TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lanza DG, Mao J, Lorenzo I, Liao L, Seavitt JR, Ljungberg MC, Simpson EM, DeMayo FJ, Heaney JD. An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing. Genesis. 2024 Apr; 62(2):e23589. PMID: 38523431; PMCID: PMC10987075.
      Citations:    Fields:    Translation:AnimalsCells
    2. Yu X, He T, Tong Z, Liao L, Huang S, Fakhouri WD, Edwards DP, Xu J. Molecular mechanisms of TWIST1-regulated transcription in EMT and cancer metastasis. EMBO Rep. 2023 11 06; 24(11):e56902. PMID: 37680145; PMCID: PMC10626429.
      Citations: 1     Fields:    Translation:Humans
    3. Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarcelli NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu Y. Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. J Clin Invest. 2023 07 17; 133(14). PMID: 37261917; PMCID: PMC10348766.
      Citations:    Fields:    Translation:AnimalsCells
    4. He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli NA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y, Sadaf Farooqi I. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. Nat Med. 2022 12; 28(12):2537-2546. PMID: 36536256; PMCID: PMC9800280.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    5. Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Muntau AC, Blau N, Sutton VR, Zhang S, Lin C, Yang L, Gu?ant JL, Schiff M, Feillet F. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021 08 06; 373(6555):662-673. PMID: 34353949; PMCID: PMC9714245.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    6. Kruse RL, Barzi M, Legras X, Pankowicz FP, Furey N, Liao L, Xu J, Bissig-Choisat B, Slagle BL, Bissig KD. A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome. JHEP Rep. 2021 Apr; 3(2):100252. PMID: 33733079; PMCID: PMC7940981.
      Citations: 1     
    7. Arian S, Rubin J, Chakchouk I, Sharif M, Mahadevan SK, Erfani H, Shelly K, Liao L, Lorenzo I, Ramakrishnan R, Van den Veyver IB. Reproductive Outcomes from Maternal Loss of Nlrp2 Are Not Improved by IVF or Embryo Transfer Consistent with Oocyte-Specific Defect. Reprod Sci. 2021 07; 28(7):1850-1865. PMID: 33090377; PMCID: PMC8060370.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O'Rahilly S, Tong Q, UK10K Consortium, O'Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 04 12; 10(1):1718. PMID: 30979869; PMCID: PMC6461669.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    9. Lee DK, Liu Y, Liao L, Li W, Danielpour D, Xu J. Neuroendocrine prostate carcinoma cells originate from the p63-expressing basal cells but not the pre-existing adenocarcinoma cells in mice. Cell Res. 2019 05; 29(5):420-422. PMID: 30778177; PMCID: PMC6796947.
      Citations: 4     Fields:    Translation:AnimalsCells
    10. Lanza DG, Gaspero A, Lorenzo I, Liao L, Zheng P, Wang Y, Deng Y, Cheng C, Zhang C, Seavitt JR, DeMayo FJ, Xu J, Dickinson ME, Beaudet AL, Heaney JD. Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles. BMC Biol. 2018 Jun 21; 16(1):69. PMID: 29925370; PMCID: PMC6011517.
      Citations: 25     Fields:    Translation:AnimalsCells
    11. Xu Y, Lee DK, Feng Z, Xu Y, Bu W, Li Y, Liao L, Xu J. Breast tumor cell-specific knockout of Twist1 inhibits cancer cell plasticity, dissemination, and lung metastasis in mice. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):11494-11499. PMID: 29073077; PMCID: PMC5664488.
      Citations: 50     Fields:    Translation:Animals
    12. Qin L, Xu Y, Yu X, Toneff MJ, Li D, Liao L, Martinez JD, Li Y, Xu J. The histone demethylase Kdm3a is required for normal epithelial proliferation, ductal elongation and tumor growth in the mouse mammary gland. Oncotarget. 2017 Oct 17; 8(49):84761-84775. PMID: 29156681; PMCID: PMC5689571.
