Mitogen-Activated Protein Kinase 1
"Mitogen-Activated Protein Kinase 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
| Descriptor ID |
D019950
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567.249.500 D12.644.360.450.169.500 D12.776.476.450.169.500
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 1- Mitogen-Activated Protein Kinase 1
- Mitogen Activated Protein Kinase 1
- p42 MAPK
- p42(Mitogen-Activated Protein Kinase)
- p42(Mapk) Kinase
- p42 MAP Kinase
- MAP Kinase, p42
- MAPK2 Mitogen-Activated Protein Kinase
- MAPK2 Mitogen Activated Protein Kinase
- Extracellular Signal-Regulated Kinase 2
- Extracellular Signal Regulated Kinase 2
- Mitogen-Activated Protein Kinase 2
- Mitogen Activated Protein Kinase 2
- MAPK1 Mitogen-Activated Protein Kinase
- MAPK1 Mitogen Activated Protein Kinase
- p42(Mapk)
- MAP Kinase 2
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 1".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 1".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 1" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 1999 | 1 | 1 | 2 |
| 2000 | 1 | 1 | 2 |
| 2001 | 2 | 3 | 5 |
| 2002 | 1 | 5 | 6 |
| 2003 | 0 | 3 | 3 |
| 2004 | 2 | 2 | 4 |
| 2005 | 1 | 5 | 6 |
| 2006 | 0 | 4 | 4 |
| 2007 | 2 | 7 | 9 |
| 2008 | 2 | 3 | 5 |
| 2009 | 2 | 2 | 4 |
| 2010 | 1 | 6 | 7 |
| 2011 | 1 | 2 | 3 |
| 2012 | 1 | 2 | 3 |
| 2013 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2017 | 1 | 1 | 2 |
| 2018 | 0 | 2 | 2 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 1" by people in Profiles.
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ADSL deficiency is a secondary mitochondrial disease affecting organelle homeostasis and ERK2/AKT signaling in a linear genotype-phenotype relation. Cell Rep. 2025 Sep 23; 44(9):116230.
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Cell lineage tracing links ERa loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype. Proc Natl Acad Sci U S A. 2021 05 25; 118(21).
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Tie-2 Cre-Mediated Deficiency of Extracellular Signal-Regulated Kinase 2 Potentiates Experimental Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Neonatal Mice. Int J Mol Sci. 2020 Mar 31; 21(7).
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Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo. Nat Commun. 2019 11 19; 10(1):5232.
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A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability. Mol Psychiatry. 2020 10; 25(10):2504-2516.
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Hyperoxia Disrupts Extracellular Signal-Regulated Kinases 1/2-Induced Angiogenesis in the Developing Lungs. Int J Mol Sci. 2018 May 20; 19(5).
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Endocrine, Paracrine, and Autocrine Signaling Pathways That Regulate Ovulation. Trends Endocrinol Metab. 2018 05; 29(5):313-325.
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Genetic Variants Within Molecular Targets of Antipsychotic Treatment: Effects on Treatment Response, Schizophrenia Risk, and Psychopathological Features. J Mol Neurosci. 2018 Jan; 64(1):62-74.
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Activating MAPK1 (ERK2) mutation in an aggressive case of disseminated juvenile xanthogranuloma. Oncotarget. 2017 Jul 11; 8(28):46065-46070.
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ERK2-Dependent Phosphorylation of CSN6 Is Critical in Colorectal Cancer Development. Cancer Cell. 2015 Aug 10; 28(2):183-97.