"F-Box Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of proteins that share the F-BOX MOTIF and are involved in protein-protein interactions. They play an important role in process of protein ubiquition by associating with a variety of substrates and then associating into SCF UBIQUITIN LIGASE complexes. They are held in the ubiquitin-ligase complex via binding to SKP DOMAIN PROTEINS.
| Descriptor ID |
D044783
|
| MeSH Number(s) |
D12.776.157.169
|
| Concept/Terms |
F-Box Proteins- F-Box Proteins
- F Box Proteins
- F-Box Domain Protein
- Domain Protein, F-Box
- F Box Domain Protein
- Protein, F-Box Domain
- F-Box Protein Family
- F Box Protein Family
- Protein Family, F-Box
|
Below are MeSH descriptors whose meaning is more general than "F-Box Proteins".
Below are MeSH descriptors whose meaning is more specific than "F-Box Proteins".
This graph shows the total number of publications written about "F-Box Proteins" by people in this website by year, and whether "F-Box Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 4 | 0 | 4 |
| 2007 | 3 | 2 | 5 |
| 2008 | 2 | 0 | 2 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 3 | 0 | 3 |
| 2012 | 3 | 0 | 3 |
| 2013 | 5 | 0 | 5 |
| 2014 | 2 | 0 | 2 |
| 2015 | 5 | 2 | 7 |
| 2016 | 0 | 1 | 1 |
| 2017 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 3 | 0 | 3 |
| 2022 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "F-Box Proteins" by people in Profiles.
-
Functional analysis of a novel de novo variant in PPP5C associated with microcephaly, seizures, and developmental delay. Mol Genet Metab. 2022 05; 136(1):65-73.
-
The GSK-3?-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function. Cell Rep. 2020 09 15; 32(11):108140.
-
An F-Box Protein, Mdm30, Interacts with TREX Subunit Sub2 To Regulate Cellular Abundance Cotranscriptionally in Orchestrating mRNA Export Independently of Splicing and Mitochondrial Function. Mol Cell Biol. 2020 03 16; 40(7).
-
Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40. Am J Physiol Endocrinol Metab. 2020 05 01; 318(5):E625-E635.
-
OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages. EBioMedicine. 2020 Jan; 51:102569.
-
Biallelic mutation of FBXL7 suggests a novel form of Hennekam syndrome. Am J Med Genet A. 2020 01; 182(1):189-194.
-
The FBXW2-MSX2-SOX2 axis regulates stem cell property and drug resistance of cancer cells. Proc Natl Acad Sci U S A. 2019 10 08; 116(41):20528-20538.
-
Pre-clinical evaluation of cysteamine bitartrate as a therapeutic agent for mitochondrial respiratory chain disease. Hum Mol Genet. 2019 06 01; 28(11):1837-1852.
-
Clinical significance of FBXO17 gene expression in high-grade glioma. BMC Cancer. 2018 Jul 31; 18(1):773.
-
Molecular and clinical spectra of FBXL4 deficiency. Hum Mutat. 2017 12; 38(12):1649-1659.