"src Homology Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.
| Descriptor ID |
D018909
|
| MeSH Number(s) |
G02.111.570.820.709.275.750.500.750
|
| Concept/Terms |
src Homology Domains- src Homology Domains
- Homology Domain, src
- Homology Domains, src
- src Homology Domain
- SH Domains
- SH Domain
SH2 Domain- SH2 Domain
- SH2 Domains
- src Homology Region 2 Domain
|
Below are MeSH descriptors whose meaning is more general than "src Homology Domains".
Below are MeSH descriptors whose meaning is more specific than "src Homology Domains".
This graph shows the total number of publications written about "src Homology Domains" by people in this website by year, and whether "src Homology Domains" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2001 | 1 | 1 | 2 |
| 2002 | 0 | 2 | 2 |
| 2003 | 2 | 2 | 4 |
| 2004 | 2 | 3 | 5 |
| 2006 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2023 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "src Homology Domains" by people in Profiles.
-
Combined immunodeficiency caused by pathogenic variants in the ZAP70 C-terminal SH2 domain. Front Immunol. 2023; 14:1155883.
-
Small molecule targeting of the STAT5/6 Src homology 2 (SH2) domains to inhibit allergic airway disease. J Biol Chem. 2018 06 29; 293(26):10026-10040.
-
Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25; 58(22):8970-84.
-
Evidence for SH2 domain-containing 5'-inositol phosphatase-2 (SHIP2) contributing to a lymphatic dysfunction. PLoS One. 2014; 9(11):e112548.
-
Cbl-associated protein regulates assembly and function of two tension-sensing structures in Drosophila. Development. 2013 Feb 01; 140(3):627-38.
-
A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis. J Exp Ther Oncol. 2012; 10(2):155-62.
-
Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3. J Med Chem. 2011 May 26; 54(10):3549-63.
-
Binding constraints on the evolution of enzymes and signalling proteins: the important role of negative pleiotropy. Proc Biol Sci. 2011 Jul 07; 278(1714):1930-5.
-
On modeling peptidomimetics in complex with the SH2 domain of Stat3. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:3229-32.
-
The N terminus of Cbl-c regulates ubiquitin ligase activity by modulating affinity for the ubiquitin-conjugating enzyme. J Biol Chem. 2010 Jul 30; 285(31):23687-98.