"Integrin alpha4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that is unique in that it does not contain an I-domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane, as in other integrin alpha subunits.
| Descriptor ID |
D039441
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.450
|
| Concept/Terms |
Integrin alpha4- Integrin alpha4
- CD49d Antigens
- Antigens, CD49d
- CD49d Antigen
- alpha4 Integrin
- Integrin, alpha4
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha4".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha4".
This graph shows the total number of publications written about "Integrin alpha4" by people in this website by year, and whether "Integrin alpha4" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 1 | 0 | 1 |
| 2005 | 0 | 1 | 1 |
| 2013 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Integrin alpha4" by people in Profiles.
-
CD49d shows superior performance characteristics for flow cytometric prognostic testing in chronic lymphocytic leukemia/small lymphocytic lymphoma. Cytometry B Clin Cytom. 2018 01; 94(1):129-135.
-
Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95.
-
Effects of murine and human bone marrow-derived mesenchymal stem cells on cuprizone induced demyelination. PLoS One. 2013; 8(7):e69795.
-
Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet. 2013 May 15; 22(10):2119-27.
-
Vascular ligand-receptor mapping by direct combinatorial selection in cancer patients. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18637-42.
-
Cellular and molecular mechanisms of coronary vessel development. Vasc Med. 2005 Feb; 10(1):37-44.
-
Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol. 2003 Jun 15; 170(12):5912-8.
-
Role of alpha4 integrin and VCAM-1 in CD18-independent neutrophil migration across mouse cardiac endothelium. Circ Res. 2002 Mar 22; 90(5):562-9.
-
Alpha4 integrin is expressed during peripheral nerve regeneration and enhances neurite outgrowth. J Neurosci. 2001 Sep 01; 21(17):6732-44.
-
Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses. Nature. 1999 Dec 09; 402(6762):676-81.