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SEAN HARTIG

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    R01DK139397     (WU, HUAIZHU)Sep 18, 2024 - May 31, 2029
    NIH
    MICRORNA REGULATION OF ADIPOSE TISSUE IMMUNE RESPONSE IN OBESITY
    Role: Co-Principal Investigator
    R01DK138018     (HARTIG, SEAN)Mar 20, 2024 - Feb 29, 2028
    NIH
    Molecular regulation of leptin bioavailability
    Role: Principal Investigator
    R01DK126042     (LAKE, JORDAN E)Sep 10, 2020 - Jun 30, 2025
    NIH
    Metabolic impact of FGF-21 in adipose tissue and liver of PLWH
    Role: Co-Principal Investigator
    R01DK114356     (HARTIG, SEAN)Aug 18, 2017 - Jun 30, 2026
    NIH
    Metabolic Impacts of Type II Interferon Signals in Obesity
    Role: Principal Investigator
    R03DK105006     (HARTIG, SEAN)Apr 1, 2016 - Mar 31, 2018
    NIH
    Regulation of SYSTEMIC INSULIN SENSITIVITY by miRNA-30a
    Role: Principal Investigator
    K01DK096093     (HARTIG, SEAN)Apr 1, 2013 - Jan 31, 2017
    NIH
    A novel axis regulates adipocyte plasticity
    Role: Principal Investigator
    F32DK085970     (HARTIG, SEAN)Sep 25, 2009 - Sep 24, 2011
    NIH
    Unique Roles of p160 Coactivators during Human Adipogenesis
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shao LJ, Elizondo F, Gao F, Lieu EL, Reddi B, Elizondo M, Mahmud I, Eckel-Mahan K, Scherer PE, Ge X, Wu H, Hartig S, Sun K. Myeloid MMP14 couples extracellular proteolysis to inflammatory and metabolic remodeling during obesity. Cell Rep. 2026 Jul 28; 45(7):117681. PMID: 42424144; PMCID: PMC13479528.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Chen Y, Chen C, Zhou D, Liu P, L?pez-Valiente RE, Liu Y, La CM, Xavier IB, Hartig SM, Saha P, Sun Z, Han L, Guan D. RHINO: An Integrative Multi-Omics Framework Linking Circadian Physiology to Precision Medicine. Adv Sci (Weinh). 2026 Jul 07; e76371. PMID: 42411506; PMCID: PMC13339356.
      Citations:    Fields:    
    3. Ahmed AA, Steenwinkel TE, Patton BK, Jiang P, Meyer MD, Rishi JK, Leng M, Saltzman AB, Anaya ES, Sharif M, McKenzie LJ, Detti L, Malovannaya A, Hartig SM, Pangas SA. NEDDylation maintains oocyte quality by stabilizing mitochondrial transcription. Sci Adv. 2026 Jun 19; 12(25):eaec3505. PMID: 42308310; PMCID: PMC13274606.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Lieu EL, Herman MA, Hartig SM. Toward Scientific Rigor: Setting Standards for Indirect Calorimetry Analysis and Reporting. Diabetes. 2026 03 01; 75(3):401-402. PMID: 41405847; PMCID: PMC12928740.
      Citations:    Fields:    Translation:HumansAnimals
    5. Anaya ES, Dion W, Saha PK, Cox AR, de Groot E, Ahmed AA, Felix JB, Zhu B, Pangas SA, Hartig SM. A Mouse Model of Lipoatrophy Reveals Relationships Between Beige Fat Appearance and Female Fertility. Endocrinology. 2025 Dec 05; 167(1). PMID: 41206127; PMCID: PMC12686663.
      Citations:    Fields:    Translation:Animals
    6. Banks AS, Allison DB, Alquier T, Austad SN, Auwerx J, Ayala JE, Baur JA, Carobbio S, Churchill GA, Dall M, de Cabo R, Donato J, Dragano NRV, Elias CF, Ferrante AW, Finck BN, Galgani JE, Gerhart-Hines Z, Goodyear LJ, Grobe JL, Gupta RK, Habegger KM, Hartig SM, Hevener AL, Heymsfield SB, Holman CD, de Angelis MH, James DE, Kazak L, Kim JB, Klingenspor M, Kong X, Kooijman S, Lantier L, Lloyd KCK, Lo JC, Lodhi IJ, MacLean PS, McGuinness OP, Medina-G?mez G, Mirmira RG, Morrison CD, Morton GJ, M?ller TD, Ogawa Y, Pajuelo-Reguera D, Potthoff MJ, Qi N, Reitman ML, Rensen PCN, Rozman J, Rutkowsky JM, Sakamoto K, Scherer PE, Schwartz GJ, Sedlacek R, Selloum M, Shaikh SR, Chen S, Shulman GI, ?kop V, Soukas AA, Speakman JR, Spiegelman BM, Steinberg GR, Svensson KJ, Thyfault JP, Tiganis T, Titchenell PM, Turner N, Velloso LA, Vidal-Puig A, Ward CS, Williams AS, Wolfrum C, Xu AW, Xu Y, Zierath JR, International Indirect Calorimetry Consensus Committee (IICCC). A consensus guide to preclinical indirect calorimetry experiments. Nat Metab. 2025 Sep; 7(9):1765-1780. PMID: 40993210; PMCID: PMC12974399.
