"Ectodysplasins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
| Descriptor ID |
D053331
|
| MeSH Number(s) |
D12.644.276.374.750.186 D12.776.395.550.275 D12.776.467.374.750.186 D12.776.543.550.275 D23.529.374.750.186
|
| Concept/Terms |
Ectodysplasins- Ectodysplasins
- Ectodysplasin-A
- Ectodysplasin A
- Ectodysplasin
|
Below are MeSH descriptors whose meaning is more general than "Ectodysplasins".
Below are MeSH descriptors whose meaning is more specific than "Ectodysplasins".
This graph shows the total number of publications written about "Ectodysplasins" by people in this website by year, and whether "Ectodysplasins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
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Below are the most recent publications written about "Ectodysplasins" by people in Profiles.
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Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes. Neuroscience. 2012 Sep 27; 221:214-24.
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Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis. Eur J Hum Genet. 2010 Jan; 18(1):19-25.
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Genetics and human malformations. J Craniofac Surg. 2009 Sep; 20 Suppl 2:1652-4.
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Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009 Jul; 17(1):49-61.
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Genotype, phenotype, and karyotype correlation in the XO mouse model of Turner Syndrome. J Hered. 2008 Sep-Oct; 99(5):512-7.
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A novel Gln358Glu mutation in ectodysplasin A associated with X-linked dominant incisor hypodontia. Am J Med Genet A. 2007 Feb 15; 143(4):390-4.
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X-linked anhidrotic ectodermal dysplasia with immunodeficiency is caused by impaired NF-kappaB signaling. Nat Genet. 2001 Mar; 27(3):277-85.
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Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development. 2000 Nov; 127(21):4691-700.
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TROY, a newly identified member of the tumor necrosis factor receptor superfamily, exhibits a homology with Edar and is expressed in embryonic skin and hair follicles. J Biol Chem. 2000 Jul 07; 275(27):20742-7.
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Involvement of a novel Tnf receptor homologue in hair follicle induction. Nat Genet. 1999 Aug; 22(4):370-4.