45):4567-77. PMID: 21666717; PMCID: PMC3175328.
      Citations: 39     Fields:    Translation:HumansCells
    646. Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, Ju Z, Cantley LC, Scherer SE, Liang H, Lu KH, Broaddus RR, Mills GB. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov. 2011 Jul; 1(2):170-85. PMID: 21984976; PMCID: PMC3187555.
      Citations: 220     Fields:    Translation:HumansCells
    647. Harmens H, Norris DA, Cooper DM, Mills G, Steinnes E, Kubin E, Th?ni L, Aboal JR, Alber R, Carballeira A, Coskun M, De Temmerman L, Frolova M, Gonz?lez-Miqueo L, Jeran Z, Leblond S, Liiv S, Mankovsk? B, Pesch R, Poikolainen J, R?hling A, Santamaria JM, Simon?i? P, Schr?der W, Suchara I, Yurukova L, Zechmeister HG. Nitrogen concentrations in mosses indicate the spatial distribution of atmospheric nitrogen deposition in Europe. Environ Pollut. 2011 Oct; 159(10):2852-60. PMID: 21620544.
      Citations: 16     Fields:    Translation:AnimalsPHPublic Health
    648. Zwang Y, Sas-Chen A, Drier Y, Shay T, Avraham R, Lauriola M, Shema E, Lidor-Nili E, Jacob-Hirsch J, Amariglio N, Lu Y, Mills GB, Rechavi G, Oren M, Domany E, Yarden Y. Two phases of mitogenic signaling unveil roles for p53 and EGR1 in elimination of inconsistent growth signals. Mol Cell. 2011 May 20; 42(4):524-35. PMID: 21596316; PMCID: PMC3100487.
      Citations: 54     Fields:    Translation:HumansCells
    649. Stronach EA, Alfraidi A, Rama N, Datler C, Studd JB, Agarwal R, Guney TG, Gourley C, Hennessy BT, Mills GB, Mai A, Brown R, Dina R, Gabra H. HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer. Cancer Res. 2011 Jul 01; 71(13):4412-22. PMID: 21571862; PMCID: PMC3130134.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    650. Valero V, Wingate H, Chada S, Liu Y, Palalon F, Mills G, Keyomarsi K, Hunt KK. MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells. Cancer Gene Ther. 2011 Jul; 18(7):510-9. PMID: 21546925; PMCID: PMC3875403.
      Citations: 5     Fields:    Translation:HumansCells
    651. Rexer BN, Ham AJ, Rinehart C, Hill S, Granja-Ingram Nde M, Mills GB, Dave B, Chang JC, Liebler DC, Arteaga CL, Gonz?lez-Angulo AM. Phosphoproteomic mass spectrometry profiling links Src family kinases to escape from HER2 tyrosine kinase inhibition. Oncogene. 2011 Oct 06; 30(40):4163-74. PMID: 21499296; PMCID: PMC3204390.
      Citations: 68     Fields:    Translation:HumansCells
    652. Halder G, Mills GB. Drosophila in cancer research: to boldly go where no one has gone before. Oncogene. 2011 Sep 29; 30(39):4063-6. PMID: 21499298.
      Citations: 5     Fields:    Translation:AnimalsCells
    653. Gonzalez-Angulo AM, Ferrer-Lozano J, Stemke-Hale K, Sahin A, Liu S, Barrera JA, Burgues O, Lluch AM, Chen H, Hortobagyi GN, Mills GB, Meric-Bernstam F. PI3K pathway mutations and PTEN levels in primary and metastatic breast cancer. Mol Cancer Ther. 2011 Jun; 10(6):1093-101. PMID: 21490305; PMCID: PMC3112276.
      Citations: 116     Fields:    Translation:HumansCells
    654. Gupte R, Patil R, Liu J, Wang Y, Lee SC, Fujiwara Y, Fells J, Bolen AL, Emmons-Thompson K, Yates CR, Siddam A, Panupinthu N, Pham TC, Baker DL, Parrill AL, Mills GB, Tigyi G, Miller DD. Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity. ChemMedChem. 2011 May 02; 6(5):922-35. PMID: 21465666; PMCID: PMC3517046.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    655. Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia. 2011 Mar; 13(3):286-98. PMID: 21390191; PMCID: PMC3050871.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    656. Miller TW, Balko JM, Ghazoui Z, Dunbier A, Anderson H, Dowsett M, Mills GB, Miller WR, Wu H, Shyr Y, Arteaga CL, Gonz?lez-Angulo AM. A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance. Clin Cancer Res. 2011 Apr 01; 17(7):2024-34. PMID: 21346144; PMCID: PMC3221728.
      Citations: 47     Fields:    Translation:HumansCells
    657. Ghosh R, Narasanna A, Wang SE, Liu S, Chakrabarty A, Balko JM, Mills GB, Penuel E, Winslow J, Sperinde J, Dua R, Pidaparthi S, Mukherjee A, Leitzel K, Kostler WJ, Lipton A, Bates M, Arteaga CL, Gonz?lez-Angulo AM. Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers. Cancer Res. 2011 Mar 01; 71(5):1871-82. PMID: 21324925; PMCID: PMC3221734.
      Citations: 89     Fields:    Translation:HumansCells
    658. Tabchy A, Hennessy BT, Gonzalez-Angulo AM, Bernstam FM, Lu Y, Mills GB. Quantitative proteomic analysis in breast cancer. Drugs Today (Barc). 2011 Feb; 47(2):169-82. PMID: 21431104.
      Citations: 11     Fields:    Translation:Humans
    659. Tabchy A, Tigyi G, Mills GB. Location, location, location: a crystal-clear view of autotaxin saturating LPA receptors. Nat Struct Mol Biol. 2011 Feb; 18(2):117-8. PMID: 21289650; PMCID: PMC3584164.
      Citations: 11     Fields:    Translation:Animals
    660. Gonzalez-Angulo AM, Timms KM, Liu S, Chen H, Litton JK, Potter J, Lanchbury JS, Stemke-Hale K, Hennessy BT, Arun BK, Hortobagyi GN, Do KA, Mills GB, Meric-Bernstam F. Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer. Clin Cancer Res. 2011 Mar 01; 17(5):1082-9. PMID: 21233401; PMCID: PMC3048924.
      Citations: 232     Fields:    Translation:Humans
    661. Han CH, Huang YJ, Lu KH, Liu Z, Mills GB, Wei Q, Wang LE. Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer. J Exp Clin Cancer Res. 2011 Jan 07; 30:5. PMID: 21214932; PMCID: PMC3025876.
      Citations: 10     Fields:    Translation:Humans
    662. Claerhout S, Lorenzi PL, Weinstein JN, Mills GB. MODULATION OF AUTOPHAGY AND ITS POTENTIAL FOR CANCER THERAPY. Drugs Future. 2011; 36(12). PMID: 25419038; PMCID: PMC4239665.
      Citations: 1     
    663. Mitra S, Cheng KW, Mills GB. Rab GTPases implicated in inherited and acquired disorders. Semin Cell Dev Biol. 2011 Feb; 22(1):57-68. PMID: 21147240; PMCID: PMC3395236.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    664. Nanjundan M, Byers LA, Carey MS, Siwak DR, Raso MG, Diao L, Wang J, Coombes KR, Roth JA, Mills GB, Wistuba II, Minna JD, Heymach JV. Proteomic profiling identifies pathways dysregulated in non-small cell lung cancer and an inverse association of AMPK and adhesion pathways with recurrence. J Thorac Oncol. 2010 Dec; 5(12):1894-904. PMID: 21124077; PMCID: PMC3374718.
      Citations: 27     Fields:    Translation:HumansCells
    665. Hennessy BT, Lu Y, Gonzalez-Angulo AM, Carey MS, Myhre S, Ju Z, Davies MA, Liu W, Coombes K, Meric-Bernstam F, Bedrosian I, McGahren M, Agarwal R, Zhang F, Overgaard J, Alsner J, Neve RM, Kuo WL, Gray JW, Borresen-Dale AL, Mills GB. A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clin Proteomics. 2010 Dec; 6(4):129-51. PMID: 21691416; PMCID: PMC3116520.
      Citations: 131     
    666. Deus HF, Veiga DF, Freire PR, Weinstein JN, Mills GB, Almeida JS. Exposing the cancer genome atlas as a SPARQL endpoint. J Biomed Inform. 2010 Dec; 43(6):998-1008. PMID: 20851208; PMCID: PMC3071752.
      Citations: 12     Fields:    
    667. Park SY, Jeong KJ, Panupinthu N, Yu S, Lee J, Han JW, Kim JM, Lee JS, Kang J, Park CG, Mills GB, Lee HY. Lysophosphatidic acid augments human hepatocellular carcinoma cell invasion through LPA1 receptor and MMP-9 expression. Oncogene. 2011 Mar 17; 30(11):1351-9. PMID: 21102517.
      Citations: 67     Fields:    Translation:HumansCells
    668. Woodman SE, Mills GB. Are oncogenes sufficient to cause human cancer? Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20599-600. PMID: 21084639; PMCID: PMC2996413.
      Citations: 4     Fields:    Translation:HumansCells
    669. Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 2010 Nov 16; 18(5):423-35. PMID: 21075308; PMCID: PMC3022383.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    670. Lui VW, Wong EY, Ho K, Ng PK, Lau CP, Tsui SK, Tsang CM, Tsao SW, Cheng SH, Ng MH, Ng YK, Lam EK, Hong B, Lo KW, Mok TS, Chan AT, Mills GB. Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death. Oncogene. 2011 Mar 03; 30(9):1127-34. PMID: 21057531; PMCID: PMC3428712.
      Citations: 33     Fields:    Translation:HumansCells
    671. McAuliffe PF, Meric-Bernstam F, Mills GB, Gonzalez-Angulo AM. Deciphering the role of PI3K/Akt/mTOR pathway in breast cancer biology and pathogenesis. Clin Breast Cancer. 2010 Nov; 10 Suppl 3:S59-65. PMID: 21115423.
      Citations: 54     Fields:    Translation:HumansCells
    672. Cheng X, Xia W, Yang JY, Hsu JL, Chou CK, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochem Biophys Res Commun. 2010 Dec 03; 403(1):103-7. PMID: 21040707; PMCID: PMC3001223.
      Citations: 14     Fields:    Translation:HumansAnimals
    673. Anderson CE, Brice SJ, Brown BC, Bugel L, Conrad JM, Dharmapalan R, Djurcic Z, Fleming BT, Ford R, Garcia FG, Garvey GT, Mirabal J, Grange J, Green JA, Imlay R, Johnson RA, Karagiorgi G, Katori T, Kobilarcik T, Linden SK, Louis WC, Mahn KB, Marsh W, Mauger C, Metcalf W, Mills GB, Moore CD, Mousseau J, Nelson RH, Nguyen V, Nienaber P, Nowak JA, Osmanov B, Pavlovic Z, Perevalov D, Polly CC, Ray H, Roe BP, Russell AD, Schirato R, Shaevitz MH, Sorel M, Spitz J, Stancu I, Stefanski RJ, Tayloe R, Tzanov M, Van de Water RG, Wascko MO, White DH, Wilking MJ, Zeller GP, Zimmerman ED, MiniBooNE Collaboration, Aguilar-Arevalo AA. Event excess in the MiniBooNE search for ??????e oscillations. Phys Rev Lett. 2010 Oct 29; 105(18):181801. PMID: 21231096.
      Citations: 3     Fields:    
    674. Gupte R, Siddam A, Lu Y, Li W, Fujiwara Y, Panupinthu N, Pham TC, Baker DL, Parrill AL, Gotoh M, Murakami-Murofushi K, Kobayashi S, Mills GB, Tigyi G, Miller DD. Synthesis and pharmacological evaluation of the stereoisomers of 3-carba cyclic-phosphatidic acid. Bioorg Med Chem Lett. 2010 Dec 15; 20(24):7525-8. PMID: 21051230; PMCID: PMC3040411.
      Citations: 6     Fields:    Translation:Animals
    675. Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 2011 Feb 10; 30(6):724-36. PMID: 20890303; PMCID: PMC3017639.
      Citations: 14     Fields:    Translation:HumansCells
    676. Luyimbazi D, Akcakanat A, McAuliffe PF, Zhang L, Singh G, Gonzalez-Angulo AM, Chen H, Do KA, Zheng Y, Hung MC, Mills GB, Meric-Bernstam F. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol Cancer Ther. 2010 Oct; 9(10):2770-84. PMID: 20876744; PMCID: PMC2965451.
      Citations: 33     Fields:    Translation:HumansCells
    677. Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D. Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. 2011 Jan 27; 30(4):457-70. PMID: 20856200; PMCID: PMC3010301.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    678. Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Res. 2010 Oct 01; 70(19):7684-9. PMID: 20841468; PMCID: PMC2948588.
      Citations: 9     Fields:    Translation:AnimalsCells
    679. Cai D, Shames DS, Raso MG, Xie Y, Kim YH, Pollack JR, Girard L, Sullivan JP, Gao B, Peyton M, Nanjundan M, Byers L, Heymach J, Mills G, Gazdar AF, Wistuba I, Kodadek T, Minna JD. Steroid receptor coactivator-3 expression in lung cancer and its role in the regulation of cancer cell survival and proliferation. Cancer Res. 2010 Aug 15; 70(16):6477-85. PMID: 20663904; PMCID: PMC2922434.
      Citations: 30     Fields:    Translation:HumansCells
    680. Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS. PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One. 2010 Jul 23; 5(7):e11729. PMID: 20668531; PMCID: PMC2909213.
      Citations: 43     Fields:    Translation:HumansCells
    681. Iadevaia S, Lu Y, Morales FC, Mills GB, Ram PT. Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis. Cancer Res. 2010 Sep 01; 70(17):6704-14. PMID: 20643779; PMCID: PMC2932856.
      Citations: 92     Fields:    Translation:HumansCells
    682. Hennessy BT, Timms KM, Carey MS, Gutin A, Meyer LA, Flake DD, Abkevich V, Potter J, Pruss D, Glenn P, Li Y, Li J, Gonzalez-Angulo AM, McCune KS, Markman M, Broaddus RR, Lanchbury JS, Lu KH, Mills GB. Somatic mutations in BRCA1 and BRCA2 could expand the number of patients that benefit from poly (ADP ribose) polymerase inhibitors in ovarian cancer. J Clin Oncol. 2010 Aug 01; 28(22):3570-6. PMID: 20606085; PMCID: PMC2917312.
      Citations: 171     Fields:    Translation:Humans
    683. Alexander JS, Harris MK, Wells SR, Mills G, Chalamidas K, Ganta VC, McGee J, Jennings MH, Gonzalez-Toledo E, Minagar A. Alterations in serum MMP-8, MMP-9, IL-12p40 and IL-23 in multiple sclerosis patients treated with interferon-beta1b. Mult Scler. 2010 Jul; 16(7):801-9. PMID: 20621951.
      Citations: 15     Fields:    Translation:HumansCells
    684. Creighton CJ, Fu X, Hennessy BT, Casa AJ, Zhang Y, Gonzalez-Angulo AM, Lluch A, Gray JW, Brown PH, Hilsenbeck SG, Osborne CK, Mills GB, Lee AV, Schiff R. Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer. Breast Cancer Res. 2010; 12(3):R40. PMID: 20569503; PMCID: PMC2917035.
      Citations: 117     Fields:    Translation:HumansCells
    685. Amos CI, Gorlov IP, Dong Q, Wu X, Zhang H, Lu EY, Scheet P, Greisinger AJ, Mills GB, Spitz MR. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. J Natl Cancer Inst. 2010 Aug 04; 102(15):1199-205. PMID: 20554942; PMCID: PMC2914761.
      Citations: 41     Fields:    Translation:HumansCells
    686. Bast RC, Mills GB. Personalizing therapy for ovarian cancer: BRCAness and beyond. J Clin Oncol. 2010 Aug 01; 28(22):3545-8. PMID: 20547987.
      Citations: 35     Fields:    Translation:Humans
    687. Altman MK, Gopal V, Jia W, Yu S, Hall H, Mills GB, McGinnis AC, Bartlett MG, Jiang G, Madan D, Prestwich GD, Xu Y, Davies MA, Murph MM. Targeting melanoma growth and viability reveals dualistic functionality of the phosphonothionate analogue of carba cyclic phosphatidic acid. Mol Cancer. 2010 Jun 09; 9:140. PMID: 20529378; PMCID: PMC2895597.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    688. Miller TW, Hennessy BT, Fox EM, Mills GB, Chen H, Higham C, Shyr Y, Arteaga CL, Gonz?lez-Angulo AM, Garc?a-Echeverr?a C. Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer. J Clin Invest. 2010 Jul; 120(7):2406-13. PMID: 20530877; PMCID: PMC2898598.
      Citations: 211     Fields:    Translation:HumansCells
    689. Agarwal R, Carey M, Hennessy B, Mills GB. PI3K pathway-directed therapeutic strategies in cancer. Curr Opin Investig Drugs. 2010 Jun; 11(6):615-28. PMID: 20496256.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    690. Smith DM, Patel S, Raffoul F, Haller E, Mills GB, Nanjundan M. Arsenic trioxide induces a beclin-1-independent autophagic pathway via modulation of SnoN/SkiL expression in ovarian carcinoma cells. Cell Death Differ. 2010 Dec; 17(12):1867-81. PMID: 20508647; PMCID: PMC2932795.
      Citations: 67     Fields:    Translation:HumansCells
    691. Yang G, Rosen DG, Liu G, Yang F, Guo X, Xiao X, Xue F, Mercado-Uribe I, Huang J, Lin SH, Mills GB, Liu J. CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. Clin Cancer Res. 2010 Aug 01; 16(15):3875-86. PMID: 20505188; PMCID: PMC2930833.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    692. Loi S, Haibe-Kains B, Majjaj S, Lallemand F, Durbecq V, Larsimont D, Gonzalez-Angulo AM, Pusztai L, Symmans WF, Bardelli A, Ellis P, Tutt AN, Gillett CE, Hennessy BT, Mills GB, Phillips WA, Piccart MJ, Speed TP, McArthur GA, Sotiriou C. PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10208-13. PMID: 20479250; PMCID: PMC2890442.
      Citations: 173     Fields:    Translation:HumansCells
    693. Carey MS, Agarwal R, Gilks B, Swenerton K, Kalloger S, Santos J, Ju Z, Lu Y, Zhang F, Coombes KR, Miller D, Huntsman D, Mills GB, Hennessy BT. Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy. Clin Cancer Res. 2010 May 15; 16(10):2852-60. PMID: 20460476; PMCID: PMC2877659.
      Citations: 32     Fields:    Translation:HumansCells
    694. Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, Walker CL. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog. 2010 May; 49(5):429-39. PMID: 20146253; PMCID: PMC3818129.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    695. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15; 16(12):3171-81. PMID: 20423983; PMCID: PMC2930838.
      Citations: 63     Fields:    Translation:HumansCells
    696. Gonzalez-Angulo AM, Hennessy BT, Mills GB. Future of personalized medicine in oncology: a systems biology approach. J Clin Oncol. 2010 Jun 01; 28(16):2777-83. PMID: 20406928; PMCID: PMC2881854.
      Citations: 80     Fields:    Translation:Humans
    697. Lu ZH, Shvartsman MB, Lee AY, Shao JM, Murray MM, Kladney RD, Fan D, Krajewski S, Chiang GG, Mills GB, Arbeit JM. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. Cancer Res. 2010 Apr 15; 70(8):3287-98. PMID: 20388784; PMCID: PMC2855737.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    698. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One. 2010 Mar 26; 5(3):e9910. PMID: 20361045; PMCID: PMC2845649.
      Citations: 23     Fields:    Translation:HumansCells
    699. Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B, Zuo D, St-Arnaud R, Mills GB, Dedhar S, Marshall CJ, Muller WJ. Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer. Oncogene. 2010 Jun 10; 29(23):3374-85. PMID: 20305688.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    700. Panupinthu N, Lee HY, Mills GB. Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression. Br J Cancer. 2010 Mar 16; 102(6):941-6. PMID: 20234370; PMCID: PMC2844037.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    701. Mills GB, Yarden Y. The rebirth of a phoenix: ovarian cancers are addicted to ErbB-3. Cancer Cell. 2010 Mar 16; 17(3):217-8. PMID: 20227035.
      Citations: 9     Fields:    
    702. Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5012-7. PMID: 20194747; PMCID: PMC2841923.
      Citations: 97     Fields:    Translation:HumansCells
    703. Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):4153-8. PMID: 20160076; PMCID: PMC2840158.
      Citations: 319     Fields:    Translation:HumansAnimalsCells
    704. Park ES, Rabinovsky R, Carey M, Hennessy BT, Agarwal R, Liu W, Ju Z, Deng W, Lu Y, Woo HG, Kim SB, Cheong JH, Garraway LA, Weinstein JN, Mills GB, Lee JS, Davies MA. Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set. Mol Cancer Ther. 2010 Feb; 9(2):257-67. PMID: 20124458; PMCID: PMC4085051.
      Citations: 49     Fields:    Translation:HumansCells
    705. Tsavachidou-Fenner D, Tannir N, Tamboli P, Liu W, Petillo D, Teh B, Mills GB, Jonasch E. Gene and protein expression markers of response to combined antiangiogenic and epidermal growth factor targeted therapy in renal cell carcinoma. Ann Oncol. 2010 Aug; 21(8):1599-1606. PMID: 20089566; PMCID: PMC4092253.
      Citations: 24     Fields:    Translation:HumansCTClinical Trials
    706. Zheng J, Mercado-Uribe I, Rosen DG, Chang B, Liu P, Yang G, Malpica A, Naora H, Auersperg N, Mills GB, Bast RC, Liu J. Induction of papillary carcinoma in human ovarian surface epithelial cells using combined genetic elements and peritoneal microenvironment. Cell Cycle. 2010 Jan 01; 9(1):140-6. PMID: 20016289; PMCID: PMC2931318.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    707. An J, Wei Q, Liu Z, Lu KH, Cheng X, Mills GB, Wang LE. Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis. Int J Mol Epidemiol Genet. 2010; 1(1):1-10. PMID: 20689651; PMCID: PMC2916180.