      Citations: 6     Fields:    Translation:HumansAnimals
    7. Ortiz AR, Nay K, Stork BA, Dean AM, Hartig SM, Coarfa C, Tegegne S, Asquith CR, Frigo DE, York B, Means AR, Febbraio MA, Scott JW. Myeloid-specific CAMKK2 deficiency protects against diet-induced obesity and insulin resistance by rewiring metabolic gene expression and enhancing energy expenditure. Mol Metab. 2025 Nov; 101:102250. PMID: 40945690; PMCID: PMC12493246.
      Citations:    Fields:    Translation:AnimalsCells
    8. Agarwal N, Saha P, Ramirez Bustamante CE, Hartig SM, Herman MA, Balasubramanyam A, Lake JE. Liver-specific Expression of HIV-1 Viral Protein R Causes Hepatic Steatosis and Glucose Intolerance in Male Mice. J Endocr Soc. 2025 Oct; 9(10):bvaf132. PMID: 40980543; PMCID: PMC12445674.
      Citations:    
    9. Felix JB, Saha PK, de Groot EL, Tan L, Sharp R, Anaya ES, Li Y, Quang H, Saidi N, Abushamat L, Ballantyne CM, Amos CI, Lorenzi PL, Klein S, Gao X, Hartig SM. N-acetylaspartate from fat cells regulates postprandial body temperature. Nat Metab. 2025 Aug; 7(8):1524-1535. PMID: 40702167; PMCID: PMC12373498.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Debroy P, Pike F, Gawrieh S, Corey KE, Hartig S, Balasubramanyam A, Ailstock K, Funderburg N, Lake JE. Circulating fibroblast growth factor 21 and growth differentiation factor 15 are associated with severity of hepatic steatosis in people with HIV. HIV Med. 2025 Sep; 26(9):1457-1462. PMID: 40497366; PMCID: PMC12229270.
      Citations: 3     Fields:    Translation:Humans
    11. Saha PK, Sharp R, Cox AR, Habib R, Bolt MJ, Felix JB, Ramirez Bustamante CE, Li X, Jung SY, Kim KH, Sun K, Wu H, Klein S, Hartig SM, Saha PK, Sharp R, Cox AR, Habib R, Bolt MJ, Felix JB, Ramirez Bustamante CE, Li X, Jung SY, Kim KH, Sun K, Wu H, Klein S, Hartig SM. The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesity. J Clin Invest. 2025 Aug 01; 135(15). PMID: 40471675; PMCID: PMC12321386.
      Citations:    Fields:    Translation:HumansAnimals
    12. Shao LJ, Elizondo F, Gao F, Habib R, Li X, Pham K, Ysaguirre J, Elizondo M, Shirazi S, Eckel-Mahan KL, Hartig S, Wu H, Sun K, Shao LJ, Elizondo F, Gao F, Habib R, Li X, Pham K, Ysaguirre J, Elizondo M, Shirazi S, Eckel-Mahan KL, Hartig S, Wu H, Sun K. Functional regulation of macrophages by Ces1d-mediated lipid signaling in immunometabolism. Mol Metab. 2025 Jul; 97:102166. PMID: 40349771; PMCID: PMC12145999.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    13. Abushamat LA, Yu B, Hoogeveen RC, Sun C, Cheng C, Hartig SM, Herman MA, Balasubramanyam A, Reusch JE, Selvin E, Ndumele CE, Nambi V, Ballantyne CM. Erythritol, Erythronate, and Cardiovascular Outcomes in Older?Adults?in the ARIC Study. JACC Adv. 2025 Mar; 4(3):101605. PMID: 39983608; PMCID: PMC11889355.
      Citations: 2     
    14. Masschelin PM, Ochsner SA, Hartig SM, McKenna NJ, Cox AR. Islet single-cell transcriptomic profiling during obesity-induced beta cell expansion in female mice. iScience. 2025 Mar 21; 28(3):112031. PMID: 40104055; PMCID: PMC11914824.
