| Item Type | Name |
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Academic Article
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A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer.
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Concept
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MAP Kinase Signaling System
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Concept
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Protein Kinase C
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Concept
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MAP Kinase Kinase 2
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Concept
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CDC2-CDC28 Kinases
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Concept
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Cyclin-Dependent Kinase 6
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Concept
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Mitogen-Activated Protein Kinases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinases
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Concept
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MAP Kinase Kinase Kinase 1
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Concept
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S-Phase Kinase-Associated Proteins
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Concept
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p38 Mitogen-Activated Protein Kinases
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Concept
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Cyclin-Dependent Kinases
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Concept
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CDC2 Protein Kinase
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Concept
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Protein Kinase Inhibitors
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Concept
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Ribosomal Protein S6 Kinases, 70-kDa
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Concept
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Mitogen-Activated Protein Kinase 1
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Concept
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Receptor Protein-Tyrosine Kinases
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Concept
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MAP Kinase Kinase 7
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Concept
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Mitogen-Activated Protein Kinase Kinases
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Concept
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src-Family Kinases
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Concept
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Protein Kinases
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Concept
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Cyclin-Dependent Kinase 2
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Concept
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rho-Associated Kinases
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Concept
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Extracellular Signal-Regulated MAP Kinases
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Concept
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JNK Mitogen-Activated Protein Kinases
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Concept
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Focal Adhesion Protein-Tyrosine Kinases
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Concept
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Calcium-Calmodulin-Dependent Protein Kinase Type 2
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Concept
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MAP Kinase Kinase Kinases
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Concept
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Cyclin-Dependent Kinase 4
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Concept
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Mitogen-Activated Protein Kinase 3
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Concept
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Cyclin-Dependent Kinase Inhibitor Proteins
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Concept
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Cyclin-Dependent Kinase Inhibitor p27
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Concept
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MAP Kinase Kinase 4
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Concept
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Phosphatidylinositol 3-Kinases
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Concept
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Janus Kinases
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Concept
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Protein Kinase C-delta
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Concept
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Cyclin-Dependent Kinase Inhibitor p16
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Concept
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MAP Kinase Kinase 1
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Academic Article
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Acquired resistance to erlotinib in A-431 epidermoid cancer cells requires down-regulation of MMAC1/PTEN and up-regulation of phosphorylated Akt.
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Academic Article
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Novel mechanism of reduced proliferation in ovarian clear cell carcinoma cells: cytoplasmic sequestration of CDK2 by p27.
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Academic Article
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Status of the anaplastic lymphoma kinase (ALK) gene in inflammatory breast carcinoma.
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Academic Article
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PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.
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Academic Article
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Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells.
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Academic Article
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Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer.
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Academic Article
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MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model.
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Academic Article
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Role of epidermal growth factor receptor in breast cancer.
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Academic Article
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Cyclin A-associated kinase activity is needed for paclitaxel sensitivity.
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Academic Article
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Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.
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Academic Article
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Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity.
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Academic Article
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PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase.
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Academic Article
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Dependence of paclitaxel sensitivity on a functional spindle assembly checkpoint.
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Academic Article
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P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.
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Academic Article
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Targeting p70S6K prevented lung metastasis in a breast cancer xenograft model.
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Academic Article
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Different gene expressions are associated with the different molecular subtypes of inflammatory breast cancer.
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Academic Article
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TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase.
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Academic Article
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Future directions of bone-targeted therapy for metastatic breast cancer.
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Academic Article
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Silencing kinase-interacting stathmin gene enhances erlotinib sensitivity by inhibiting Ser?? p27 phosphorylation in epidermal growth factor receptor-expressing breast cancer.
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Academic Article
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Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells.
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Academic Article
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BMP-4 regulates the dorsal-ventral differences in FGF/MAPKK-mediated mesoderm induction in Xenopus.
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Academic Article
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A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.
