SEAN HARTIG

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    F32DK085970     (HARTIG, SEAN)Sep 25, 2009 - Sep 24, 2011
    NIH
    Unique Roles of p160 Coactivators during Human Adipogenesis
    Role: Principal Investigator

    K01DK096093     (HARTIG, SEAN)Apr 1, 2013 - Jan 31, 2017
    NIH
    A novel axis regulates adipocyte plasticity
    Role: Principal Investigator

    R03DK105006     (HARTIG, SEAN)Apr 1, 2016 - Mar 31, 2018
    NIH
    Regulation of SYSTEMIC INSULIN SENSITIVITY by miRNA-30a
    Role: Principal Investigator

    R01DK114356     (HARTIG, SEAN)Aug 18, 2017 - May 31, 2022
    NIH
    An anti-diabetic microRNA that promotes metabolically healthy obesity
    Role: Principal Investigator

    R01DK126042     (LAKE, JORDAN E)Sep 10, 2020 - Jun 30, 2025
    NIH
    Metabolic impact of FGF-21 in adipose tissue and liver of PLWH
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Agarwal N, Iyer D, Saha P, Cox AR, Xia Y, Utay NS, Somasundaram A, Schubert U, Lake JE, Hartig SM, Balasubramanyam A. HIV-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis. Diabetes. 2021 Jul 07. PMID: 34233931.
      Citations:    Fields:    
    2. Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X. Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nat Commun. 2021 03 26; 12(1):1927. PMID: 33772019.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Cox AR, Chernis N, Kim KH, Masschelin PM, Saha PK, Briley SM, Sharp R, Li X, Felix JB, Sun Z, Moore DD, Pangas SA, Hartig SM. Ube2i deletion in adipocytes causes lipoatrophy in mice. Mol Metab. 2021 06; 48:101221. PMID: 33771728.
      Citations:    Fields:    
    4. Felix JB, Cox AR, Hartig SM. Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion. Trends Endocrinol Metab. 2021 05; 32(5):320-332. PMID: 33712368.
      Citations:    Fields:    
    5. Antony A, Lian Z, Perrard XD, Perrard J, Liu H, Cox AR, Saha P, Hennighausen L, Hartig SM, Ballantyne CM, Wu H. Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet. Diabetes. 2021 03; 70(3):720-732. PMID: 33323395.
      Citations: 1     Fields:    
    6. Lee SH, Choi JM, Jung SY, Cox AR, Hartig SM, Moore DD, Kim KH. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation. Biochem Biophys Res Commun. 2021 01 01; 534:864-870. PMID: 33168190.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Cox AR, Chernis N, Bader DA, Saha PK, Masschelin PM, Felix JB, Sharp R, Lian Z, Putluri V, Rajapakshe K, Kim KH, Villareal DT, Armamento-Villareal R, Wu H, Coarfa C, Putluri N, Hartig SM. STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity. Diabetes. 2020 12; 69(12):2630-2641. PMID: 32994273.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Saha PK, Hamilton MP, Rajapakshe K, Putluri V, Felix JB, Masschelin P, Cox AR, Bajaj M, Putluri N, Coarfa C, Hartig SM. miR-30a targets gene networks that promote browning of human and mouse adipocytes. Am J Physiol Endocrinol Metab. 2020 10 01; 319(4):E667-E677. PMID: 32799658.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Ko MS, Yun JY, Baek IJ, Jang JE, Hwang JJ, Lee SE, Heo SH, Bader DA, Lee CH, Han J, Moon JS, Lee JM, Hong EG, Lee IK, Kim SW, Park JY, Hartig SM, Kang UJ, Moore DD, Koh EH, Lee KU. Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice. Autophagy. 2021 05; 17(5):1205-1221. PMID: 32400277.
      Citations: 3     Fields:    
    10. Treviño LS, Dong J, Kaushal A, Katz TA, Jangid RK, Robertson MJ, Grimm SL, Ambati CSR, Putluri V, Cox AR, Kim KH, May TD, Gallo MR, Moore DD, Hartig SM, Foulds CE, Putluri N, Coarfa C, Walker CL. Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood. Nat Commun. 2020 05 08; 11(1):2316. PMID: 32385268.
      Citations: 8     Fields:    Translation:AnimalsCells
    11. Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. FASEB J. 2020 06; 34(6):8265-8282. PMID: 32294302.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Dong B, Zhou Y, Wang W, Scott J, Kim K, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig SM, York RB, Yang F, Moore DD. Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice. Hepatology. 2020 05; 71(5):1559-1574. PMID: 31506976.
      Citations: 15     Fields:    Translation:AnimalsCells
    13. Hartig SM, Cox AR. Paracrine signaling in islet function and survival. J Mol Med (Berl). 2020 04; 98(4):451-467. PMID: 32067063.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    14. Masschelin PM, Cox AR, Chernis N, Hartig SM. The Impact of Oxidative Stress on Adipose Tissue Energy Balance. Front Physiol. 2019; 10:1638. PMID: 32038305.
      Citations: 15     