      Citations: 12     
    708. Davies MA, Stemke-Hale K, Lin E, Tellez C, Deng W, Gopal YN, Woodman SE, Calderone TC, Ju Z, Lazar AJ, Prieto VG, Aldape K, Mills GB, Gershenwald JE. Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic Melanoma. Clin Cancer Res. 2009 Dec 15; 15(24):7538-7546. PMID: 19996208; PMCID: PMC2805170.
      Citations: 113     Fields:    
    709. Siwak DR, Carey M, Hennessy BT, Nguyen CT, McGahren Murray MJ, Nolden L, Mills GB. Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges. J Oncol. 2010; 2010:568938. PMID: 20037743; PMCID: PMC2796463.
      Citations: 53     
    710. Liu S, Murph M, Panupinthu N, Mills GB. ATX-LPA receptor axis in inflammation and cancer. Cell Cycle. 2009 Nov 15; 8(22):3695-701. PMID: 19855166; PMCID: PMC4166520.
      Citations: 56     Fields:    Translation:AnimalsCells
    711. Han CH, Wei Q, Lu KK, Liu Z, Mills GB, Wang LE. Polymorphisms in the survivin promoter are associated with age of onset of ovarian cancer. Int J Clin Exp Med. 2009 Oct 31; 2(4):289-99. PMID: 20057973; PMCID: PMC2802047.
      Citations: 10     
    712. Hong B, Lui VW, Hui EP, Lu Y, Leung HS, Wong EY, Cheng SH, Ng MH, Mills GB, Chan AT. Reverse phase protein array identifies novel anti-invasion mechanisms of YC-1. Biochem Pharmacol. 2010 Mar 15; 79(6):842-52. PMID: 19879857.
      Citations: 9     Fields:    Translation:HumansCells
    713. Byers LA, Sen B, Saigal B, Diao L, Wang J, Nanjundan M, Cascone T, Mills GB, Heymach JV, Johnson FM. Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer. Clin Cancer Res. 2009 Nov 15; 15(22):6852-61. PMID: 19861436; PMCID: PMC2935176.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    714. Anderson CE, Brice SJ, Brown BC, Bugel L, Conrad JM, Djurcic Z, Fleming BT, Ford R, Garcia FG, Garvey GT, Gonzales J, Grange J, Green C, Green JA, Imlay R, Johnson RA, Karagiorgi G, Katori T, Kobilarcik T, Linden SK, Louis WC, Mahn KB, Marsh W, Mauger C, McGary VT, Metcalf W, Mills GB, Moore CD, Mousseau J, Nelson RH, Nienaber P, Nowak JA, Osmanov B, Pavlovic Z, Perevalov D, Polly CC, Ray H, Roe BP, Russell AD, Shaevitz MH, Sorel M, Spitz J, Stancu I, Stefanski RJ, Tayloe R, Tzanov M, Van de Water RG, Wascko MO, White DH, Wilking MJ, Zeller GP, Zimmerman ED, MiniBooNE Collaboration, Aguilar-Arevalo AA. Search for electron antineutrino appearance at the deltam(2) approximately 1 eV(2) Scale. Phys Rev Lett. 2009 Sep 11; 103(11):111801. PMID: 19792365.
      Citations:    Fields:    
    715. Spizzo R, Nicoloso MS, Lupini L, Lu Y, Fogarty J, Rossi S, Zagatti B, Fabbri M, Veronese A, Liu X, Davuluri R, Croce CM, Mills G, Negrini M, Calin GA. miR-145 participates with TP53 in a death-promoting regulatory loop and targets estrogen receptor-alpha in human breast cancer cells. Cell Death Differ. 2010 Feb; 17(2):246-54. PMID: 19730444; PMCID: PMC3648637.
      Citations: 117     Fields:    Translation:HumansCells
    716. Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Louis WC, Mahn KB, Marsh W, McGary VT, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nienaber P, Nowak JA, Osmanov B, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Soderberg M, Sorel M, Spentzouris P, Spitz J, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED, MiniBooNE Collaboration. Measurement of the ratio of the numu charged-current single-pion production to quasielastic scattering with a 0.8 GeV neutrino beam on mineral oil. Phys Rev Lett. 2009 Aug 21; 103(8):081801. PMID: 19792715.
      Citations:    Fields:    
    717. Woodman SE, Trent JC, Stemke-Hale K, Lazar AJ, Pricl S, Pavan GM, Fermeglia M, Gopal YN, Yang D, Podoloff DA, Ivan D, Kim KB, Papadopoulos N, Hwu P, Mills GB, Davies MA. Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates. Mol Cancer Ther. 2009 Aug; 8(8):2079-85. PMID: 19671763; PMCID: PMC3346953.
      Citations: 68     Fields:    Translation:HumansCells
    718. Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Grange J, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Louis WC, Mahn KB, Marsh W, Mauger C, McGary VT, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Mousseau J, Nelson RH, Nienaber P, Nowak JA, Osmanov B, Ouedraogo S, Patterson RB, Pavlovic Z, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Soderberg M, Sorel M, Spentzouris P, Spitz J, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water RG, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED, MiniBooNE Collaboration. Search for muon neutrino and antineutrino disappearance in MiniBooNE. Phys Rev Lett. 2009 Aug 07; 103(6):061802. PMID: 19792551.
      Citations:    Fields:    
    719. Wu X, Ye Y, Kiemeney LA, Sulem P, Rafnar T, Matullo G, Seminara D, Yoshida T, Saeki N, Andrew AS, Dinney CP, Czerniak B, Zhang ZF, Kiltie AE, Bishop DT, Vineis P, Porru S, Buntinx F, Kellen E, Zeegers MP, Kumar R, Rudnai P, Gurzau E, Koppova K, Mayordomo JI, Sanchez M, Saez B, Lindblom A, de Verdier P, Steineck G, Mills GB, Schned A, Guarrera S, Polidoro S, Chang SC, Lin J, Chang DW, Hale KS, Majewski T, Grossman HB, Thorlacius S, Thorsteinsdottir U, Aben KK, Witjes JA, Stefansson K, Amos CI, Karagas MR, Gu J. Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer. Nat Genet. 2009 Sep; 41(9):991-5. PMID: 19648920; PMCID: PMC3313685.
      Citations: 122     Fields:    Translation:HumansCells
    720. Agarwal R, Jurisica I, Mills GB, Cheng KW. The emerging role of the RAB25 small GTPase in cancer. Traffic. 2009 Nov; 10(11):1561-8. PMID: 19719478; PMCID: PMC3258497.
      Citations: 41     Fields:    Translation:HumansAnimals
    721. Mills GB, Jurisica I, Yarden Y, Norman JC. Genomic amplicons target vesicle recycling in breast cancer. J Clin Invest. 2009 Aug; 119(8):2123-7. PMID: 19620778; PMCID: PMC2719927.
      Citations: 22     Fields:    Translation:HumansAnimals
    722. Maurer M, Su T, Saal LH, Koujak S, Hopkins BD, Barkley CR, Wu J, Nandula S, Dutta B, Xie Y, Chin YR, Kim DI, Ferris JS, Gruvberger-Saal SK, Laakso M, Wang X, Memeo L, Rojtman A, Matos T, Yu JS, Cordon-Cardo C, Isola J, Terry MB, Toker A, Mills GB, Zhao JJ, Murty VV, Hibshoosh H, Parsons R. 3-Phosphoinositide-dependent kinase 1 potentiates upstream lesions on the phosphatidylinositol 3-kinase pathway in breast carcinoma. Cancer Res. 2009 Aug 01; 69(15):6299-306. PMID: 19602588; PMCID: PMC2727605.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    723. Vasudevan KM, Barbie DA, Davies MA, Rabinovsky R, McNear CJ, Kim JJ, Hennessy BT, Tseng H, Pochanard P, Kim SY, Dunn IF, Schinzel AC, Sandy P, Hoersch S, Sheng Q, Gupta PB, Boehm JS, Reiling JH, Silver S, Lu Y, Stemke-Hale K, Dutta B, Joy C, Sahin AA, Gonzalez-Angulo AM, Lluch A, Rameh LE, Jacks T, Root DE, Lander ES, Mills GB, Hahn WC, Sellers WR, Garraway LA. AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer. Cancer Cell. 2009 Jul 07; 16(1):21-32. PMID: 19573809; PMCID: PMC2752826.
      Citations: 263     Fields:    Translation:HumansCells
    724. Li TT, Alemayehu M, Aziziyeh AI, Pape C, Pampillo M, Postovit LM, Mills GB, Babwah AV, Bhattacharya M. Beta-arrestin/Ral signaling regulates lysophosphatidic acid-mediated migration and invasion of human breast tumor cells. Mol Cancer Res. 2009 Jul; 7(7):1064-77. PMID: 19609003.
      Citations: 76     Fields:    Translation:HumansCells
    725. Dillon RL, Marcotte R, Hennessy BT, Woodgett JR, Mills GB, Muller WJ. Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res. 2009 Jun 15; 69(12):5057-64. PMID: 19491266; PMCID: PMC4151524.
      Citations: 96     Fields:    Translation:AnimalsCells
    726. Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, Zhang F, Yu S, Stephens LC, Cui X, Murrow G, Coombes K, Muller W, Hung MC, Perou CM, Lee AV, Fang X, Mills GB. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell. 2009 Jun 02; 15(6):539-50. PMID: 19477432; PMCID: PMC4157573.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    727. Bast RC, Hennessy B, Mills GB. The biology of ovarian cancer: new opportunities for translation. Nat Rev Cancer. 2009 Jun; 9(6):415-28. PMID: 19461667; PMCID: PMC2814299.
      Citations: 642     Fields:    Translation:HumansAnimals
    728. Adamson P, Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Bishai M, Brice SJ, Brown BC, Bugel L, Cao J, Choudhary BC, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Gallagher HR, Garcia FG, Garvey GT, Green C, Green JA, Harris D, Hart TL, Hawker E, Hylen J, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kopp S, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Loiacono L, Louis WC, Marchionni A, Mahn KB, Marsh W, McGregor G, Messier MD, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson JK, Nelson RH, Nguyen VT, Nienaber P, Nowak JA, Ouedraogo S, Patterson RB, Pavlovic Z, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smart W, Smith D, Sodeberg M, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Vahle P, Van de Water R, Viren B, Wascko MO, White DH, Wilking MJ, Yang HJ, Yumiceva FX, Zeller GP, Zimmerman ED, Zwaska R. Measurement of numicro and nue events in an off-axis horn-focused neutrino beam. Phys Rev Lett. 2009 May 29; 102(21):211801. PMID: 19519094.
      Citations:    Fields:    
    729. Agarwal R, Gonzalez-Angulo AM, Myhre S, Carey M, Lee JS, Overgaard J, Alsner J, Stemke-Hale K, Lluch A, Neve RM, Kuo WL, Sorlie T, Sahin A, Valero V, Keyomarsi K, Gray JW, Borresen-Dale AL, Mills GB, Hennessy BT. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer. Clin Cancer Res. 2009 Jun 01; 15(11):3654-62. PMID: 19470724; PMCID: PMC2887710.
      Citations: 67     Fields:    Translation:HumansCells
    730. Murph MM, Liu W, Yu S, Lu Y, Hall H, Hennessy BT, Lahad J, Schaner M, Helland A, Kristensen G, Mills GB, B?rresen-Dale AL. Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis. PLoS One. 2009; 4(5):e5583. PMID: 19440550; PMCID: PMC2679144.
      Citations: 25     Fields:    Translation:HumansCells
    731. Chen Y, Guggisberg N, Jorda M, Gonzalez-Angulo A, Hennessy B, Mills GB, Tan CK, Slingerland JM. Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors. Clin Cancer Res. 2009 May 15; 15(10):3396-405. PMID: 19451593.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    732. Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, Gilcrease MZ, Krishnamurthy S, Lee JS, Fridlyand J, Sahin A, Agarwal R, Joy C, Liu W, Stivers D, Baggerly K, Carey M, Lluch A, Monteagudo C, He X, Weigman V, Fan C, Palazzo J, Hortobagyi GN, Nolden LK, Wang NJ, Valero V, Gray JW, Perou CM, Mills GB. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res. 2009 May 15; 69(10):4116-24. PMID: 19435916; PMCID: PMC2737191.
      Citations: 385     Fields:    Translation:HumansCells
    733. Miller TW, Narasanna A, Guix M, Gonzalez-Angulo AM, Hennessy BT, Mills GB, Kennedy JP, Lindsley CW, Arteaga CL, P?rez-Torres M, St?l O, P?rez-Tenorio G. Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer. Cancer Res. 2009 May 15; 69(10):4192-201. PMID: 19435893; PMCID: PMC2724871.
      Citations: 80     Fields:    Translation:HumansCells
    734. Zou CY, Smith KD, Zhu QS, Liu J, McCutcheon IE, Slopis JM, Meric-Bernstam F, Peng Z, Bornmann WG, Mills GB, Lazar AJ, Pollock RE, Lev D. Dual targeting of AKT and mammalian target of rapamycin: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther. 2009 May; 8(5):1157-68. PMID: 19417153.
      Citations: 42     Fields:    Translation:HumansCells
    735. Blando J, Portis M, Benavides F, Alexander A, Mills G, Dave B, Conti CJ, Kim J, Walker CL. PTEN deficiency is fully penetrant for prostate adenocarcinoma in C57BL/6 mice via mTOR-dependent growth. Am J Pathol. 2009 May; 174(5):1869-79. PMID: 19395652; PMCID: PMC2671275.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    736. Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell. 2009 Apr 07; 15(4):304-14. PMID: 19345329; PMCID: PMC2673492.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    737. O'Reilly KE, Warycha M, Davies MA, Rodrik V, Zhou XK, Yee H, Polsky D, Pavlick AC, Rosen N, Bhardwaj N, Mills G, Osman I. Phosphorylated 4E-BP1 is associated with poor survival in melanoma. Clin Cancer Res. 2009 Apr 15; 15(8):2872-8. PMID: 19336517; PMCID: PMC3995540.
      Citations: 28     Fields:    Translation:HumansCells
    738. Aguilar-Arevalo AA, Anderson CE, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Karagiorgi G, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Linden SK, Link JM, Liu Y, Louis WC, Mahn KB, Marsh W, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nguyen VT, Nienaber P, Nowak JA, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Sodeberg M, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED, MiniBooNE Collaboration. Unexplained excess of electronlike events from a 1-GeV neutrino beam. Phys Rev Lett. 2009 Mar 13; 102(10):101802. PMID: 19392103.
      Citations:    Fields:    
    739. Zinner RG, Barrett BL, Popova E, Damien P, Volgin AY, Gelovani JG, Lotan R, Tran HT, Pisano C, Mills GB, Mao L, Hong WK, Lippman SM, Miller JH. Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells. Mol Cancer Ther. 2009 Mar; 8(3):521-32. PMID: 19276160.
      Citations: 23     Fields:    Translation:HumansCells
    740. Gonzalez-Angulo AM, Stemke-Hale K, Palla SL, Carey M, Agarwal R, Meric-Berstam F, Traina TA, Hudis C, Hortobagyi GN, Gerald WL, Mills GB, Hennessy BT. Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer. Clin Cancer Res. 2009 Apr 01; 15(7):2472-8. PMID: 19276248.
      Citations: 96     Fields:    Translation:Humans
    741. Nikolova DA, Asangani IA, Nelson LD, Hughes DP, Siwak DR, Mills GB, Harms A, Buchholz E, Pilz LR, Manegold C, Allgayer H. Cetuximab attenuates metastasis and u-PAR expression in non-small cell lung cancer: u-PAR and E-cadherin are novel biomarkers of cetuximab sensitivity. Cancer Res. 2009 Mar 15; 69(6):2461-70. PMID: 19276367.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    742. Hung MC, Mills GB, Yu D. Oxygen sensor boosts growth factor signaling. Nat Med. 2009 Mar; 15(3):246-7. PMID: 19265822.
      Citations: 3     Fields:    Translation:HumansCells
    743. Tuna M, Knuutila S, Mills GB. Uniparental disomy in cancer. Trends Mol Med. 2009 Mar; 15(3):120-8. PMID: 19246245.
      Citations: 71     Fields:    Translation:Humans
    744. Wang Y, Carlton VE, Karlin-Neumann G, Sapolsky R, Zhang L, Moorhead M, Wang ZC, Richardson AL, Warren R, Walther A, Bondy M, Sahin A, Krahe R, Tuna M, Thompson PA, Spellman PT, Gray JW, Mills GB, Faham M. High quality copy number and genotype data from FFPE samples using Molecular Inversion Probe (MIP) microarrays. BMC Med Genomics. 2009 Feb 19; 2:8. PMID: 19228381; PMCID: PMC2649948.
      Citations: 43     Fields:    
    745. Lai SY, Koppikar P, Thomas SM, Childs EE, Egloff AM, Seethala RR, Branstetter BF, Gooding WE, Muthukrishnan A, Mountz JM, Lui VW, Shin DM, Agarwala SS, Johnson R, Couture LA, Myers EN, Johnson JT, Mills G, Argiris A, Grandis JR. Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms. J Clin Oncol. 2009 Mar 10; 27(8):1235-42. PMID: 19204206; PMCID: PMC2667824.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    746. Zhang L, Wei Q, Mao L, Liu W, Mills GB, Coombes K. Serial dilution curve: a new method for analysis of reverse phase protein array data. Bioinformatics. 2009 Mar 01; 25(5):650-4. PMID: 19176552; PMCID: PMC2647837.
      Citations: 30     Fields:    
    747. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. PMID: 19147570; PMCID: PMC2737189.
      Citations: 178     Fields:    Translation:HumansCells
    748. Hennessy BT, Gonzalez-Angulo AM, Carey MS, Mills GB. A systems approach to analysis of molecular complexity in breast cancer. Clin Cancer Res. 2009 Jan 15; 15(2):417-9. PMID: 19147744; PMCID: PMC4161015.
      Citations: 4     Fields:    Translation:HumansCells
    749. Pamuklar Z, Federico L, Liu S, Umezu-Goto M, Dong A, Panchatcharam M, Fulkerson Z, Fulerson Z, Berdyshev E, Natarajan V, Fang X, van Meeteren LA, Moolenaar WH, Mills GB, Morris AJ, Smyth SS. Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis. J Biol Chem. 2009 Mar 13; 284(11):7385-94. PMID: 19139100; PMCID: PMC2652269.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    750. Ihle NT, Lemos R, Wipf P, Yacoub A, Mitchell C, Siwak D, Mills GB, Dent P, Kirkpatrick DL, Powis G. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res. 2009 Jan 01; 69(1):143-50. PMID: 19117997; PMCID: PMC2613546.
      Citations: 137     Fields:    Translation:HumansAnimalsCells
    751. Cheng KW, Agarwal R, Mills GB. Ras-superfamily GTP-ases in ovarian cancer. Cancer Treat Res. 2009; 149:229-40. PMID: 19763439.
      Citations: 7     Fields:    Translation:HumansCells
    752. Freire P, Vilela M, Deus H, Kim YW, Koul D, Colman H, Aldape KD, Bogler O, Yung WK, Coombes K, Mills GB, Vasconcelos AT, Almeida JS. Exploratory analysis of the copy number alterations in glioblastoma multiforme. PLoS One. 2008; 3(12):e4076. PMID: 19115005; PMCID: PMC2605252.
      Citations: 24     Fields:    Translation:Humans
    753. Stanislaus R, Carey M, Deus HF, Coombes K, Hennessy BT, Mills GB, Almeida JS. RPPAML/RIMS: a metadata format and an information management system for reverse phase protein arrays. BMC Bioinformatics. 2008 Dec 22; 9:555. PMID: 19102773; PMCID: PMC2639439.
      Citations: 7     Fields:    
    754. Kim WY, Chang DJ, Hennessy B, Kang HJ, Yoo J, Han SH, Kim YS, Park HJ, Seo SY, Geo SY, Mills G, Kim KW, Hong WK, Suh YG, Lee HY. A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy. Cancer Prev Res (Phila). 2008 Dec; 1(7):577-87. PMID: 19139008; PMCID: PMC2738643.
      Citations: 19     Fields:    Translation:HumansCells
    755. Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Mills GB, Liao WS, Bast RC. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J Clin Invest. 2008 Dec; 118(12):3917-29. PMID: 19033662; PMCID: PMC2582930.
      Citations: 212     Fields:    Translation:HumansAnimalsCells
    756. Yu S, Murph MM, Lu Y, Liu S, Hall HS, Liu J, Stephens C, Fang X, Mills GB. Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J Natl Cancer Inst. 2008 Nov 19; 100(22):1630-42. PMID: 19001604; PMCID: PMC2720766.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    757. Mosesson Y, Mills GB, Yarden Y. Derailed endocytosis: an emerging feature of cancer. Nat Rev Cancer. 2008 Nov; 8(11):835-50. PMID: 18948996.
      Citations: 334     Fields:    Translation:HumansCells
    758. Kornblau SM, Tibes R, Qiu YH, Chen W, Kantarjian HM, Andreeff M, Coombes KR, Mills GB. Functional proteomic profiling of AML predicts response and survival. Blood. 2009 Jan 01; 113(1):154-64. PMID: 18840713; PMCID: PMC2951831.
      Citations: 132     Fields:    Translation:HumansCells
    759. Lambert LA, Qiao N, Hunt KK, Lambert DH, Mills GB, Meijer L, Keyomarsi K. Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res. 2008 Oct 01; 68(19):7966-74. PMID: 18829554; PMCID: PMC2561224.
      Citations: 44     Fields:    Translation:HumansCells
    760. Davies MA, Stemke-Hale K, Tellez C, Calderone TL, Deng W, Prieto VG, Lazar AJ, Gershenwald JE, Mills GB. A novel AKT3 mutation in melanoma tumours and cell lines. Br J Cancer. 2008 Oct 21; 99(8):1265-8. PMID: 18813315; PMCID: PMC2570525.
      Citations: 114     Fields:    Translation:HumansCells
    761. Wei Y, Xia W, Zhang Z, Liu J, Wang H, Adsay NV, Albarracin C, Yu D, Abbruzzese JL, Mills GB, Bast RC, Hortobagyi GN, Hung MC. Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog. 2008 Sep; 47(9):701-6. PMID: 18176935; PMCID: PMC2580832.
