XANDER WEHRENS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Space Medicine
    DivisionCenter for Space Medicine

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Cardiology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Cardiology


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    R01HL089598     (WEHRENS, XANDER H.T.)Aug 1, 2007 - Jun 30, 2023
    NIH/NHLBI
    Ryanodine receptor regulation in post-operative atrial fibrillation
    Role: Principal Investigator

    R01HL091947     (WEHRENS, XANDER H.T.)Apr 1, 2008 - Sep 10, 2010
    NIH/NHLBI
    Regulation of Sarcoplasmic Reticulum Calcium Release in Heart Failure
    Role: Principal Investigator

    R01HL117641     (WEHRENS, XANDER H.T.)Apr 1, 2014 - Mar 31, 2018
    NIH/NHLBI
    Determining the Role of Junctophilin-2 in Cardiac Disease
    Role: Principal Investigator

    R41HL129570     (WEHRENS, XANDER H.T.)Aug 1, 2015 - Jul 31, 2016
    NIH/NHLBI
    Development of novel compounds for the treatment of atrial fibrillation
    Role: Principal Investigator

    R01HL147108     (WEHRENS, XANDER H.T.)Apr 15, 2019 - Feb 28, 2023
    NIH/NHLBI
    Mechanisms underlying atrial fibrillation associated with chronic kidney disease
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cely-Ortiz A, Felice JI, Díaz-Zegarra LA, Valverde CA, Federico M, Palomeque J, Wehrens XHT, Kranias EG, Aiello EA, Lascano EC, Negroni JA, Mattiazzi A. Determinants of Ca2+ release restitution: Insights from genetically altered animals and mathematical modeling. J Gen Physiol. 2020 Nov 02; 152(11). PMID: 32986800.
      Citations:    Fields:    
    2. Campbell H, Aguilar-Sanchez Y, Quick AP, Dobrev D, Wehrens X. SPEG: a key regulator of cardiac calcium homeostasis. Cardiovasc Res. 2020 Oct 17. PMID: 33067609.
      Citations:    Fields:    
    3. Heijman J, Muna AP, Veleva T, Molina CE, Sutanto H, Tekook M, Wang Q, Abu-Taha IH, Gorka M, Künzel S, El-Armouche A, Reichenspurner H, Kamler M, Nikolaev V, Ravens U, Li N, Nattel S, Wehrens XHT, Dobrev D. Atrial Myocyte NLRP3/CaMKII Nexus Forms a Substrate for Postoperative Atrial Fibrillation. Circ Res. 2020 Sep 25; 127(8):1036-1055. PMID: 32762493.
      Citations: 2     Fields:    
    4. Campbell HM, Quick AP, Abu-Taha I, Chiang DY, Kramm CF, Word TA, Brandenburg S, Hulsurkar M, Alsina KM, Liu HB, Martin B, Uhlenkamp D, Moore OM, Lahiri SK, Corradini E, Kamler M, Heck AJR, Lehnart SE, Dobrev D, Wehrens XHT. Loss of SPEG Inhibitory Phosphorylation of Ryanodine Receptor Type-2 Promotes Atrial Fibrillation. Circulation. 2020 Sep 22; 142(12):1159-1172. PMID: 32683896.
      Citations: 1     Fields:    
    5. Marian AJ, Asatryan B, Wehrens XHT. Genetic basis and molecular biology of cardiac arrhythmias in cardiomyopathies. Cardiovasc Res. 2020 Jul 15; 116(9):1600-1619. PMID: 32348453.
      Citations: 2     Fields:    
    6. Lahiri SK, Quick AP, Samson-Couterie B, Hulsurkar M, Elzenaar I, van Oort RJ, Wehrens XHT. Nuclear localization of a novel calpain-2 mediated junctophilin-2 C-terminal cleavage peptide promotes cardiomyocyte remodeling. Basic Res Cardiol. 2020 06 26; 115(4):49. PMID: 32592107.
