"Integrin alphaV" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.
| Descriptor ID |
D039564
|
| MeSH Number(s) |
D12.776.543.750.705.408.100.900
|
| Concept/Terms |
Integrin alphaV- Integrin alphaV
- alphaV, Integrin
- alpha(V) Integrin
- Integrin alpha V
- alpha V, Integrin
- CD51 Antigens
- alphav Integrin
- Integrin, alphav
- Antigens, CD51
- CD51 Antigen
- Antigen, CD51
|
Below are MeSH descriptors whose meaning is more general than "Integrin alphaV".
Below are MeSH descriptors whose meaning is more specific than "Integrin alphaV".
This graph shows the total number of publications written about "Integrin alphaV" by people in this website by year, and whether "Integrin alphaV" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2001 | 0 | 1 | 1 |
| 2002 | 1 | 2 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 1 | 0 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2010 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
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Below are the most recent publications written about "Integrin alphaV" by people in Profiles.
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aV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Glia. 2021 01; 69(1):91-108.
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Syndecan-4 ectodomain evokes mobilization of podocyte TRPC6 channels and their associated pathways: An essential role for integrin signaling. Biochim Biophys Acta. 2015 Oct; 1853(10 Pt A):2610-20.
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miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells. Cancer Res. 2015 May 01; 75(9):1859-67.
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Loss of epithelial p53 and av integrin cooperate through Akt to induce squamous cell carcinoma yet prevent remodeling of the tumor microenvironment. Oncogene. 2015 Jan 22; 34(4):516-24.
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Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24.
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Analysis of av integrin protein expression in human eyelid and periorbital squamous cell carcinomas. J Cutan Pathol. 2011 Jul; 38(7):570-5.
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JNK mediates insulin-like growth factor binding protein 2/integrin alpha5-dependent glioma cell migration. Int J Oncol. 2010 Jul; 37(1):143-53.
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Alphav integrins lead the way for colorectal metastases. Clin Cancer Res. 2008 Oct 15; 14(20):6351-3.
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Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol. 2008 Jun; 172(6):1740-7.
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A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell. 2006 Apr 21; 125(2):385-98.