 Caspases
"Caspases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
| Descriptor ID |
D020169
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| MeSH Number(s) |
D08.811.277.656.262.500.126 D08.811.277.656.300.200.126 D12.644.360.075.405 D12.776.476.075.405
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Caspases".
Below are MeSH descriptors whose meaning is more specific than "Caspases".
This graph shows the total number of publications written about "Caspases" by people in this website by year, and whether "Caspases" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 4 | 0 | 4 | | 1998 | 5 | 0 | 5 | | 1999 | 3 | 6 | 9 | | 2000 | 13 | 13 | 26 | | 2001 | 15 | 20 | 35 | | 2002 | 11 | 39 | 50 | | 2003 | 11 | 40 | 51 | | 2004 | 10 | 35 | 45 | | 2005 | 8 | 48 | 56 | | 2006 | 10 | 31 | 41 | | 2007 | 6 | 17 | 23 | | 2008 | 1 | 11 | 12 | | 2009 | 3 | 11 | 14 | | 2010 | 2 | 12 | 14 | | 2011 | 4 | 9 | 13 | | 2012 | 2 | 4 | 6 | | 2013 | 2 | 6 | 8 | | 2014 | 4 | 5 | 9 | | 2015 | 7 | 6 | 13 | | 2016 | 2 | 5 | 7 | | 2017 | 2 | 1 | 3 | | 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Caspases" by people in Profiles.
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Sater AP, Rael LT, Tanner AH, Lieser MJ, Acuna DL, Mains CW, Bar-Or D. Cell death after traumatic brain injury: Detrimental role of anoikis in healing. Clin Chim Acta. 2018 Jul; 482:149-154.
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Charendoff CI, Bouchier-Hayes L. Lighting Up the Pathways to Caspase Activation Using Bimolecular Fluorescence Complementation. J Vis Exp. 2018 03 05; (133).
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Jo J, Im SH, Babcock DT, Iyer SC, Gunawan F, Cox DN, Galko MJ. Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization. Cell Death Dis. 2017 05 11; 8(5):e2786.
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Zhang S, Xiao Q, Shi Z, Yu G, Ma XP, Chen H, Zhang P, Shen S, Sai-Yin HG, Chen TY, Lu PX, Wang NJ, Ren W, Huang P, Xie J, Conran C, Zheng SL, Yu L, Xu J, Jiang DK. Caspase polymorphisms and prognosis of hepatocellular carcinoma. PLoS One. 2017; 12(4):e0176802.
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Pardo PS, Hajira A, Boriek AM, Mohamed JS. MicroRNA-434-3p regulates age-related apoptosis through eIF5A1 in the skeletal muscle. Aging (Albany NY). 2017 03 22; 9(3):1012-1029.
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Cheng TC, Akey IV, Yuan S, Yu Z, Ludtke SJ, Akey CW. A Near-Atomic Structure of the Dark Apoptosome Provides Insight into Assembly and Activation. Structure. 2017 01 03; 25(1):40-52.
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Lan X, Zhao C, Chen X, Zhang P, Zang D, Wu J, Chen J, Long H, Yang L, Huang H, Carter BZ, Wang X, Shi X, Liu J. Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms. J Hematol Oncol. 2016 11 25; 9(1):129.
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Saenz DT, Fiskus W, Manshouri T, Rajapakshe K, Krieger S, Sun B, Mill CP, DiNardo C, Pemmaraju N, Kadia T, Parmar S, Sharma S, Coarfa C, Qiu P, Verstovsek S, Bhalla KN. BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells. Leukemia. 2017 03; 31(3):678-687.
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Balakrishnan K, Fu M, Onida F, Wierda WG, Keating MJ, Gandhi V. Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic. Oncotarget. 2016 Jun 28; 7(26):39458-39472.
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Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep. 2016 Jan 25; 6:18953.
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