      Citations:    Fields:    
    7. Cheedipudi SM, Hu J, Fan S, Yuan P, Karmouch J, Czernuszewicz G, Robertson MJ, Coarfa C, Hong K, Yao Y, Campbell H, Wehrens X, Gurha P, Marian AJ. Exercise restores dysregulated gene expression in a mouse model of arrhythmogenic cardiomyopathy. Cardiovasc Res. 2020 May 01; 116(6):1199-1213. PMID: 31350552.
      Citations: 5     Fields:    
    8. Himelman E, Lillo MA, Nouet J, Gonzalez JP, Zhao Q, Xie LH, Li H, Liu T, Wehrens XH, Lampe PD, Fishman GI, Shirokova N, Contreras JE, Fraidenraich D. Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy. J Clin Invest. 2020 Apr 01; 130(4):1713-1727. PMID: 31910160.
      Citations: 2     Fields:    
    9. Coban-Akdemir ZH, Charng WL, Azamian M, Paine IS, Punetha J, Grochowski CM, Gambin T, Valdes SO, Cannon B, Zapata G, Hernandez PP, Jhangiani S, Doddapaneni H, Hu J, Boricha F, Muzny DM, Boerwinkle E, Yang Y, Gibbs RA, Posey JE, Wehrens XHT, Belmont JW, Kim JJ, Miyake CY, Lupski JR, Lalani SR. Wolff-Parkinson-White syndrome: De novo variants and evidence for mutational burden in genes associated with atrial fibrillation. . 2020 06; 182(6):1387-1399. PMID: 32233023.
      Citations:    
    10. Levine AT, Born HA, Landstrom AP, Larson S, Lee WL, Dao AT, Wehrens XH, Lai YC, Anderson AE. Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. Sci Rep. 2020 03 04; 10(1):4043. PMID: 32132552.
      Citations:    Fields:    
    11. Connell P, Word TA, Wehrens XHT. Targeting pathological leak of ryanodine receptors: preclinical progress and the potential impact on treatments for cardiac arrhythmias and heart failure. Expert Opin Ther Targets. 2020 01; 24(1):25-36. PMID: 31869254.
      Citations: 1     Fields:    
    12. Greer-Short A, Musa H, Alsina KM, Ni L, Word TA, Reynolds JO, Gratz D, Lane C, El-Refaey M, Unudurthi S, Skaf M, Li N, Fedorov VV, Wehrens XHT, Mohler PJ, Hund TJ. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 03; 17(3):503-511. PMID: 31622781.
      Citations: 2     Fields:    
    13. Siebert V, Allencherril J, Ye Y, Wehrens XHT, Birnbaum Y. The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury. Cardiovasc Drugs Ther. 2019 08; 33(4):489-498. PMID: 31332654.
      Citations: 1     Fields:    Translation:HumansAnimals
    14. Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442. PMID: 31356139.
      Citations: 3     Fields:    Translation:AnimalsCells
    15. Jones EG, Mazaheri N, Maroofian R, Zamani M, Seifi T, Sedaghat A, Shariati G, Jamshidi Y, Allen HD, Wehrens XHT, Galehdari H, Landstrom AP. Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy. Sci Rep. 2019 06 21; 9(1):9038. PMID: 31227780.
      Citations: 2     Fields:    
    16. Brandenburg S, Pawlowitz J, Eikenbusch B, Peper J, Kohl T, Mitronova GY, Sossalla S, Hasenfuss G, Wehrens XH, Kohl P, Rog-Zielinska EA, Lehnart SE. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 06 20; 4(12). PMID: 31217359.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    17. Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 08 20; 140(8):681-693. PMID: 31185731.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    18. Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 04; 7(8):e14071. PMID: 31033205.
      Citations:    Fields:    Translation:AnimalsCells
    19. Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ragone MI, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Kranias EG, Wehrens XHT, Mattiazzi A. Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 03 01; 115(3):556-569. PMID: 30169578.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ. Protein Phosphatase 2A Regulates Cardiac Na+ Channels. Circ Res. 2019 03; 124(5):737-746. PMID: 30602331.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    21. Monroe TO, Hill MC, Morikawa Y, Leach JP, Heallen T, Cao S, Krijger PHL, de Laat W, Wehrens XHT, Rodney GG, Martin JF. YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo. Dev Cell. 2019 03 25; 48(6):765-779.e7. PMID: 30773489.
