"PDZ Domains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.
| Descriptor ID |
D054731
|
| MeSH Number(s) |
G02.111.570.820.709.275.750.500.500
|
| Concept/Terms |
PDZ Domains- PDZ Domains
- Domain, PDZ
- Domains, PDZ
- PDZ Domain
- PDZ Interaction Domains
- Domain, PDZ Interaction
- Domains, PDZ Interaction
- Interaction Domain, PDZ
- Interaction Domains, PDZ
- PDZ Interaction Domain
- PSD95-DLG-ZO1 Domains
- Domain, PSD95-DLG-ZO1
- Domains, PSD95-DLG-ZO1
- PSD95 DLG ZO1 Domains
- PSD95-DLG-ZO1 Domain
- DLG Homology Repeats Domains
- GLGF Repeats Domains
- Domain, GLGF Repeats
- Domains, GLGF Repeats
- GLGF Repeats Domain
- Repeats Domain, GLGF
- Repeats Domains, GLGF
- DHR Domains
- DHR Domain
- Domain, DHR
- Domains, DHR
|
Below are MeSH descriptors whose meaning is more general than "PDZ Domains".
Below are MeSH descriptors whose meaning is more specific than "PDZ Domains".
This graph shows the total number of publications written about "PDZ Domains" by people in this website by year, and whether "PDZ Domains" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2009 | 0 | 2 | 2 |
| 2010 | 1 | 3 | 4 |
| 2012 | 2 | 2 | 4 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2017 | 0 | 1 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "PDZ Domains" by people in Profiles.
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Exploring the PDZ, DUF, and LIM Domains of Pdlim5 in Dendrite Branching. Int J Mol Sci. 2024 Jul 30; 25(15).
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SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1. PLoS One. 2021; 16(6):e0251955.
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Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14-3-3 proteins in vitro. Sci Rep. 2020 10 27; 10(1):18378.
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Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding. PLoS Pathog. 2020 01; 16(1):e1008231.
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Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Neuroscience. 2017 06 14; 353:58-75.
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PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch. J Biol Chem. 2017 02 10; 292(6):2255-2265.
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NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane. Neoplasia. 2014 Apr; 16(4):365-74.e1-2.
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PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA. J Cell Sci. 2013 Oct 01; 126(Pt 19):4514-26.
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Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012 Sep 21; 287(39):33014-25.
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Regulation of interferon-? by MAGI-1 and its interaction with influenza A virus NS1 protein with ESEV PBM. PLoS One. 2012; 7(7):e41251.