Mitogen-Activated Protein Kinase 6
"Mitogen-Activated Protein Kinase 6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 97-kDa extracellular signal-regulated MAP kinase. Mitogen-activated protein kinase 6 levels increase during cellular differentiation, while in proliferating cells the enzyme is degraded rapidly via the PROTEASOME ENDOPEPTIDASE COMPLEX.
| Descriptor ID |
D048053
|
| MeSH Number(s) |
D08.811.913.696.620.682.700.567.249.875 D12.644.360.450.169.875 D12.776.476.450.169.875
|
| Concept/Terms |
Mitogen-Activated Protein Kinase 6- Mitogen-Activated Protein Kinase 6
- Mitogen Activated Protein Kinase 6
- p97MAPK Protein
- MAPK6 Mitogen-Activated Protein Kinase
- MAPK6 Mitogen Activated Protein Kinase
- ERK3 Kinase
- Kinase, ERK3
- Extracellular Signal-Regulated Kinase 3
- Extracellular Signal Regulated Kinase 3
- p97(MAPK) Protein
|
Below are MeSH descriptors whose meaning is more general than "Mitogen-Activated Protein Kinase 6".
Below are MeSH descriptors whose meaning is more specific than "Mitogen-Activated Protein Kinase 6".
This graph shows the total number of publications written about "Mitogen-Activated Protein Kinase 6" by people in this website by year, and whether "Mitogen-Activated Protein Kinase 6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2014 | 1 | 1 | 2 |
| 2016 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Mitogen-Activated Protein Kinase 6" by people in Profiles.
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Conditional ERK3 overexpression cooperates with PTEN deletion to promote lung adenocarcinoma formation in mice. Mol Oncol. 2022 03; 16(5):1184-1199.
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Structural and transcriptomic response to antenatal corticosteroids in an Erk3-null mouse model of respiratory?distress. Am J Obstet Gynecol. 2016 09; 215(3):384.e1-384.e89.
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ERK3 promotes endothelial cell functions by upregulating SRC-3/SP1-mediated VEGFR2 expression. J Cell Physiol. 2014 Oct; 229(10):1529-37.
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Administration of antenatal glucocorticoids and postnatal surfactant ameliorates respiratory distress syndrome-associated neonatal lethality in Erk3(-/-) mouse pups. Pediatr Res. 2014 Jul; 76(1):24-32.
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ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May; 122(5):1869-80.
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Downregulation of mitogen-activated protein kinases in human colon cancers. Anticancer Res. 2000 Jan-Feb; 20(1A):75-83.
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ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell. 1991 05 17; 65(4):663-75.