      Citations: 12     Fields:    Translation:AnimalsCells
    22. Ni L, Scott L, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHT. Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262. PMID: 30582449.
      Citations: 3     Fields:    Translation:AnimalsCells
    23. Nie J, Duan Q, He M, Li X, Wang B, Zhou C, Wu L, Wen Z, Chen C, Wang DW, Alsina KM, Wehrens XHT, Wang DW, Ni L. Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling. J Cell Physiol. 2019 07; 234(7):11587-11601. PMID: 30488495.
      Citations: 3     Fields:    Translation:AnimalsCells
    24. Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 11 13; 138(20):2227-2242. PMID: 29802206.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    25. Hulsurkar M, Quick AP, Wehrens XH. STAT3: a link between CaMKII-ßIV-spectrin and maladaptive remodeling? J Clin Invest. 2018 12 03; 128(12):5219-5221. PMID: 30418170.
      Citations:    Fields:    Translation:Cells
    26. Ni L, Wehrens XHT. Cardiac troponin I-more than a biomarker for myocardial ischemia? Ann Transl Med. 2018 Nov; 6(Suppl 1):S17. PMID: 30613592.
      Citations:    
    27. Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D. Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Front Physiol. 2018; 9:1383. PMID: 30356673.
      Citations:    
    28. Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L, Heck AJR, Wehrens XHT. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Circulation. 2018 10 09; 138(15):1569-1581. PMID: 29669786.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    29. Pang PD, Alsina KM, Cao S, Koushik AB, Wehrens XHT, Cooper TA. CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. J Am Heart Assoc. 2018 10 02; 7(19):e010393. PMID: 30371314.
      Citations: 2     Fields:    Translation:AnimalsCells
    30. Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 09 28; 123(8):953-963. PMID: 30355031.
      Citations: 5     Fields:    Translation:AnimalsCells
    31. Dobrev D, Fender AC, Wehrens XHT. Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter? Cardiovasc Res. 2018 09 01; 114(11):1428-1429. PMID: 29982290.
      Citations:    Fields:    Translation:HumansCells
    32. Wehrens XHT. Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development. JACC Basic Transl Sci. 2018 Aug; 3(4):518-520. PMID: 30175275.
      Citations:    
    33. Dobrev D, Wehrens XHT. Mouse Models of Cardiac Arrhythmias. Circ Res. 2018 07 20; 123(3):332-334. PMID: 30026380.
      Citations: 1     Fields:    Translation:Animals
    34. Campbell HM, Wehrens XHT. Genetics of atrial fibrillation: an update. Curr Opin Cardiol. 2018 05; 33(3):304-310. PMID: 29461262.
      Citations: 2     Fields:    Translation:Humans
    35. Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHT. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682. PMID: 29654126.
      Citations: 4     Fields:    Translation:AnimalsCells
    36. Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt DM, Pautler RG, Valderrábano M, Wehrens XH, Anderson AE. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018 Jun; 3(2):213-223. PMID: 29881800.
      Citations:    
    37. Klipp RC, Li N, Wang Q, Word TA, Sibrian-Vazquez M, Strongin RM, Wehrens XHT, Abramson JJ. EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586. PMID: 29248564.
      Citations: 5     Fields:    Translation:AnimalsCells
    38. Kitagawa MG, Reynolds JO, Wehrens XHT, Bryan RM, Pandit LM. Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension. Front Med (Lausanne). 2017; 4:177. PMID: 29109948.
      Citations:    
    39. Lezcano N, Mariángelo JIE, Vittone L, Wehrens XHT, Said M, Mundiña-Weilenmann C. Early effects of Epac depend on the fine-tuning of the sarcoplasmic reticulum Ca2+ handling in cardiomyocytes. J Mol Cell Cardiol. 2018 01; 114:1-9. PMID: 29037982.