      Citations: 119     Fields:    Translation:Humans
    762. Short JD, Houston KD, Dere R, Cai SL, Kim J, Johnson CL, Broaddus RR, Shen J, Miyamoto S, Tamanoi F, Kwiatkowski D, Mills GB, Walker CL. AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res. 2008 Aug 15; 68(16):6496-506. PMID: 18701472; PMCID: PMC3011867.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    763. Grote T, Siwak DR, Fritsche HA, Joy C, Mills GB, Simeone D, Whitcomb DC, Logsdon CD. Validation of reverse phase protein array for practical screening of potential biomarkers in serum and plasma: accurate detection of CA19-9 levels in pancreatic cancer. Proteomics. 2008 Aug; 8(15):3051-60. PMID: 18615426; PMCID: PMC2992687.
      Citations: 34     Fields:    Translation:Humans
    764. Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Mills GB, Hennessy BT, Bernards R. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res. 2008 Aug 01; 68(15):6084-91. PMID: 18676830; PMCID: PMC2680495.
      Citations: 498     Fields:    Translation:Humans
    765. Yokoyama T, Iwado E, Kondo Y, Aoki H, Hayashi Y, Georgescu MM, Sawaya R, Hess KR, Mills GB, Kawamura H, Hashimoto Y, Urata Y, Fujiwara T, Kondo S. Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells. Gene Ther. 2008 Sep; 15(17):1233-9. PMID: 18580968.
      Citations: 41     Fields:    Translation:AnimalsCells
    766. Hasegawa Y, Murph M, Yu S, Tigyi G, Mills GB. Lysophosphatidic acid (LPA)-induced vasodilator-stimulated phosphoprotein mediates lamellipodia formation to initiate motility in PC-3 prostate cancer cells. Mol Oncol. 2008 Jun; 2(1):54-69. PMID: 19081821; PMCID: PMC2597858.
      Citations: 18     Fields:    Translation:HumansCells
    767. Nanjundan M, Cheng KW, Zhang F, Lahad J, Kuo WL, Schmandt R, Smith-McCune K, Fishman D, Gray JW, Mills GB. Overexpression of SnoN/SkiL, amplified at the 3q26.2 locus, in ovarian cancers: a role in ovarian pathogenesis. Mol Oncol. 2008 Aug; 2(2):164-81. PMID: 19383336; PMCID: PMC2598416.
      Citations: 17     Fields:    Translation:HumansCells
    768. Metcalfe KA, Birenbaum-Carmeli D, Lubinski J, Gronwald J, Lynch H, Moller P, Ghadirian P, Foulkes WD, Klijn J, Friedman E, Kim-Sing C, Ainsworth P, Rosen B, Domchek S, Wagner T, Tung N, Manoukian S, Couch F, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group. International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers. Int J Cancer. 2008 May 01; 122(9):2017-22. PMID: 18196574; PMCID: PMC2936778.
      Citations: 110     Fields:    Translation:HumansPHPublic Health
    769. Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN, Stanbridge EJ, Lee EY. Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors. Cancer Res. 2008 May 01; 68(9):3243-50. PMID: 18451150; PMCID: PMC2929908.
      Citations: 139     Fields:    Translation:AnimalsCells
    770. Murph MM, Nguyen GH, Radhakrishna H, Mills GB. Sharpening the edges of understanding the structure/function of the LPA1 receptor: expression in cancer and mechanisms of regulation. Biochim Biophys Acta. 2008 Sep; 1781(9):547-57. PMID: 18501205; PMCID: PMC2565514.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    771. Zhu QS, Ren W, Korchin B, Lahat G, Dicker A, Lu Y, Mills G, Pollock RE, Lev D. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer Res. 2008 Apr 15; 68(8):2895-903. PMID: 18413758; PMCID: PMC4174465.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    772. Amos CI, Wu X, Broderick P, Gorlov IP, Gu J, Eisen T, Dong Q, Zhang Q, Gu X, Vijayakrishnan J, Sullivan K, Matakidou A, Wang Y, Mills G, Doheny K, Tsai YY, Chen WV, Shete S, Spitz MR, Houlston RS. Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet. 2008 May; 40(5):616-22. PMID: 18385676; PMCID: PMC2713680.
      Citations: 671     Fields:    Translation:HumansCells
    773. Liu S, Fang X, Hall H, Yu S, Smith D, Lu Z, Fang D, Liu J, Stephens LC, Woodgett JR, Mills GB. Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5248-53. PMID: 18367674; PMCID: PMC2278194.
      Citations: 11     Fields:    Translation:AnimalsCells
    774. Raphael BJ, Volik S, Yu P, Wu C, Huang G, Linardopoulou EV, Trask BJ, Waldman F, Costello J, Pienta KJ, Mills GB, Bajsarowicz K, Kobayashi Y, Sridharan S, Paris PL, Tao Q, Aerni SJ, Brown RP, Bashir A, Gray JW, Cheng JF, de Jong P, Nefedov M, Ried T, Padilla-Nash HM, Collins CC. A sequence-based survey of the complex structural organization of tumor genomes. Genome Biol. 2008; 9(3):R59. PMID: 18364049; PMCID: PMC2397511.
      Citations: 21     Fields:    Translation:HumansCells
    775. Astanehe A, Arenillas D, Wasserman WW, Leung PC, Dunn SE, Davies BR, Mills GB, Auersperg N. Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer. J Cell Sci. 2008 Mar 01; 121(Pt 5):664-74. PMID: 18270270.
      Citations: 37     Fields:    Translation:HumansCells
    776. Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, Yokoyama T, Hollingsworth EF, Kobayashi R, Hess K, Shinojima N, Shingu T, Tamada Y, Zhang L, Conrad C, Bogler O, Mills G, Sawaya R, Kondo S. Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. Autophagy. 2008 May; 4(4):467-75. PMID: 18259115.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    777. Ji Y, Lu Y, Mills GB. Bayesian models based on test statistics for multiple hypothesis testing problems. Bioinformatics. 2008 Apr 01; 24(7):943-9. PMID: 18245123.
      Citations: 2     Fields:    
    778. Aguilar-Arevalo AA, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Link JM, Liu Y, Louis WC, Mahn KB, Marsh W, Martin PS, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nienaber P, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED, MiniBooNE Collaboration. Measurement of muon neutrino quasielastic scattering on carbon. Phys Rev Lett. 2008 Jan 25; 100(3):032301. PMID: 18232974.
      Citations: 1     Fields:    
    779. Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, Cheng X, Chang KJ, Hsiao CD, Tsai FJ, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol. 2008 Feb; 10(2):138-48. PMID: 18204439; PMCID: PMC2376808.
      Citations: 324     Fields:    Translation:HumansAnimalsCells
    780. Muller M, Obeyesekere M, Mills GB, Ram PT. Network topology determines dynamics of the mammalian MAPK1,2 signaling network: bifan motif regulation of C-Raf and B-Raf isoforms by FGFR and MC1R. FASEB J. 2008 May; 22(5):1393-403. PMID: 18171696.
      Citations: 10     Fields:    Translation:HumansCells
    781. Garlich JR, De P, Dey N, Su JD, Peng X, Miller A, Murali R, Lu Y, Mills GB, Kundra V, Shu HK, Peng Q, Durden DL. A vascular targeted pan phosphoinositide 3-kinase inhibitor prodrug, SF1126, with antitumor and antiangiogenic activity. Cancer Res. 2008 Jan 01; 68(1):206-15. PMID: 18172313.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    782. Hennessy BT, Murph M, Nanjundan M, Carey M, Auersperg N, Almeida J, Coombes KR, Liu J, Lu Y, Gray JW, Mills GB. Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead. Adv Exp Med Biol. 2008; 617:23-40. PMID: 18497028; PMCID: PMC2844243.
      Citations: 7     Fields:    Translation:HumansAnimals
    783. Murph MM, Smith DL, Hennessy B, Lu Y, Joy C, Coombes KR, Mills GB. Individualized molecular medicine: linking functional proteomics to select therapeutics targeting the PI3K pathway for specific patients. Adv Exp Med Biol. 2008; 622:183-95. PMID: 18546628.
      Citations: 6     Fields:    Translation:Humans
    784. Ashworth A, Balkwill F, Bast RC, Berek JS, Kaye A, Boyd JA, Mills G, Weinstein JN, Woolley K, Workman P. Opportunities and challenges in ovarian cancer research, a perspective from the 11th Ovarian cancer action/HHMT Forum, Lake Como, March 2007. Gynecol Oncol. 2008 Mar; 108(3):652-7. PMID: 18096210.
      Citations: 10     Fields:    Translation:Humans
    785. Hennessy BT, Lu Y, Poradosu E, Yu Q, Yu S, Hall H, Carey MS, Ravoori M, Gonzalez-Angulo AM, Birch R, Henderson IC, Kundra V, Mills GB. Pharmacodynamic markers of perifosine efficacy. Clin Cancer Res. 2007 Dec 15; 13(24):7421-31. PMID: 18094426.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    786. Gajewiak J, Tsukahara R, Tsukahara T, Fujiwara Y, Yu S, Lu Y, Murph M, Mills GB, Tigyi G, Prestwich GD. Alkoxymethylenephosphonate analogues of (Lyso) phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor. ChemMedChem. 2007 Dec; 2(12):1789-98. PMID: 17952880.
      Citations: 7     Fields:    Translation:HumansCells
    787. Murph M, Mills GB. Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Rev Mol Med. 2007 Oct 15; 9(28):1-18. PMID: 17935635.
      Citations: 35     Fields:    Translation:Cells
    788. Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 2007 Oct; 12(4):395-402. PMID: 17936563.
      Citations: 657     Fields:    Translation:HumansCellsCTClinical Trials
    789. Guan Y, Kuo WL, Stilwell JL, Takano H, Lapuk AV, Fridlyand J, Mao JH, Yu M, Miller MA, Santos JL, Kalloger SE, Carlson JW, Ginzinger DG, Celniker SE, Mills GB, Huntsman DG, Gray JW. Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res. 2007 Oct 01; 13(19):5745-55. PMID: 17908964.
      Citations: 194     Fields:    Translation:HumansCells
    790. Lu CH, Wyszomierski SL, Tseng LM, Sun MH, Lan KH, Neal CL, Mills GB, Hortobagyi GN, Esteva FJ, Yu D. Preclinical testing of clinically applicable strategies for overcoming trastuzumab resistance caused by PTEN deficiency. Clin Cancer Res. 2007 Oct 01; 13(19):5883-8. PMID: 17908983.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    791. Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell. 2007 Oct; 13(4):496-510. PMID: 17925226.
      Citations: 194     Fields:    Translation:HumansAnimalsCells
    792. Fujiwara K, Iwado E, Mills GB, Sawaya R, Kondo S, Kondo Y. Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy. Int J Oncol. 2007 Oct; 31(4):753-60. PMID: 17786305.
      Citations: 60     Fields:    Translation:HumansCells
    793. Lu Y, Li X, Liang K, Luwor R, Siddik ZH, Mills GB, Mendelsohn J, Fan Z. Epidermal growth factor receptor (EGFR) ubiquitination as a mechanism of acquired resistance escaping treatment by the anti-EGFR monoclonal antibody cetuximab. Cancer Res. 2007 Sep 01; 67(17):8240-7. PMID: 17804738.
      Citations: 79     Fields:    Translation:HumansCells
    794. Xu ZX, Liang J, Haridas V, Gaikwad A, Connolly FP, Mills GB, Gutterman JU. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ. 2007 Nov; 14(11):1948-57. PMID: 17690712.
      Citations: 36     Fields:    Translation:HumansCells
    795. Estrella VC, Eder AM, Liu S, Pustilnik TB, Tabassam FH, Claret FX, Gallick GE, Mills GB, Wiener JR. Lysophosphatidic acid induction of urokinase plasminogen activator secretion requires activation of the p38MAPK pathway. Int J Oncol. 2007 Aug; 31(2):441-9. PMID: 17611702.
      Citations: 15     Fields:    Translation:HumansCells
    796. Brugge J, Hung MC, Mills GB. A new mutational AKTivation in the PI3K pathway. Cancer Cell. 2007 Aug; 12(2):104-7. PMID: 17692802.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    797. Chu I, Arnaout A, Loiseau S, Sun J, Seth A, McMahon C, Chun K, Hennessy B, Mills GB, Nawaz Z, Slingerland JM. Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer. J Clin Invest. 2007 Aug; 117(8):2205-15. PMID: 17627304; PMCID: PMC1906730.
      Citations: 49     Fields:    Translation:HumansCells
    798. Hu J, He X, Baggerly KA, Coombes KR, Hennessy BT, Mills GB. Non-parametric quantification of protein lysate arrays. Bioinformatics. 2007 Aug 01; 23(15):1986-94. PMID: 17599930.
      Citations: 129     Fields:    
    799. Yamasaki F, Johansen MJ, Zhang D, Krishnamurthy S, Felix E, Bartholomeusz C, Aguilar RJ, Kurisu K, Mills GB, Hortobagyi GN, Ueno NT. Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt. Cancer Res. 2007 Jun 15; 67(12):5779-88. PMID: 17575145.
      Citations: 47     Fields:    Translation:HumansCells
    800. Aguilar-Arevalo AA, Bazarko AO, Brice SJ, Brown BC, Bugel L, Cao J, Coney L, Conrad JM, Cox DC, Curioni A, Djurcic Z, Finley DA, Fleming BT, Ford R, Garcia FG, Garvey GT, Green C, Green JA, Hart TL, Hawker E, Imlay R, Johnson RA, Kasper P, Katori T, Kobilarcik T, Kourbanis I, Koutsoliotas S, Laird EM, Link JM, Liu Y, Louis WC, Mahn KB, Marsh W, Martin PS, McGregor G, Metcalf W, Meyers PD, Mills F, Mills GB, Monroe J, Moore CD, Nelson RH, Nienaber P, Ouedraogo S, Patterson RB, Perevalov D, Polly CC, Prebys E, Raaf JL, Ray H, Roe BP, Russell AD, Sandberg V, Schirato R, Schmitz D, Shaevitz MH, Shoemaker FC, Smith D, Sorel M, Spentzouris P, Stancu I, Stefanski RJ, Sung M, Tanaka HA, Tayloe R, Tzanov M, Van de Water R, Wascko MO, White DH, Wilking MJ, Yang HJ, Zeller GP, Zimmerman ED, MiniBooNE Collaboration. Search for electron neutrino appearance at the Delta m2 approximately 1 eV2 scale. Phys Rev Lett. 2007 Jun 08; 98(23):231801. PMID: 17677898.
      Citations: 3     Fields:    
    801. Aoki H, Iwado E, Eller MS, Kondo Y, Fujiwara K, Li GZ, Hess KR, Siwak DR, Sawaya R, Mills GB, Gilchrest BA, Kondo S. Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cells. FASEB J. 2007 Sep; 21(11):2918-30. PMID: 17449721.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    802. Nanjundan M, Nakayama Y, Cheng KW, Lahad J, Liu J, Lu K, Kuo WL, Smith-McCune K, Fishman D, Gray JW, Mills GB. Amplification of MDS1/EVI1 and EVI1, located in the 3q26.2 amplicon, is associated with favorable patient prognosis in ovarian cancer. Cancer Res. 2007 Apr 01; 67(7):3074-84. PMID: 17409414.
      Citations: 72     Fields:    Translation:HumansCells
    803. Zhang Q, Bhola NE, Lui VW, Siwak DR, Thomas SM, Gubish CT, Siegfried JM, Mills GB, Shin D, Grandis JR. Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer. Mol Cancer Ther. 2007 Apr; 6(4):1414-24. PMID: 17431120.
      Citations: 40     Fields:    Translation:HumansCells
    804. Amit I, Citri A, Shay T, Lu Y, Katz M, Zhang F, Tarcic G, Siwak D, Lahad J, Jacob-Hirsch J, Amariglio N, Vaisman N, Segal E, Rechavi G, Alon U, Mills GB, Domany E, Yarden Y. A module of negative feedback regulators defines growth factor signaling. Nat Genet. 2007 Apr; 39(4):503-12. PMID: 17322878.
      Citations: 236     Fields:    Translation:HumansCells
    805. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem. 2007 Apr 13; 282(15):11221-9. PMID: 17287208; PMCID: PMC1850976.
      Citations: 411     Fields:    Translation:HumansAnimalsCells
    806. Badour K, McGavin MK, Zhang J, Freeman S, Vieira C, Filipp D, Julius M, Mills GB, Siminovitch KA. Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc Natl Acad Sci U S A. 2007 Jan 30; 104(5):1593-8. PMID: 17242350; PMCID: PMC1785243.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    807. Liang J, Shao SH, Xu ZX, Hennessy B, Ding Z, Larrea M, Kondo S, Dumont DJ, Gutterman JU, Walker CL, Slingerland JM, Mills GB. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol. 2007 Feb; 9(2):218-24. PMID: 17237771.
      Citations: 408     Fields:    Translation:HumansCells
    808. Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W, Mills GB, Ohsaka A, Nagaoka I, Andreeff M, Konopleva M. Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res. 2007 Jan 15; 67(2):684-94. PMID: 17234779.
      Citations: 82     Fields:    Translation:HumansCells
    809. Bast RC, Brewer M, Zou C, Hernandez MA, Daley M, Ozols R, Lu K, Lu Z, Badgwell D, Mills GB, Skates S, Zhang Z, Chan D, Lokshin A, Yu Y. Prevention and early detection of ovarian cancer: mission impossible? Recent Results Cancer Res. 2007; 174:91-100. PMID: 17302189.
      Citations: 35     Fields:    Translation:HumansAnimalsPHPublic Health
    810. Murph M, Tanaka T, Pang J, Felix E, Liu S, Trost R, Godwin AK, Newman R, Mills G. Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis. Methods Enzymol. 2007; 433:1-25. PMID: 17954226.
      Citations: 34     Fields:    Translation:HumansPHPublic Health
    811. Younes MN, Yigitbasi OG, Yazici YD, Jasser SA, Bucana CD, El-Naggar AK, Mills GB, Myers JN. Effects of the integrin-linked kinase inhibitor QLT0267 on squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg. 2007 Jan; 133(1):15-23. PMID: 17224516.
      Citations: 17     Fields:    Translation:HumansCells
    812. Acconcia F, Manavathi B, Mascarenhas J, Talukder AH, Mills G, Kumar R. An inherent role of integrin-linked kinase-estrogen receptor alpha interaction in cell migration. Cancer Res. 2006 Nov 15; 66(22):11030-8. PMID: 17108142.
      Citations: 16     Fields:    Translation:HumansCells
    813. Murph M, Tanaka T, Liu S, Mills GB. Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer. Clin Cancer Res. 2006 Nov 15; 12(22):6598-602. PMID: 17121877.
      Citations: 22     Fields:    Translation:HumansAnimals
    814. Stemke-Hale K, Hennessy B, Mills GB, Mitra R. Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein. Curr Oncol Rep. 2006 Nov; 8(6):484-91. PMID: 17040626.
      Citations: 5     Fields:    Translation:HumansCells
    815. Ping B, He X, Xia W, Lee DF, Wei Y, Yu D, Mills G, Shi D, Hung MC. Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. Int J Oncol. 2006 Nov; 29(5):1103-10. PMID: 17016640.
      Citations: 10     Fields:    Translation:HumansCells
    816. Davies M, Hennessy B, Mills GB. Point mutations of protein kinases and individualised cancer therapy. Expert Opin Pharmacother. 2006 Nov; 7(16):2243-61. PMID: 17059381.
      Citations: 9     Fields:    Translation:Humans
    817. Nanjundan M, Zhang F, Schmandt R, Smith-McCune K, Mills GB. Identification of a novel splice variant of AML1b in ovarian cancer patients conferring loss of wild-type tumor suppressive functions. Oncogene. 2007 Apr 19; 26(18):2574-84. PMID: 17072347.
      Citations: 6     Fields:    Translation:HumansCells
    818. Yang G, Rosen DG, Zhang Z, Bast RC, Mills GB, Colacino JA, Mercado-Uribe I, Liu J. The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16472-7. PMID: 17060621; PMCID: PMC1637606.
      Citations: 149     Fields:    Translation:HumansCells
    819. Ding Z, Liang J, Lu Y, Yu Q, Songyang Z, Lin SY, Mills GB. A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15014-9. PMID: 17018644; PMCID: PMC1636760.
      Citations: 46     Fields:    Translation:HumansCells
    820. Tibes R, Qiu Y, Lu Y, Hennessy B, Andreeff M, Mills GB, Kornblau SM. Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells. Mol Cancer Ther. 2006 Oct; 5(10):2512-21. PMID: 17041095.
      Citations: 400     Fields:    Translation:HumansCells
    821. Iwamaru A, Kondo Y, Iwado E, Aoki H, Fujiwara K, Yokoyama T, Mills GB, Kondo S. Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells. Oncogene. 2007 Mar 22; 26(13):1840-51. PMID: 17001313.
      Citations: 56     Fields:    Translation:HumansCells
    822. Almeida JS, Chen C, Gorlitsky R, Stanislaus R, Aires-de-Sousa M, Bohn A, Chang A, Zhang F, Mitra R, Mills GB, Wang X, Deus HF, Eleut?rio P, Carri?o J, Maretzek A. Data integration gets 'Sloppy'. Nat Biotechnol. 2006 Sep; 24(9):1070-1. PMID: 16964209.
      Citations: 10     Fields:    
    823. Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 Aug; 10(2):145-57. PMID: 16872911; PMCID: PMC1557410.
      Citations: 79     Fields:    Translation:HumansCells
    824. Yang G, Rosen DG, Mercado-Uribe I, Colacino JA, Mills GB, Bast RC, Zhou C, Liu J. Knockdown of p53 combined with expression of the catalytic subunit of telomerase is sufficient to immortalize primary human ovarian surface epithelial cells. Carcinogenesis. 2007 Jan; 28(1):174-82. PMID: 16829690.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    825. Liang K, Lu Y, Li X, Zeng X, Glazer RI, Mills GB, Fan Z. Differential roles of phosphoinositide-dependent protein kinase-1 and akt1 expression and phosphorylation in breast cancer cell resistance to Paclitaxel, Doxorubicin, and gemcitabine. Mol Pharmacol. 2006 Sep; 70(3):1045-52. PMID: 16782806.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    826. Baker DL, Fujiwara Y, Pigg KR, Tsukahara R, Kobayashi S, Murofushi H, Uchiyama A, Murakami-Murofushi K, Koh E, Bandle RW, Byun HS, Bittman R, Fan D, Murph M, Mills GB, Tigyi G. Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. J Biol Chem. 2006 Aug 11; 281(32):22786-93. PMID: 16782709; PMCID: PMC3505596.
