"Caspases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
| Descriptor ID |
D020169
|
| MeSH Number(s) |
D08.811.277.656.262.500.126 D08.811.277.656.300.200.126 D12.644.360.075.405 D12.776.476.075.405
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Caspases".
Below are MeSH descriptors whose meaning is more specific than "Caspases".
This graph shows the total number of publications written about "Caspases" by people in this website by year, and whether "Caspases" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 2 | 0 | 2 |
| 1997 | 6 | 0 | 6 |
| 1998 | 8 | 1 | 9 |
| 1999 | 5 | 4 | 9 |
| 2000 | 12 | 13 | 25 |
| 2001 | 10 | 13 | 23 |
| 2002 | 10 | 25 | 35 |
| 2003 | 10 | 36 | 46 |
| 2004 | 9 | 34 | 43 |
| 2005 | 7 | 42 | 49 |
| 2006 | 10 | 27 | 37 |
| 2007 | 6 | 16 | 22 |
| 2008 | 2 | 9 | 11 |
| 2009 | 3 | 10 | 13 |
| 2010 | 2 | 10 | 12 |
| 2011 | 5 | 9 | 14 |
| 2012 | 2 | 4 | 6 |
| 2013 | 2 | 6 | 8 |
| 2014 | 4 | 4 | 8 |
| 2015 | 7 | 5 | 12 |
| 2016 | 2 | 5 | 7 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 2 | 3 |
| 2020 | 1 | 1 | 2 |
| 2021 | 1 | 1 | 2 |
| 2022 | 3 | 2 | 5 |
| 2023 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Caspases" by people in Profiles.
-
Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 05; 30(5):1097-1154.
-
HDAC inhibitors suppress protein poly(ADP-ribosyl)ation and DNA repair protein levels and phosphorylation status in hematologic cancer cells: implications for their use in combination with PARP inhibitors and chemotherapeutic drugs. Oncotarget. 2022 10 14; 13:1122-1135.
-
Apoptosis Detection in Retinal Ganglion Cells Using Quantitative Changes in Multichannel Fluorescence Colocalization. Biosensors (Basel). 2022 Aug 28; 12(9).
-
Lethal and Non-Lethal Functions of Caspases in the DNA Damage Response. Cells. 2022 06 10; 11(12).
-
Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages. J Vis Exp. 2022 04 06; (182).
-
Cellular autophagy, an unbidden effect of caspase inhibition by zVAD-fmk. FEBS J. 2022 06; 289(11):3097-3100.
-
Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity. Mol Cell. 2021 11 18; 81(22):4579-4590.
-
Noncanonical Roles of Caspase-4 and Caspase-5 in Heme-Driven IL-1? Release and Cell Death. J Immunol. 2021 04 15; 206(8):1878-1889.
-
Caspase-8 loss radiosensitizes head and neck squamous cell carcinoma to SMAC mimetic-induced necroptosis. JCI Insight. 2020 12 03; 5(23).
-
Targeting apoptotic caspases in cancer. Biochim Biophys Acta Mol Cell Res. 2020 06; 1867(6):118688.