Immunoreceptor Tyrosine-Based Activation Motif
"Immunoreceptor Tyrosine-Based Activation Motif" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A conserved AMINO ACID SEQUENCE located in the intracellular domains of a family of transmembrane proteins involved in various IMMUNE RESPONSES. The CONSENSUS SEQUENCE of this motif is YXXL(or I)X(6-8)YXXL(or I) (where X denotes any amino acid). When phosphorylated ITAM motifs provide docking sites for PROTEIN TYROSINE KINASES of the Syk family thus forming signaling complexes which lead to activation of immune responses.
| Descriptor ID |
D061625
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| MeSH Number(s) |
G02.111.570.820.709.275.500.440
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| Concept/Terms |
Immunoreceptor Tyrosine-Based Activation Motif- Immunoreceptor Tyrosine-Based Activation Motif
- Immunoreceptor Tyrosine Based Activation Motif
- Immuno-Receptor Tyrosine-Based Activation Motif
- Immuno Receptor Tyrosine Based Activation Motif
- Immune Receptor Tyrosine-Based Activation Motif
- Immune Receptor Tyrosine Based Activation Motif
|
Below are MeSH descriptors whose meaning is more general than "Immunoreceptor Tyrosine-Based Activation Motif".
Below are MeSH descriptors whose meaning is more specific than "Immunoreceptor Tyrosine-Based Activation Motif".
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Below are the most recent publications written about "Immunoreceptor Tyrosine-Based Activation Motif" by people in Profiles.
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Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol. 2013 Mar; 14(3):262-70.