      Citations:    
    15. Walkey CJ, Snow KJ, Bulcha J, Cox AR, Martinez AE, Ljungberg MC, Lanza DG, De Giorgi M, Chuecos MA, Alves-Bezerra M, Suarez CF, Hartig SM, Hilsenbeck SG, Hsu CW, Saville E, Gaitan Y, Duryea J, Hannigan S, Dickinson ME, Mirochnitchenko O, Wang D, Lutz CM, Heaney JD, Gao G, Murray SA, Lagor WR, Lanza DG, Hilsenbeck SG, Heaney JD, Lagor WR. A comprehensive atlas of AAV tropism in the mouse. Mol Ther. 2025 Mar 05; 33(3):1282-1299. PMID: 39863928; PMCID: PMC11897767.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    16. Hartig SM, Herman MA. Advancing de novo lipogenesis: Genetic and metabolic insights. Cell Metab. 2025 Jan 07; 37(1):3-4. PMID: 39778518; PMCID: PMC13050314.
      Citations:    Fields:    Translation:HumansAnimalsCells
    17. Anaya ES, de Groot EL, Lydon JP, Pangas SA, Hartig SM. Contributions of white adipose tissue to energy requirements for female reproduction. Trends Endocrinol Metab. 2024 09; 35(9):809-820. PMID: 38749883; PMCID: PMC11387141.
      Citations:    Fields:    Translation:HumansAnimals
    18. Lee SH, Suh JH, Heo MJ, Choi JM, Yang Y, Jung HJ, Gao Z, Yongmei Y, Jung SY, Kolonin MG, Cox AR, Hartig SM, Eltzschig HK, Ju C, Moore DD, Kim KH, Lee SH, Suh JH, Heo MJ, Choi JM, Yang Y, Jung HJ, Gao Z, Yu Y, Jung SY, Kolonin MG, Cox AR, Hartig SM, Eltzschig HK, Ju C, Moore DD, Kim KH. The Hepatokine Orosomucoid 2 Mediates Beneficial Metabolic Effects of Bile Acids. Diabetes. 2024 05 01; 73(5):701-712. PMID: 38320268; PMCID: PMC11043061.
      Citations: 4     Fields:    Translation:Animals
    19. Wang Q, Hartig SM, Ballantyne CM, Wu H. The multifaceted life of macrophages in white adipose tissue: Immune shift couples with metabolic switch. Immunol Rev. 2024 07; 324(1):11-24. PMID: 38683173; PMCID: PMC11262992.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    20. Ramirez Bustamante CE, Agarwal N, Cox AR, Hartig SM, Lake JE, Balasubramanyam A. Adipose Tissue Dysfunction and Energy Balance Paradigms in People Living With HIV. Endocr Rev. 2024 03 04; 45(2):190-209. PMID: 37556371; PMCID: PMC10911955.
      Citations:    Fields:    Translation:Humans
    21. Briley SM, Ahmed AA, Steenwinkel TE, Jiang P, Hartig SM, Schindler K, Pangas SA. Global SUMOylation in mouse oocytes maintains oocyte identity and regulates chromatin remodeling and transcriptional silencing at the end of folliculogenesis. Development. 2023 09 01; 150(17). PMID: 37676777; PMCID: PMC10499029.
      Citations:    Fields:    Translation:AnimalsCells
    22. Burris TP, de Vera IMS, Cote I, Flaveny CA, Wanninayake US, Chatterjee A, Walker JK, Steinauer N, Zhang J, Coons LA, Korach KS, Cain DW, Hollenberg AN, Webb P, Forrest D, Jetten AM, Edwards DP, Grimm SL, Hartig S, Lange CA, Richer JK, Sartorius CA, Tetel M, Billon C, Elgendy B, Hegazy L, Griffett K, Peinetti N, Burnstein KL, Hughes TS, Sitaula S, Stayrook KR, Culver A, Murray MH, Finck BN, Cidlowski JA. International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily-Update 2023. Pharmacol Rev. 2023 11; 75(6):1233-1318. PMID: 37586884; PMCID: PMC10595025.
      Citations:    Fields:    Translation:Humans
    23. Grimm SL, Reddick S, Dong X, Leek C, Wang AX, Gutierrez MC, Hartig SM, Moorthy B, Coarfa C, Lingappan K. Loss of microRNA-30a and sex-specific effects on the neonatal hyperoxic lung injury. Biol Sex Differ. 2023 08 08; 14(1):50. PMID: 37553579; PMCID: PMC10408139.