      Citations: 7     Fields:    
    13. Wu H, Bi J, Peng Y, Huo L, Yu X, Yang Z, Zhou Y, Qin L, Xu Y, Liao L, Xie Y, Conneely OM, Jonkers J, Xu J. Nuclear receptor NR4A1 is a tumor suppressor down-regulated in triple-negative breast cancer. Oncotarget. 2017 Aug 15; 8(33):54364-54377. PMID: 28903348; PMCID: PMC5589587.
      Citations: 22     Fields:    
    14. Welte T, Kim IS, Tian L, Gao X, Wang H, Li J, Holdman XB, Herschkowitz JI, Pond A, Xie G, Kurley S, Nguyen T, Liao L, Dobrolecki LE, Pang L, Mo Q, Edwards DP, Huang S, Xin L, Xu J, Li Y, Lewis MT, Wang T, Westbrook TF, Rosen JM, Zhang XH. Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation. Nat Cell Biol. 2016 06; 18(6):632-44. PMID: 27183469; PMCID: PMC4884142.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    15. Liu Z, Oyola MG, Zhou S, Chen X, Liao L, Tien JC, Mani SK, Xu J. Knockout of the Histone Demethylase Kdm3b Decreases Spermatogenesis and Impairs Male Sexual Behaviors. Int J Biol Sci. 2015; 11(12):1447-57. PMID: 26681924; PMCID: PMC4672002.
      Citations: 8     Fields:    Translation:Animals
    16. Qin L, Xu Y, Xu Y, Ma G, Liao L, Wu Y, Li Y, Wang X, Wang X, Jiang J, Wang J, Xu J. NCOA1 promotes angiogenesis in breast tumors by simultaneously enhancing both HIF1a- and AP-1-mediated VEGFa transcription. Oncotarget. 2015 Sep 15; 6(27):23890-904. PMID: 26287601; PMCID: PMC4695159.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    17. Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao L, Zhou S, Xu J, Lonard DM, O'Malley BW. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10; 28(2):240-52. PMID: 26267537; PMCID: PMC4536575.
      Citations: 46     Fields:    Translation:HumansCells
    18. Chen X, Qin L, Liu Z, Liao L, Martin JF, Xu J. Knockout of SRC-1 and SRC-3 in Mice Decreases Cardiomyocyte Proliferation and Causes a Noncompaction Cardiomyopathy Phenotype. Int J Biol Sci. 2015; 11(9):1056-72. PMID: 26221073; PMCID: PMC4515817.
      Citations: 12     Fields:    Translation:AnimalsCells
    19. Liu Z, Chen X, Zhou S, Liao L, Jiang R, Xu J. The histone H3K9 demethylase Kdm3b is required for somatic growth and female reproductive function. Int J Biol Sci. 2015; 11(5):494-507. PMID: 25892958; PMCID: PMC4400382.
      Citations: 14     Fields:    Translation:Animals
    20. Tien JC, Liao L, Liu Y, Liu Z, Lee DK, Wang F, Xu J. The steroid receptor coactivator-3 is required for developing neuroendocrine tumor in the mouse prostate. Int J Biol Sci. 2014; 10(10):1116-27. PMID: 25332686; PMCID: PMC4202028.
      Citations: 6     Fields:    Translation:Animals
    21. Qin L, Wu YL, Toneff MJ, Li D, Liao L, Gao X, Bane FT, Tien JC, Xu Y, Feng Z, Yang Z, Xu Y, Theissen SM, Li Y, Young L, Xu J. NCOA1 Directly Targets M-CSF1 Expression to Promote Breast Cancer Metastasis. Cancer Res. 2014 Jul 01; 74(13):3477-88. PMID: 24769444; PMCID: PMC4083628.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    22. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517. PMID: 24390736; PMCID: PMC3947477.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    23. Xu Y, Xu Y, Liao L, Zhou N, Theissen SM, Liao XH, Nguyen H, Ludwig T, Qin L, Martinez JD, Jiang J, Xu J. Inducible knockout of Twist1 in young and adult mice prolongs hair growth cycle and has mild effects on general health, supporting Twist1 as a preferential cancer target. Am J Pathol. 2013 Oct; 183(4):1281-1292. PMID: 23906809; PMCID: PMC3791869.