      Citations: 60     Fields:    Translation:HumansCells
    827. Kelloff GJ, Lippman SM, Dannenberg AJ, Sigman CC, Pearce HL, Reid BJ, Szabo E, Jordan VC, Spitz MR, Mills GB, Papadimitrakopoulou VA, Lotan R, Aggarwal BB, Bresalier RS, Kim J, Arun B, Lu KH, Thomas ME, Rhodes HE, Brewer MA, Follen M, Shin DM, Parnes HL, Siegfried JM, Evans AA, Blot WJ, Chow WH, Blount PL, Maley CC, Wang KK, Lam S, Lee JJ, Dubinett SM, Engstrom PF, Meyskens FL, O'Shaughnessy J, Hawk ET, Levin B, Nelson WG, Hong WK, AACR Task Force on Cancer Prevention. Progress in chemoprevention drug development: the promise of molecular biomarkers for prevention of intraepithelial neoplasia and cancer--a plan to move forward. Clin Cancer Res. 2006 Jun 15; 12(12):3661-97. PMID: 16778094.
      Citations: 88     Fields:    Translation:HumansCells
    828. Rosen DG, Yang G, Deavers MT, Malpica A, Kavanagh JJ, Mills GB, Liu J. Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma. Cancer. 2006 May 01; 106(9):1925-32. PMID: 16568440.
      Citations: 36     Fields:    Translation:Humans
    829. Zhang Q, Thomas SM, Lui VW, Xi S, Siegfried JM, Fan H, Smithgall TE, Mills GB, Grandis JR. Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation. Proc Natl Acad Sci U S A. 2006 May 02; 103(18):6901-6. PMID: 16641105; PMCID: PMC1458991.
      Citations: 73     Fields:    Translation:HumansCells
    830. Hennessy BT, Nanjundan M, Cheng KW, Nolden L, Mills GB. Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer. Eur J Hum Genet. 2006 Apr; 14(4):381-3. PMID: 16418735.
      Citations: 8     Fields:    Translation:HumansCells
    831. Zeng Z, Samudio IJ, Zhang W, Estrov Z, Harris D, Frolova O, Hail N, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M, Pelicano H. Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia. Cancer Res. 2006 Apr 01; 66(7):3737-46. PMID: 16585200.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    832. Friedman E, Kotsopoulos J, Lubinski J, Lynch HT, Ghadirian P, Neuhausen SL, Isaacs C, Weber B, Foulkes WD, Moller P, Rosen B, Kim-Sing C, Gershoni-Baruch R, Ainsworth P, Daly M, Tung N, Eisen A, Olopade OI, Karlan B, Saal HM, Garber JE, Rennert G, Gilchrist D, Eng C, Offit K, Osborne M, Sun P, Narod SA, Hereditary Breast Cancer Clinical Study Group. Spontaneous and therapeutic abortions and the risk of breast cancer among BRCA mutation carriers. Breast Cancer Res. 2006; 8(2):R15. PMID: 16563180; PMCID: PMC1557713.
      Citations: 21     Fields:    Translation:Humans
    833. Li X, Lu Y, Jin W, Liang K, Mills GB, Fan Z. Autophosphorylation of Akt at threonine 72 and serine 246. A potential mechanism of regulation of Akt kinase activity. J Biol Chem. 2006 May 12; 281(19):13837-13843. PMID: 16549426.
      Citations: 12     Fields:    Translation:HumansCells
    834. Balkwill FR, Ashworth A, Bast RC, Berek JS, Boyd J, Disis ML, Gabra H, Gore ME, Hamilton TC, Jacobs IJ, Kaye SB, Kohn EC, Mills GB, Urban ND. 10th Biennial Helene Harris Memorial Trust meeting. Cancer Res. 2006 Mar 15; 66(6):2904-6. PMID: 16540635.
      Citations:    Fields:    Translation:HumansAnimals
    835. Visentin B, Vekich JA, Sibbald BJ, Cavalli AL, Moreno KM, Matteo RG, Garland WA, Lu Y, Yu S, Hall HS, Kundra V, Mills GB, Sabbadini RA. Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell. 2006 Mar; 9(3):225-38. PMID: 16530706.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    836. Koul D, Shen R, Bergh S, Sheng X, Shishodia S, Lafortune TA, Lu Y, de Groot JF, Mills GB, Yung WK. Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma. Mol Cancer Ther. 2006 Mar; 5(3):637-44. PMID: 16546978.
      Citations: 38     Fields:    Translation:HumansCells
    837. Lee Z, Swaby RF, Liang Y, Yu S, Liu S, Lu KH, Bast RC, Mills GB, Fang X. Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer. Cancer Res. 2006 Mar 01; 66(5):2740-8. PMID: 16510595.
      Citations: 39     Fields:    Translation:HumansCells
    838. Qian L, Xu Y, Simper T, Jiang G, Aoki J, Umezu-Goto M, Arai H, Yu S, Mills GB, Tsukahara R, Makarova N, Fujiwara Y, Tigyi G, Prestwich GD. Phosphorothioate analogues of alkyl lysophosphatidic acid as LPA3 receptor-selective agonists. ChemMedChem. 2006 Mar; 1(3):376-83. PMID: 16892372.
      Citations: 11     Fields:    Translation:AnimalsCells
    839. Hennessy BT, Mills GB. Ovarian cancer: homeobox genes, autocrine/paracrine growth, and kinase signaling. Int J Biochem Cell Biol. 2006; 38(9):1450-6. PMID: 16682246.
      Citations: 7     Fields:    Translation:HumansCells
    840. O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D, Lane H, Hofmann F, Hicklin DJ, Ludwig DL, Baselga J, Rosen N. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006 Feb 01; 66(3):1500-8. PMID: 16452206; PMCID: PMC3193604.
      Citations: 1153     Fields:    Translation:HumansCells
    841. Georgakis GV, Li Y, Rassidakis GZ, Medeiros LJ, Mills GB, Younes A. Inhibition of the phosphatidylinositol-3 kinase/Akt promotes G1 cell cycle arrest and apoptosis in Hodgkin lymphoma. Br J Haematol. 2006 Feb; 132(4):503-11. PMID: 16412023.
      Citations: 34     Fields:    Translation:HumansCells
    842. Mandal M, Younes M, Swan EA, Jasser SA, Doan D, Yigitbasi O, McMurphey A, Ludwick J, El-Naggar AK, Bucana C, Mills GB, Myers JN. The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. Oral Oncol. 2006 Apr; 42(4):430-9. PMID: 16442835; PMCID: PMC1414640.
      Citations: 26     Fields:    Translation:HumansCells
    843. Barcenas CH, Hosain GM, Arun B, Zong J, Zhou X, Chen J, Cortada JM, Mills GB, Tomlinson GE, Miller AR, Strong LC, Amos CI. Assessing BRCA carrier probabilities in extended families. J Clin Oncol. 2006 Jan 20; 24(3):354-60. PMID: 16421416.
      Citations: 33     Fields:    Translation:Humans
    844. Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov. 2005 Dec; 4(12):988-1004. PMID: 16341064.
      Citations: 805     Fields:    Translation:HumansAnimalsCells
    845. Zhu QS, Xia L, Mills GB, Lowell CA, Touw IP, Corey SJ. G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood. 2006 Mar 01; 107(5):1847-56. PMID: 16282349; PMCID: PMC1895701.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    846. Harrison RM, Yin J, Tilling RM, Cai X, Seakins PW, Hopkins JR, Lansley DL, Lewis AC, Hunter MC, Heard DE, Carpenter LJ, Creasey DJ, Lee JD, Pilling MJ, Carslaw N, Emmerson KM, Redington A, Derwent RG, Ryall D, Mills G, Penkett SA. Measurement and modelling of air pollution and atmospheric chemistry in the U.K. West Midlands conurbation: overview of the PUMA Consortium project. Sci Total Environ. 2006 May 01; 360(1-3):5-25. PMID: 16289266.
      Citations: 4     Fields:    Translation:PHPublic Health
    847. Koul D, Shen R, Bergh S, Lu Y, de Groot JF, Liu TJ, Mills GB, Yung WK. Targeting integrin-linked kinase inhibits Akt signaling pathways and decreases tumor progression of human glioblastoma. Mol Cancer Ther. 2005 Nov; 4(11):1681-8. PMID: 16275989.
      Citations: 35     Fields:    Translation:HumansCells
    848. Huang G, Krig S, Kowbel D, Xu H, Hyun B, Volik S, Feuerstein B, Mills GB, Stokoe D, Yaswen P, Collins C. ZNF217 suppresses cell death associated with chemotherapy and telomere dysfunction. Hum Mol Genet. 2005 Nov 01; 14(21):3219-25. PMID: 16203743.
      Citations: 30     Fields:    Translation:HumansCells
    849. Marquez RT, Baggerly KA, Patterson AP, Liu J, Broaddus R, Frumovitz M, Atkinson EN, Smith DI, Hartmann L, Fishman D, Berchuck A, Whitaker R, Gershenson DM, Mills GB, Bast RC, Lu KH. Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon. Clin Cancer Res. 2005 Sep 01; 11(17):6116-26. PMID: 16144910.
      Citations: 119     Fields:    Translation:Humans
    850. Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP, Kango-Singh M, Lu KH, Warneke CL, Atkinson EN, Bedrosian I, Keyomarsi K, Kuo WL, Gray JW, Yin JC, Liu J, Halder G, Mills GB. Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12519-24. PMID: 16116079; PMCID: PMC1188258.
      Citations: 103     Fields:    Translation:HumansAnimals
    851. Younes MN, Kim S, Yigitbasi OG, Mandal M, Jasser SA, Dakak Yazici Y, Schiff BA, El-Naggar A, Bekele BN, Mills GB, Myers JN. Integrin-linked kinase is a potential therapeutic target for anaplastic thyroid cancer. Mol Cancer Ther. 2005 Aug; 4(8):1146-56. PMID: 16093430.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    852. Nishimoto A, Yu Y, Lu Z, Mao X, Ren Z, Watowich SS, Mills GB, Liao WS, Chen X, Bast RC, Luo RZ. A Ras homologue member I directly inhibits signal transducers and activators of transcription 3 translocation and activity in human breast and ovarian cancer cells. Cancer Res. 2005 Aug 01; 65(15):6701-10. PMID: 16061651.
      Citations: 14     Fields:    Translation:HumansCells
    853. Liu Z, Wang LE, Wang L, Lu KH, Mills GB, Bondy ML, Wei Q. Methylation and messenger RNA expression of p15INK4b but not p16INK4a are independent risk factors for ovarian cancer. Clin Cancer Res. 2005 Jul 01; 11(13):4968-76. PMID: 16000597.
      Citations: 11     Fields:    Translation:HumansCells
    854. Rosen DG, Ludes-Meyers JH, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB, Aldaz CM, Nunez MI, Abba MC. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer. 2005 Jun 27; 5:64. PMID: 15982416; PMCID: PMC1173095.
      Citations: 39     Fields:    Translation:Humans
    855. Lahad JP, Mills GB, Coombes KR. Stem cell-ness: a "magic marker" for cancer. J Clin Invest. 2005 Jun; 115(6):1463-7. PMID: 15931383; PMCID: PMC1137015.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    856. Mandal M, Kim S, Younes MN, Jasser SA, El-Naggar AK, Mills GB, Myers JN. The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. Br J Cancer. 2005 May 23; 92(10):1899-905. PMID: 15870708; PMCID: PMC2361761.
      Citations: 27     Fields:    Translation:HumansCells
    857. Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich GD. Structure-activity relationships of fluorinated lysophosphatidic acid analogues. J Med Chem. 2005 May 05; 48(9):3319-27. PMID: 15857137.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    858. Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB, Kondo S. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res. 2005 Apr 15; 65(8):3336-46. PMID: 15833867.
      Citations: 210     Fields:    Translation:HumansCells
    859. Cheng KW, Lahad JP, Gray JW, Mills GB. Emerging role of RAB GTPases in cancer and human disease. Cancer Res. 2005 Apr 01; 65(7):2516-9. PMID: 15805241.
      Citations: 89     Fields:    Translation:Humans
    860. Dong J, Peng J, Zhang H, Mondesire WH, Jian W, Mills GB, Hung MC, Meric-Bernstam F. Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. Cancer Res. 2005 Mar 01; 65(5):1961-72. PMID: 15753396.
      Citations: 40     Fields:    Translation:HumansCells
    861. Sheehan KM, Calvert VS, Kay EW, Lu Y, Fishman D, Espina V, Aquino J, Speer R, Araujo R, Mills GB, Liotta LA, Petricoin EF, Wulfkuhle JD. Use of reverse phase protein microarrays and reference standard development for molecular network analysis of metastatic ovarian carcinoma. Mol Cell Proteomics. 2005 Apr; 4(4):346-55. PMID: 15671044.
      Citations: 95     Fields:    Translation:HumansCells
    862. Spitz MR, Wu X, Mills G. Integrative epidemiology: from risk assessment to outcome prediction. J Clin Oncol. 2005 Jan 10; 23(2):267-75. PMID: 15637390.
      Citations: 20     Fields:    Translation:HumansPHPublic Health
    863. Cheng KW, Lu Y, Mills GB. Assay of Rab25 function in ovarian and breast cancers. Methods Enzymol. 2005; 403:202-15. PMID: 16473588.
      Citations: 28     Fields:    Translation:HumansCells
    864. Meric-Bernstam F, Mills GB. Mammalian target of rapamycin. Semin Oncol. 2004 Dec; 31(6 Suppl 16):10-7; discussion 33. PMID: 15799239.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    865. Le XF, Lammayot A, Gold D, Lu Y, Mao W, Chang T, Patel A, Mills GB, Bast RC. Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling. J Biol Chem. 2005 Jan 21; 280(3):2092-104. PMID: 15504738.
      Citations: 25     Fields:    Translation:HumansCells
    866. Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu KH, Fishman D, Gray JW, Mills GB. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med. 2004 Nov; 10(11):1251-6. PMID: 15502842.
      Citations: 211     Fields:    Translation:HumansAnimalsCells
    867. Mondesire WH, Jian W, Zhang H, Ensor J, Hung MC, Mills GB, Meric-Bernstam F. Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells. Clin Cancer Res. 2004 Oct 15; 10(20):7031-42. PMID: 15501983.
      Citations: 115     Fields:    Translation:HumansCells
    868. Liu S, Yu S, Hasegawa Y, Lapushin R, Xu HJ, Woodgett JR, Mills GB, Fang X. Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. J Biol Chem. 2004 Dec 03; 279(49):51075-81. PMID: 15466414; PMCID: PMC5328675.
      Citations: 19     Fields:    Translation:AnimalsCells
    869. Umezu-Goto M, Tanyi J, Lahad J, Liu S, Yu S, Lapushin R, Hasegawa Y, Lu Y, Trost R, Bevers T, Jonasch E, Aldape K, Liu J, James RD, Ferguson CG, Xu Y, Prestwich GD, Mills GB. Lysophosphatidic acid production and action: validated targets in cancer? J Cell Biochem. 2004 Aug 15; 92(6):1115-40. PMID: 15258897.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    870. Lu KH, Patterson AP, Wang L, Marquez RT, Atkinson EN, Baggerly KA, Ramoth LR, Rosen DG, Liu J, Hellstrom I, Smith D, Hartmann L, Fishman D, Berchuck A, Schmandt R, Whitaker R, Gershenson DM, Mills GB, Bast RC. Selection of potential markers for epithelial ovarian cancer with gene expression arrays and recursive descent partition analysis. Clin Cancer Res. 2004 May 15; 10(10):3291-300. PMID: 15161682.
      Citations: 172     Fields:    Translation:HumansCells
    871. Sellappan S, Grijalva R, Zhou X, Yang W, Eli MB, Mills GB, Yu D. Lineage infidelity of MDA-MB-435 cells: expression of melanocyte proteins in a breast cancer cell line. Cancer Res. 2004 May 15; 64(10):3479-85. PMID: 15150101.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    872. Cheng KW, Lahad JP, Mills GB. Analysis of molecular aberrations in ovarian cancer allows novel target identification. J Obstet Gynaecol Can. 2004 May; 26(5):461-74. PMID: 15151733.
      Citations:    Fields:    Translation:HumansCells
    873. Auerbach LB, Burman RL, Caldwell DO, Church ED, Cochran AK, Donahue JB, Fazely AR, Garvey GT, Gunasingha RM, Imlay RL, Kahrimanis G, Louis WC, Majkic R, Malik A, McIlhany KL, Metcalf WJ, Mills GB, Rupnik D, Sandberg VD, Smith D, Somodi RF, Stancu I, Strossman WD, Sung M, Tayloe R, VanDalen GJ, Vernon W, Wadia N, White DH, Yellin S, Yi H, LSND Collaboration. Search for pi(0)-->nu(mu)nu(mu) decays in the LSND detector. Phys Rev Lett. 2004 Mar 05; 92(9):091801. PMID: 15089459.
      Citations:    Fields:    
    874. Liu J, Yang G, Thompson-Lanza JA, Glassman A, Hayes K, Patterson A, Marquez RT, Auersperg N, Yu Y, Hahn WC, Mills GB, Bast RC. A genetically defined model for human ovarian cancer. Cancer Res. 2004 Mar 01; 64(5):1655-63. PMID: 14996724.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    875. Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, Mills GB, Hung MC, Meric-Bernstam F. Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res. 2004 Feb 01; 10(3):1013-23. PMID: 14871980.
      Citations: 114     Fields:    Translation:HumansCells
    876. Kohn EC, Lu Y, Wang H, Yu Q, Yu S, Hall H, Smith DL, Meric-Bernstam F, Hortobagyi GN, Mills GB. Molecular therapeutics: promise and challenges. Semin Oncol. 2004 Feb; 31(1 Suppl 3):39-53. PMID: 15052542.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    877. Zhao S, Konopleva M, Cabreira-Hansen M, Xie Z, Hu W, Milella M, Estrov Z, Mills GB, Andreeff M. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia. 2004 Feb; 18(2):267-75. PMID: 14628071.
      Citations: 43     Fields:    Translation:HumansCells
    878. Andreeff M, Milella M, Carter BZ, Tabe Y, Ricciardi MR, Sneed T, Ruvolo P, Contractor R, Tsao T, Schober W, Evans R, McQueen T, Zeng Z, Kornblau SM, McCubrey J, Estey E, Mills GB, Reed JC, Konopleva M. Targeted therapy of AML new concepts. Ann Hematol. 2004; 83 Suppl 1:S51-3. PMID: 15124670.
      Citations: 5     Fields:    Translation:HumansCells
    879. Qian L, Xu Y, Hasegawa Y, Aoki J, Mills GB, Prestwich GD. Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity. J Med Chem. 2003 Dec 18; 46(26):5575-8. PMID: 14667211.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    880. Fang X, Yu S, Bast RC, Liu S, Xu HJ, Hu SX, LaPushin R, Claret FX, Aggarwal BB, Lu Y, Mills GB. Mechanisms for lysophosphatidic acid-induced cytokine production in ovarian cancer cells. J Biol Chem. 2004 Mar 05; 279(10):9653-61. PMID: 14670967.
      Citations: 88     Fields:    Translation:HumansCells
    881. Kohn EC, Mills GB, Liotta L. Promising directions for the diagnosis and management of gynecological cancers. Int J Gynaecol Obstet. 2003 Oct; 83 Suppl 1:203-9. PMID: 14763176.
      Citations: 2     Fields:    Translation:Humans
    882. Mills GB, Kohn E, Lu Y, Eder A, Fang X, Wang H, Bast RC, Gray J, Jaffe R, Hortobagyi G. Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer. Semin Oncol. 2003 Oct; 30(5 Suppl 16):93-104. PMID: 14613030.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    883. Balkwill F, Bast RC, Berek J, Chenevix-Trench G, Gore M, Hamilton T, Jacobs I, Mills G, Souhami R, Urban N, Orsulic S, Smyth J, Ursulic S. Current research and treatment for epithelial ovarian cancer. A Position Paper from the Helene Harris Memorial Trust. Eur J Cancer. 2003 Sep; 39(13):1818-27. PMID: 12932658.
      Citations: 1     Fields:    Translation:Humans
    884. Clair T, Aoki J, Koh E, Bandle RW, Nam SW, Ptaszynska MM, Mills GB, Schiffmann E, Liotta LA, Stracke ML. Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate. Cancer Res. 2003 Sep 01; 63(17):5446-53. PMID: 14500380.
      Citations: 83     Fields:    Translation:AnimalsCells
    885. Tanyi JL, Hasegawa Y, Lapushin R, Morris AJ, Wolf JK, Berchuck A, Lu K, Smith DI, Kalli K, Hartmann LC, McCune K, Fishman D, Broaddus R, Cheng KW, Atkinson EN, Yamal JM, Bast RC, Felix EA, Newman RA, Mills GB. Role of decreased levels of lipid phosphate phosphatase-1 in accumulation of lysophosphatidic acid in ovarian cancer. Clin Cancer Res. 2003 Sep 01; 9(10 Pt 1):3534-45. PMID: 14506139.
      Citations: 36     Fields:    Translation:HumansCells
    886. Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer. 2003 Aug; 3(8):582-91. PMID: 12894246.
      Citations: 463     Fields:    Translation:HumansCells
    887. Lu Y, Yu Q, Liu JH, Zhang J, Wang H, Koul D, McMurray JS, Fang X, Yung WK, Siminovitch KA, Mills GB. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades. J Biol Chem. 2003 Oct 10; 278(41):40057-66. PMID: 12869565.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    888. Hu SX, Wang S, Wang JP, Mills GB, Zhou Y, Xu HJ. Expression of endogenous granzyme B in a subset of human primary breast carcinomas. Br J Cancer. 2003 Jul 07; 89(1):135-9. PMID: 12838314; PMCID: PMC2394226.
      Citations: 14     Fields:    Translation:HumansCells
    889. Shvartsman HS, Lu KH, Lee J, Lillie J, Deavers MT, Clifford S, Wolf JK, Mills GB, Bast RC, Gershenson DM, Schmandt R. Overexpression of kallikrein 10 in epithelial ovarian carcinomas. Gynecol Oncol. 2003 Jul; 90(1):44-50. PMID: 12821340.