      Citations: 5     Fields:    Translation:Animals
    24. Masschelin PM, Saha P, Ochsner SA, Cox AR, Kim KH, Felix JB, Sharp R, Li X, Tan L, Park JH, Wang L, Putluri V, Lorenzi PL, Nuotio-Antar AM, Sun Z, Kaipparettu BA, Putluri N, Moore DD, Summers SA, McKenna NJ, Hartig SM. Vitamin B2 enables regulation of fasting glucose availability. Elife. 2023 07 07; 12. PMID: 37417957; PMCID: PMC10328530.
      Citations: 10     Fields:    Translation:AnimalsCells
    25. Heo MJ, Suh JH, Lee SH, Poulsen KL, An YA, Moorthy B, Hartig SM, Moore DD, Kim KH. Aryl hydrocarbon receptor maintains hepatic mitochondrial homeostasis in mice. Mol Metab. 2023 06; 72:101717. PMID: 37004989; PMCID: PMC10106517.
      Citations:    Fields:    Translation:AnimalsCells
    26. He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli NA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y, Sadaf Farooqi I. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. Nat Med. 2022 12; 28(12):2537-2546. PMID: 36536256; PMCID: PMC9800280.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    27. Cox AR, Masschelin PM, Saha PK, Felix JB, Sharp R, Lian Z, Xia Y, Chernis N, Bader DA, Kim KH, Li X, Yoshino J, Li X, Li G, Sun Z, Wu H, Coarfa C, Moore DD, Klein S, Sun K, Hartig SM. The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice. Cell Metab. 2022 12 06; 34(12):1932-1946.e7. PMID: 36243005; PMCID: PMC9742315.
      Citations: 14     Fields:    Translation:Animals
    28. Tovy A, Reyes JM, Zhang L, Huang YH, Rosas C, Daquinag AC, Guzman A, Ramabadran R, Chen CW, Gu T, Gupta S, Ortinau L, Park D, Cox AR, Rau RE, Hartig SM, Kolonin MG, Goodell MA. Constitutive loss of DNMT3A causes morbid obesity through misregulation of adipogenesis. Elife. 2022 05 30; 11. PMID: 35635747; PMCID: PMC9150890.
      Citations: 21     Fields:    Translation:Animals
    29. Agarwal N, Ramirez Bustamante CE, Wu H, Armamento-Villareal R, Lake JE, Balasubramanyam A, Hartig SM. Heightened levels of plasma growth differentiation factor 15 in men living with HIV. Physiol Rep. 2022 05; 10(9):e15293. PMID: 35510313; PMCID: PMC9069165.
      Citations: 1     Fields:    Translation:Humans
    30. Kim KH, Hartig SM. Contributions of microRNAs to Peripheral Insulin Sensitivity. Endocrinology. 2022 02 01; 163(2). PMID: 34882766; PMCID: PMC8758341.
      Citations:    Fields:    Translation:HumansAnimals
    31. Hong CH, Ko MS, Kim JH, Cho H, Lee CH, Yoon JE, Yun JY, Baek IJ, Jang JE, Lee SE, Cho YK, Baek JY, Oh SJ, Lee BY, Lim JS, Lee J, Hartig SM, Lee KU, Choi JW, Kim S, Koh EH, Conde de la Rosa L, Garcia-Ruiz C, Fern?ndez-Checa JC. Sphingosine 1-Phosphate Receptor 4 Promotes Nonalcoholic Steatohepatitis by Activating NLRP3 Inflammasome. Cell Mol Gastroenterol Hepatol. 2022; 13(3):925-947. PMID: 34890841; PMCID: PMC8810559.
      Citations: 1     Fields:    Translation:HumansAnimals
    32. Agarwal N, Iyer D, Saha P, Cox AR, Xia Y, Utay NS, Somasundaram A, Schubert U, Lake JE, Hartig SM, Balasubramanyam A. HIV-1 Viral Protein R Couples Metabolic Inflexibility With White Adipose Tissue Thermogenesis. Diabetes. 2021 09; 70(9):2014-2025. PMID: 34233931; PMCID: PMC8576429.
      Citations: 1     Fields:    Translation:Humans
    33. Mao H, Li L, Fan Q, Angelini A, Saha PK, Wu H, Ballantyne CM, Hartig SM, Xie L, Pi X. Loss of bone morphogenetic protein-binding endothelial regulator causes insulin resistance. Nat Commun. 2021 03 26; 12(1):1927. PMID: 33772019; PMCID: PMC7997910.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    34. Cox AR, Chernis N, Kim KH, Masschelin PM, Saha PK, Briley SM, Sharp R, Li X, Felix JB, Sun Z, Moore DD, Pangas SA, Hartig SM. Ube2i deletion in adipocytes causes lipoatrophy in mice. Mol Metab. 2021 06; 48:101221. PMID: 33771728; PMCID: PMC8080079.
