Oligodendrocyte Transcription Factor 2
"Oligodendrocyte Transcription Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix transcription factor that is required for differentiation of OLIGODENDROCYTES and motor neurons in the spinal cord, and development of somatic motor neurons in the hindbrain.
| Descriptor ID |
D000076104
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| MeSH Number(s) |
D12.776.260.103.798 D12.776.631.654 D12.776.930.125.782
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Oligodendrocyte Transcription Factor 2".
Below are MeSH descriptors whose meaning is more specific than "Oligodendrocyte Transcription Factor 2".
This graph shows the total number of publications written about "Oligodendrocyte Transcription Factor 2" by people in this website by year, and whether "Oligodendrocyte Transcription Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2006 | 0 | 3 | 3 |
| 2007 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Oligodendrocyte Transcription Factor 2" by people in Profiles.
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Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse. Cancer Cell. 2019 09 16; 36(3):302-318.e7.
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A Revised Diagnostic Classification of Canine Glioma: Towards Validation of the Canine Glioma Patient as a Naturally Occurring Preclinical Model for Human Glioma. J Neuropathol Exp Neurol. 2018 11 01; 77(11):1039-1054.
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Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression. Mol Cancer Res. 2017 05; 15(5):507-520.
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Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci. 2014 Oct; 17(10):1322-9.
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Mesenchymal differentiation mediated by NF-?B promotes radiation resistance in glioblastoma. Cancer Cell. 2013 Sep 09; 24(3):331-46.
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Novel HSP90 inhibitor NVP-HSP990 targets cell-cycle regulators to ablate Olig2-positive glioma tumor-initiating cells. Cancer Res. 2013 May 15; 73(10):3062-74.
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Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis. Lancet Oncol. 2012 Aug; 13(8):838-48.
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Expression of oligodendroglial differentiation markers in pilocytic astrocytomas identifies two clinical subsets and shows a significant correlation with proliferation index and progression free survival. J Neurooncol. 2008 Jan; 86(2):183-90.
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Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007 Feb 15; 53(4):503-17.
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The transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord. Neuron. 2006 Dec 21; 52(6):953-68.