"RING Finger Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.
| Descriptor ID |
D054829
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| MeSH Number(s) |
G02.111.570.820.709.275.500.985.500 G02.111.570.820.709.275.750.500.625
|
| Concept/Terms |
RING Finger Domains- RING Finger Domains
- Domains, RING Finger
- RING Finger Domain
- RING Finger Motifs
- RING Finger Motif
|
Below are MeSH descriptors whose meaning is more general than "RING Finger Domains".
Below are MeSH descriptors whose meaning is more specific than "RING Finger Domains".
This graph shows the total number of publications written about "RING Finger Domains" by people in this website by year, and whether "RING Finger Domains" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "RING Finger Domains" by people in Profiles.
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Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms. Carcinogenesis. 2018 07 30; 39(8):1026-1036.
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BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science. 2011 Oct 28; 334(6055):525-8.
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RNF185, a novel mitochondrial ubiquitin E3 ligase, regulates autophagy through interaction with BNIP1. PLoS One. 2011; 6(9):e24367.
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E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol. 2009 Jun; 16(6):658-66.
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Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. BMC Evol Biol. 2008 Aug 01; 8:225.