S-Phase Kinase-Associated Proteins
"S-Phase Kinase-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.
| Descriptor ID |
D044786
|
| MeSH Number(s) |
D12.776.157.743
|
| Concept/Terms |
S-Phase Kinase-Associated Proteins- S-Phase Kinase-Associated Proteins
- Kinase-Associated Proteins, S-Phase
- Proteins, S-Phase Kinase-Associated
- S Phase Kinase Associated Proteins
- Skp Domain Protein
- S-Phase Kinase Associated Protein
- S Phase Kinase Associated Protein
- Skp Domain Proteins
Skp2 Proteins- Skp2 Proteins
- p45(SKP2) Protein
- p45(SKP2)
- Skp2 Protein
- p45 SKP2
- SKP2, p45
- SCF(SKP2)
Skp1 Proteins- Skp1 Proteins
- p19(SKP1) Protein
- Skp1 Protein
- p19 SKP1
- SKP1, p19
|
Below are MeSH descriptors whose meaning is more general than "S-Phase Kinase-Associated Proteins".
Below are MeSH descriptors whose meaning is more specific than "S-Phase Kinase-Associated Proteins".
This graph shows the total number of publications written about "S-Phase Kinase-Associated Proteins" by people in this website by year, and whether "S-Phase Kinase-Associated Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2016 | 1 | 1 | 2 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "S-Phase Kinase-Associated Proteins" by people in Profiles.
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Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2. Sci Signal. 2024 Dec 17; 17(867):eadk4122.
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CDK4/6 inhibitor palbociclib promotes SARS-CoV-2?cell entry by down-regulating SKP2 dependent ACE2 degradation. Antiviral Res. 2023 04; 212:105558.
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A gene signature consisting of ubiquitin ligases and deubiquitinating enzymes of SKP2 is associated with clinical outcome in breast cancer. Sci Rep. 2022 02 15; 12(1):2478.
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SKP2- and OTUD1-regulated non-proteolytic ubiquitination of YAP promotes YAP nuclear localization and activity. Nat Commun. 2018 06 11; 9(1):2269.
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Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing. Eur J Hum Genet. 2017 01; 25(1):73-78.
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Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 06 02; 534(7605):55-62.
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Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis. Hepatology. 2016 Mar; 63(3):898-913.
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Skp2-Mediated RagA Ubiquitination Elicits a Negative Feedback to Prevent Amino-Acid-Dependent mTORC1 Hyperactivation by Recruiting GATOR1. Mol Cell. 2015 Jun 18; 58(6):989-1000.
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Ablation of galectin-3 induces p27(KIP1)-dependent premature senescence without oncogenic stress. Cell Death Differ. 2014 Nov; 21(11):1769-79.
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Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 01; 154(3):556-68.