"Crystallins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterogeneous family of water-soluble structural proteins found in cells of the vertebrate lens. The presence of these proteins accounts for the transparency of the lens. The family is composed of four major groups, alpha, beta, gamma, and delta, and several minor groups, which are classed on the basis of size, charge, immunological properties, and vertebrate source. Alpha, beta, and delta crystallins occur in avian and reptilian lenses, while alpha, beta, and gamma crystallins occur in all other lenses.
| Descriptor ID |
D003459
|
| MeSH Number(s) |
D12.776.306.366
|
| Concept/Terms |
Crystallins- Crystallins
- Lens Proteins
- Proteins, Lens
- Crystallin
|
Below are MeSH descriptors whose meaning is more general than "Crystallins".
Below are MeSH descriptors whose meaning is more specific than "Crystallins".
This graph shows the total number of publications written about "Crystallins" by people in this website by year, and whether "Crystallins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 0 | 1 | 1 |
| 1996 | 1 | 4 | 5 |
| 1997 | 1 | 1 | 2 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Crystallins" by people in Profiles.
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Amelioration of desmin network defects by aB-crystallin overexpression confers cardioprotection in a mouse model of dilated cardiomyopathy caused by LMNA gene mutation. J Mol Cell Cardiol. 2018 12; 125:73-86.
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Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics. Oncotarget. 2017 Jul 18; 8(29):48222-48239.
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Dominant inhibition of lens placode formation in mice. Dev Biol. 2008 Nov 01; 323(1):53-63.
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Elevated insulin signaling disrupts the growth and differentiation pattern of the mouse lens. Mol Vis. 2007 Mar 26; 13:397-407.
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Ras signaling is essential for lens cell proliferation and lens growth during development. Dev Biol. 2006 Oct 15; 298(2):403-14.
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CREB-binding protein/p300 co-activation of crystallin gene expression. J Biol Chem. 2002 Jul 05; 277(27):24081-9.
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Inhibition of crystallin expression and induction of apoptosis by lens-specific E1A expression in transgenic mice. Oncogene. 2002 Feb 07; 21(7):1028-37.
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Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation. Development. 2001 Oct; 128(20):3995-4010.
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Secreted FGFR3, but not FGFR1, inhibits lens fiber differentiation. Development. 2001 May; 128(9):1617-27.
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Myofibrillar disruption in hypocontractile myocardium showing perfusion-contraction matches and mismatches. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1320-34.