"Integrin alpha4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits.
| Descriptor ID |
D039441
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.450
|
| Concept/Terms |
Integrin alpha4- Integrin alpha4
- CD49d Antigens
- Antigens, CD49d
- CD49d Antigen
- alpha4 Integrin
- Integrin, alpha4
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4".
This graph shows the total number of publications written about "Integrin alpha4" by people in this website by year, and whether "Integrin alpha4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alpha4" by people in Profiles.
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Multiple non-catalytic ADAMs are novel integrin a4 ligands. Mol Cell Biochem. 2018 May; 442(1-2):29-38.
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VCAM1 acts in parallel with CD69 and is required for the initiation of oligodendrocyte myelination. Nat Commun. 2016 11 23; 7:13478.
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CD49d shows superior performance characteristics for flow cytometric prognostic testing in chronic lymphocytic leukemia/small lymphocytic lymphoma. Cytometry B Clin Cytom. 2018 01; 94(1):129-135.
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Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95.
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CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia. J Clin Oncol. 2014 Mar 20; 32(9):897-904.
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Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination. PLoS One. 2013; 8(7):e69795.
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Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet. 2013 May 15; 22(10):2119-27.
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Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18637-42.
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Constitutive expression of the alpha4 integrin correlates with tumorigenicity and lymph node metastasis of the B16 murine melanoma. Neoplasia. 2010 Feb; 12(2):173-82.
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Role of alpha 4 integrin (CD49d) in the pathogenesis of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4898-904.