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Academic Article
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A truncated bone morphogenetic protein 4 receptor alters the fate of ventral mesoderm to dorsal mesoderm: roles of animal pole tissue in the development of ventral mesoderm.
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Academic Article
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Cloning of a Drosophila melanogaster homologue of the mouse type-I bone morphogenetic proteins-2/-4 receptor: a potential decapentaplegic receptor.
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Academic Article
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Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.
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Academic Article
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Involvement of Ras/Raf/AP-1 in BMP-4 signaling during Xenopus embryonic development.
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Academic Article
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TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.
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Academic Article
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Cloning of rat type I receptor cDNA for bone morphogenetic protein-2 and bone morphogenetic protein-4, and the localization compared with that of the ligands.
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Academic Article
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Interaction between soluble type I receptor for bone morphogenetic protein and bone morphogenetic protein-4.
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Academic Article
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A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts.
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Academic Article
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Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts.
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Academic Article
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Role of TAK1 and TAB1 in BMP signaling in early Xenopus development.
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Academic Article
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BRAM1, a BMP receptor-associated molecule involved in BMP signalling.
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Academic Article
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Role of dpp signalling in prepattern formation of the dorsocentral mechanosensory organ in Drosophila melanogaster.
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Academic Article
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In vivo analysis using variants of zebrafish BMPR-IA: range of action and involvement of BMP in ectoderm patterning.
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Academic Article
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XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway.
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Academic Article
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p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis.
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Academic Article
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Extracellular matrix-associated bone morphogenetic proteins are essential for differentiation of murine osteoblastic cells in vitro.
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Academic Article
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Restricted expression of the receptor serine/threonine kinase BMPR-IB in zebrafish.
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Academic Article
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TAK1 participates in c-Jun N-terminal kinase signaling during Drosophila development.
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Academic Article
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Molecular analysis of external genitalia formation: the role of fibroblast growth factor (Fgf) genes during genital tubercle formation.
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Academic Article
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Dorsal spinal cord inhibits oligodendrocyte development.
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Academic Article
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Identification of the ligand-binding site of the BMP type IA receptor for BMP-4.
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Academic Article
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Inhibition of BMP activity by the FGF signal promotes posterior neural development in zebrafish.
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Academic Article
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The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling.
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Academic Article
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The prickle-related gene in vertebrates is essential for gastrulation cell movements.
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Academic Article
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PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements.
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Academic Article
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A genome-wide survey of the genes for planar polarity signaling or convergent extension-related genes in Ciona intestinalis and phylogenetic comparisons of evolutionary conserved signaling components.
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Academic Article
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Essential role of MARCKS in cortical actin dynamics during gastrulation movements.
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Academic Article
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Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction.
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Academic Article
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Screening of FGF target genes in Xenopus by microarray: temporal dissection of the signalling pathway using a chemical inhibitor.
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Academic Article
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FGF signal regulates gastrulation cell movements and morphology through its target NRH.
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Academic Article
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XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation.
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Academic Article
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Xenopus Wnt-5a induces an ectopic larval tail at injured site, suggesting a crucial role for noncanonical Wnt signal in tail regeneration.
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Academic Article
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Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity.
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Academic Article
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Growth suppression of low HER-2/neu-expressing breast cancer cell line MDA-MB-435 by tyrosine kinase inhibitor emodin.
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Academic Article
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Novel functional assay for spindle-assembly checkpoint by cyclin-dependent kinase activity to predict taxane chemosensitivity in breast tumor patient.
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Academic Article
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Antagonism of tumoral prolactin receptor promotes autophagy-related cell death.
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Academic Article
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A class I histone deacetylase inhibitor, entinostat, enhances lapatinib efficacy in HER2-overexpressing breast cancer cells through FOXO3-mediated Bim1 expression.
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Academic Article
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Gene signature-guided dasatinib therapy in metastatic breast cancer.
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Academic Article
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Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials.