    15. Chernis N, Masschelin P, Cox AR, Hartig SM. Bisphenol AF promotes inflammation in human white adipocytes. Am J Physiol Cell Physiol. 2020 01 01; 318(1):C63-C72. PMID: 31596606.
      Citations: 2     Fields:    Translation:HumansCells
    16. Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Phillips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Coll TF, Richards JS. S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight. 2019 07 02; 5. PMID: 31265437.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. Cox AR, Chernis N, Masschelin PM, Hartig SM. Immune Cells Gate White Adipose Tissue Expansion. Endocrinology. 2019 07 01; 160(7):1645-1658. PMID: 31107528.
      Citations: 8     Fields:    Translation:AnimalsCells
    18. Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatol Commun. 2019 Jan; 3(1):147-159. PMID: 30620001.
      Citations: 2     
    19. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 01; 1(1):70-85. PMID: 31198906.
      Citations: 29     Translation:HumansAnimalsCells
    20. Villanueva H, Grimm S, Dhamne S, Rajapakshe K, Visbal A, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DP. The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. J Mammary Gland Biol Neoplasia. 2018 12; 23(4):237-248. PMID: 30338425.
      Citations: 6     Fields:    Translation:HumansAnimals
    21. Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes. J Autoimmun. 2019 01; 96:50-58. PMID: 30122420.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. 2018 12; 67(12):2541-2553. PMID: 30002134.
      Citations: 15     Fields:    Translation:Animals
    23. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 04 02; 128(4):1283-1299. PMID: 29480818.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    24. Koh EH, Chen Y, Bader DA, Hamilton MP, He B, York B, Kajimura S, McGuire SE, Hartig SM. Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis. J Biol Chem. 2016 Nov 18; 291(47):24747-24755. PMID: 27758866.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    25. Grimm SL, Hartig SM, Edwards DP. Progesterone Receptor Signaling Mechanisms. J Mol Biol. 2016 09 25; 428(19):3831-49. PMID: 27380738.
      Citations: 34     Fields:    Translation:HumansCells
    26. Zhang Z, Lanz RB, Xiao L, Wang L, Hartig SM, Ittmann MM, Feng Q, He B. The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors. Oncotarget. 2016 Jun 21; 7(25):37993-38003. PMID: 27191272.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    27. Hamilton MP, Rajapakshe KI, Bader DA, Cerne JZ, Smith EA, Coarfa C, Hartig SM, McGuire SE. The Landscape of microRNA Targeting in Prostate Cancer Defined by AGO-PAR-CLIP. Neoplasia. 2016 06; 18(6):356-70. PMID: 27292025.
      Citations: 18     Fields:    Translation:HumansCells
    28. Lin JZ, Martagón AJ, Cimini SL, Gonzalez DD, Tinkey DW, Biter A, Baxter JD, Webb P, Gustafsson JÅ, Hartig SM, Phillips KJ. Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat. Cell Rep. 2015 Nov 24; 13(8):1528-37. PMID: 26586443.
      Citations: 38     Fields:    Translation:AnimalsCells
    29. Hartig SM, Hamilton MP, Bader DA, McGuire SE. The miRNA Interactome in Metabolic Homeostasis. Trends Endocrinol Metab. 2015 Dec; 26(12):733-745. PMID: 26492831.
      Citations: 19     Fields:    Translation:HumansAnimals
    30. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol. 2015 Sep; 29(9):1320-33. PMID: 26192107.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    31. He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18261-6. PMID: 25489091.
      Citations: 46     Fields:    Translation:HumansCells
    32. Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451. PMID: 24945252.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    33. Cerne JZ, Hartig SM, Hamilton MP, Chew SA, Mitsiades N, Poulaki V, McGuire SE. Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. Invest Ophthalmol Vis Sci. 2014 Apr 07; 55(4):2130-9. PMID: 24595385.
      Citations: 3     Fields:    Translation:HumansCells
    34. Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405. PMID: 24438340.
      Citations: 8     Fields:    Translation:HumansCells
    35. Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B. Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun. 2013 May 03; 434(2):357-62. PMID: 23567971.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    36. McDonough PM, Maciejewski-Lenoir D, Hartig SM, Hanna RA, Whittaker R, Heisel A, Nicoll JB, Buehrer BM, Christensen K, Mancini MG, Mancini MA, Edwards DP, Price JH. Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis. PLoS One. 2013; 8(2):e55511. PMID: 23405163.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    37. Hamilton MP, Rajapakshe K, Hartig SM, Reva B, McLellan MD, Kandoth C, Ding L, Zack TI, Gunaratne PH, Wheeler DA, Coarfa C, McGuire SE. Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun. 2013; 4:2730. PMID: 24220575.