      Citations: 10     Fields:    Translation:HumansCells
    890. Lu Y, Wang H, Mills GB. Targeting PI3K-AKT pathway for cancer therapy. Rev Clin Exp Hematol. 2003 Jun; 7(2):205-28. PMID: 14763163.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    891. Knuefermann C, Lu Y, Liu B, Jin W, Liang K, Wu L, Schmidt M, Mills GB, Mendelsohn J, Fan Z. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene. 2003 May 22; 22(21):3205-12. PMID: 12761490.
      Citations: 168     Fields:    Translation:HumansCells
    892. Luo RZ, Fang X, Marquez R, Liu SY, Mills GB, Liao WS, Yu Y, Bast RC. ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers. Oncogene. 2003 May 15; 22(19):2897-909. PMID: 12771940.
      Citations: 42     Fields:    Translation:HumansCells
    893. Bianco R, Shin I, Ritter CA, Yakes FM, Basso A, Rosen N, Tsurutani J, Dennis PA, Mills GB, Arteaga CL. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene. 2003 May 08; 22(18):2812-22. PMID: 12743604.
      Citations: 129     Fields:    Translation:HumansCells
    894. Lee HY, Srinivas H, Xia D, Lu Y, Superty R, LaPushin R, Gomez-Manzano C, Gal AM, Walsh GL, Force T, Ueki K, Mills GB, Kurie JM. Evidence that phosphatidylinositol 3-kinase- and mitogen-activated protein kinase kinase-4/c-Jun NH2-terminal kinase-dependent Pathways cooperate to maintain lung cancer cell survival. J Biol Chem. 2003 Jun 27; 278(26):23630-8. PMID: 12714585.
      Citations: 18     Fields:    Translation:HumansCells
    895. Liang K, Jin W, Knuefermann C, Schmidt M, Mills GB, Ang KK, Milas L, Fan Z. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Mol Cancer Ther. 2003 Apr; 2(4):353-60. PMID: 12700279.
      Citations: 35     Fields:    Translation:HumansCells
    896. Mansouri A, Ridgway LD, Korapati AL, Zhang Q, Tian L, Wang Y, Siddik ZH, Mills GB, Claret FX. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem. 2003 May 23; 278(21):19245-56. PMID: 12637505.
      Citations: 126     Fields:    Translation:HumansCells
    897. Tanyi JL, Morris AJ, Wolf JK, Fang X, Hasegawa Y, Lapushin R, Auersperg N, Sigal YJ, Newman RA, Felix EA, Atkinson EN, Mills GB. The human lipid phosphate phosphatase-3 decreases the growth, survival, and tumorigenesis of ovarian cancer cells: validation of the lysophosphatidic acid signaling cascade as a target for therapy in ovarian cancer. Cancer Res. 2003 Mar 01; 63(5):1073-82. PMID: 12615725.
      Citations: 54     Fields:    Translation:HumansCells
    898. Aytac U, Sato K, Yamochi T, Ohnuma K, Mills GB, Morimoto C, Dang NH. Effect of CD26/dipeptidyl peptidase IV on Jurkat sensitivity to G2/M arrest induced by topoisomerase II inhibitors. Br J Cancer. 2003 Feb 10; 88(3):455-62. PMID: 12569391; PMCID: PMC2747550.
      Citations: 6     Fields:    Translation:HumansCells
    899. Le XF, Hittelman WN, Liu J, McWatters A, Li C, Mills GB, Bast RC. Paclitaxel induces inactivation of p70 S6 kinase and phosphorylation of Thr421 and Ser424 via multiple signaling pathways in mitosis. Oncogene. 2003 Jan 30; 22(4):484-97. PMID: 12555062.
      Citations: 19     Fields:    Translation:HumansCells
    900. Hasegawa Y, Erickson JR, Goddard GJ, Yu S, Liu S, Cheng KW, Eder A, Bandoh K, Aoki J, Jarosz R, Schrier AD, Lynch KR, Mills GB, Fang X. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. J Biol Chem. 2003 Apr 04; 278(14):11962-9. PMID: 12554733.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    901. Cui X, Zhang P, Deng W, Oesterreich S, Lu Y, Mills GB, Lee AV. Insulin-like growth factor-I inhibits progesterone receptor expression in breast cancer cells via the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway: progesterone receptor as a potential indicator of growth factor activity in breast cancer. Mol Endocrinol. 2003 Apr; 17(4):575-88. PMID: 12554765.
      Citations: 81     Fields:    Translation:HumansCells
    902. Mills GB, Fang X, Lu Y, Hasegawa Y, Eder A, Tanyi J, Tabassam FH, Mao M, Wang H, Cheng KW, Nakayama Y, Kuo W, Erickson J, Gershenson D, Kohn EC, Jaffe R, Bast RC, Gray J. Specific keynote: molecular therapeutics in ovarian cancer. Gynecol Oncol. 2003 Jan; 88(1 Pt 2):S88-92; discussion S93-6. PMID: 12586094.
      Citations: 3     Fields:    Translation:HumansCells
    903. Wiener JR, Windham TC, Estrella VC, Parikh NU, Thall PF, Deavers MT, Bast RC, Mills GB, Gallick GE. Activated SRC protein tyrosine kinase is overexpressed in late-stage human ovarian cancers. Gynecol Oncol. 2003 Jan; 88(1):73-9. PMID: 12504632.
      Citations: 70     Fields:    Translation:HumansCells
    904. Liotta LA, Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C, Fishman DA, Kohn EC. General keynote: proteomic patterns in sera serve as biomarkers of ovarian cancer. Gynecol Oncol. 2003 Jan; 88(1 Pt 2):S25-8; discussion S37-42. PMID: 12586081.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    905. Gray JW, Suzuki S, Kuo WL, Polikoff D, Deavers M, Smith-McCune K, Berchuck A, Pinkel D, Albertson D, Mills GB. Specific keynote: genome copy number abnormalities in ovarian cancer. Gynecol Oncol. 2003 Jan; 88(1 Pt 2):S16-21; discussion S22-4. PMID: 12586079.
      Citations: 10     Fields:    Translation:HumansCells
    906. Bast RC, Mills GB. General keynote: molecular therapeutics and pharmocogenomics. Gynecol Oncol. 2003 Jan; 88(1 Pt 2):S84-7; discussion S93-6. PMID: 12586093.
      Citations:    Fields:    Translation:Humans
    907. Bondar VM, Sweeney-Gotsch B, Andreeff M, Mills GB, McConkey DJ. Inhibition of the phosphatidylinositol 3'-kinase-AKT pathway induces apoptosis in pancreatic carcinoma cells in vitro and in vivo. Mol Cancer Ther. 2002 Oct; 1(12):989-97. PMID: 12481421.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    908. Umezu-Goto M, Kishi Y, Taira A, Hama K, Dohmae N, Takio K, Yamori T, Mills GB, Inoue K, Aoki J, Arai H. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol. 2002 Jul 22; 158(2):227-33. PMID: 12119361; PMCID: PMC2173129.
      Citations: 358     Fields:    Translation:AnimalsCells
    909. Tanyi JL, Lapushin R, Eder A, Auersperg N, Tabassam FH, Roth JA, Gu J, Fang B, Mills GB, Wolf J. Identification of tissue- and cancer-selective promoters for the introduction of genes into human ovarian cancer cells. Gynecol Oncol. 2002 Jun; 85(3):451-8. PMID: 12051873.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    910. Koul D, Jasser SA, Lu Y, Davies MA, Shen R, Shi Y, Mills GB, Yung WK. Motif analysis of the tumor suppressor gene MMAC/PTEN identifies tyrosines critical for tumor suppression and lipid phosphatase activity. Oncogene. 2002 Apr 04; 21(15):2357-64. PMID: 11948419.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    911. Fang X, Yu S, Tanyi JL, Lu Y, Woodgett JR, Mills GB. Convergence of multiple signaling cascades at glycogen synthase kinase 3: Edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase C-dependent intracellular pathway. Mol Cell Biol. 2002 Apr; 22(7):2099-110. PMID: 11884598; PMCID: PMC133668.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    912. Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C, Fishman DA, Kohn EC, Liotta LA. Use of proteomic patterns in serum to identify ovarian cancer. Lancet. 2002 Feb 16; 359(9306):572-7. PMID: 11867112.
      Citations: 474     Fields:    Translation:HumansPHPublic Health
    913. Hu L, Hofmann J, Lu Y, Mills GB, Jaffe RB. Inhibition of phosphatidylinositol 3'-kinase increases efficacy of paclitaxel in in vitro and in vivo ovarian cancer models. Cancer Res. 2002 Feb 15; 62(4):1087-92. PMID: 11861387.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    914. Buchholz TA, Wu X, Hussain A, Tucker SL, Mills GB, Haffty B, Bergh S, Story M, Geara FB, Brock WA. Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 or BRCA2. Int J Cancer. 2002 Feb 10; 97(5):557-61. PMID: 11807777.
      Citations: 25     Fields:    Translation:HumansCellsCTClinical Trials
    915. Bast RC, Urban N, Shridhar V, Smith D, Zhang Z, Skates S, Lu K, Liu J, Fishman D, Mills G. Early detection of ovarian cancer: promise and reality. Cancer Treat Res. 2002; 107:61-97. PMID: 11775462.
      Citations: 40     Fields:    Translation:HumansPHPublic Health
    916. Mills GB. Mechanisms underlying chemoprevention of ovarian cancer. Clin Cancer Res. 2002 Jan; 8(1):7-10. PMID: 11801533.
      Citations: 2     Fields:    Translation:Humans
    917. Mills GB, Eder A, Fang X, Hasegawa Y, Mao M, Lu Y, Tanyi J, Tabassam FH, Wiener J, Lapushin R, Yu S, Parrott JA, Compton T, Tribley W, Fishman D, Stack MS, Gaudette D, Jaffe R, Furui T, Aoki J, Erickson JR. Critical role of lysophospholipids in the pathophysiology, diagnosis, and management of ovarian cancer. Cancer Treat Res. 2002; 107:259-83. PMID: 11775454.
      Citations: 33     Fields:    Translation:HumansCells
    918. Le XF, Marcelli M, McWatters A, Nan B, Mills GB, O'Brian CA, Bast RC. Heregulin-induced apoptosis is mediated by down-regulation of Bcl-2 and activation of caspase-7 and is potentiated by impairment of protein kinase C alpha activity. Oncogene. 2001 Dec 13; 20(57):8258-69. PMID: 11781840.
      Citations: 9     Fields:    Translation:HumansCells
    919. Zhu Y, Spitz MR, Lei L, Mills GB, Wu X. A single nucleotide polymorphism in the matrix metalloproteinase-1 promoter enhances lung cancer susceptibility. Cancer Res. 2001 Nov 01; 61(21):7825-9. PMID: 11691799.
      Citations: 52     Fields:    Translation:HumansCells
    920. Bast RC, Mills GB, Young RC. Translational research--traffic on the bridge. Biomed Pharmacother. 2001 Nov; 55(9-10):565-71. PMID: 11769968.
      Citations: 4     Fields:    Translation:Humans
    921. Mills GB, Bast RC, Srivastava S. Future for ovarian cancer screening: novel markers from emerging technologies of transcriptional profiling and proteomics. J Natl Cancer Inst. 2001 Oct 03; 93(19):1437-9. PMID: 11584052.
      Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
    922. Mills GB, Lu Y, Fang X, Wang H, Eder A, Mao M, Swaby R, Cheng KW, Stokoe D, Siminovitch K, Jaffe R, Gray J. The role of genetic abnormalities of PTEN and the phosphatidylinositol 3-kinase pathway in breast and ovarian tumorigenesis, prognosis, and therapy. Semin Oncol. 2001 Oct; 28(5 Suppl 16):125-41. PMID: 11706404.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    923. Aytac U, Claret FX, Ho L, Sato K, Ohnuma K, Mills GB, Cabanillas F, Morimoto C, Dang NH. Expression of CD26 and its associated dipeptidyl peptidase IV enzyme activity enhances sensitivity to doxorubicin-induced cell cycle arrest at the G(2)/M checkpoint. Cancer Res. 2001 Oct 01; 61(19):7204-10. PMID: 11585756.
      Citations: 7     Fields:    Translation:HumansCells
    924. Mills GB, Lu Y, Kohn EC. Linking molecular therapeutics to molecular diagnostics: inhibition of the FRAP/RAFT/TOR component of the PI3K pathway preferentially blocks PTEN mutant cells in vitro and in vivo. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10031-3. PMID: 11526226; PMCID: PMC56908.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    925. Shridhar V, Lee J, Pandita A, Iturria S, Avula R, Staub J, Morrissey M, Calhoun E, Sen A, Kalli K, Keeney G, Roche P, Cliby W, Lu K, Schmandt R, Mills GB, Bast RC, James CD, Couch FJ, Hartmann LC, Lillie J, Smith DI. Genetic analysis of early- versus late-stage ovarian tumors. Cancer Res. 2001 Aug 01; 61(15):5895-904. PMID: 11479231.
      Citations: 58     Fields:    Translation:HumansCells
    926. Liu B, Fang M, Lu Y, Mills GB, Fan Z. Involvement of JNK-mediated pathway in EGF-mediated protection against paclitaxel-induced apoptosis in SiHa human cervical cancer cells. Br J Cancer. 2001 Jul 20; 85(2):303-11. PMID: 11461094; PMCID: PMC2364054.
      Citations: 15     Fields:    Translation:HumansCells
    927. Mujoo K, Haridas V, Hoffmann JJ, Hutter LK, Lu Y, Blake ME, Jayatilake GS, Bailey D, Mills GB, Gutterman JU, W?chter GA. Triterpenoid saponins from Acacia victoriae (Bentham) decrease tumor cell proliferation and induce apoptosis. Cancer Res. 2001 Jul 15; 61(14):5486-90. PMID: 11454696.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    928. Braunstein I, Cohen-Barak O, Shachaf C, Ravel Y, Yalon-Hacohen M, Mills GB, Tzukerman M, Skorecki KL. Human telomerase reverse transcriptase promoter regulation in normal and malignant human ovarian epithelial cells. Cancer Res. 2001 Jul 15; 61(14):5529-36. PMID: 11454703.
      Citations: 11     Fields:    Translation:HumansCells
    929. Ho L, Aytac U, Stephens LC, Ohnuma K, Mills GB, McKee KS, Neumann C, LaPushin R, Cabanillas F, Abbruzzese JL, Morimoto C, Dang NH. In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299. Clin Cancer Res. 2001 Jul; 7(7):2031-40. PMID: 11448921.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    930. Wolf BB, Schuler M, Li W, Eggers-Sedlet B, Lee W, Tailor P, Fitzgerald P, Mills GB, Green DR. Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activity. J Biol Chem. 2001 Sep 07; 276(36):34244-51. PMID: 11429402.
      Citations: 24     Fields:    Translation:HumansCells
    931. Hu YL, Tee MK, Goetzl EJ, Auersperg N, Mills GB, Ferrara N, Jaffe RB. Lysophosphatidic acid induction of vascular endothelial growth factor expression in human ovarian cancer cells. J Natl Cancer Inst. 2001 May 16; 93(10):762-8. PMID: 11353786.
      Citations: 61     Fields:    Translation:HumansCells
    932. Cuevas BD, Lu Y, Mao M, Zhang J, LaPushin R, Siminovitch K, Mills GB. Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase. J Biol Chem. 2001 Jul 20; 276(29):27455-61. PMID: 11337495.
      Citations: 94     Fields:    Translation:AnimalsCells
    933. Erickson JR, Hasegawa Y, Fang X, Eder A, Mao M, Furui T, Aoki J, Morris A, Mills GB. Lysophosphatidic acid and ovarian cancer: a paradigm for tumorogenesis and patient management. Prostaglandins Other Lipid Mediat. 2001 Apr; 64(1-4):63-81. PMID: 11324708.
      Citations: 7     Fields:    Translation:HumansCells
    934. Asselin E, Mills GB, Tsang BK. XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res. 2001 Mar 01; 61(5):1862-8. PMID: 11280739.
      Citations: 126     Fields:    Translation:HumansCells
    935. Bast RC, Mills GB. Alterations in oncogenes, tumor suppressor genes, and growth factors associated with epithelial ovarian cancers. Methods Mol Med. 2001; 39:37-48. PMID: 21340756.
      Citations: 1     Fields:    
    936. Kruzelock RP, Cuevas BD, Wiener JR, Xu FJ, Yu Y, Cabeza-Arvelaiz Y, Pershouse M, Lovell MM, Killary AM, Mills GB, Bast RC. Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer. Oncogene. 2000 Dec 14; 19(54):6277-85. PMID: 11175342.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    937. Mao M, Fang X, Lu Y, Lapushin R, Bast RC, Mills GB. Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells. Biochem J. 2000 Dec 01; 352 Pt 2:475-82. PMID: 11085941; PMCID: PMC1221479.
      Citations: 25     Fields:    Translation:HumansCells
    938. Fang X, Yu S, LaPushin R, Lu Y, Furui T, Penn LZ, Stokoe D, Erickson JR, Bast RC, Mills GB. Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase. Biochem J. 2000 Nov 15; 352 Pt 1:135-43. PMID: 11062066; PMCID: PMC1221440.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    939. Fang X, Yu SX, Lu Y, Bast RC, Woodgett JR, Mills GB. Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11960-5. PMID: 11035810; PMCID: PMC17277.
      Citations: 351     Fields:    Translation:HumansAnimalsCells
    940. Suzuki S, Moore DH, Ginzinger DG, Godfrey TE, Barclay J, Powell B, Pinkel D, Zaloudek C, Lu K, Mills G, Berchuck A, Gray JW. An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res. 2000 Oct 01; 60(19):5382-5. PMID: 11034075.
      Citations: 31     Fields:    Translation:HumansCells
    941. Imai A, Furui T, Tamaya T, Mills GB. A gonadotropin-releasing hormone-responsive phosphatase hydrolyses lysophosphatidic acid within the plasma membrane of ovarian cancer cells. J Clin Endocrinol Metab. 2000 Sep; 85(9):3370-5. PMID: 10999836.
      Citations: 11     Fields:    Translation:HumansCells
    942. Le XF, Vadlamudi R, McWatters A, Bae DS, Mills GB, Kumar R, Bast RC. Differential signaling by an anti-p185(HER2) antibody and heregulin. Cancer Res. 2000 Jul 01; 60(13):3522-31. PMID: 10910064.
      Citations: 6     Fields:    Translation:HumansCells
    943. Eder AM, Sasagawa T, Mao M, Aoki J, Mills GB. Constitutive and lysophosphatidic acid (LPA)-induced LPA production: role of phospholipase D and phospholipase A2. Clin Cancer Res. 2000 Jun; 6(6):2482-91. PMID: 10873103.
      Citations: 45     Fields:    Translation:HumansCells
    944. Macdonald JS, Jacobson JL, Ketchel SJ, Weiss G, Taylor S, Mills G, Kuebler JP, Rivkin S, Conrad M. A phase II trial of topotecan in esophageal carcinoma: a Southwest Oncology Group study (SWOG 9339). Invest New Drugs. 2000 May; 18(2):199-202. PMID: 10857998.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    945. Fang X, Gaudette D, Furui T, Mao M, Estrella V, Eder A, Pustilnik T, Sasagawa T, Lapushin R, Yu S, Jaffe RB, Wiener JR, Erickson JR, Mills GB. Lysophospholipid growth factors in the initiation, progression, metastases, and management of ovarian cancer. Ann N Y Acad Sci. 2000 Apr; 905:188-208. PMID: 10818454.
      Citations: 71     Fields:    Translation:HumansCells
    946. Erickson JR, Espinal G, Mills GB. Analysis of the EDG2 receptor based on the structure/activity relationship of LPA. Ann N Y Acad Sci. 2000 Apr; 905:279-81. PMID: 10818464.
      Citations:    Fields:    Translation:AnimalsCells
    947. Hu L, Zaloudek C, Mills GB, Gray J, Jaffe RB. In vivo and in vitro ovarian carcinoma growth inhibition by a phosphatidylinositol 3-kinase inhibitor (LY294002). Clin Cancer Res. 2000 Mar; 6(3):880-6. PMID: 10741711.
      Citations: 91     Fields:    Translation:HumansAnimalsCells
    948. Ramondetta L, Mills GB, Burke TW, Wolf JK. Adenovirus-mediated expression of p53 or p21 in a papillary serous endometrial carcinoma cell line (SPEC-2) results in both growth inhibition and apoptotic cell death: potential application of gene therapy to endometrial cancer. Clin Cancer Res. 2000 Jan; 6(1):278-84. PMID: 10656459.
      Citations: 7     Fields:    Translation:HumansCells
    949. Le XF, McWatters A, Wiener J, Wu JY, Mills GB, Bast RC. Anti-HER2 antibody and heregulin suppress growth of HER2-overexpressing human breast cancer cells through different mechanisms. Clin Cancer Res. 2000 Jan; 6(1):260-70. PMID: 10656457.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    950. Bast RC, Yu Y, Xu FJ, Le XF, Mills GB. Molecular approaches to management of epithelial ovarian cancer. Int J Gynecol Cancer. 2000 Jan; 10(S1):2-7. PMID: 11240724.
      Citations:    Fields:    
    951. Furui T, LaPushin R, Mao M, Khan H, Watt SR, Watt MA, Lu Y, Fang X, Tsutsui S, Siddik ZH, Bast RC, Mills GB. Overexpression of edg-2/vzg-1 induces apoptosis and anoikis in ovarian cancer cells in a lysophosphatidic acid-independent manner. Clin Cancer Res. 1999 Dec; 5(12):4308-18. PMID: 10632375.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    952. Gershenson DM, Deavers M, Diaz S, Tortolero-Luna G, Miller BE, Bast RC, Mills GB, Silva EG. Prognostic significance of p53 expression in advanced-stage ovarian serous borderline tumors. Clin Cancer Res. 1999 Dec; 5(12):4053-8. PMID: 10632339.
      Citations: 4     Fields:    Translation:Humans
    953. Lu Y, Lin YZ, LaPushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K, Mills GB. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. 1999 Nov 25; 18(50):7034-45. PMID: 10597304.
      Citations: 94     Fields:    Translation:HumansCells
    954. Fang X, Yu S, Eder A, Mao M, Bast RC, Boyd D, Mills GB. Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway. Oncogene. 1999 Nov 18; 18(48):6635-40. PMID: 10597268.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    955. Xu F, Yu Y, Le XF, Boyer C, Mills GB, Bast RC. The outcome of heregulin-induced activation of ovarian cancer cells depends on the relative levels of HER-2 and HER-3 expression. Clin Cancer Res. 1999 Nov; 5(11):3653-60. PMID: 10589783.
