S-Phase Kinase-Associated Proteins
"S-Phase Kinase-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.
| Descriptor ID |
D044786
|
| MeSH Number(s) |
D12.776.157.743
|
| Concept/Terms |
S-Phase Kinase-Associated Proteins- S-Phase Kinase-Associated Proteins
- Kinase-Associated Proteins, S-Phase
- Proteins, S-Phase Kinase-Associated
- S Phase Kinase Associated Proteins
- Skp Domain Protein
- S-Phase Kinase Associated Protein
- S Phase Kinase Associated Protein
- Skp Domain Proteins
Skp2 Proteins- Skp2 Proteins
- p45(SKP2) Protein
- p45(SKP2)
- Skp2 Protein
- p45 SKP2
- SKP2, p45
- SCF(SKP2)
Skp1 Proteins- Skp1 Proteins
- p19(SKP1) Protein
- Skp1 Protein
- p19 SKP1
- SKP1, p19
|
Below are MeSH descriptors whose meaning is more general than "S-Phase Kinase-Associated Proteins".
Below are MeSH descriptors whose meaning is more specific than "S-Phase Kinase-Associated Proteins".
This graph shows the total number of publications written about "S-Phase Kinase-Associated Proteins" by people in this website by year, and whether "S-Phase Kinase-Associated Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 1 | 2 | 3 |
| 2019 | 1 | 0 | 1 |
| 2024 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "S-Phase Kinase-Associated Proteins" by people in Profiles.
-
Castration-resistant prostate cancer is resensitized to androgen deprivation by autophagy-dependent apoptosis induced by blocking SKP2. Sci Signal. 2024 12 17; 17(867):eadk4122.
-
A novel thyroid hormone receptor isoform, TR?2-46, promotes SKP2 expression and retinoblastoma cell proliferation. J Biol Chem. 2019 02 22; 294(8):2961-2969.
-
Variants in SKP1, PROB1, and IL17B genes at keratoconus 5q31.1-q35.3 susceptibility locus identified by whole-exome sequencing. Eur J Hum Genet. 2017 01; 25(1):73-78.
-
Proteogenomics connects somatic mutations to signalling in breast cancer. Nature. 2016 06 02; 534(7605):55-62.
-
Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis. Hepatology. 2016 Mar; 63(3):898-913.
-
Rb suppresses human cone-precursor-derived retinoblastoma tumours. Nature. 2014 Oct 16; 514(7522):385-8.
-
Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 01; 154(3):556-68.
-
TRIP6 regulates p27 KIP1 to promote tumorigenesis. Mol Cell Biol. 2013 Apr; 33(7):1394-409.
-
Raloxifene inhibits growth of RT4 urothelial carcinoma cells via estrogen receptor-dependent induction of apoptosis and inhibition of proliferation. Horm Cancer. 2013 Feb; 4(1):24-35.
-
The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 2012 May 25; 149(5):1098-111.