      Citations: 8     Fields:    Translation:AnimalsCells
    35. Felix JB, Cox AR, Hartig SM. Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion. Trends Endocrinol Metab. 2021 05; 32(5):320-332. PMID: 33712368; PMCID: PMC8035226.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    36. Antony A, Lian Z, Perrard XD, Perrard J, Liu H, Cox AR, Saha P, Hennighausen L, Hartig SM, Ballantyne CM, Wu H. Deficiency of Stat1 in CD11c+ Cells Alters Adipose Tissue Inflammation and Improves Metabolic Dysfunctions in Mice Fed a High-Fat Diet. Diabetes. 2021 03; 70(3):720-732. PMID: 33323395; PMCID: PMC7897343.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    37. Lee SH, Choi JM, Jung SY, Cox AR, Hartig SM, Moore DD, Kim KH. The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation. Biochem Biophys Res Commun. 2021 01 01; 534:864-870. PMID: 33168190; PMCID: PMC7785631.
      Citations: 3     Fields:    Translation:AnimalsCells
    38. Cox AR, Chernis N, Bader DA, Saha PK, Masschelin PM, Felix JB, Sharp R, Lian Z, Putluri V, Rajapakshe K, Kim KH, Villareal DT, Armamento-Villareal R, Wu H, Coarfa C, Putluri N, Hartig SM. STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity. Diabetes. 2020 12; 69(12):2630-2641. PMID: 32994273; PMCID: PMC7679774.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    39. Saha PK, Hamilton MP, Rajapakshe K, Putluri V, Felix JB, Masschelin P, Cox AR, Bajaj M, Putluri N, Coarfa C, Hartig SM. miR-30a targets gene networks that promote browning of human and mouse adipocytes. Am J Physiol Endocrinol Metab. 2020 10 01; 319(4):E667-E677. PMID: 32799658; PMCID: PMC7864240.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    40. Ko MS, Yun JY, Baek IJ, Jang JE, Hwang JJ, Lee SE, Heo SH, Bader DA, Lee CH, Han J, Moon JS, Lee JM, Hong EG, Lee IK, Kim SW, Park JY, Hartig SM, Kang UJ, Moore DD, Koh EH, Lee KU. Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice. Autophagy. 2021 05; 17(5):1205-1221. PMID: 32400277; PMCID: PMC8143238.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Dong J, Kaushal A, Katz TA, Jangid RK, Robertson MJ, Grimm SL, Ambati CSR, Putluri V, Cox AR, Kim KH, May TD, Gallo MR, Moore DD, Hartig SM, Foulds CE, Putluri N, Coarfa C, Walker CL, Trevi?o LS. Epigenome environment interactions accelerate epigenomic aging and unlock metabolically restricted epigenetic reprogramming in adulthood. Nat Commun. 2020 05 08; 11(1):2316. PMID: 32385268; PMCID: PMC7210260.
      Citations: 16     Fields:    Translation:AnimalsCells
    42. Li X, Yang L, Mao Z, Pan X, Zhao Y, Gu X, Eckel-Mahan K, Zuo Z, Tong Q, Hartig SM, Cheng X, Du G, Moore DD, Bellen HJ, Sesaki H, Sun K. Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue. FASEB J. 2020 06; 34(6):8265-8282. PMID: 32294302; PMCID: PMC7336545.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    43. Dong B, Zhou Y, Wang W, Scott J, Kim K, Sun Z, Guo Q, Lu Y, Gonzales NM, Wu H, Hartig SM, York RB, Yang F, Moore DD. Vitamin D Receptor Activation in Liver Macrophages Ameliorates Hepatic Inflammation, Steatosis, and Insulin Resistance in Mice. Hepatology. 2020 05; 71(5):1559-1574. PMID: 31506976.
      Citations: 30     Fields:    Translation:AnimalsCells
    44. Hartig SM, Cox AR. Paracrine signaling in islet function and survival. J Mol Med (Berl). 2020 04; 98(4):451-467. PMID: 32067063; PMCID: PMC7899133.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    45. Masschelin PM, Cox AR, Chernis N, Hartig SM. The Impact of Oxidative Stress on Adipose Tissue Energy Balance. Front Physiol. 2019; 10:1638. PMID: 32038305; PMCID: PMC6987041.
      Citations: 32     
    46. Chernis N, Masschelin P, Cox AR, Hartig SM. Bisphenol AF promotes inflammation in human white adipocytes. Am J Physiol Cell Physiol. 2020 01 01; 318(1):C63-C72. PMID: 31596606; PMCID: PMC6985838.