      Citations: 17     Fields:    Translation:HumansCells
    956. Wolf JK, Mills GB, Bazzet L, Bast RC, Roth JA, Gershenson DM. Adenovirus-mediated p53 growth inhibition of ovarian cancer cells is independent of endogenous p53 status. Gynecol Oncol. 1999 Nov; 75(2):261-6. PMID: 10525383.
      Citations: 7     Fields:    Translation:HumansCells
    957. Pustilnik TB, Estrella V, Wiener JR, Mao M, Eder A, Watt MA, Bast RC, Mills GB. Lysophosphatidic acid induces urokinase secretion by ovarian cancer cells. Clin Cancer Res. 1999 Nov; 5(11):3704-10. PMID: 10589790.
      Citations: 49     Fields:    Translation:HumansCells
    958. Cuevas B, Lu Y, Watt S, Kumar R, Zhang J, Siminovitch KA, Mills GB. SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. J Biol Chem. 1999 Sep 24; 274(39):27583-9. PMID: 10488096.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    959. Mills GB, Schmandt R, Gershenson D, Bast RC. Should therapy of ovarian cancer patients be individualized based on underlying genetic defects? Clin Cancer Res. 1999 Sep; 5(9):2286-8. PMID: 10499594.
      Citations:    Fields:    Translation:HumansCells
    960. Zebrowski BK, Liu W, Ramirez K, Akagi Y, Mills GB, Ellis LM. Markedly elevated levels of vascular endothelial growth factor in malignant ascites. Ann Surg Oncol. 1999 Jun; 6(4):373-8. PMID: 10379858.
      Citations: 79     Fields:    Translation:Humans
    961. Zhang J, Somani AK, Watt S, Mills GB, Siminovitch KA. The Src-homology domain 2-bearing protein tyrosine phosphatase-1 inhibits antigen receptor-induced apoptosis of activated peripheral T cells. J Immunol. 1999 Jun 01; 162(11):6359-67. PMID: 10352248.
      Citations: 8     Fields:    Translation:AnimalsCells
    962. Wolf JK, Kim TE, Fightmaster D, Bodurka D, Gershenson DM, Mills G, Wharton JT. Growth suppression of human ovarian cancer cell lines by the introduction of a p16 gene via a recombinant adenovirus. Gynecol Oncol. 1999 Apr; 73(1):27-34. PMID: 10094876.
      Citations: 5     Fields:    Translation:HumansCells
    963. Hagopian GS, Mills GB, Khokhar AR, Bast RC, Siddik ZH. Expression of p53 in cisplatin-resistant ovarian cancer cell lines: modulation with the novel platinum analogue (1R, 2R-diaminocyclohexane)(trans-diacetato)(dichloro)-platinum(IV). Clin Cancer Res. 1999 Mar; 5(3):655-63. PMID: 10100719.
      Citations: 30     Fields:    Translation:HumansCells
    964. Yu Y, Xu F, Peng H, Fang X, Zhao S, Li Y, Cuevas B, Kuo WL, Gray JW, Siciliano M, Mills GB, Bast RC. NOEY2 (ARHI), an imprinted putative tumor suppressor gene in ovarian and breast carcinomas. Proc Natl Acad Sci U S A. 1999 Jan 05; 96(1):214-9. PMID: 9874798; PMCID: PMC15119.
      Citations: 93     Fields:    Translation:HumansCells
    965. Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet. 1999 Jan; 21(1):99-102. PMID: 9916799.
      Citations: 275     Fields:    Translation:HumansCells
    966. Siminovitch KA, Lamhonwah AM, Somani AK, Cardiff R, Mills GB. Involvement of the SHP-1 tyrosine phosphatase in regulating B lymphocyte antigen receptor signaling, proliferation and transformation. Curr Top Microbiol Immunol. 1999; 246:291-7; discussion 298. PMID: 10396068.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    967. Mills G, Morgan J, Hales G, Smith D. Acute hypersensitivity with delavirdine. Antivir Ther. 1999; 4(1):51. PMID: 10682129.
      Citations:    Fields:    Translation:Humans
    968. Davies MA, Lu Y, Sano T, Fang X, Tang P, LaPushin R, Koul D, Bookstein R, Stokoe D, Yung WK, Mills GB, Steck PA. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis. Cancer Res. 1998 Dec 01; 58(23):5285-90. PMID: 9850049.
      Citations: 46     Fields:    Translation:HumansCells
    969. Lu Y, Cuevas B, Gibson S, Khan H, LaPushin R, Imboden J, Mills GB. Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase. J Immunol. 1998 Nov 15; 161(10):5404-12. PMID: 9820515.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    970. Koul D, Obeyesekere NU, Gutterman JU, Mills GB, Choubey D. p202 self-associates through a sequence conserved among the members of the 200-family proteins. FEBS Lett. 1998 Oct 30; 438(1-2):21-4. PMID: 9821952.
      Citations: 8     Fields:    Translation:AnimalsCells
    971. Haas-Kogan D, Shalev N, Wong M, Mills G, Yount G, Stokoe D. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Curr Biol. 1998 Oct 22; 8(21):1195-8. PMID: 9799739.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    972. Bast RC, Xu FJ, Yu YH, Barnhill S, Zhang Z, Mills GB. CA 125: the past and the future. Int J Biol Markers. 1998 Oct-Dec; 13(4):179-87. PMID: 10228898.
      Citations: 111     Fields:    Translation:Humans
    973. Koul D, Lapushin R, Xu HJ, Mills GB, Gutterman JU, Choubey D. p202 prevents apoptosis in murine AKR-2B fibroblasts. Biochem Biophys Res Commun. 1998 Jun 18; 247(2):379-82. PMID: 9642135.
      Citations: 6     Fields:    Translation:AnimalsCells
    974. Patton SE, Martin ML, Nelsen LL, Fang X, Mills GB, Bast RC, Ostrowski MC. Activation of the ras-mitogen-activated protein kinase pathway and phosphorylation of ets-2 at position threonine 72 in human ovarian cancer cell lines. Cancer Res. 1998 May 15; 58(10):2253-9. PMID: 9605774.
      Citations: 14     Fields:    Translation:HumansCells
    975. Gibson S, Truitt K, Lu Y, Lapushin R, Khan H, Imboden JB, Mills GB. Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK. Biochem J. 1998 Mar 15; 330 ( Pt 3):1123-8. PMID: 9494076; PMCID: PMC1219252.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    976. Radvanyi LG, Raju K, Spaner D, Mills GB, Miller RG. Interleukin-2 reverses the defect in activation-induced apoptosis in T cells from autoimmune lpr mice. Cell Immunol. 1998 Jan 10; 183(1):1-12. PMID: 9578714.
      Citations: 3     Fields:    Translation:AnimalsCells
    977. Fang X, Jin X, Xu HJ, Liu L, Peng HQ, Hogg D, Roth JA, Yu Y, Xu F, Bast RC, Mills GB. Expression of p16 induces transcriptional downregulation of the RB gene. Oncogene. 1998 Jan 08; 16(1):1-8. PMID: 9467937.
      Citations: 12     Fields:    Translation:HumansCells
    978. Pusztai L, Siddik ZH, Mills GB, Bast RC. Physiologic and pathologic drug resistance in ovarian carcinoma--a hypothesis based on a clonal progression model. Acta Oncol. 1998; 37(7-8):629-40. PMID: 10050979.
      Citations: 2     Fields:    Translation:Humans
    979. Shi Y, Wang R, Sharma A, Gao C, Collins M, Penn L, Mills GB. Dissociation of cytokine signals for proliferation and apoptosis. J Immunol. 1997 Dec 01; 159(11):5318-28. PMID: 9548471.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    980. Shi YF, Hill M, Novak A, Chen ZQ, Wang RX, Liew CC, Mills GB. Human hematopoietic cell express two forms of the cytokine receptor common gamma-chain (gamma c). Cell Res. 1997 Dec; 7(2):195-205. PMID: 9444398.
      Citations:    Fields:    Translation:HumansCells
    981. Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, Swedlund B, Hansen KL, Vinson VL, Gumpper KL, Ellis L, El-Naggar A, Frazier M, Jasser S, Langford LA, Lee J, Mills GB, Pershouse MA, Pollack RE, Tornos C, Troncoso P, Yung WK, Fujii G, Berson A, Steck PA, et al. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines. Cancer Res. 1997 Dec 01; 57(23):5221-5. PMID: 9393738.
      Citations: 119     Fields:    Translation:HumansCells
    982. Xu HJ, Zhou Y, Ji W, Perng GS, Kruzelock R, Kong CT, Bast RC, Mills GB, Li J, Hu SX. Reexpression of the retinoblastoma protein in tumor cells induces senescence and telomerase inhibition. Oncogene. 1997 Nov 20; 15(21):2589-96. PMID: 9399646.
      Citations: 36     Fields:    Translation:Humans
    983. Okkenhaug K, Clavreul A, Couez D, Gibson S, Mills GB, Mak TW, Rottapel R, Mareng?re LE. The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28. J Immunol. 1997 Oct 01; 159(7):3220-9. PMID: 9317120.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    984. Xu FJ, Stack S, Boyer C, O'Briant K, Whitaker R, Mills GB, Yu YH, Bast RC. Heregulin and agonistic anti-p185(c-erbB2) antibodies inhibit proliferation but increase invasiveness of breast cancer cells that overexpress p185(c-erbB2): increased invasiveness may contribute to poor prognosis. Clin Cancer Res. 1997 Sep; 3(9):1629-34. PMID: 9815853.
      Citations: 17     Fields:    Translation:HumansCells
    985. Somani AK, Bignon JS, Mills GB, Siminovitch KA, Branch DR. Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase. J Biol Chem. 1997 Aug 22; 272(34):21113-9. PMID: 9261115.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    986. Fang X, Gibson S, Flowers M, Furui T, Bast RC, Mills GB. Lysophosphatidylcholine stimulates activator protein 1 and the c-Jun N-terminal kinase activity. J Biol Chem. 1997 May 23; 272(21):13683-9. PMID: 9153219.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    987. Okita M, Gaudette DC, Mills GB, Holub BJ. Elevated levels and altered fatty acid composition of plasma lysophosphatidylcholine(lysoPC) in ovarian cancer patients. Int J Cancer. 1997 Mar 28; 71(1):31-4. PMID: 9096662.
      Citations: 38     Fields:    Translation:Humans
    988. Wang R, Fang Q, Zhang L, Radvany L, Sharma A, Noben-Trauth N, Mills GB, Shi Y. CD28 ligation prevents bacterial toxin-induced septic shock in mice by inducing IL-10 expression. J Immunol. 1997 Mar 15; 158(6):2856-61. PMID: 9058822.
      Citations: 8     Fields:    Translation:AnimalsCells
    989. Phipps DJ, Read SE, Piovesan JP, Mills GB, Branch DR. HIV infection in vitro enhances the activity of src-family protein tyrosine kinases. AIDS. 1996 Sep; 10(11):1191-8. PMID: 8883579.
      Citations: 10     Fields:    Translation:HumansCells
    990. Frankel A, Mills GB. Peptide and lipid growth factors decrease cis-diamminedichloroplatinum-induced cell death in human ovarian cancer cells. Clin Cancer Res. 1996 Aug; 2(8):1307-13. PMID: 9816301.
      Citations: 14     Fields:    Translation:Humans
    991. Radvanyi LG, Shi Y, Mills GB, Miller RG. Cell cycle progression out of G1 sensitizes primary-cultured nontransformed T cells to TCR-mediated apoptosis. Cell Immunol. 1996 Jun 15; 170(2):260-73. PMID: 8660826.
      Citations: 5     Fields:    Translation:AnimalsCells
    992. Teng JM, Liu XR, Mills GB, Dupont B. CD28-mediated cytotoxicity by the human leukemic NK cell line YT involves tyrosine phosphorylation, activation of phosphatidylinositol 3-kinase, and protein kinase C. J Immunol. 1996 May 01; 156(9):3222-32. PMID: 8617944.
      Citations: 9     Fields:    Translation:HumansCells
    993. Wiener JR, Kassim SK, Yu Y, Mills GB, Bast RC. Transfection of human ovarian cancer cells with the HER-2/neu receptor tyrosine kinase induces a selective increase in PTP-H1, PTP-1B, PTP-alpha expression. Gynecol Oncol. 1996 May; 61(2):233-40. PMID: 8626139.
      Citations: 6     Fields:    Translation:HumansCells
    994. Gibson S, August A, Kawakami Y, Kawakami T, Dupont B, Mills GB. The EMT/ITK/TSK (EMT) tyrosine kinase is activated during TCR signaling: LCK is required for optimal activation of EMT. J Immunol. 1996 Apr 15; 156(8):2716-22. PMID: 8609388.
      Citations: 24     Fields:    Translation:HumansCells
    995. Yousefi S, Hoessli DC, Blaser K, Mills GB, Simon HU. Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J Exp Med. 1996 Apr 01; 183(4):1407-14. PMID: 8666899; PMCID: PMC2192537.
      Citations: 34     Fields:    Translation:HumansCells
    996. Gibson S, August A, Branch D, Dupont B, Mills GM. Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK. J Biol Chem. 1996 Mar 22; 271(12):7079-83. PMID: 8636141.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    997. Radvanyi LG, Shi Y, Vaziri H, Sharma A, Dhala R, Mills GB, Miller RG. CD28 costimulation inhibits TCR-induced apoptosis during a primary T cell response. J Immunol. 1996 Mar 01; 156(5):1788-98. PMID: 8596028.
      Citations: 42     Fields:    Translation:AnimalsCells
    998. Rahim SG, Trivedi N, Bogunovic-Batchelor MV, Hardy GW, Mills G, Selway JW, Snowden W, Littler E, Coe PL, Basnak I, Whale RF, Walker RT. Synthesis and anti-herpes virus activity of 2'-deoxy-4'-thiopyrimidine nucleosides. J Med Chem. 1996 Feb 02; 39(3):789-95. PMID: 8576922.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    999. Breitz H, Mills G, Siegel J, Stabin M, Wessels BW. The 10th International Conference on Monoclonal Antibody Immunoconjugates for Cancer: Radiodosimetry and Radiopharmaceuticals for Therapy. Cancer Biother Radiopharm. 1996 Feb; 11(1):25-42. PMID: 10851518.
      Citations:    Fields:    Translation:Humans
    1000. Jurisicova A, Casper RF, MacLusky NJ, Mills GB, Librach CL. HLA-G expression during preimplantation human embryo development. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):161-5. PMID: 8552596; PMCID: PMC40198.
      Citations: 52     Fields:    Translation:HumansCells
    1001. Truitt KE, Shi J, Gibson S, Segal LG, Mills GB, Imboden JB. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. J Immunol. 1995 Nov 15; 155(10):4702-10. PMID: 7594470.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    1002. Hurteau JA, Woolas RP, Jacobs IJ, Oram DC, Kurman CC, Rubin LA, Nelson DL, Berchuck A, Bast RC, Mills GB. Soluble interleukin-2 receptor alpha is elevated in sera of patients with benign ovarian neoplasms and epithelial ovarian cancer. Cancer. 1995 Nov 01; 76(9):1615-20. PMID: 8635066.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    1003. Teodorczyk-Injeyan JA, Cembrzynska-Nowak M, Lalani S, Peters WJ, Mills GB. Immune deficiency following thermal trauma is associated with apoptotic cell death. J Clin Immunol. 1995 Nov; 15(6):318-28. PMID: 8576318.
      Citations: 12     Fields:    Translation:HumansCells
    1004. Xu Y, Gaudette DC, Boynton JD, Frankel A, Fang XJ, Sharma A, Hurteau J, Casey G, Goodbody A, Mellors A, et al. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients. Clin Cancer Res. 1995 Oct; 1(10):1223-32. PMID: 9815916.
      Citations: 91     Fields:    Translation:Humans
    1005. Kawakami Y, Yao L, Tashiro M, Gibson S, Mills GB, Kawakami T. Activation and interaction with protein kinase C of a cytoplasmic tyrosine kinase, Itk/Tsk/Emt, on Fc epsilon RI cross-linking on mast cells. J Immunol. 1995 Oct 01; 155(7):3556-62. PMID: 7561053.
      Citations: 18     Fields:    Translation:AnimalsCells
    1006. Goldsmith MA, Lai SY, Xu W, Amaral MC, Kuczek ES, Parent LJ, Mills GB, Tarr KL, Longmore GD, Greene WC. Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain. J Biol Chem. 1995 Sep 15; 270(37):21729-37. PMID: 7665592.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    1007. Mogil RJ, Radvanyi L, Gonzalez-Quintial R, Miller R, Mills G, Theofilopoulos AN, Green DR. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo. Int Immunol. 1995 Sep; 7(9):1451-8. PMID: 7495753.
      Citations: 43     Fields:    Translation:AnimalsCells
    1008. Hamneg?rd CH, Wragg S, Mills G, Kyroussis D, Road J, Daskos G, Bake B, Moxham J, Green M. The effect of lung volume on transdiaphragmatic pressure. Eur Respir J. 1995 Sep; 8(9):1532-6. PMID: 8575580.
      Citations: 6     Fields:    Translation:Humans
    1009. Shi Y, Radvanyi LG, Sharma A, Shaw P, Green DR, Miller RG, Mills GB. CD28-mediated signaling in vivo prevents activation-induced apoptosis in the thymus and alters peripheral lymphocyte homeostasis. J Immunol. 1995 Aug 15; 155(4):1829-37. PMID: 7543534.
      Citations: 10     Fields:    Translation:AnimalsCells
    1010. Xu Y, Fang XJ, Casey G, Mills GB. Lysophospholipids activate ovarian and breast cancer cells. Biochem J. 1995 Aug 01; 309 ( Pt 3):933-40. PMID: 7639713; PMCID: PMC1135721.
      Citations: 79     Fields:    Translation:HumansCells
    1011. Phipps DJ, Reed-Doob P, MacFadden DK, Piovesan JP, Mills GB, Branch DR. An octapeptide analogue of HIV gp120 modulates protein tyrosine kinase activity in activated peripheral blood T lymphocytes. Clin Exp Immunol. 1995 Jun; 100(3):412-8. PMID: 7539724; PMCID: PMC1534470.
      Citations: 2     Fields:    Translation:HumansCells
    1012. Xu Y, Casey G, Mills GB. Effect of lysophospholipids on signaling in the human Jurkat T cell line. J Cell Physiol. 1995 Jun; 163(3):441-50. PMID: 7775587.
      Citations: 16     Fields:    Translation:HumansCells
    1013. Hamneg?ard CH, Wragg S, Kyroussis D, Mills G, Bake B, Green M, Moxham J. Mouth pressure in response to magnetic stimulation of the phrenic nerves. Thorax. 1995 Jun; 50(6):620-4. PMID: 7638802; PMCID: PMC1021259.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    1014. Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med. 1995 Jun 01; 181(6):2077-84. PMID: 7539038; PMCID: PMC2192043.
      Citations: 57     Fields:    Translation:AnimalsCells
    1015. Shi Y, Frankel A, Radvanyi LG, Penn LZ, Miller RG, Mills GB. Rapamycin enhances apoptosis and increases sensitivity to cisplatin in vitro. Cancer Res. 1995 May 01; 55(9):1982-8. PMID: 7728769.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    1016. Branch DR, Mills GB. pp60c-src expression is induced by activation of normal human T lymphocytes. J Immunol. 1995 Apr 15; 154(8):3678-85. PMID: 7535811.
      Citations: 9     Fields:    Translation:HumansCells
    1017. Kyroussis D, Mills G, Hamnegard CH, Wragg S, Road J, Green M, Moxham J. Inspiratory muscle relaxation rate assessed from sniff nasal pressure. Thorax. 1994 Nov; 49(11):1127-33. PMID: 7831629; PMCID: PMC475274.
      Citations: 11     Fields:    Translation:Humans
    1018. Xu FJ, Boyer CM, Bae DS, Wu S, Greenwald M, O'Briant K, Yu YH, Mills GB, Bast RC. The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-A chain immunotoxin. Int J Cancer. 1994 Oct 15; 59(2):242-7. PMID: 7927925.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    1019. August A, Gibson S, Kawakami Y, Kawakami T, Mills GB, Dupont B. CD28 is associated with and induces the immediate tyrosine phosphorylation and activation of the Tec family kinase ITK/EMT in the human Jurkat leukemic T-cell line. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9347-51. PMID: 7524075; PMCID: PMC44809.
      Citations: 63     Fields:    Translation:HumansCells
    1020. Tsao PW, Mills GB, Diaz RJ, Radde IC, Parkinson D, Waddell J, Wilson GJ, Coles JG. Evidence that increases in lymphocyte tyrosine phosphorylation precede cardiac allograft rejection. Effects of cyclosporine and potential use in clinical management. Transplantation. 1994 Aug 27; 58(4):451-7. PMID: 7521079.
      Citations: 1     Fields:    Translation:AnimalsCells
    1021. Hurteau J, Rodriguez GC, Whitaker RS, Shah S, Mills G, Bast RC, Berchuck A. Transforming growth factor-beta inhibits proliferation of human ovarian cancer cells obtained from ascites. Cancer. 1994 Jul 01; 74(1):93-9. PMID: 8004589.
      Citations: 11     Fields:    Translation:HumansCells
    1022. Simon HU, Tsao PW, Siminovitch KA, Mills GB, Blaser K. Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma. J Immunol. 1994 Jul 01; 153(1):364-77. PMID: 8207248.
      Citations: 13     Fields:    Translation:HumansCells
    1023. Swierkosz EM, Newman FK, Anderson EL, Nugent SL, Mills GB, Belshe RB. Multidose, live attenuated, cold-recombinant, trivalent influenza vaccine in infants and young children. J Infect Dis. 1994 May; 169(5):1121-4. PMID: 8169405.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    1024. Hurteau JA, Simon HU, Kurman C, Rubin L, Mills GB. Levels of soluble interleukin-2 receptor-alpha are elevated in serum and ascitic fluid from epithelial ovarian cancer patients. Am J Obstet Gynecol. 1994 Mar; 170(3):918-28. PMID: 8141226.
