"MAP Kinase Kinase 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mitogen-activated protein kinase kinase with specificity for JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES and the RETINOID X RECEPTORS. It takes part in a SIGNAL TRANSDUCTION pathway that is activated in response to cellular stress.
| Descriptor ID |
D048670
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| MeSH Number(s) |
D08.811.913.696.620.682.700.565.400 D08.811.913.696.620.682.725.200.400 D12.644.360.440.400 D12.776.476.440.400
|
| Concept/Terms |
MAP Kinase Kinase 4- MAP Kinase Kinase 4
- JN Kinase Kinase
- JNK Kinase
- Jun Amino-Terminal Kinase Kinase
- Jun Amino Terminal Kinase Kinase
- JNK-Activating Protein Kinase
- JNK Activating Protein Kinase
- Protein Kinase, JNK-Activating
- SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1
- SAP Kinase Extracellular Signal Regulated Kinase Kinase 1
- SEK1 Protein Kinase
- Protein Kinase, SEK1
- Mitogen-Activated Protein Kinase Kinase 4
- Mitogen Activated Protein Kinase Kinase 4
- MEK4 Protein Kinase
- Protein Kinase, MEK4
- JNKK1 Protein Kinase
- Kinase, JNKK1 Protein
- Protein Kinase, JNKK1
- Stress-Activated Protein Kinase Kinase 1
- Stress Activated Protein Kinase Kinase 1
- SAPK-ERK Kinase 1
- SAPK ERK Kinase 1
- SAP Kinase Kinase 1
|
Below are MeSH descriptors whose meaning is more general than "MAP Kinase Kinase 4".
Below are MeSH descriptors whose meaning is more specific than "MAP Kinase Kinase 4".
This graph shows the total number of publications written about "MAP Kinase Kinase 4" by people in this website by year, and whether "MAP Kinase Kinase 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 1 | 1 | 2 |
| 2002 | 2 | 1 | 3 |
| 2005 | 0 | 4 | 4 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 4 | 4 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 2 | 3 |
| 2011 | 2 | 1 | 3 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2018 | 1 | 1 | 2 |
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Below are the most recent publications written about "MAP Kinase Kinase 4" by people in Profiles.
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Human pancreatic microenvironment promotes ?-cell differentiation via non-canonical WNT5A/JNK and BMP signaling. Nat Commun. 2022 04 12; 13(1):1952.
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Cytotoxicity of Gymnopilus purpureosquamulosus extracts on hematologic malignant cells through activation of the SAPK/JNK signaling pathway. PLoS One. 2021; 16(5):e0252541.
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RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis. Int J Mol Sci. 2018 Sep 06; 19(9).
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DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):E8027-E8036.
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Mass Spectrometry-Based Proteomics Reveals Potential Roles of NEK9 and MAP2K4 in Resistance to PI3K Inhibition in Triple-Negative Breast Cancers. Cancer Res. 2018 05 15; 78(10):2732-2746.
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Up-regulation of SFTPB expression and attenuation of acute lung injury by pulmonary epithelial cell-specific NAMPT knockdown. FASEB J. 2018 07; 32(7):3583-3596.
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The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018 02; 24(2):213-223.
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MKK4 activates non-canonical NF?B signaling by promoting NF?B2-p100 processing. Biochem Biophys Res Commun. 2017 09 16; 491(2):337-342.
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Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017 02 16; 542(7641):362-366.
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c-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun. Oncogene. 2017 05 04; 36(18):2599-2608.