Platelet Membrane Glycoprotein IIb
"Platelet Membrane Glycoprotein IIb" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Platelet membrane glycoprotein IIb is an integrin alpha subunit that heterodimerizes with INTEGRIN BETA3 to form PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX. It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size.
| Descriptor ID |
D040201
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.950
|
| Concept/Terms |
Platelet Membrane Glycoprotein IIb- Platelet Membrane Glycoprotein IIb
- Antigens, CD41
- CD41 Antigens
- CD41 Cell Surface Antigen
- GPalpha IIb
- GP IIb
- Membrane Glycoprotein IIb
- Glycoprotein IIb, Membrane
- Plasma Membrane Glycoprotein IIb
- Integrin alpha IIb
- Integrin alphaIIb
- alphaIIb, Integrin
- CD41 Antigen
- Antigen, CD41
- HUPL-ml Surface Antigen
- Antigen, HUPL-ml Surface
- HUPL ml Surface Antigen
- Surface Antigen, HUPL-ml
|
Below are MeSH descriptors whose meaning is more general than "Platelet Membrane Glycoprotein IIb".
Below are MeSH descriptors whose meaning is more specific than "Platelet Membrane Glycoprotein IIb".
This graph shows the total number of publications written about "Platelet Membrane Glycoprotein IIb" by people in this website by year, and whether "Platelet Membrane Glycoprotein IIb" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Platelet Membrane Glycoprotein IIb" by people in Profiles.
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JAK2-V617F and interferon-a induce megakaryocyte-biased stem cells characterized by decreased long-term functionality. Blood. 2021 04 22; 137(16):2139-2151.
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Co-stimulatory effect of TLR2 and TLR4 stimulation on megakaryocytic development is mediated through PI3K/NF-?B and XBP-1 loop. Cell Signal. 2021 04; 80:109924.
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Pulmonary Arterial Thrombosis in a Murine Model of Blunt Thoracic Trauma. Shock. 2018 12; 50(6):696-705.
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Associations between dietary patterns and flow cytometry-measured biomarkers of inflammation and cellular activation in the Atherosclerosis Risk in Communities (ARIC) Carotid Artery MRI Study. Atherosclerosis. 2010 Sep; 212(1):260-7.
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Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med. 2007 Dec 24; 204(13):3103-11.
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Molecular mechanisms of prothrombotic risk due to genetic variations in platelet genes: Enhanced outside-in signaling through the Pro33 variant of integrin beta3. Exp Biol Med (Maywood). 2006 May; 231(5):505-13.
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Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24; 499(3):315-24.
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Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling. J Biol Chem. 2004 Aug 06; 279(32):33039-42.
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Effects of valsartan and valeryl 4-hydroxy valsartan on human platelets: a possible additional mechanism for clinical benefits. J Cardiovasc Pharmacol. 2004 May; 43(5):677-84.