      Citations: 1     Fields:    Translation:HumansCells
    1025. Truitt KE, Mills GB, Turck CW, Imboden JB. SH2-dependent association of phosphatidylinositol 3'-kinase 85-kDa regulatory subunit with the interleukin-2 receptor beta chain. J Biol Chem. 1994 Feb 25; 269(8):5937-43. PMID: 7509794.
      Citations: 14     Fields:    Translation:HumansCells
    1026. Simon HU, Mills GB, Kozlowski M, Hogg D, Branch D, Ishimi Y, Siminovitch KA. Molecular characterization of hNRP, a cDNA encoding a human nucleosome-assembly-protein-I-related gene product involved in the induction of cell proliferation. Biochem J. 1994 Jan 15; 297 ( Pt 2):389-97. PMID: 8297347; PMCID: PMC1137842.
      Citations: 25     Fields:    Translation:HumansCells
    1027. Hogg D, Guidos C, Bailey D, Amendola A, Groves T, Davidson J, Schmandt R, Mills G. Cell cycle dependent regulation of the protein kinase TTK. Oncogene. 1994 Jan; 9(1):89-96. PMID: 8302607.
      Citations: 15     Fields:    Translation:HumansCells
    1028. Schmandt R, Hill M, Amendola A, Mills GB, Hogg D. IL-2-induced expression of TTK, a serine, threonine, tyrosine kinase, correlates with cell cycle progression. J Immunol. 1994 Jan 01; 152(1):96-105. PMID: 8254211.
      Citations: 8     Fields:    Translation:HumansCells
    1029. Hack N, Sue-A-Quan A, Mills GB, Skorecki KL. Expression of human tyrosine kinase-negative epidermal growth factor receptor amplifies signaling through endogenous murine epidermal growth factor receptor. J Biol Chem. 1993 Dec 15; 268(35):26441-6. PMID: 8253771.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    1030. Schmandt R, Mills GB. Genomic components of carcinogenesis. Clin Chem. 1993 Nov; 39(11 Pt 2):2375-85. PMID: 8222249.
      Citations: 2     Fields:    Translation:Humans
    1031. Mills GB, Schmandt R, Gibson S, Leung B, Hill M, May C, Shi YF, Branch DR, Radvanyi L, Truitt KE, et al. Transmembrane signaling by the interleukin-2 receptor: progress and conundrums. Semin Immunol. 1993 Oct; 5(5):345-64. PMID: 8260651.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    1032. Gibson S, Leung B, Squire JA, Hill M, Arima N, Goss P, Hogg D, Mills GB. Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. Blood. 1993 Sep 01; 82(5):1561-72. PMID: 8364206.
      Citations: 25     Fields:    Translation:HumansCells
    1033. Cyopick P, Culliton R, Brockhausen I, Sutherland DR, Mills GB, Baker M. Role of aberrant sialylation of chronic myeloid leukemia granulocytes on binding and signal transduction by chemotactic peptides and colony stimulating factors. Leuk Lymphoma. 1993 Sep; 11(1-2):79-90. PMID: 8220157.
      Citations: 3     Fields:    Translation:HumansCells
    1034. Franklin RA, Mazer B, Sawami H, Mills GB, Terada N, Lucas JJ, Gelfand EW. Platelet-activating factor triggers the phosphorylation and activation of MAP-2 kinase and S6 peptide kinase activity in human B cell lines. J Immunol. 1993 Aug 15; 151(4):1802-10. PMID: 7688385.
      Citations: 4     Fields:    Translation:HumansCells
    1035. Radvanyi LG, Mills GB, Miller RG. Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death. J Immunol. 1993 Jun 15; 150(12):5704-15. PMID: 8515084.
      Citations: 25     Fields:    Translation:AnimalsCells
    1036. Matthews KE, Mills GB, Horsfall W, Hack N, Skorecki K, Keating A. Bead transfection: rapid and efficient gene transfer into marrow stromal and other adherent mammalian cells. Exp Hematol. 1993 May; 21(5):697-702. PMID: 8513872.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    1037. Fang XJ, Keating A, Flowers M, Liew CC, Gupta H, Mills GB, Sherman M. The v-raf oncogene enhances tumorigenicity and suppresses differentiation in vivo in a rat hepatocyte cell line. Carcinogenesis. 1993 Apr; 14(4):669-74. PMID: 7682480.
      Citations: 3     Fields:    Translation:AnimalsCells
    1038. Yuan S, Trachtenberg J, Mills GB, Brown TJ, Xu F, Keating A. Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA. Cancer Res. 1993 Mar 15; 53(6):1304-11. PMID: 8443809.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    1039. Mills GB, Arima N, May C, Hill M, Schmandt R, Li J, Miyamoto NG, Greene WC. Neither the LCK nor the FYN kinases are obligatory for IL-2-mediated signal transduction in HTLV-I-infected human T cells. Int Immunol. 1992 Nov; 4(11):1233-43. PMID: 1472476.
      Citations: 12     Fields:    Translation:Cells
    1040. Simon HU, Mills GB, Hashimoto S, Siminovitch KA. Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome. J Clin Invest. 1992 Oct; 90(4):1396-405. PMID: 1401074; PMCID: PMC443185.
      Citations: 16     Fields:    Translation:HumansCells
    1041. Mills GB, Schmandt R, McGill M, Amendola A, Hill M, Jacobs K, May C, Rodricks AM, Campbell S, Hogg D. Expression of TTK, a novel human protein kinase, is associated with cell proliferation. J Biol Chem. 1992 Aug 05; 267(22):16000-6. PMID: 1639825.
      Citations: 58     Fields:    Translation:HumansCells
    1042. Gallion HH, Liu PY, Alberts DE, O'Toole RV, O'Sullivan J, Mills G, Smith HO, Hynes HE. Phase II trial of amonafide in previously treated patients with advanced ovarian cancer: a Southwest Oncology Group study. Gynecol Oncol. 1992 Aug; 46(2):230-2. PMID: 1500027.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    1043. Schmandt R, Fung M, Arima N, Zhang N, Leung B, May C, Gibson S, Hill M, Green W, Mills GB. T-lymphocyte proliferation: tyrosine kinases in interleukin 2 signal transduction. Baillieres Clin Haematol. 1992 Jul; 5(3):551-73. PMID: 1457964.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    1044. Bacus SS, Stancovski I, Huberman E, Chin D, Hurwitz E, Mills GB, Ullrich A, Sela M, Yarden Y. Tumor-inhibitory monoclonal antibodies to the HER-2/Neu receptor induce differentiation of human breast cancer cells. Cancer Res. 1992 May 01; 52(9):2580-9. PMID: 1373672.
      Citations: 24     Fields:    Translation:HumansAnimals
    1045. Lazarus AH, Mills GB, Crow AR, Delovitch TL. Antigen-induced Fc receptor-dependent and -independent B cell desensitization. An elevation in [Ca2+]i is not sufficient and protein kinase C activation is not required for these pathways of surface IgM-mediated desensitization. J Immunol. 1991 Sep 15; 147(6):1739-45. PMID: 1890301.
      Citations: 2     Fields:    Translation:AnimalsCells
    1046. Fung MR, Scearce RM, Hoffman JA, Peffer NJ, Hammes SR, Hosking JB, Schmandt R, Kuziel WA, Haynes BF, Mills GB, et al. A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor. J Immunol. 1991 Aug 15; 147(4):1253-60. PMID: 1869821.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    1047. Roifman CM, Chin K, Gazit A, Mills GB, Gilon C, Levitzki A. Tyrosine phosphorylation is an essential event in the stimulation of B lymphocytes by Staphylococcus aureus Cowan I. J Immunol. 1991 May 01; 146(9):2965-71. PMID: 1707926.
      Citations: 1     Fields:    Translation:HumansCells
    1048. Mills GB, Zhang N, Schmandt R, Fung M, Greene W, Mellors A, Hogg D. Transmembrane signalling by interleukin 2. Biochem Soc Trans. 1991 Apr; 19(2):277-87. PMID: 1889610.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    1049. Padeh S, Levitzki A, Gazit A, Mills GB, Roifman CM. Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation. J Clin Invest. 1991 Mar; 87(3):1114-8. PMID: 1705565; PMCID: PMC329909.
      Citations: 13     Fields:    Translation:HumansCells
    1050. Jordan ML, Vidgen DF, Wright J, Odell M, Mills GB. Sustained increases in cytosolic calcium during T lymphocyte allosensitization, proliferation, and acquisition of locomotor function. Transplantation. 1991 Feb; 51(2):464-8. PMID: 1825245.
      Citations: 2     Fields:    Translation:AnimalsCells
    1051. Klotz LH, Kulkarni C, Mills G. End stage renal disease serum contains a specific renal cell growth factor. J Urol. 1991 Jan; 145(1):156-60. PMID: 1984082.
      Citations: 1     Fields:    Translation:HumansCells
    1052. Sutherland DR, Yeo E, Ryan A, Mills GB, Bailey D, Baker MA. Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets. Blood. 1991 Jan 01; 77(1):84-93. PMID: 1984805.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    1053. Stamatoglou SC, Ge RC, Mills G, Butters TD, Zaidi F, Hughes RC. Identification of a novel glycoprotein (AGp110) involved in interactions of rat liver parenchymal cells with fibronectin. J Cell Biol. 1990 Nov; 111(5 Pt 1):2117-27. PMID: 2229188; PMCID: PMC2116319.
      Citations: 5     Fields:    Translation:AnimalsCells
    1054. Stanley JB, Gorczynski R, Huang CK, Love J, Mills GB. Tyrosine phosphorylation is an obligatory event in IL-2 secretion. J Immunol. 1990 Oct 01; 145(7):2189-98. PMID: 1697878.
      Citations: 13     Fields:    Translation:AnimalsCells
    1055. Mills GB, May C, Hill M, Campbell S, Shaw P, Marks A. Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells. J Clin Invest. 1990 Sep; 86(3):851-5. PMID: 2394835; PMCID: PMC296802.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    1056. McGroarty RJ, Mills GB, de Harven E. Immunogold labeling of the low-affinity (55 kd) IL2 receptor on the surface of IL2 receptor-bearing cultured cells and mitogen-activated peripheral blood lymphocytes. J Leukoc Biol. 1990 Sep; 48(3):213-9. PMID: 2391447.
      Citations:    Fields:    Translation:HumansCells
    1057. Schuh AC, Sutherland DR, Horsfall W, Mills GB, Dube I, Baker MA, Siminovitch K, Bailey D, Keating A. Chronic myeloid leukemia arising in a progenitor common to T cells and myeloid cells. Leukemia. 1990 Sep; 4(9):631-6. PMID: 2168506.
      Citations: 1     Fields:    Translation:HumansCells
    1058. Cruz TF, Mills G, Pritzker KP, Kandel RA. Inverse correlation between tyrosine phosphorylation and collagenase production in chondrocytes. Biochem J. 1990 Aug 01; 269(3):717-21. PMID: 1697163; PMCID: PMC1131646.
      Citations: 5     Fields:    Translation:AnimalsCells
    1059. Kandel RA, Pritzker KP, Mills GB, Cruz TF. Fetal bovine serum inhibits chondrocyte collagenase production: interleukin 1 reverses this effect. Biochim Biophys Acta. 1990 Jul 12; 1053(2-3):130-4. PMID: 2166583.
      Citations: 3     Fields:    Translation:AnimalsCells
    1060. Haliotis T, Trimble W, Chow S, Bull S, Mills G, Girard P, Kuo JF, Hozumi N. Expression of ras oncogene leads to down-regulation of protein kinase C. Int J Cancer. 1990 Jun 15; 45(6):1177-83. PMID: 2190939.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    1061. Lazarus AH, Mills GB, Delovitch TL. Antigen-induced Ca2+ signaling and desensitization in B cells. J Immunol. 1990 Jun 01; 144(11):4147-55. PMID: 2341715.
      Citations: 3     Fields:    Translation:AnimalsCells
    1062. Mills GB, Zhang N, May C, Hill M, Chung A. Suramin prevents binding of interleukin 2 to its cell surface receptor: a possible mechanism for immunosuppression. Cancer Res. 1990 May 15; 50(10):3036-42. PMID: 1692253.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    1063. Mills GB, Hill M, McGill M, May C, Stanley J, Stewart DJ, Mellors A, Gelfand EW. Interrelationship between signals transduced by phytohemagglutinin and interleukin 1. J Cell Physiol. 1990 Mar; 142(3):539-51. PMID: 1690213.
      Citations: 2     Fields:    Translation:AnimalsCells
    1064. Mills GB, May C, McGill M, Fung M, Baker M, Sutherland R, Greene WC. Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated. J Biol Chem. 1990 Feb 25; 265(6):3561-7. PMID: 2303462.
      Citations: 33     Fields:    Translation:HumansCells
    1065. Grinstein S, Furuya W, Lu DJ, Mills GB. Vanadate stimulates oxygen consumption and tyrosine phosphorylation in electropermeabilized human neutrophils. J Biol Chem. 1990 Jan 05; 265(1):318-27. PMID: 1688431.
      Citations: 20     Fields:    Translation:HumansCells
    1066. Burdett E, Mills GB, Klip A. Effect of GTP gamma S on insulin binding and tyrosine phosphorylation in liver membranes and L6 muscle cells. Am J Physiol. 1990 Jan; 258(1 Pt 1):C99-108. PMID: 2105654.
      Citations: 6     Fields:    Translation:AnimalsCells
    1067. Mills GB, May C, Hill M, Gelfand EW. Role of protein kinase C in interleukin 1, anti-T3, and mitogenic lectin-induced interleukin 2 secretion. J Cell Physiol. 1989 Nov; 141(2):310-7. PMID: 2808540.
      Citations: 2     Fields:    Translation:AnimalsCells
    1068. Vandewaa EA, Mills G, Chen GZ, Foster LA, Bennett JL. Physiological role of HMG-CoA reductase in regulating egg production by Schistosoma mansoni. Am J Physiol. 1989 Sep; 257(3 Pt 2):R618-25. PMID: 2782464.
      Citations: 13     Fields:    Translation:AnimalsCells
    1069. Stanley JB, Gorczynski RM, Delovitch TL, Mills GB. IL-2 secretion is pertussis toxin sensitive in a T lymphocyte hybridoma. J Immunol. 1989 May 15; 142(10):3546-52. PMID: 2523928.
      Citations: 3     Fields:    Translation:AnimalsCells
    1070. Hardy GW, Lowe LA, Mills G, Sang PY, Simpkin DS, Follenfant RL, Shankley C, Smith TW. Peripherally acting enkephalin analogues. 2. Polar tri- and tetrapeptides. J Med Chem. 1989 May; 32(5):1108-18. PMID: 2709377.
      Citations: 1     Fields:    Translation:Animals
    1071. Ebanks R, Roifman C, Mellors A, Mills GB. The diacylglycerol analogue, 1,2-sn-dioctanoylglycerol, induces an increase in cytosolic free Ca2+ and cytosolic acidification of T lymphocytes through a protein kinase C-independent process. Biochem J. 1989 Mar 15; 258(3):689-98. PMID: 2786413; PMCID: PMC1138421.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    1072. Mills GB, May C, Hill M, Ebanks R, Roifman C, Mellors A, Gelfand EW. Physiologic activation of protein kinase C limits IL-2 secretion. J Immunol. 1989 Mar 15; 142(6):1995-2003. PMID: 2784146.
      Citations: 4     Fields:    Translation:AnimalsCells
    1073. Bjorge JD, Kudlow JE, Mills GB, Paterson AJ. Inhibition of stimulus-dependent epidermal growth factor receptor and transforming growth factor-alpha mRNA accumulation by the protein kinase C inhibitor staurosporine. FEBS Lett. 1989 Jan 30; 243(2):404-8. PMID: 2465187.
      Citations:    Fields:    Translation:HumansCells
    1074. Church JG, Mills GB, Buick RN. Activation of the Na+/H+ antiport is not required for epidermal growth factor-dependent gene expression, growth inhibition or proliferation in human breast cancer cells. Biochem J. 1989 Jan 01; 257(1):151-7. PMID: 2537620; PMCID: PMC1135549.
      Citations:    Fields:    Translation:HumansCells
    1075. Kumagai N, Benedict SH, Mills GB, Gelfand EW. Cyclosporin A inhibits initiation but not progression of human T cell proliferation triggered by phorbol esters and calcium ionophores. J Immunol. 1988 Dec 01; 141(11):3747-52. PMID: 3263432.
      Citations: 3     Fields:    Translation:HumansCells
    1076. Kumagai N, Benedict SH, Mills GB, Gelfand EW. Induction of competence and progression signals in human T lymphocytes by phorbol esters and calcium ionophores. J Cell Physiol. 1988 Nov; 137(2):329-36. PMID: 3263971.
      Citations: 6     Fields:    Translation:HumansCells
    1077. Mills GB, Girard P, Grinstein S, Gelfand EW. Interleukin-2 induces proliferation of T lymphocyte mutants lacking protein kinase C. Cell. 1988 Oct 07; 55(1):91-100. PMID: 2844411.
      Citations: 23     Fields:    Translation:AnimalsCells
    1078. Haliotis T, Trimble W, Chow S, Mills G, Girard P, Kuo JF, Govindji N, Hozumi N. The cell biology of ras-induced transformation: insights from studies utilizing an inducible hybrid oncogene system. Anticancer Res. 1988 Sep-Oct; 8(5A):935-45. PMID: 2845854.
      Citations:    Fields:    Translation:HumansAnimalsCells
    1079. Mills GB, May C, McGill M, Roifman CM, Mellors A. A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action. Cancer Res. 1988 Mar 01; 48(5):1066-71. PMID: 3422589.
      Citations: 40     Fields:    Translation:HumansCells
    1080. Teodorczyk-Injeyan JA, Sparkes BG, Falk RE, Peters WJ, Mills GB. Interleukin-2 secretion and transmembrane signalling in burned patients. J Trauma. 1988 Feb; 28(2):152-7. PMID: 3126303.
      Citations: 4     Fields:    Translation:HumansCells
    1081. Schaffer FM, Benedict SH, Petsche D, Lau A, Williams BR, Mills GB, Gelfand EW. Interferon and phorbol esters down-regulate sIgM expression by independent pathways. J Cell Physiol. 1988 Feb; 134(2):245-52. PMID: 2831237.
      Citations:    Fields:    Translation:Cells
    1082. Kumagai N, Benedict SH, Mills GB, Gelfand EW. Comparison of phorbol ester/calcium ionophore and phytohemagglutinin-induced signaling in human T lymphocytes. Demonstration of interleukin 2-independent transferrin receptor gene expression. J Immunol. 1988 Jan 01; 140(1):37-43. PMID: 3121740.
      Citations: 5     Fields:    Translation:Cells
    1083. Mills GB, May C. Binding of interleukin 2 to its 75-kDa intermediate affinity receptor is sufficient to activate Na+/H+ exchange. J Immunol. 1987 Dec 15; 139(12):4083-7. PMID: 2826580.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    1084. Roifman CM, Mills GB, Stewart D, Cheung RK, Grinstein S, Gelfand EW. Response of human B cells to different anti-immunoglobulin isotypes: absence of a correlation between early activation events and cell proliferation. Eur J Immunol. 1987 Dec; 17(12):1737-42. PMID: 3500860.
      Citations: 5     Fields:    Translation:HumansCells
    1085. Tilchen EJ, Fleming T, Mills G, Oishi N, Bonnett JD, Natale RB, Harker G, Coltman CA. Phase II evaluation of diaziquone in pancreatic carcinoma: a Southwest Oncology Group Study. Cancer Treat Rep. 1987 Dec; 71(12):1309-10. PMID: 3690548.
      Citations: 1     Fields:    Translation:Humans
    1086. Kumagai N, Benedict SH, Mills GB, Gelfand EW. Requirements for the simultaneous presence of phorbol esters and calcium ionophores in the expression of human T lymphocyte proliferation-related genes. J Immunol. 1987 Sep 01; 139(5):1393-9. PMID: 3114365.
      Citations: 19     Fields:    Translation:HumansCells
    1087. Benedict SH, Mills GB, Gelfand EW. Interleukin 2 activates a receptor-associated protein kinase. J Immunol. 1987 Sep 01; 139(5):1694-7. PMID: 3040857.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    1088. Estrov Z, Roifman C, Mills G, Grunberger T, Gelfand EW, Freedman MH. The regulatory role of interleukin 2-responsive T lymphocytes on human marrow granulopoiesis. Blood. 1987 Apr; 69(4):1161-6. PMID: 3103713.
      Citations: 2     Fields:    Translation:HumansCells
    1089. Teodorczyk-Injeyan JA, Sparkes BG, Mills GB, Falk RE, Peters WJ. Impaired expression of interleukin-2 receptor (IL2R) in the immunosuppressed burned patient: reversal by exogenous IL2. J Trauma. 1987 Feb; 27(2):180-7. PMID: 3102753.
      Citations: 6     Fields:    Translation:HumansCells
    1090. Gelfand EW, Mills GB, Cheung RK, Lee JW, Grinstein S. Transmembrane ion fluxes during activation of human T lymphocytes: role of Ca2+, Na+/H+ exchange and phospholipid turnover. Immunol Rev. 1987 Feb; 95:59-87. PMID: 2437015.
      Citations: 38     Fields:    Translation:HumansCells
    1091. Roifman CM, Mills GB, Cheung RK, Gelfand EW. Mitogenic response of human thymocytes: identification of functional Ca2+-dependent and independent signals. Clin Exp Immunol. 1986 Oct; 66(1):139-49. PMID: 3100117; PMCID: PMC1542650.
      Citations: 4     Fields:    Translation:HumansCells
    1092. Hughes RC, Mills G. Functional differences in the interactions of glycosylation-deficient cell lines with fibronectin, laminin, and type IV collagen. J Cell Physiol. 1986 Sep; 128(3):402-12. PMID: 2943748.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    1093. Mills GB, Stewart DJ, Mellors A, Gelfand EW. Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells. J Immunol. 1986 Apr 15; 136(8):3019-24. PMID: 3082978.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    1094. Mills GB, Cheung RK, Cragoe EJ, Grinstein S, Gelfand EW. Activation of the Na+/H+ antiport is not required for lectin-induced proliferation of human T lymphocytes. J Immunol. 1986 Feb 15; 136(4):1150-4. PMID: 3003191.
