"Integrin alpha6" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.
| Descriptor ID |
D039503
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.550
|
| Concept/Terms |
Integrin alpha6- Integrin alpha6
- alpha6, Integrin
- CD49f Antigens
- alpha6 Integrin
- Integrin, alpha6
- Antigens, CD49f
- CD49f Antigen
- Antigen, CD49f
- alpha(6) Integrin
|
Below are MeSH descriptors whose meaning is more general than "Integrin alpha6".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha6".
This graph shows the total number of publications written about "Integrin alpha6" by people in this website by year, and whether "Integrin alpha6" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 2 | 2 |
| 2001 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2013 | 1 | 2 | 3 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha6" by people in Profiles.
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AhR ligand aminoflavone suppresses a6-integrin-Src-Akt signaling to attenuate tamoxifen resistance in breast cancer cells. J Cell Physiol. 2018 01; 234(1):108-121.
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Human hematopoietic stem cells from mobilized peripheral blood can be purified based on CD49f integrin expression. Blood. 2015 Sep 24; 126(13):1631-3.
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Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Res. 2013 Nov; 11(3):990-1002.
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Expansion of breast cancer stem cells with fibrous scaffolds. Integr Biol (Camb). 2013 May; 5(5):768-77.
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Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells. Oncogene. 2014 Jan 23; 33(4):440-8.
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Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency. Breast Cancer Res. 2013; 15(5):R77.
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Biologic markers in axillary node-negative breast cancer: differential expression in invasive ductal carcinoma versus invasive lobular carcinoma. Clin Breast Cancer. 2006 Dec; 7(5):396-400.
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GDNF family receptor alpha1 phenotype of spermatogonial stem cells in immature mouse testes. Biol Reprod. 2005 Nov; 73(5):1011-6.
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Characterization of integrin expression in the mouse ovary. Biol Reprod. 2002 Sep; 67(3):743-51.
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Tyrosine phosphorylation of the beta 4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J Biol Chem. 2001 Jan 12; 276(2):1494-502.