Tripartite Motif-Containing Protein 28
"Tripartite Motif-Containing Protein 28" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A tripartite motif protein consisting of an N-terminal RING finger, two B-box type ZINC FINGERS, and C-terminal PHD domain. It functions as a transcriptional repressor by associating with Kruppel-association box domain (KRAB domain) transcription factors and has E3-SUMO-ligase activity towards itself and also sumoylates INTERFERON REGULATORY FACTOR-7 to reduce its activity as a transcriptional activator. It can also function as a ubiquitin protein ligase towards TUMOR SUPPRESSOR PROTEIN P53.
| Descriptor ID |
D000076183
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| MeSH Number(s) |
D08.811.464.938.750.782 D12.776.260.703.675 D12.776.930.780.911 D12.776.934.875
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Tripartite Motif-Containing Protein 28".
Below are MeSH descriptors whose meaning is more specific than "Tripartite Motif-Containing Protein 28".
This graph shows the total number of publications written about "Tripartite Motif-Containing Protein 28" by people in this website by year, and whether "Tripartite Motif-Containing Protein 28" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2016 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tripartite Motif-Containing Protein 28" by people in Profiles.
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TRIM28 modulates nuclear receptor signaling to regulate uterine function. Nat Commun. 2023 08 01; 14(1):4605.
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LncRNA PVT-1 promotes osteosarcoma cancer stem-like properties through direct interaction with TRIM28 and TSC2 ubiquitination. Oncogene. 2022 Dec; 41(50):5373-5384.
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Depleting Trim28 in adult mice is well tolerated and reduces levels of a-synuclein and tau. Elife. 2018 06 04; 7.
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TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene. 2017 05 25; 36(21):2991-3001.
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TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife. 2016 10 25; 5.
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ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells. Nucleic Acids Res. 2016 Feb 18; 44(3):1118-32.
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KAP1 promotes proliferation and metastatic progression of breast cancer cells. Cancer Res. 2015 Jan 15; 75(2):344-55.
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Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6841-6.
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TRIM28 mediates chromatin modifications at the TCRa enhancer and regulates the development of T and natural killer T cells. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):20083-8.