      Citations: 5     Fields:    Translation:HumansCells
    1095. Grinstein S, Mack E, Mills GB. Osmotic activation of the Na+/H+ antiport in protein kinase C-depleted lymphocytes. Biochem Biophys Res Commun. 1986 Jan 14; 134(1):8-13. PMID: 3004445.
      Citations: 6     Fields:    Translation:AnimalsCells
    1096. Mills GB, Lee JW, Cheung RK, Gelfand EW. Characterization of the requirements for human T cell mitogenesis by using suboptimal concentrations of phytohemagglutinin. J Immunol. 1985 Nov; 135(5):3087-93. PMID: 2995486.
      Citations: 11     Fields:    Translation:HumansCells
    1097. Mills GB, Cragoe EJ, Gelfand EW, Grinstein S. Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation. J Biol Chem. 1985 Oct 15; 260(23):12500-7. PMID: 2995378.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    1098. Dosch HM, Ledgley CJ, White D, Lam P, Mills GB. Lymphocyte function in human bone marrow. II. Characterization of an interleukin 2-sensitive T precursor-cell population. J Clin Immunol. 1985 Sep; 5(5):345-56. PMID: 3902872.
      Citations: 1     Fields:    Translation:HumansCells
    1099. Mills GB, Ledgley CJ, Hibi T, White D, Lam P, Dosch HM. Lymphocyte function in human bone marrow. I. Characterization of two T cell populations regulating immunoglobulin secretion. J Immunol. 1985 May; 134(5):3036-41. PMID: 3156927.
      Citations: 5     Fields:    Translation:HumansCells
    1100. Gelfand EW, Cheung RK, Mills GB, Grinstein S. Mitogens trigger a calcium-independent signal for proliferation in phorbol-ester-treated lymphocytes. Nature. 1985 May 30-Jun 5; 315(6018):419-20. PMID: 3923369.
      Citations: 11     Fields:    Translation:HumansCells
    1101. Mills GB, Cheung RK, Grinstein S, Gelfand EW. Interleukin 2-induced lymphocyte proliferation is independent of increases in cytosolic-free calcium concentrations. J Immunol. 1985 Apr; 134(4):2431-5. PMID: 3919094.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    1102. Mills GB, Cheung RK, Grinstein S, Gelfand EW. Increase in cytosolic free calcium concentration is an intracellular messenger for the production of interleukin 2 but not for expression of the interleukin 2 receptor. J Immunol. 1985 Mar; 134(3):1640-3. PMID: 3918108.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    1103. Mills GB, Hannigan G, Stewart D, Mellors A, Williams B, Gelfand EW. Interferons do not signal cells through rapid alterations in phosphatidylinositide hydrolysis, cytoplasmic free calcium, or cytoplasmic alkalinization. Prog Clin Biol Res. 1985; 202:357-67. PMID: 2421315.
      Citations:    Fields:    Translation:HumansCells
    1104. Hughes RC, Mills G. Analysis by lectin affinity chromatography of N-linked glycans of BHK cells and ricin-resistant mutants. Biochem J. 1983 Jun 01; 211(3):575-87. PMID: 6882361; PMCID: PMC1154402.
      Citations: 13     Fields:    Translation:AnimalsCells
    1105. Roodman GD, Clare CN, Mills G. Congenital dyserythropoietic anaemia type II (CDA-II): chromosomal banding studies and adherent cell effects on erythroid colony (CFU-E) and burst (BFU-E) formation. Br J Haematol. 1982 Mar; 50(3):499-507. PMID: 7066202.
      Citations: 1     Fields:    Translation:HumansCells
    1106. Mills GB, Paetkau V. Generation of cytotoxic lymphocytes to syngeneic tumor by using co-stimulator (Interleukin 2). J Immunol. 1980 Nov; 125(5):1897-903. PMID: 6159395.
      Citations: 16     Fields:    Translation:AnimalsCells
    1107. Mills GB, Carlson G, Paetkau V. Generation of cytotoxic lymphocytes to syngeneic tumors by using co-stimulator (Interleukin 2): in vivo activity. J Immunol. 1980 Nov; 125(5):1904-9. PMID: 6968766.
      Citations: 12     Fields:    Translation:AnimalsCells
    1108. Slaga TJ, Gleason GL, Mills G, Ewald L, Fu PP, Lee HM, Harvey RG. Comparison of the skin tumor-initiating activities of dihydrodiols and diol-epoxides of various polycyclic aromatic hydrocarbons. Cancer Res. 1980 Jun; 40(6):1981-4. PMID: 7371034.
      Citations: 4     Fields:    Translation:Animals
    1109. Paetkau V, Shaw J, Caplan B, Mills GB, Lee KC. Interleukin 2 in cell-mediated immune responses. J Supramol Struct. 1980; 13(2):271-80. PMID: 6972471.
      Citations: 2     Fields:    Translation:AnimalsCells
    1110. Pena SD, Mills G, Hughes RC. Two-dimensional electrophoresis of surface glycoproteins of normal BHK cells and ricin resistant mutants. Biochim Biophys Acta. 1979 Jan 05; 550(1):100-9. PMID: 760785.
      Citations: 6     Fields:    Translation:Cells
    1111. Harris J, Mills G. Family psychiatry: communicating with the network. Practitioner. 1978 Dec; 221(1326):829-35. PMID: 748898.
      Citations:    Fields:    Translation:Humans
    1112. Shaw J, Monticone V, Mills G, Paetkau V. Effects of costimulator on immune responses in vitro. J Immunol. 1978 Jun; 120(6):1974-80. PMID: 149174.
      Citations: 19     Fields:    Translation:AnimalsCells
    1113. Mills G, Monticone V. The role of macrophages in thymocyte mitogenesis. J Immunol. 1976 Oct; 117(4):1325-30. PMID: 1086324.
      Citations: 15     Fields:    Translation:AnimalsCells
    1114. Gerhart S, Mills G, Monticone V, Paetkau V. Quantitative analysis of the proliferative activity induced in murine thymocytes by concanavalin A. J Immunol. 1976 Oct; 117(4):1314-9. PMID: 1086322.
      Citations: 1     Fields:    Translation:AnimalsCells
    1115. Paetkau V, Mills G, Gerhart S, Monticone V. Proliferation of murine thymic lymphocytes in vitro is mediated by the concanavalin A-induced release of a lymphokine (costimulator). J Immunol. 1976 Oct; 117(4):1320-4. PMID: 1086323.
      Citations: 27     Fields:    Translation:AnimalsCells
    1116. McGregor DH, Mills G, Boudet RA. Intramural squamous cell carcinoma of the esophagus. Cancer. 1976 Mar; 37(3):1556-61. PMID: 1260674.
      Citations: 10     Fields:    Translation:Humans
    1117. Douglas RB, Brown P, Knight K, Mills G, Wilson G. Letter: Effects of entonox on respiratory function. Br Med J. 1974 May 04; 2(5913):277. PMID: 4827094; PMCID: PMC1610506.
      Citations: 1     Fields:    Translation:Humans
    1118. mTOR inhibitors suppress homologous recombination repair and synergize with PARP inhibitors via regulating SUV39H1 in BRCA-proficient triple-negative breast cancer. Clinical Cancer Research. 22:1699-1712.
    1119. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget. 7:40252-40265.
    1120. Targeting KRas-dependent tumour growth, circulating tumour cells and metastasis in vivo by clinically significant miR-193a-3p. Oncogene.
    1121. The Molecular Taxonomy of Primary Prostate Cancer. Cell. 163:1011-1025.
    1122. MAPK activation predicts poor outcome and the MEK inhibitor, selumetinib, reverses antiestrogen resistance in ER-positive high-grade serous ovarian cancer. Clinical Cancer Research. 22:935-947.
    1123. Clinical outcomes based on multigene profiling in metastatic breast cancer patients. Oncotarget. 7:76362-76373.
    1124. Bias from removing read duplication in ultra-deep sequencing experiments. Bioinformatics. 30:1073-1080.
    1125. Erratum. Nature Genetics. 41:1156.
    1126. Functional annotation of rare gene aberration drivers of pancreatic cancer. Nature Communications. 7.
    1127. Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy. eLife. 4.
    1128. The PI3K/AKT Pathway and Renal Cell Carcinoma. Journal of Genetics and Genomics.
    1129. Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities. Cancer Discovery. 5:861-878.
    1130. Functional proteomics identifies miRNAs to target a p27/Myc/phospho-Rb signature in breast and ovarian cancer. Oncogene.
    1131. Local-mass preserving prior distributions for nonparametric bayesian models. Bayesian Analysis. 9:307-330.
    1132. Early Detection of Cancer. 335-347.
    1133. Comprehensive genomic analysis identifies novel subtypes and targets of triple-negative breast cancer. Clinical Cancer Research. 21:1688-1698.
    1134. American Journal of Cancer Research. 6:27-37.
    1135. Mutation profiling in cholangiocarcinoma. PLoS One. 9.
    1136. Robust selection algorithm (RSA) for multi-omic biomarker discovery; integration with functional network analysis to identify miRNA regulated pathways in multiple cancers. PLoS One. 10.
    1137. Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours. Nature Communications. 6.
    1138. Metabolic stress induces a Wnt-dependent cancer stem cell-like state transition. Cell Death and Disease. 6.
    1139. Role of membrane potential in the regulation of T-cell activation. Federation Proceedings. 44.
    1140. High intratumoral stromal content defines reactive breast cancer as a low-risk breast cancer subtype. Clinical Cancer Research. 22:5068-5078.
    1141. Erratum. Journal of Cellular Physiology. 205:158-159.
    1142. Personalized preclinical trials in BRAF Inhibitor-resistant patient-derived xenograft models identify second-line combination therapies. Clinical Cancer Research. 22:1592-1602.
    1143. Transgenic expression of the mitochondrial chaperone TNFR-associated protein 1 (TRAP1) accelerates prostate cancer development. Journal of Biological Chemistry. 291:25247-25254.
    1144. Erratum. Cell. 157:753.
    1145. eLife. 4.
    1146. ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS (Proceedings of the National Academy of Sciences (2010) 107 (4153-4158) DOI. Proceedings of the National Academy of Sciences of the United States of America. 109:8352.
    1147. Correction. PLoS One. 8.
    1148. Cadherin endocytosis. Nature Reviews Cancer. 9:143.
    1149. Modulation of breast cancer risk biomarkers by high-dose omega-3 fatty acids. Cancer Prevention Research. 8:922-931.
    1150. Clinical next generation sequencing to identify actionable aberrations in a phase I program. Oncotarget. 6:20099-20110.
    1151. The rise of genomic profiling in ovarian cancer. Expert Review of Molecular Diagnostics. 16:1337-1351.
    1152. Individualized molecular medicine. Advances in Experimental Medicine and Biology. 622:183-195.
    1153. The degree of intratumor mutational heterogeneity varies by primary tumor sub-site. Oncotarget. 7:27185-27198.
    1154. Modulation of autophagy and its potential for cancer therapy. Drugs of the Future. 36:919-925.
    1155. PKCiota promotes ovarian tumor progression through deregulation of cyclin E. Oncogene.
    1156. Cell cycle dependent regulation of the protein kinase TTK. Oncogene. 9.
    1157. Interleukin 2 rapidly increases intracellular pH in interleukin 2-sensitive cells. Federation Proceedings. 44.
    1158. Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression. Journal of Lipid Research. 57:25-35.
    1159. Cytokines and mechanisms of lymphocyte activation. Immunology and Allergy Clinics of North America. 9:21-43.
    1160. Aberrant vesicular trafficking contributes to altered polarity and metabolism in cancer. 95-123.
    1161. Erratum. PLoS One. 11.
    1162. Association of somatic mutations of ADAMTS genes with chemotherapy sensitivity and survival in high-grade serous ovarian carcinoma. JAMA oncology. 1:486-494.
    1163. Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. Journal of Hepatology. 65:325-333.
    1164. Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function. Oncogene.
    1165. Modulators of lysophosphatidic acid signalling. Expert Opinion on Therapeutic Patents. 13:1619-1634.
    1166. Ability to generate patient-derived Breast cancer xenografts is enhanced in chemoresistant disease and predicts poor patient outcomes. PLoS One. 10.
    1167. Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma. Hepatology. 63:159-172.
    1168. Integrative protein-based prognostic model for early-stage endometrioid endometrial cancer. Clinical Cancer Research. 22:513-523.
    1169. Identification of variant-specific functions of PIK3CA by rapid phenotyping of rare mutations. Cancer Research. 75:5341-5354.
    1170. Cyclin e associates with the lipogenic enzyme ATP-citrate lyase to enable malignant growth of breast cancer cells. Cancer Research. 76:2406-2418.
    1171. Therapeutic potential of phosphoinositide 3-kinase inhibitors. Expert Opinion on Therapeutic Patents. 14:703-732.
    1172. Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis (Cancer Research (2010) 70, (3287-3298) DOI. Cancer Research. 70:4785.
    1173. Multiplatform-based molecular subtypes of non-small-cell lung cancer. Oncogene.
    1174. Phosphorylation of the IL2 receptor involves an inducible protein kinase. Federation Proceedings. 44:3143.
    1175. Inihibition of PI3K by LY294002 promotes apoptosis and dephosphorylates bad in myeloid leukemias. Blood. 96.
    1176. Using reverse-phase protein arrays as pharmacodynamic assays for functional proteomics, biomarker discovery, and drug development in cancer. Seminars in Oncology. 43:476-483.
    1177. PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer. Breast Diseases. 22:370-371.
    1178. Erratum. Journal of Immunology. 146:3260.
    1179. Comparison of gene expression patterns across 12 tumor types identifies a cancer supercluster characterized by TP53 mutations and cell cycle defects. Oncogene.
    1180. Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors. Journal of Clinical Investigation. 126:1834-1856.
    1181. Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance. Cell. 164:293-309.
    1182. Retrospective review of MET gene mutations. Oncoscience. 2:533-541.
    1183. Molecular targets for epithelial ovarian cancer. 606-618.
    1184. Cardiac glycosides display selective efficacy for STK11 mutant lung cancer. Scientific Reports. 6.
    1185. Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure. Cell Cycle. 14:2323-2332.
    1186. Oncogene.
    1187. Homeostasis of redox status derived from glucose metabolic pathway could be the key to understanding the Warburg effect. American Journal of Cancer Research. 5:1265-1280.
    1188. HSP70 inhibition limits FAK-dependent invasion and enhances the response to melanoma treatment with BRAF inhibitors. Cancer Research. 76:2720-2730.
    1189. Molecular Mechanisms of Pathogenesis and Progression of Epithelial Ovarian Cancer. 625-645.
    1190. Integrated molecular and clinical analysis of AKT activation in metastatic melanoma. Clinical Cancer Research. 15:7538-7546.
    1191. BRAF Mutation testing in cell-free DNA from the plasma of patients with advanced cancers using a rapid, automated molecular diagnostics system. Molecular Cancer Therapeutics. 15:1397-1404.
    1192. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene. 34:5447-5459.
    1193. Alkoxymethylenephosphonate analogues of (Lyso)phosphatidic acid stimulate signaling networks coupled to the LPA2 receptor (ChemMedChem (2007) 2, (1789-1798)). ChemMedChem. 3:200.
    1194. Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer. PLoS One. 10.
    1195. Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma. Cell Reports. 14:2476-2489.
    1196. Erratum. Journal of Cellular Biochemistry. 93:427.
    1197. Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types. BMC Genomics. 17.
    1198. Rab11-FIP1C is a critical negative regulator in ErbB2-mediated mammary tumor progression. Cancer Research. 76:2662-2674.
    1199. Incidental germline variants in 1000 advanced cancers on a prospective somatic genomic profiling protocol. Annals of Oncology. 27:795-800.
    1200. Erratum. Oncogene. 35:801.
    1201. Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]. Genome Biology. 16.
    1202. An integrated molecular analysis of lung adenocarcinomas identifies potential therapeutic targets among TTF1-negative tumors, including DNA Repair Proteins and Nrf2. Clinical Cancer Research. 21:3480-3491.
    1203. Molecular Pathogenesis of Ovarian Cancer.
    1204. Phosphatase PTP4A3 promotes triple-negative breast cancer growth and predicts poor patient survival. Cancer Research. 76:1942-1953.
    1205. Erratum. European Journal of Cancer. 40:628.
    1206. Shrewd AKT regulation to survive. Oncoscience. 1:113-114.
    1207. Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer. Genome Medicine. 7.
    1208. Erratum. Journal of Immunology. 163:1092.
    1209. Understanding the Functions of Lysophosphatidic Acid Receptors in Cancer. 641-659.
    1210. Applications of proteomics to clinical questions in breast cancer. 623-639.
    1211. Activation of phosphatidylinositol 3-kinase (PI3K) as a predictor of clinical outcome in breast cancer patients. Breast Cancer Research and Treatment. 69:267.
    1212. Erratum. EMBO Reports. 15:1000.
    1213. Erratum. Journal of Clinical Investigation. 123:5410.
    1214. Towards a Unified Approach to New Target Discovery in Breast Cancer. 167-207.
    1215. Erratum. Bioinformatics. 29:819.
    1216. hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. Oncogene.
    1217. P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. Oncogene.
    1218. Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic Cancer. Cell Reports. 16:2017-2031.
    1219. Letter to the editor (Reply). Journal of Immunology. 146:402-403.
    1220. Inferring causal molecular networks. Nature Methods. 13:310-318.
    1221. Comprehensive molecular portraits of human breast tumours. Nature. 490:61-70.
    1222. Utility of a molecular prescreening program in advanced colorectal cancer for enrollment on biomarker-selected clinical trials. Annals of Oncology. 27:1068-1074.
    1223. Messenger rna expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis. International Journal of Molecular Epidemiology and Genetics. 1:1-10.
    1224. The Genomic Landscape and Clinical Relevance of A-to-I RNA Editing in Human Cancers. Cancer Cell. 28:515-528.
    1225. Modulation of breast cancer risk biomarkers by high-dose omega-3 fatty acids. Cancer Prevention Research. 8:912-921.
    1226. 068 Isolation of a possible human counterpart to the murine XLR genes. Fresenius' Journal of Analytical Chemistry. 343:125-126.
    1227. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients. Molecular Oncology. 9:1694-1703.
    1228. RCP induces Slug expression and cancer cell invasion by stabilizing β1 integrin. Oncogene.
    1229. RADical response puts an exceptional responder in CHKmate. Cancer Discovery. 4:988-990.
    1230. Erratum. Journal of Clinical Investigation. 115:2298.
    1231. Loss of ARID1A activates ANXA1, which serves as a predictive biomarker for trastuzumab resistance. Clinical Cancer Research. 22:5238-5248.
    1232. Targeting of PYK2 synergizes with EGFR antagonists in basal-like TNBC and circumvents HER3-associated resistance via the NEDD4-NDRG1 axis. Cancer Research. 77:86-99.
    1233. Genomic technologies in cancer research, drug discovery and development. CME Journal of Gynecologic Oncology. 7:16-24.
    1234. New era of integrated cancer biomarker discovery using reverse-phase protein arrays. Drug Metabolism and Pharmacokinetics. 31:34-45.
    1235. Erratum. Nature Genetics. 41:1156.
    1236. TransVar. Nature Methods. 12:1002-1003.
    1237. Erratum. Journal of Biological Chemistry. 284:21100.
    1238. A Bayesian hierarchical model for inference across related reverse phase protein arrays experiments. Journal of Applied Statistics. 41:2483-2492.
    1239. Emerging genomic technology in cancer research. CME Journal of Gynecologic Oncology. 9:62-72.
    1240. Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis. Cell Reports. 13:2395-2402.
    1241. Glucose starvation induces mutation and lineage-dependent adaptive responses in a large collection of cancer cell lines. International Journal of Oncology. 48:67-72.
    1242. The right drugs at the right time for the right patient. Drug Discovery Today.
    1243. Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell. 28:529-540.
    1244. Corrigendum. Nature Communications. 6.
    1245. cMET activation and EGFR-directed therapy resistance in triple-negative breast cancer. Journal of Cancer. 5:745-753.
    1246. Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance. Nature Communications. 6.
    1247. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene.
    1248. Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway. Scientific Reports. 6.
    1249. Comprehensive Characterization of Molecular Differences in Cancer between Male and Female Patients. Cancer Cell. 29:711-722.
    1250. ERK and p38 MAPK activities determine sensitivity to PI3K/mTOR inhibition via regulation of MYC and YAP. Cancer Research. 76:7168-7180.
    1251. AZD5153. Molecular Cancer Therapeutics. 15:2563-2574.
    1252. Genomic correlate of exceptional erlotinib response in head and neck squamous cell carcinoma. JAMA oncology. 1:238-244.
    1253. Proteomic characterization of head and neck cancer patient-derived xenografts. Molecular Cancer Research. 14:278-286.
    1254. Use of submitogenic concentrations of phytohemagglutinin to dissect the requirements for induction of cell proliferation. Federation Proceedings. 44.
    1255. Molecular Pathogenesis of Epithelial Ovarian Cancer. 441-454.
    1256. Introduction. Seminars in Immunology. 5:297-298.
    1257. Direct Upregulation of STAT3 by MicroRNA-551b-3p Deregulates Growth and Metastasis of Ovarian Cancer. Cell Reports. 15:1493-1504.
    1258. A putative biomarker signature for clinically effective AKT inhibition. Oncotarget. 6:41736-41749.
    1259. Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer. Cell. 163:506-519.
    1260. Sparse Bayesian graphical models for RPPA time course data. 113-117.
    1261. Feasibility of large-scale genomic testing to facilitate enrollment onto genomically matched clinical trials. Journal of Clinical Oncology. 33:2753-2762.
    1262. Large-scale drug screens support precision medicine. Cancer Discovery. 5:1130-1132.
    1263. Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set. BMC Medicine. 14.
    1264. Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. Breast Cancer Research and Treatment. 1-14.
    1265. Targeting ncRNAs in the 3q26.2 amplicon. Oncoscience. 2:671-672.
    1266. Chapter 19 Activation of Lymphocytes by Lymphokines. Current Topics in Membranes and Transport. 35:495-535.
    1267. Molecular approaches to management of epithelial ovarian cancer. International Journal of Gynecological Cancer. 10:2-7.
    1268. A comprehensive comparison of normalization methods for loading control and variance stabilization of reverse-phase protein array data. Cancer Informatics. 13:109-117.
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