      Citations: 59     Fields:    Translation:HumansCells
    38. Hartig SM. Basic image analysis and manipulation in ImageJ. Curr Protoc Mol Biol. 2013; Chapter 14:Unit14.15. PMID: 23547012.
      Citations: 73     Fields:    
    39. Hartig SM, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA. Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes. Chem Biol. 2012 Sep 21; 19(9):1126-41. PMID: 22999881.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    40. Mediwala SN, Sun H, Szafran AT, Hartig SM, Sonpavde G, Hayes TG, Thiagarajan P, Mancini MA, Marcelli M. The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way. Prostate. 2013 Feb 15; 73(3):267-77. PMID: 22821817.
      Citations: 22     Fields:    Translation:HumansCells
    41. Chen W, Chang B, Saha P, Hartig SM, Li L, Reddy VT, Yang Y, Yechoor V, Mancini MA, Chan L. Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol. 2012 Mar; 32(6):1099-111. PMID: 22269949.
      Citations: 58     Fields:    Translation:AnimalsCells
    42. Avila H, Wang H, Chauhan S, Hartig S, Boyd DD. Accelerated urokinase-receptor protein turnover triggered by interference with the addition of the glycolipid anchor. Biochem J. 2011 Mar 01; 434(2):233-42. PMID: 21143195.
      Citations: 1     Fields:    Translation:HumansCells
    43. Hartig SM, He B, Long W, Buehrer BM, Mancini MA. Homeostatic levels of SRC-2 and SRC-3 promote early human adipogenesis. J Cell Biol. 2011 Jan 10; 192(1):55-67. PMID: 21220509.
      Citations: 21     Fields:    Translation:HumansCells
    44. Hartig SM, Newberg JY, Bolt MJ, Szafran AT, Marcelli M, Mancini MA. Automated microscopy and image analysis for androgen receptor function. Methods Mol Biol. 2011; 776:313-31. PMID: 21796534.
      Citations: 10     Fields:    Translation:HumansCells
    45. Szafran AT, Sun H, Hartig S, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M. Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine. Adv Exp Med Biol. 2011; 707:63-5. PMID: 21691957.
      Citations: 2     Fields:    Translation:HumansCells
    46. Pichot CS, Arvanitis C, Hartig SM, Jensen SA, Bechill J, Marzouk S, Yu J, Frost JA, Corey SJ. Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp. Cancer Res. 2010 Nov 01; 70(21):8347-56. PMID: 20940394.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    47. Szafran AT, Hartig S, Sun H, Uray IP, Szwarc M, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M. Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine. PLoS One. 2009 Dec 09; 4(12):e8179. PMID: 20011049.
      Citations: 11     Fields:    Translation:HumansCells
    48. Feng Y, Hartig SM, Bechill JE, Blanchard EG, Caudell E, Corey SJ. The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis. J Biol Chem. 2010 Feb 12; 285(7):4348-54. PMID: 19920150.
      Citations: 20     Fields:    Translation:AnimalsCells
    49. Hartig SM, Ishikura S, Hicklen RS, Feng Y, Blanchard EG, Voelker KA, Pichot CS, Grange RW, Raphael RM, Klip A, Corey SJ. The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2. J Cell Sci. 2009 Jul 01; 122(Pt 13):2283-91. PMID: 19509061.
      Citations: 26     Fields:    Translation:AnimalsCells
    50. Hartig SM, Greene RR, DasGupta J, Carlesso G, Dikov MM, Prokop A, Davidson JM. Multifunctional nanoparticulate polyelectrolyte complexes. Pharm Res. 2007 Dec; 24(12):2353-69. PMID: 17932727.
      Citations: 25     Fields:    Translation:HumansAnimals
    51. Hartig SM, Greene RR, Carlesso G, Higginbotham JN, Khan WN, Prokop A, Davidson JM. Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells. Biomaterials. 2007 Sep; 28(26):3843-55. PMID: 17560645.
      Citations: 9     Fields:    Translation:HumansCells
    52. Hartig SM, Carlesso G, Davidson JM, Prokop A. Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights. Biomacromolecules. 2007 Jan; 8(1):265-72. PMID: 17206816.
      Citations: 4     Fields:    
    53. Hartig S, Fries S, Balcarcel RR. Reduced mitochondrial membrane potential and metabolism correspond to acute chloroform toxicity of in vitro hepatocytes. J Appl Toxicol. 2005 Jul-Aug; 25(4):310-7. PMID: 16025433.
      Citations: 3     Fields:    Translation:AnimalsCells
    54. Burapatana V, Butler EE, Chauhan G, Hartig S, Kincaid H, Wang T, Samsudin S, Tanner RD. Effect of lidocaine on ovalbumin and egg albumin foam stability. Appl Biochem Biotechnol. 2003; 105 -108:905-11. PMID: 12721427.
      Citations:    Fields:    
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