      Citations: 17     Fields:    Translation:Animals
    24. Tien JC, Liu Z, Liao L, Wang F, Xu Y, Wu YL, Zhou N, Ittmann M, Xu J. The steroid receptor coactivator-3 is required for the development of castration-resistant prostate cancer. Cancer Res. 2013 Jul 01; 73(13):3997-4008. PMID: 23650284; PMCID: PMC3732785.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    25. Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O'Malley BW, Xu Y, Zhu L. Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology. 2013 Jan; 154(1):150-8. PMID: 23211707; PMCID: PMC3529365.
      Citations: 28     Fields:    Translation:AnimalsCells
    26. Kawagoe J, Li Q, Mussi P, Liao L, Lydon JP, DeMayo FJ, Xu J. Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation. Dev Cell. 2012 Oct 16; 23(4):858-65. PMID: 23079602; PMCID: PMC3479668.
      Citations: 19     Fields:    Translation:Animals
    27. Dearth RK, Kuiatse I, Wang YF, Liao L, Hilsenbeck SG, Brown PH, Xu J, Lee AV. A moderate elevation of circulating levels of IGF-I does not alter ErbB2 induced mammary tumorigenesis. BMC Cancer. 2011 Aug 25; 11:377. PMID: 21867536; PMCID: PMC3189189.
      Citations: 5     Fields:    Translation:AnimalsCells
    28. Hong J, Zhou J, Fu J, He T, Qin J, Wang L, Liao L, Xu J. Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness. Cancer Res. 2011 Jun 01; 71(11):3980-90. PMID: 21502402; PMCID: PMC3107354.
      Citations: 127     Fields:    Translation:HumansCells
    29. Qin L, Chen X, Wu Y, Feng Z, He T, Wang L, Liao L, Xu J. Steroid receptor coactivator-1 upregulates integrin a5 expression to promote breast cancer cell adhesion and migration. Cancer Res. 2011 Mar 01; 71(5):1742-51. PMID: 21343398; PMCID: PMC3076137.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    30. Fu J, Qin L, He T, Qin J, Hong J, Wong J, Liao L, Xu J. The TWIST/Mi2/NuRD protein complex and its essential role in cancer metastasis. Cell Res. 2011 Feb; 21(2):275-89. PMID: 20714342; PMCID: PMC3193433.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    31. Liu Z, Zhou S, Liao L, Chen X, Meistrich M, Xu J. Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis. J Biol Chem. 2010 Jan 22; 285(4):2758-70. PMID: 19910458; PMCID: PMC2807331.
      Citations: 64     Fields:    Translation:AnimalsCells
    32. Xu J, Liao L, Qin J, Xu J, Liu D, Songyang Z. Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK. J Biol Chem. 2009 May 22; 284(21):14377-85. PMID: 19293151; PMCID: PMC2682886.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    33. Wang S, Yuan Y, Liao L, Kuang SQ, Tien JC, O'Malley BW, Xu J. Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):151-6. PMID: 19109434; PMCID: PMC2629242.
      Citations: 66     Fields:    Translation:Animals
    34. Liu Z, Liao L, Zhou S, Xu J. Generation and validation of a mouse line with a floxed SRC-3/AIB1 allele for conditional knockout. Int J Biol Sci. 2008 Jul 23; 4(4):202-7. PMID: 18690289; PMCID: PMC2491728.
      Citations: 8     Fields:    Translation:AnimalsCells
    35. Qin L, Liao L, Redmond A, Young L, Yuan Y, Chen H, O'Malley BW, Xu J. The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression. Mol Cell Biol. 2008 Oct; 28(19):5937-50. PMID: 18644862; PMCID: PMC2547002.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    36. Liao L, Chen X, Wang S, Parlow AF, Xu J. Steroid receptor coactivator 3 maintains circulating insulin-like growth factor I (IGF-I) by controlling IGF-binding protein 3 expression. Mol Cell Biol. 2008 Apr; 28(7):2460-9. PMID: 18212051; PMCID: PMC2268437.
