Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes.

Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes. Cell Syst. 2018 Mar 28; 6(3):329-342.e6.

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subject areas

Animals
Antineoplastic Agents
Breast Neoplasms
Cell Line, Tumor
Databases, Genetic
Drug Resistance, Neoplasm
Enzyme Inhibitors
Female
Gene Expression Regulation, Neoplastic
Genes, erbB-2
High-Throughput Screening Assays
Humans
MCF-7 Cells
Mice
Protein Kinase Inhibitors
Protein-Tyrosine Kinases
Proto-Oncogene Proteins c-met
Quinazolines
Quinolines
Receptor, ErbB-2
Receptor, ErbB-3
Signal Transduction
Tumor Microenvironment
Xenograft Model Antitumor Assays