"Connexin 26" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A gap junction protein encoded by the Gap Junction Beta 2 or GJB2 gene. In the cochlea and epidermis, its hexamers form channels between cells that open to allow cell-to-cell diffusion of small molecules as well as recycling of potassium. Mutations in Connexin 26 are associated with congenital SENSORINEURAL HEARING LOSS.
| Descriptor ID |
D000072259
|
| MeSH Number(s) |
D12.776.543.585.250.100
|
| Concept/Terms |
Connexin 26- Connexin 26
- 26, Connexin
- beta2 Connexin
- Connexin, beta2
- Connexin beta-2
- Connexin beta 2
- beta-2, Connexin
- Connexin Cx26
- Cx26, Connexin
|
Below are MeSH descriptors whose meaning is more general than "Connexin 26".
Below are MeSH descriptors whose meaning is more specific than "Connexin 26".
This graph shows the total number of publications written about "Connexin 26" by people in this website by year, and whether "Connexin 26" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
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Below are the most recent publications written about "Connexin 26" by people in Profiles.
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DNA Diagnostics of Hereditary Hearing Loss: A Targeted Resequencing Approach Combined with a Mutation Classification System. Hum Mutat. 2016 08; 37(8):812-9.
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Challenges and solutions for gene identification in the presence of familial locus heterogeneity. Eur J Hum Genet. 2015 Sep; 23(9):1207-15.
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GJB2 mutations are rare in probands with hearing loss in Chinese assortative mating families. Int J Pediatr Otorhinolaryngol. 2014 Feb; 78(2):244-7.
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Crossing the junction in the gap of melanoma brain metastasis. Pigment Cell Melanoma Res. 2013 Jul; 26(4):435-7.
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A sensitive and specific diagnostic test for hearing loss using a microdroplet PCR-based approach and next generation sequencing. Am J Med Genet A. 2013 Jan; 161A(1):145-52.
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Unique spectrum of GJB2 mutations in Mexico. Int J Pediatr Otorhinolaryngol. 2012 Nov; 76(11):1678-80.
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Metastatic squamous cell carcinoma of the oropharynx in a child with a mutation in the Connexin 26 gene. J Pediatr Hematol Oncol. 2011 Jul; 33(5):387-9.
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Comprehensive diagnostic battery for evaluating sensorineural hearing loss in children. Otol Neurotol. 2011 Feb; 32(2):259-64.
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DNA sequence analysis of SLC26A5, encoding prestin, in a patient-control cohort: identification of fourteen novel DNA sequence variations. PLoS One. 2009 Jun 02; 4(6):e5762.
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GJB2 mutation spectrum in 2,063 Chinese patients with nonsyndromic hearing impairment. J Transl Med. 2009 Apr 14; 7:26.