"Thioguanine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
| Descriptor ID |
D013866
|
| MeSH Number(s) |
D03.633.100.759.854
|
| Concept/Terms |
Thioguanine- Thioguanine
- 2-Amino-6-Purinethiol
- 2 Amino 6 Purinethiol
- Tioguanine
- 6-Thioguanine
- 6 Thioguanine
Tabloid- Tabloid
- Thioguanine Tabloid
- Thioguanin-GSK
- Thioguanin GSK
- ThioguaninGSK
|
Below are MeSH descriptors whose meaning is more general than "Thioguanine".
Below are MeSH descriptors whose meaning is more specific than "Thioguanine".
This graph shows the total number of publications written about "Thioguanine" by people in this website by year, and whether "Thioguanine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 1 | 0 | 1 |
| 1999 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 1 | 2 |
| 2018 | 1 | 0 | 1 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thioguanine" by people in Profiles.
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Sinusoidal Obstruction Syndrome of the Liver Associated With 6-Mercaptopurine During Maintenance in a Child With T-cell Acute Lymphoblastic Leukemia. J Pediatr Hematol Oncol. 2023 01 01; 45(1):e121-e123.
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Prevention of mercaptopurine-induced hypoglycemia using allopurinol to reduce methylated thiopurine metabolites. Pediatr Blood Cancer. 2019 04; 66(4):e27577.
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Augmented Berlin-Frankfurt-M?nster therapy in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL). Cancer. 2014 Dec 01; 120(23):3660-8.
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Intensively timed combination chemotherapy for the induction of adult patients with acute myeloid leukemia: long-term follow-up of a phase 2 study. Cancer. 2010 Nov 15; 116(22):5272-8.
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Utility of azathioprine metabolite measurements in post-transplant recurrent autoimmune and immune-mediated hepatitis. Pediatr Transplant. 2004 Dec; 8(6):571-5.
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Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel disease. Am J Surg Pathol. 2004 Sep; 28(9):1204-11.
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6-thioguanine can cause serious liver injury in inflammatory bowel disease patients. Gastroenterology. 2003 Aug; 125(2):298-303.
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Azathioprine metabolite measurements in the treatment of autoimmune hepatitis in pediatric patients: a preliminary report. J Pediatr Gastroenterol Nutr. 2002 Sep; 35(3):391-8.
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Thioguanine administered as a continuous intravenous infusion to pediatric patients is metabolized to the novel metabolite 8-hydroxy-thioguanine. J Pharmacol Exp Ther. 1999 Nov; 291(2):870-4.
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A pediatric phase I trial and pharmacokinetic study of thioguanine administered by continuous i.v. infusion. Clin Cancer Res. 1997 May; 3(5):713-7.