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Academic Article
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MEK Inhibitor Selumetinib (AZD6244; ARRY-142886) Prevents Lung Metastasis in a Triple-Negative Breast Cancer Xenograft Model.
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Academic Article
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Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases.
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Academic Article
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Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer.
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Academic Article
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Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer.
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Academic Article
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Growth suppression of low HER-2/neu-expressing breast cancer cell line MDA-MB-435 by tyrosine kinase inhibitor emodin
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Academic Article
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c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun
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Academic Article
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Antitumor activity of KW-2450 against triple-negative breast cancer by inhibiting Aurora A and B kinases
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Academic Article
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Novel functional assay for spindle-assembly checkpoint by cyclin-dependent kinase activity to predict taxane chemosensitivity in breast tumor patient
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Academic Article
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Genes coding for cyclin-dependent kinase inhibitors are fragile in Xenopus.
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Academic Article
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c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun.
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Academic Article
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Early clinical development of epidermal growth factor receptor targeted therapy in breast cancer.
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Academic Article
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Androgen Receptor Function and Androgen Receptor-Targeted Therapies in Breast Cancer: A Review.
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Academic Article
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Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer.
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Academic Article
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Identification of frequent somatic mutations in inflammatory breast cancer.
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Academic Article
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MEK and PI3K catalytic activity as predictor of the response to molecularly targeted agents in triple-negative breast cancer.
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Academic Article
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Prior systemic treatment increased the incidence of somatic mutations in metastatic breast cancer.
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Academic Article
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Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation.
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Academic Article
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Preclinical and phase I clinical studies of KW-2450, a dual IGF-1R/IR tyrosine kinase inhibitor, in combination with lapatinib and letrozole.
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Academic Article
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ST8SIA1 Regulates Tumor Growth and Metastasis in TNBC by Activating the FAK-AKT-mTOR Signaling Pathway.
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Academic Article
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Inflammatory breast cancer biology: the tumour microenvironment is key.
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Academic Article
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Cooperative Effect of Oncogenic MET and PIK3CA in an HGF-Dominant Environment in Breast Cancer.
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Academic Article
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Mechanical Force Induces Phosphorylation-Mediated Signaling that Underlies Tissue Response and Robustness in Xenopus Embryos.
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Academic Article
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Anti-tumor and anti-metastasis efficacy of E6201, a MEK1 inhibitor, in preclinical models of triple-negative breast cancer.
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Concept
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Glycogen Synthase Kinase 3 beta
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Concept
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Myristoylated Alanine-Rich C Kinase Substrate
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Concept
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Class I Phosphatidylinositol 3-Kinases
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Concept
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TOR Serine-Threonine Kinases
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Concept
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Aurora Kinase A
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Concept
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Aurora Kinase B
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Academic Article
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NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non-inflammatory breast cancers.
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Academic Article
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Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis.
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Academic Article
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JNK Signaling in Stem Cell Self-Renewal and Differentiation.
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Academic Article
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Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer.
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Academic Article
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A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer.
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Academic Article
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Comparison of the genomic alterations present in tumor samples from patients with metastatic inflammatory versus non-inflammatory breast cancer reveals AURKA as a potential treatment target.
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Academic Article
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Stabilization of E-cadherin adhesions by COX-2/GSK3? signaling is a targetable pathway in metastatic breast cancer.
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Academic Article
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Identification of Kinase Targets for Enhancing the Antitumor Activity of Eribulin in Triple-Negative Breast Cell Lines.
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Academic Article
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Targeting chemotherapy resistance in mesenchymal triple-negative breast cancer: a phase II trial of neoadjuvant angiogenic and mTOR inhibition with chemotherapy.
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Academic Article
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Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer.
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Academic Article
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Correction: Maternal Embryonic Leucine Zipper Kinase Is Associated with Metastasis in Triple-negative Breast Cancer.
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Academic Article
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Comprehensive Analysis Identifies Variability in PI3K Pathway Alterations in Triple-Negative Breast Cancer Subtypes.
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