"Bestrophins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein family characterized by a highly conserved N-terminus and four to six transmembrane helices; they function as bicarbonate permeable, calcium-activated chloride channels. Bestrophin-1 (BEST-1) and bestrophin-2 are highly expressed in human RETINAL PIGMENT EPITHELIUM cells and mutations in the BEST-1 gene are associated with VITELLIFORM MACULAR DYSTROPHY, TYPE 2.
| Descriptor ID |
D000075002
|
| MeSH Number(s) |
D12.776.157.530.400.175.063 D12.776.306.228 D12.776.543.550.450.175.063 D12.776.543.585.400.175.063
|
| Concept/Terms |
Bestrophins- Bestrophins
- Bestrophin Proteins
- Bestrophin Family
Bestrophin-1- Bestrophin-1
- Bestrophin 1
- BEST-1 Protein
- BEST 1 Protein
Bestrophin-2- Bestrophin-2
- Bestrophin 2
- BEST-2 Protein
- BEST 2 Protein
|
Below are MeSH descriptors whose meaning is more general than "Bestrophins".
Below are MeSH descriptors whose meaning is more specific than "Bestrophins".
This graph shows the total number of publications written about "Bestrophins" by people in this website by year, and whether "Bestrophins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2001 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Bestrophins" by people in Profiles.
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Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts. Commun Biol. 2023 08 16; 6(1):852.
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Targeted sequencing identifies a missense variant in the BEST3 gene associated with antihypertensive response to hydrochlorothiazide. Pharmacogenet Genomics. 2018 11; 28(11):251-255.
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Dbest1, a Drosophila homolog of human Bestrophin, is not required for viability or photoreceptor integrity. Genesis. 2001 Nov; 31(3):130-6.