"Integrin alpha5" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.
| Descriptor ID |
D039482
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.500
|
| Concept/Terms |
Integrin alpha5- Integrin alpha5
- alpha5, Integrin
- alpha(5) Integrin
- alpha5 Integrin
- Integrin, alpha5
- VLA-5 alpha Chain
- VLA 5 alpha Chain
- alpha Chain, VLA-5
- CD49e Antigens
- Platelet Glycoprotein Ic
- Glycoprotein Ic, Platelet
- Ic, Platelet Glycoprotein
- Integrin alphaF
- alphaF, Integrin
- CD49e Antigen
- Antigen, CD49e
- Antigens, CD49e
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha5".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha5".
This graph shows the total number of publications written about "Integrin alpha5" by people in this website by year, and whether "Integrin alpha5" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2004 | 0 | 2 | 2 |
| 2006 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2011 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2021 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha5" by people in Profiles.
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Protective effects of macrophage-specific integrin a5 in myocardial infarction are associated with accentuated angiogenesis. Nat Commun. 2023 Nov 20; 14(1):7555.
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Extracellular cathepsin Z signals through the a5 integrin and augments NLRP3 inflammasome activation. J Biol Chem. 2022 01; 298(1):101459.
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Expression of a5-integrin, a7-integrin, ?-cadherin, and N-cadherin in localized prostate cancer. Urol Oncol. 2016 Apr; 34(4):165.e11-8.
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Molecular characterization of the tumor-suppressive function of nischarin in breast cancer. J Natl Cancer Inst. 2011 Oct 19; 103(20):1513-28.
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Steroid receptor coactivator-1 upregulates integrin a5 expression to promote breast cancer cell adhesion and migration. Cancer Res. 2011 Mar 01; 71(5):1742-51.
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Monocyte CD49e and 110-120 kDa fibronectin fragments: HIV prognostic indicators independent of viral load and CD4 T-cell counts. AIDS. 2009 Nov 13; 23(17):2247-53.
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Implications of increased tissue transglutaminase (TG2) expression in drug-resistant breast cancer (MCF-7) cells. Oncogene. 2006 May 18; 25(21):3049-58.
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An interaction between insulin-like growth factor-binding protein 2 (IGFBP2) and integrin alpha5 is essential for IGFBP2-induced cell mobility. J Biol Chem. 2006 May 19; 281(20):14085-91.
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Monocyte activation by circulating fibronectin fragments in HIV-1-infected patients. J Immunol. 2004 Aug 01; 173(3):2190-8.
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Hypoxia induces adhesion molecules on cancer cells: A missing link between Warburg effect and induction of selectin-ligand carbohydrates. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):8132-7.