      Citations: 4     Fields:    Translation:HumansCells
    47. Ren YA, Monkkonen T, Lewis MT, Bernard DJ, Christian HC, Jorgez CJ, Moore JA, Landua JD, Chin HM, Chen W, Singh S, Kim IS, Zhang XH, Xia Y, Phillips KJ, MacKay H, Waterland RA, Ljungberg MC, Saha PK, Hartig SM, Richards JS, Coll TF. S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation. JCI Insight. 2019 07 02; 5. PMID: 31265437; PMCID: PMC6675546.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    48. Cox AR, Chernis N, Masschelin PM, Hartig SM. Immune Cells Gate White Adipose Tissue Expansion. Endocrinology. 2019 07 01; 160(7):1645-1658. PMID: 31107528; PMCID: PMC6591013.
      Citations: 13     Fields:    Translation:AnimalsCells
    49. Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatol Commun. 2019 Jan; 3(1):147-159. PMID: 30620001; PMCID: PMC6312660.
      Citations: 3     Fields:    
    50. Bader DA, Hartig SM, Putluri V, Foley C, Hamilton MP, Smith EA, Saha PK, Panigrahi A, Walker C, Zong L, Martini-Stoica H, Chen R, Rajapakshe K, Coarfa C, Sreekumar A, Mitsiades N, Bankson JA, Ittmann MM, O'Malley BW, Putluri N, McGuire SE. Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer. Nat Metab. 2019 01; 1(1):70-85. PMID: 31198906; PMCID: PMC6563330.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    51. Villanueva H, Grimm S, Dhamne S, Rajapakshe K, Visbal A, Davis CM, Ehli EA, Hartig SM, Coarfa C, Edwards DP. The Emerging Roles of Steroid Hormone Receptors in Ductal Carcinoma in Situ (DCIS) of the Breast. J Mammary Gland Biol Neoplasia. 2018 12; 23(4):237-248. PMID: 30338425; PMCID: PMC6244884.
      Citations: 6     Fields:    Translation:HumansAnimals
    52. Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes. J Autoimmun. 2019 01; 96:50-58. PMID: 30122420; PMCID: PMC6541442.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    53. Koh EH, Chernis N, Saha PK, Xiao L, Bader DA, Zhu B, Rajapakshe K, Hamilton MP, Liu X, Perera D, Chen X, York B, Trauner M, Coarfa C, Bajaj M, Moore DD, Deng T, McGuire SE, Hartig SM. miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity. Diabetes. 2018 12; 67(12):2541-2553. PMID: 30002134; PMCID: PMC6245225.
      Citations: 27     Fields:    Translation:Animals
    54. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 04 02; 128(4):1283-1299. PMID: 29480818; PMCID: PMC5873887.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    55. Koh EH, Chen Y, Bader DA, Hamilton MP, He B, York B, Kajimura S, McGuire SE, Hartig SM. Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis. J Biol Chem. 2016 Nov 18; 291(47):24747-24755. PMID: 27758866; PMCID: PMC5114422.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    56. Grimm SL, Hartig SM, Edwards DP. Progesterone Receptor Signaling Mechanisms. J Mol Biol. 2016 09 25; 428(19):3831-49. PMID: 27380738.
      Citations: 51     Fields:    Translation:HumansCells
    57. Zhang Z, Lanz RB, Xiao L, Wang L, Hartig SM, Ittmann MM, Feng Q, He B. The tumor suppressive miR-200b subfamily is an ERG target gene in human prostate tumors. Oncotarget. 2016 Jun 21; 7(25):37993-38003. PMID: 27191272; PMCID: PMC5122366.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    58. Hamilton MP, Rajapakshe KI, Bader DA, Cerne JZ, Smith EA, Coarfa C, Hartig SM, McGuire SE. The Landscape of microRNA Targeting in Prostate Cancer Defined by AGO-PAR-CLIP. Neoplasia. 2016 06; 18(6):356-70. PMID: 27292025; PMCID: PMC4909715.
      Citations: 26     Fields:    Translation:HumansCells
    59. Lin JZ, Cimini SL, Tinkey DW, Biter A, Baxter JD, Webb P, Hartig SM, Phillips KJ, Martag?n AJ, Gonzalez DD, Gustafsson J?. Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat. Cell Rep. 2015 Nov 24; 13(8):1528-37. PMID: 26586443; PMCID: PMC4662916.
      Citations: 44     Fields:    Translation:AnimalsCells
    60. Hartig SM, Hamilton MP, Bader DA, McGuire SE. The miRNA Interactome in Metabolic Homeostasis. Trends Endocrinol Metab. 2015 Dec; 26(12):733-745. PMID: 26492831; PMCID: PMC4673013.
