"Integrin alpha2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that primarily combines with INTEGRIN BETA1 to form the INTEGRIN ALPHA2BETA1 heterodimer. It contains a domain which has homology to collagen-binding domains found in von Willebrand factor.
| Descriptor ID |
D039421
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.350
|
| Concept/Terms |
Integrin alpha2- Integrin alpha2
- alpha2, Integrin
- GPIa
- alpha2 Integrin
- Integrin, alpha2
- Platelet Glycoprotein Ia
- Glycoprotein Ia, Platelet
- Antigens, CD49b
- CD49b Antigens
- VLA-2 alpha Chain
- VLA 2 alpha Chain
- alpha Chain, VLA-2
- CD49b Antigen
- Antigen, CD49b
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha2".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha2".
This graph shows the total number of publications written about "Integrin alpha2" by people in this website by year, and whether "Integrin alpha2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2015 | 1 | 1 | 2 |
| 2023 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha2" by people in Profiles.
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Molecular dynamics simulations corroborate recombinant expression studies carried out on three aIIb ?-propeller mutations reported in Indian Glanzmann thrombasthenia patients. J Cell Biochem. 2023 07; 124(7):989-1001.
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Integrin a2?1 inhibits MST1 kinase phosphorylation and activates Yes-associated protein oncogenic signaling in hepatocellular carcinoma. Oncotarget. 2016 Nov 22; 7(47):77683-77695.
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Free hemoglobin increases von Willebrand factor-mediated platelet adhesion in vitro: implications for circulatory devices. Blood. 2015 Nov 12; 126(20):2338-41.
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Human uterine leiomyoma stem/progenitor cells expressing CD34 and CD49b initiate tumors in vivo. J Clin Endocrinol Metab. 2015 Apr; 100(4):E601-6.
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Distinct roles for the a , ? and ?1 isoforms of protein phosphatase 1 in the outside-in aIIb?3 integrin signalling-dependent functions. Thromb Haemost. 2013 Jan; 109(1):118-26.
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An engineered alpha1 integrin-binding collagenous sequence. J Biol Chem. 2010 Oct 01; 285(40):31046-54.
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Mechanism of activation and functional role of protein kinase Ceta in human platelets. J Biol Chem. 2009 May 15; 284(20):13413-13421.
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Genetic variation responsible for mouse strain differences in integrin alpha 2 expression is associated with altered platelet responses to collagen. Blood. 2004 May 01; 103(9):3396-402.
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VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109-23.