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SEAN M. HARTIG

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Endocrinology
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
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    F32DK085970     (HARTIG, SEAN)Sep 25, 2009 - Sep 24, 2011
    NIH/NIDDK
    Unique Roles of p160 Coactivators during Human Adipogenesis
    Role: Principal Investigator

    K01DK096093     (HARTIG, SEAN)Apr 1, 2013 - Jan 31, 2016
    NIH/NIDDK
    A novel axis regulates adipocyte plasticity
    Role: Principal Investigator

    R03DK105006     (HARTIG, SEAN)Apr 1, 2016 - Mar 31, 2018
    NIH/NIDDK
    Regulation of SYSTEMIC INSULIN SENSITIVITY by miRNA-30a
    Role: Principal Investigator

    R01DK114356     (HARTIG, SEAN)Aug 18, 2017 - May 31, 2022
    NIH/NIDDK
    An anti-diabetic microRNA that promotes metabolically healthy obesity
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Phillips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Coll TF, Richards JS. S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight. 2019 Jul 02; 5. PMID: 31265437.
      View in: PubMed
    2. Cox AR, Chernis N, Masschelin PM, Hartig SM. Immune Cells Gate White Adipose Tissue Expansion. Endocrinology. 2019 Jul 01; 160(7):1645-1658. PMID: 31107528.
      View in: PubMed
    3. Villanueva H, Grimm SL, Dhamne S, Rajapakshe K, Visbal AP, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DP. Correction to: The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. J Mammary Gland Biol Neoplasia. 2019 Mar; 24(1):109-110. PMID: 30465315.
      View in: PubMed
    4. Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatol Commun. 2019 Jan; 3(1):147-159. PMID: 30620001.
      View in: PubMed
    5. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 Jan; 1(1):70-85. PMID: 31198906.
      View in: PubMed
    6. Villanueva H, Grimm S, Dhamne S, Rajapakshe K, Visbal A, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DP. The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. J Mammary Gland Biol Neoplasia. 2018 Dec; 23(4):237-248. PMID: 30338425.
      View in: PubMed
    7. Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes. J Autoimmun. 2019 Jan; 96:50-58. PMID: 30122420.
      View in: PubMed
    8. Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. 2018 12; 67(12):2541-2553. PMID: 30002134.
      View in: PubMed
    9. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 Apr 02; 128(4):1283-1299. PMID: 29480818.
      View in: PubMed
    10. Koh EH, Chen Y, Bader DA, Hamilton MP, He B, York B, Kajimura S, McGuire SE, Hartig SM. Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis. J Biol Chem. 2016 Nov 18; 291(47):24747-24755. PMID: 27758866.
      View in: PubMed
    11. Grimm SL, Hartig SM, Edwards DP. Progesterone Receptor Signaling Mechanisms. J Mol Biol. 2016 09 25; 428(19):3831-49. PMID: 27380738.
      View in: PubMed
    12. Zhang Z, Lanz RB, Xiao L, Wang L, Hartig SM, Ittmann MM, Feng Q, He B. The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors. Oncotarget. 2016 Jun 21; 7(25):37993-38003. PMID: 27191272.
      View in: PubMed
    13. Hamilton MP, Rajapakshe KI, Bader DA, Cerne JZ, Smith EA, Coarfa C, Hartig SM, McGuire SE. The Landscape of microRNA Targeting in Prostate Cancer Defined by AGO-PAR-CLIP. Neoplasia. 2016 06; 18(6):356-70. PMID: 27292025.
      View in: PubMed
    14. Lin JZ, Martagón AJ, Cimini SL, Gonzalez DD, Tinkey DW, Biter A, Baxter JD, Webb P, Gustafsson JÅ, Hartig SM, Phillips KJ. Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat. Cell Rep. 2015 Nov 24; 13(8):1528-37. PMID: 26586443.
      View in: PubMed
    15. Hartig SM, Hamilton MP, Bader DA, McGuire SE. The miRNA Interactome in Metabolic Homeostasis. Trends Endocrinol Metab. 2015 Dec; 26(12):733-745. PMID: 26492831.
      View in: PubMed
    16. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol. 2015 Sep; 29(9):1320-33. PMID: 26192107.
      View in: PubMed
    17. He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18261-6. PMID: 25489091.
      View in: PubMed
    18. Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451. PMID: 24945252.
      View in: PubMed
    19. Cerne JZ, Hartig SM, Hamilton MP, Chew SA, Mitsiades N, Poulaki V, McGuire SE. Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. Invest Ophthalmol Vis Sci. 2014 Apr 07; 55(4):2130-9. PMID: 24595385.
      View in: PubMed
    20. Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405. PMID: 24438340.
      View in: PubMed