      Citations: 1     Fields:    Translation:AnimalsCells
    40. Karmouch J, Zhou QQ, Miyake CY, Lombardi R, Kretzschmar K, Bannier-Hélaouët M, Clevers H, Wehrens XHT, Willerson JT, Marian AJ. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017 Dec 08; 121(12):1346-1359. PMID: 29018034.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    41. Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M. Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017 09 07; 2(17). PMID: 28878117.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    42. Miyake CY, Asaki SY, Webster G, Czosek RJ, Atallah J, Avasarala K, Rao SO, Thomas PE, Kim JJ, Valdes SO, de la Uz C, Wang Y, Wehrens XHT, Abrams D. Circadian Variation of Ventricular Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia. JACC Clin Electrophysiol. 2017 11; 3(11):1308-1317. PMID: 29759629.
      Citations: 2     Fields:    Translation:Humans
    43. Landstrom AP, Dobrev D, Wehrens XHT. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993. PMID: 28596175.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    44. Dobrev D, Wehrens XHT. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 06 15; 595(12):4001-4008. PMID: 28181690.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    45. Federico M, Portiansky EL, Sommese L, Alvarado FJ, Blanco PG, Zanuzzi CN, Dedman J, Kaetzel M, Wehrens XHT, Mattiazzi A, Palomeque J. Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017 06 15; 595(12):4089-4108. PMID: 28105734.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    46. Quick AP, Landstrom AP, Wang Q, Beavers DL, Reynolds JO, Barreto-Torres G, Tran V, Showell J, Philippen LE, Morris SA, Skapura D, Bos JM, Pedersen SE, Pautler RG, Ackerman MJ, Wehrens XH. Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci. 2017 Feb; 2(1):56-67. PMID: 28393127.
      Citations:    
    47. Heijman J, Ghezelbash S, Wehrens XH, Dobrev D. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 02; 103:110-120. PMID: 28077320.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    48. Hinton AO, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644. PMID: 28006821.
      Citations: 2     Fields:    Translation:Animals
    49. Herrera JA, Ward CS, Wehrens XH, Neul JL. Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis. Hum Mol Genet. 2016 11 15; 25(22):4983-4995. PMID: 28159985.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063.
      Citations: 2     Fields:    Translation:AnimalsCells
    51. Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. J Physiol. 2016 11 01; 594(21):6433-6435. PMID: 27800622.
      Citations:    Fields:    
    52. Li N, Wang Q, Sibrian-Vazquez M, Klipp RC, Reynolds JO, Word TA, Scott L, Salama G, Strongin RM, Abramson JJ, Wehrens XHT. Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs. Int J Cardiol. 2017 Jan 15; 227:668-673. PMID: 27838126.
      Citations: 9     Fields:    Translation:Animals
    53. Munro ML, Jayasinghe ID, Wang Q, Quick A, Wang W, Baddeley D, Wehrens XH, Soeller C. Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci. 2016 12 01; 129(23):4388-4398. PMID: 27802169.
      Citations: 14     Fields:    Translation:AnimalsCells
    54. Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, Wehrens XH. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017 Jan 06; 120(1):110-119. PMID: 27729468.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    55. Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol. 2016 Dec 15; 225:371-380. PMID: 27760414.
      Citations: 19     Fields:    Translation:AnimalsCells
    56. Wang Q, Wehrens XH. Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy. Ann Transl Med. 2016 Oct; 4(Suppl 1):S23. PMID: 27867991.
      Citations:    
    57. Chiang DY, Heck AJ, Dobrev D, Wehrens XH. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172. PMID: 27663175.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    58. Aiba I, Wehrens XH, Noebels JL. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903. PMID: 27482086.
      Citations: 13     Fields:    Translation:AnimalsCells
    59. Becerra R, Román B, Di Carlo MN, Mariangelo JI, Salas M, Sanchez G, Donoso P, Schinella GR, Vittone L, Wehrens XH, Mundiña-Weilenmann C, Said M. Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. . 2016 09 01; 311(3):H713-24. PMID: 27422983.