      Citations: 30     Fields:    Translation:HumansAnimals
    37. Chung AC, Zhou S, Liao L, Tien JC, Greenberg NM, Xu J. Genetic ablation of the amplified-in-breast cancer 1 inhibits spontaneous prostate cancer progression in mice. Cancer Res. 2007 Jun 15; 67(12):5965-75. PMID: 17575167; PMCID: PMC2898573.
      Citations: 32     Fields:    Translation:Animals
    38. Mussi P, Liao L, Park SE, Ciana P, Maggi A, Katzenellenbogen BS, Xu J, O'Malley BW. Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A. 2006 Nov 07; 103(45):16716-21. PMID: 17065319; PMCID: PMC1636521.
      Citations: 25     Fields:    Translation:AnimalsCells
    39. Liao L, Dearth RK, Zhou S, Britton OL, Lee AV, Xu J. Liver-specific overexpression of the insulin-like growth factor-I enhances somatic growth and partially prevents the effects of growth hormone deficiency. Endocrinology. 2006 Aug; 147(8):3877-88. PMID: 16709615.
      Citations: 33     Fields:    Translation:AnimalsCells
    40. Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005 Sep 01; 65(17):7993-8002. PMID: 16140972.
      Citations: 57     Fields:    Translation:AnimalsCells
    41. Zhang H, Kuang SQ, Liao L, Zhou S, Xu J. Haploid inactivation of the amplified-in-breast cancer 3 coactivator reduces the inhibitory effect of peroxisome proliferator-activated receptor gamma and retinoid X receptor on cell proliferation and accelerates polyoma middle-T antigen-induced mammary tumorigenesis in mice. Cancer Res. 2004 Oct 01; 64(19):7169-77. PMID: 15466215.
      Citations: 19     Fields:    Translation:AnimalsCells
    42. Mark M, Yoshida-Komiya H, Gehin M, Liao L, Tsai MJ, O'Malley BW, Chambon P, Xu J. Partially redundant functions of SRC-1 and TIF2 in postnatal survival and male reproduction. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4453-8. PMID: 15070739; PMCID: PMC384768.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    43. Kuang SQ, Liao L, Zhang H, Lee AV, O'Malley BW, Xu J. AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice. Cancer Res. 2004 Mar 01; 64(5):1875-85. PMID: 14996752.
      Citations: 89     Fields:    Translation:AnimalsCells
    44. Zhang H, Liao L, Kuang SQ, Xu J. Spatial distribution of the messenger ribonucleic acid and protein of the nuclear receptor coactivator, amplified in breast cancer-3, in mice. Endocrinology. 2003 Apr; 144(4):1435-43. PMID: 12639927.
      Citations: 11     Fields:    Translation:Animals
    45. Nishihara E, Yoshida-Komiya H, Chan CS, Liao L, Davis RL, O'Malley BW, Xu J. SRC-1 null mice exhibit moderate motor dysfunction and delayed development of cerebellar Purkinje cells. J Neurosci. 2003 Jan 01; 23(1):213-22. PMID: 12514218; PMCID: PMC6742154.
      Citations: 51     Fields:    Translation:AnimalsCells
    46. Liao L, Kuang SQ, Yuan Y, Gonzalez SM, O'Malley BW, Xu J. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. J Steroid Biochem Mol Biol. 2002 Dec; 83(1-5):3-14. PMID: 12650696.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    47. Kuang SQ, Liao L, Zhang H, Pereira FA, Yuan Y, DeMayo FJ, Ko L, Xu J. Deletion of the cancer-amplified coactivator AIB3 results in defective placentation and embryonic lethality. J Biol Chem. 2002 Nov 22; 277(47):45356-60. PMID: 12368298.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    48. Liao L, Kuang SQ, Yuan YH, Xu JM. A rapid and cost-effective screening method for identification of targeted embryonic stem cells. Shi Yan Sheng Wu Xue Bao. 2002 Sep; 35(3):163-8. PMID: 15344375.
      Citations:    Fields:    Translation:AnimalsCells
    49. Yuan Y, Liao L, Tulis DA, Xu J. Steroid receptor coactivator-3 is required for inhibition of neointima formation by estrogen. Circulation. 2002 Jun 04; 105(22):2653-9. PMID: 12045172.
      Citations: 29     Fields:    Translation:Animals
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