Mitogen-Activated Protein Kinase 1
"Mitogen-Activated Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
| Descriptor ID |
D019950
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567.249.500 D12.644.360.450.169.500 D12.776.476.450.169.500
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 1- Mitogen-Activated Protein Kinase 1
- Mitogen Activated Protein Kinase 1
- p42 MAPK
- p42(Mitogen-Activated Protein Kinase)
- p42(Mapk) Kinase
- p42 MAP Kinase
- MAP Kinase, p42
- MAPK2 Mitogen-Activated Protein Kinase
- MAPK2 Mitogen Activated Protein Kinase
- Extracellular Signal-Regulated Kinase 2
- Extracellular Signal Regulated Kinase 2
- Mitogen-Activated Protein Kinase 2
- Mitogen Activated Protein Kinase 2
- MAPK1 Mitogen-Activated Protein Kinase
- MAPK1 Mitogen Activated Protein Kinase
- p42(Mapk)
- MAP Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 1".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 1" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 5 | 7 |
| 2002 | 1 | 5 | 6 |
| 2003 | 0 | 3 | 3 |
| 2004 | 2 | 3 | 5 |
| 2005 | 1 | 5 | 6 |
| 2006 | 0 | 4 | 4 |
| 2007 | 2 | 5 | 7 |
| 2008 | 2 | 3 | 5 |
| 2009 | 2 | 2 | 4 |
| 2010 | 1 | 5 | 6 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 2 | 3 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 1 | 1 | 2 |
| 2016 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 2 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2024 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 1" by people in Profiles.
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The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor. Dev Biol. 2024 Dec; 516:183-195.
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Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in the C. elegans germline. Proc Natl Acad Sci U S A. 2022 01 18; 119(3).
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Cell lineage tracing links ERa loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype. Proc Natl Acad Sci U S A. 2021 05 25; 118(21).
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Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer. Sci Rep. 2020 05 22; 10(1):8537.
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Tie-2 Cre-Mediated Deficiency of Extracellular Signal-Regulated Kinase 2 Potentiates Experimental Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Neonatal Mice. Int J Mol Sci. 2020 Mar 31; 21(7).
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Mechanical Stress Regulates Epithelial Tissue Integrity and Stiffness through the FGFR/Erk2 Signaling Pathway during Embryogenesis. Cell Rep. 2020 03 17; 30(11):3875-3888.e3.
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Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nat Commun. 2019 11 19; 10(1):5232.
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A Novel Class of Common Docking Domain Inhibitors That Prevent ERK2 Activation and Substrate Phosphorylation. ACS Chem Biol. 2019 06 21; 14(6):1183-1194.
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A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability. Mol Psychiatry. 2020 10; 25(10):2504-2516.
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The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 06 07; 6(1):47.