      Citations:    
    60. Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72. PMID: 27318036.
      Citations: 17     Fields:    Translation:AnimalsCells
    61. Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M. Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016 08 12; 291(33):17247-57. PMID: 27298322.
      Citations: 16     Fields:    Translation:AnimalsCells
    62. Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN. Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. Cell Rep. 2016 06 07; 15(10):2200-2213. PMID: 27239029.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    63. Mazzocchi G, Sommese L, Palomeque J, Felice JI, Di Carlo MN, Fainstein D, Gonzalez P, Contreras P, Skapura D, McCauley MD, Lascano EC, Negroni JA, Kranias EG, Wehrens XH, Valverde CA, Mattiazzi A. Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII-constitutive phosphorylation of RyR2 at site S2814. J Physiol. 2016 06 01; 594(11):3005-30. PMID: 26695843.
      Citations: 6     Fields:    Translation:AnimalsCells
    64. Wu Y, Valdivia HH, Wehrens XH, Anderson ME. A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003180. PMID: 26857906.
      Citations: 5     Fields:    Translation:AnimalsCells
    65. Schulte JS, Fehrmann E, Tekook MA, Kranick D, Fels B, Li N, Wehrens XH, Heinick A, Seidl MD, Schmitz W, Müller FU. Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016 Mar; 111(2):15. PMID: 26818679.
      Citations: 5     Fields:    Translation:AnimalsCells
    66. Li N, Dobrev D, Wehrens XH. PITX2: a master regulator of cardiac channelopathy in atrial fibrillation? Cardiovasc Res. 2016 Mar 01; 109(3):345-7. PMID: 26782118.
      Citations: 3     Fields:    Translation:Humans
    67. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. PMID: 26515697.
      Citations: 11     Fields:    Translation:Animals
    68. Heijman J, Algalarrondo V, Voigt N, Melka J, Wehrens XH, Dobrev D, Nattel S. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016 Apr 01; 109(4):467-79. PMID: 26705366.
      Citations: 43     Fields:    Translation:HumansAnimals
    69. Quick AP, Landstrom AP, Wehrens XH. Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling. Heart Rhythm. 2016 Mar; 13(3):753-4. PMID: 26598319.
      Citations: 1     Fields:    Translation:Humans
    70. Wang Q, Wang W, Wang G, Rodney GG, Wehrens XH. Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):177-84. PMID: 26555638.
      Citations: 13     Fields:    Translation:AnimalsCells
    71. Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ. Protein phosphatase 2A regulatory subunit B56a limits phosphatase activity in the heart. Sci Signal. 2015 Jul 21; 8(386):ra72. PMID: 26198358.
      Citations: 17     Fields:    Translation:AnimalsCells
    72. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    73. Landstrom AP, Sun JJ, Ray RS, Wehrens XH. It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5. PMID: 26164374.
      Citations: 1     Fields:    Translation:Animals
    74. Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC. Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circ Res. 2015 Aug 28; 117(6):536-46. PMID: 26137860.
      Citations: 26     Fields:    Translation:AnimalsCells
    75. Chiang DY, Kim JJ, Valdes SO, de la Uz C, Fan Y, Orcutt J, Domino M, Smith M, Wehrens XH, Miyake CY. Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1105-12. PMID: 26111534.
      Citations: 3     Fields:    Translation:Humans
    76. Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C. PHD2/3-dependent hydroxylation tunes cardiac response to ß-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71. PMID: 26075818.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    77. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. CaMKIId mediates ß-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. PMID: 26080362.
      Citations: 23     Fields:    Translation:AnimalsCells
    78. Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jun 03; 6:7241. PMID: 26037243.
      Citations:    Fields:    
    79. Xi Y, James Chao ZY, Yan W, Abbasi S, Yin X, Mathuria N, Patel M, Fan C, Sun J, Wu G, Wang S, Elayda M, Gao L, Wehrens XH, Lin SF, Cheng J. Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation. Heart Rhythm. 2015 Jun; 12(6):1352-61. PMID: 25748673.