      Citations: 28     Fields:    Translation:HumansAnimals
    61. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol. 2015 Sep; 29(9):1320-33. PMID: 26192107; PMCID: PMC4552434.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    62. He B, Lanz RB, Fiskus W, Geng C, Yi P, Hartig SM, Rajapakshe K, Shou J, Wei L, Shah SS, Foley C, Chew SA, Eedunuri VK, Bedoya DJ, Feng Q, Minami T, Mitsiades CS, Frolov A, Weigel NL, Hilsenbeck SG, Rosen DG, Palzkill T, Ittmann MM, Song Y, Coarfa C, O'Malley BW, Mitsiades N. GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18261-6. PMID: 25489091; PMCID: PMC4280633.
      Citations: 55     Fields:    Translation:HumansCells
    63. Caneba CA, Yang L, Baddour J, Curtis R, Win J, Hartig S, Marini J, Nagrath D. Nitric oxide is a positive regulator of the Warburg effect in ovarian cancer cells. Cell Death Dis. 2014 Jun 26; 5:e1302. PMID: 24967964; PMCID: PMC4611736.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    64. Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451. PMID: 24945252; PMCID: PMC4063709.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    65. Cerne JZ, Hartig SM, Hamilton MP, Chew SA, Mitsiades N, Poulaki V, McGuire SE. Protein kinase C inhibitors sensitize GNAQ mutant uveal melanoma cells to ionizing radiation. Invest Ophthalmol Vis Sci. 2014 Apr 07; 55(4):2130-9. PMID: 24595385; PMCID: PMC3979518.
      Citations: 4     Fields:    Translation:HumansCells
    66. Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405. PMID: 24438340; PMCID: PMC3938540.
      Citations: 8     Fields:    Translation:HumansCells
    67. Hartig SM, Feng Q, Ochsner SA, Xiao R, McKenna NJ, McGuire SE, He B. Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun. 2013 May 03; 434(2):357-62. PMID: 23567971; PMCID: PMC3763992.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    68. McDonough PM, Maciejewski-Lenoir D, Hartig SM, Hanna RA, Whittaker R, Heisel A, Nicoll JB, Buehrer BM, Christensen K, Mancini MG, Mancini MA, Edwards DP, Price JH. Differential phosphorylation of perilipin 1A at the initiation of lipolysis revealed by novel monoclonal antibodies and high content analysis. PLoS One. 2013; 8(2):e55511. PMID: 23405163; PMCID: PMC3566132.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    69. Hartig SM. Basic image analysis and manipulation in ImageJ. Curr Protoc Mol Biol. 2013; Chapter 14:Unit14.15. PMID: 23547012.
      Citations: 92     Fields:    
    70. Hamilton MP, Rajapakshe K, Hartig SM, Reva B, McLellan MD, Kandoth C, Ding L, Zack TI, Gunaratne PH, Wheeler DA, Coarfa C, McGuire SE. Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif. Nat Commun. 2013; 4:2730. PMID: 24220575; PMCID: PMC3868236.
      Citations: 69     Fields:    Translation:HumansCells
    71. Hartig SM, He B, Newberg JY, Ochsner SA, Loose DS, Lanz RB, McKenna NJ, Buehrer BM, McGuire SE, Marcelli M, Mancini MA. Feed-forward inhibition of androgen receptor activity by glucocorticoid action in human adipocytes. Chem Biol. 2012 Sep 21; 19(9):1126-41. PMID: 22999881; PMCID: PMC4259876.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    72. Mediwala SN, Sun H, Szafran AT, Hartig SM, Sonpavde G, Hayes TG, Thiagarajan P, Mancini MA, Marcelli M. The activity of the androgen receptor variant AR-V7 is regulated by FOXO1 in a PTEN-PI3K-AKT-dependent way. Prostate. 2013 Feb 15; 73(3):267-77. PMID: 22821817; PMCID: PMC3961010.
      Citations: 24     Fields:    Translation:HumansCells
    73. Chen W, Chang B, Saha P, Hartig SM, Li L, Reddy VT, Yang Y, Yechoor V, Mancini MA, Chan L. Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol. 2012 Mar; 32(6):1099-111. PMID: 22269949; PMCID: PMC3295006.
      Citations: 70     Fields:    Translation:AnimalsCells
    74. Avila H, Wang H, Chauhan S, Hartig S, Boyd DD. Accelerated urokinase-receptor protein turnover triggered by interference with the addition of the glycolipid anchor. Biochem J. 2011 Mar 01; 434(2):233-42. PMID: 21143195.