    21. Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B. Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun. 2013 May 03; 434(2):357-62. PMID: 23567971.
      View in: PubMed
    22. McDonough PM, Maciejewski-Lenoir D, Hartig SM, Hanna RA, Whittaker R, Heisel A, Nicoll JB, Buehrer BM, Christensen K, Mancini MG, Mancini MA, Edwards DP, Price JH. Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis. PLoS One. 2013; 8(2):e55511. PMID: 23405163.
      View in: PubMed
    23. Hamilton MP, Rajapakshe K, Hartig SM, Reva B, McLellan MD, Kandoth C, Ding L, Zack TI, Gunaratne PH, Wheeler DA, Coarfa C, McGuire SE. Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun. 2013; 4:2730. PMID: 24220575.
      View in: PubMed
    24. Hartig SM. Basic image analysis and manipulation in ImageJ. Curr Protoc Mol Biol. 2013; Chapter 14:Unit14.15. PMID: 23547012.
      View in: PubMed
    25. Hartig SM, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA. Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes. Chem Biol. 2012 Sep 21; 19(9):1126-41. PMID: 22999881.
      View in: PubMed
    26. Mediwala SN, Sun H, Szafran AT, Hartig SM, Sonpavde G, Hayes TG, Thiagarajan P, Mancini MA, Marcelli M. The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way. Prostate. 2013 Feb 15; 73(3):267-77. PMID: 22821817.
      View in: PubMed
    27. Chen W, Chang B, Saha P, Hartig SM, Li L, Reddy VT, Yang Y, Yechoor V, Mancini MA, Chan L. Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol. 2012 Mar; 32(6):1099-111. PMID: 22269949.
      View in: PubMed
    28. Avila H, Wang H, Chauhan S, Hartig S, Boyd DD. Accelerated urokinase-receptor protein turnover triggered by interference with the addition of the glycolipid anchor. Biochem J. 2011 Mar 01; 434(2):233-42. PMID: 21143195.
      View in: PubMed
    29. Hartig SM, He B, Long W, Buehrer BM, Mancini MA. Homeostatic levels of SRC-2 and SRC-3 promote early human adipogenesis. J Cell Biol. 2011 Jan 10; 192(1):55-67. PMID: 21220509.
      View in: PubMed
    30. Hartig SM, Newberg JY, Bolt MJ, Szafran AT, Marcelli M, Mancini MA. Automated microscopy and image analysis for androgen receptor function. Methods Mol Biol. 2011; 776:313-31. PMID: 21796534.
      View in: PubMed
    31. Szafran AT, Sun H, Hartig S, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M. Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine. Adv Exp Med Biol. 2011; 707:63-5. PMID: 21691957.
      View in: PubMed
    32. Pichot CS, Arvanitis C, Hartig SM, Jensen SA, Bechill J, Marzouk S, Yu J, Frost JA, Corey SJ. Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp. Cancer Res. 2010 Nov 01; 70(21):8347-56. PMID: 20940394.
      View in: PubMed
    33. Szafran AT, Hartig S, Sun H, Uray IP, Szwarc M, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M. Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine. PLoS One. 2009 Dec 09; 4(12):e8179. PMID: 20011049.
      View in: PubMed
    34. Feng Y, Hartig SM, Bechill JE, Blanchard EG, Caudell E, Corey SJ. The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis. J Biol Chem. 2010 Feb 12; 285(7):4348-54. PMID: 19920150.
      View in: PubMed
    35. Hartig SM, Ishikura S, Hicklen RS, Feng Y, Blanchard EG, Voelker KA, Pichot CS, Grange RW, Raphael RM, Klip A, Corey SJ. The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2. J Cell Sci. 2009 Jul 01; 122(Pt 13):2283-91. PMID: 19509061.
      View in: PubMed
    36. Hartig SM, Greene RR, DasGupta J, Carlesso G, Dikov MM, Prokop A, Davidson JM. Multifunctional nanoparticulate polyelectrolyte complexes. Pharm Res. 2007 Dec; 24(12):2353-69. PMID: 17932727.
      View in: PubMed
    37. Hartig SM, Greene RR, Carlesso G, Higginbotham JN, Khan WN, Prokop A, Davidson JM. Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells. Biomaterials. 2007 Sep; 28(26):3843-55. PMID: 17560645.
      View in: PubMed
    38. Hartig SM, Carlesso G, Davidson JM, Prokop A. Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights. Biomacromolecules. 2007 Jan; 8(1):265-72. PMID: 17206816.
      View in: PubMed
    39. Hartig S, Fries S, Balcarcel RR. Reduced mitochondrial membrane potential and metabolism correspond to acute chloroform toxicity of in vitro hepatocytes. J Appl Toxicol. 2005 Jul-Aug; 25(4):310-7. PMID: 16025433.
      View in: PubMed
    40. Burapatana V, Butler EE, Chauhan G, Hartig S, Kincaid H, Wang T, Samsudin S, Tanner RD. Effect of lidocaine on ovalbumin and egg albumin foam stability. Appl Biochem Biotechnol. 2003; 105 -108:905-11. PMID: 12721427.
      View in: PubMed
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