"Zinc Fingers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
| Descriptor ID |
D016335
|
| MeSH Number(s) |
G02.111.570.820.709.275.500.985
|
| Concept/Terms |
Zinc Fingers- Zinc Fingers
- Finger, Zinc
- Fingers, Zinc
- Zinc Finger
- Zinc Finger Motifs
- Motif, Zinc Finger
- Motifs, Zinc Finger
- Zinc Finger Motif
|
Below are MeSH descriptors whose meaning is more general than "Zinc Fingers".
Below are MeSH descriptors whose meaning is more specific than "Zinc Fingers".
This graph shows the total number of publications written about "Zinc Fingers" by people in this website by year, and whether "Zinc Fingers" was a major or minor topic of these publications.
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click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 1 | 4 |
| 1995 | 0 | 3 | 3 |
| 1996 | 1 | 8 | 9 |
| 1997 | 0 | 2 | 2 |
| 1998 | 4 | 6 | 10 |
| 1999 | 0 | 3 | 3 |
| 2000 | 2 | 6 | 8 |
| 2001 | 3 | 3 | 6 |
| 2002 | 3 | 2 | 5 |
| 2003 | 0 | 6 | 6 |
| 2004 | 1 | 7 | 8 |
| 2005 | 1 | 9 | 10 |
| 2006 | 0 | 2 | 2 |
| 2007 | 0 | 6 | 6 |
| 2008 | 0 | 3 | 3 |
| 2009 | 2 | 5 | 7 |
| 2010 | 2 | 3 | 5 |
| 2011 | 3 | 2 | 5 |
| 2012 | 1 | 2 | 3 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 4 | 5 |
| 2015 | 0 | 3 | 3 |
| 2016 | 1 | 4 | 5 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 2 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 1 | 3 | 4 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Zinc Fingers" by people in Profiles.
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Establishment of Murine Pregnancy Requires the Promyelocytic Leukemia Zinc Finger Transcription Factor. Int J Mol Sci. 2024 Mar 19; 25(6).
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Neurodevelopmental and other phenotypes recurrently associated with heterozygous BAZ2B loss-of-function variants. Am J Med Genet A. 2024 Mar; 194(3):e63445.
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Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res. 2023 09 08; 51(16):8447-8462.
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Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410-DNA interaction using small angle X-ray scattering. Nucleic Acids Res. 2023 02 28; 51(4):1674-1686.
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Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J Biol Chem. 2023 02; 299(2):102885.
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An Integrated Phenotypic and Genotypic Approach Reveals a High-Risk Subtype Association for EBF3 Missense Variants Affecting the Zinc Finger Domain. Ann Neurol. 2022 07; 92(1):138-153.
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Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization. Nat Commun. 2021 09 22; 12(1):5579.
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Testis formation in XX individuals resulting from novel pathogenic variants in Wilms' tumor 1 (WT1) gene. Proc Natl Acad Sci U S A. 2020 06 16; 117(24):13680-13688.
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A method to specifically activate the Klotho promoter by using zinc finger proteins constructed from modular building blocks and from naturally engineered Egr1 transcription factor backbone. FASEB J. 2020 06; 34(6):7234-7246.
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Drosophila Heterochromatin Stabilization Requires the Zinc-Finger Protein Small Ovary. Genetics. 2019 11; 213(3):877-895.