      Citations: 2     Fields:    Translation:HumansCells
    75. Hartig SM, He B, Long W, Buehrer BM, Mancini MA. Homeostatic levels of SRC-2 and SRC-3 promote early human adipogenesis. J Cell Biol. 2011 Jan 10; 192(1):55-67. PMID: 21220509; PMCID: PMC3019557.
      Citations: 23     Fields:    Translation:HumansCells
    76. Szafran AT, Sun H, Hartig S, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M. Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine. Adv Exp Med Biol. 2011; 707:63-5. PMID: 21691957.
      Citations: 2     Fields:    Translation:HumansCells
    77. Hartig SM, Newberg JY, Bolt MJ, Szafran AT, Marcelli M, Mancini MA. Automated microscopy and image analysis for androgen receptor function. Methods Mol Biol. 2011; 776:313-31. PMID: 21796534; PMCID: PMC4437203.
      Citations: 10     Fields:    Translation:HumansCells
    78. Pichot CS, Arvanitis C, Hartig SM, Jensen SA, Bechill J, Marzouk S, Yu J, Frost JA, Corey SJ. Cdc42-interacting protein 4 promotes breast cancer cell invasion and formation of invadopodia through activation of N-WASp. Cancer Res. 2010 Nov 01; 70(21):8347-56. PMID: 20940394; PMCID: PMC2970640.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    79. Szafran AT, Hartig S, Sun H, Uray IP, Szwarc M, Shen Y, Mediwala SN, Bell J, McPhaul MJ, Mancini MA, Marcelli M. Androgen receptor mutations associated with androgen insensitivity syndrome: a high content analysis approach leading to personalized medicine. PLoS One. 2009 Dec 09; 4(12):e8179. PMID: 20011049; PMCID: PMC2785468.
      Citations: 11     Fields:    Translation:HumansCells
    80. Feng Y, Hartig SM, Bechill JE, Blanchard EG, Caudell E, Corey SJ. The Cdc42-interacting protein-4 (CIP4) gene knock-out mouse reveals delayed and decreased endocytosis. J Biol Chem. 2010 Feb 12; 285(7):4348-54. PMID: 19920150; PMCID: PMC2836039.
      Citations: 26     Fields:    Translation:AnimalsCells
    81. Hartig SM, Ishikura S, Hicklen RS, Feng Y, Blanchard EG, Voelker KA, Pichot CS, Grange RW, Raphael RM, Klip A, Corey SJ. The F-BAR protein CIP4 promotes GLUT4 endocytosis through bidirectional interactions with N-WASp and Dynamin-2. J Cell Sci. 2009 Jul 01; 122(Pt 13):2283-91. PMID: 19509061; PMCID: PMC2723146.
      Citations: 30     Fields:    Translation:AnimalsCells
    82. Pichot CS, Hartig SM, Xia L, Arvanitis C, Monisvais D, Lee FY, Frost JA, Corey SJ. Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells. Br J Cancer. 2009 Jul 07; 101(1):38-47. PMID: 19513066; PMCID: PMC2713704.
      Citations:    
    83. Hartig SM, Greene RR, DasGupta J, Carlesso G, Dikov MM, Prokop A, Davidson JM. Multifunctional nanoparticulate polyelectrolyte complexes. Pharm Res. 2007 Dec; 24(12):2353-69. PMID: 17932727.
      Citations: 27     Fields:    Translation:HumansAnimals
    84. Hartig SM, Greene RR, Carlesso G, Higginbotham JN, Khan WN, Prokop A, Davidson JM. Kinetic analysis of nanoparticulate polyelectrolyte complex interactions with endothelial cells. Biomaterials. 2007 Sep; 28(26):3843-55. PMID: 17560645; PMCID: PMC2000344.
      Citations: 9     Fields:    Translation:HumansCells
    85. Hartig SM, Carlesso G, Davidson JM, Prokop A. Development of improved nanoparticulate polyelectrolyte complex physicochemistry by nonstoichiometric mixing of polyions with similar molecular weights. Biomacromolecules. 2007 Jan; 8(1):265-72. PMID: 17206816.
      Citations: 4     Fields:    
    86. Hartig S, Fries S, Balcarcel RR. Reduced mitochondrial membrane potential and metabolism correspond to acute chloroform toxicity of in vitro hepatocytes. J Appl Toxicol. 2005 Jul-Aug; 25(4):310-7. PMID: 16025433.
      Citations: 3     Fields:    Translation:AnimalsCells
    87. Burapatana V, Butler EE, Chauhan G, Hartig S, Kincaid H, Wang T, Samsudin S, Tanner RD. Effect of lidocaine on ovalbumin and egg albumin foam stability. Appl Biochem Biotechnol. 2003; 105 -108:905-11. PMID: 12721427.
      Citations:    Fields:    
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