      Citations: 1     Fields:    Translation:Animals
    80. Herrera JA, Ward CS, Pitcher MR, Percy AK, Skinner S, Kaufmann WE, Glaze DG, Wehrens XH, Neul JL. Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. Dis Model Mech. 2015 Apr; 8(4):363-71. PMID: 25713300.
      Citations: 7     Fields:    Translation:Animals
    81. Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015 Apr 01; 184:190-7. PMID: 25706326.
      Citations: 14     Fields:    Translation:Humans
    82. Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20; 6:6081. PMID: 25603276.
      Citations: 45     Fields:    Translation:AnimalsCells
    83. Chiang DY, Lebesgue N, Beavers DL, Alsina KM, Damen JM, Voigt N, Dobrev D, Wehrens XH, Scholten A. Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. J Am Coll Cardiol. 2015 Jan 20; 65(2):163-73. PMID: 25593058.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    84. Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, Backx PH. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFa. Nat Commun. 2015 Jan 19; 6:6018. PMID: 25598495.
      Citations: 25     Fields:    Translation:Animals
    85. Shirokova N, Kang C, Fernandez-Tenorio M, Wang W, Wang Q, Wehrens XHT, Niggli E. Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophys J. 2014 Dec 16; 107(12):2815-2827. PMID: 25517148.
      Citations: 4     Fields:    Translation:AnimalsCells
    86. Van Wagoner DR, Piccini JP, Albert CM, Anderson ME, Benjamin EJ, Brundel B, Califf RM, Calkins H, Chen PS, Chiamvimonvat N, Darbar D, Eckhardt LL, Ellinor PT, Exner DV, Fogel RI, Gillis AM, Healey J, Hohnloser SH, Kamel H, Lathrop DA, Lip GY, Mehra R, Narayan SM, Olgin J, Packer D, Peters NS, Roden DM, Ross HM, Sheldon R, Wehrens XH. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. Heart Rhythm. 2015 Jan; 12(1):e5-e29. PMID: 25460864.
      Citations: 29     Fields:    Translation:Humans
    87. Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22. PMID: 25389315.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    88. Yang X, Wang T, Lin X, Yue X, Wang Q, Wang G, Fu Q, Ai X, Chiang DY, Miyake CY, Wehrens XHT, Chang J. Genetic deletion of Rnd3/RhoE results in mouse heart calcium leakage through upregulation of protein kinase A signaling. Circ Res. 2015 Jan 02; 116(1):e1-e10. PMID: 25348166.
      Citations: 12     Fields:    Translation:AnimalsCells
    89. Nabben M, van Bree BWJ, Lenaers E, Hoeks J, Hesselink MKC, Schaart G, Gijbels MJJ, Glatz JFC, da Silva GJJ, de Windt LJ, Tian R, Mike E, Skapura DG, Wehrens XHT, Schrauwen P. Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death. Basic Res Cardiol. 2014; 109(6):447. PMID: 25344084.
      Citations: 6     Fields:    Translation:AnimalsCells
    90. Pandit LM, Lloyd EE, Reynolds JO, Lawrence WS, Reynolds C, Wehrens XH, Bryan RM. TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process. Hypertension. 2014 Dec; 64(6):1260-5. PMID: 25245387.
      Citations: 8     Fields:    Translation:Animals
    91. Respress JL, Gershovich PM, Wang T, Reynolds JO, Skapura DG, Sutton JP, Miyake CY, Wehrens XH. Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice. Int J Cardiol. 2014 Oct 20; 176(3):994-1000. PMID: 25227892.
      Citations: 3     Fields:    Translation:AnimalsCells
    92. Wang W, Landstrom AP, Wang Q, Munro ML, Beavers D, Ackerman MJ, Soeller C, Wehrens XH. Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice. . 2014 Nov 01; 307(9):H1317-26. PMID: 25193470.
      Citations:    
    93. Di Carlo MN, Said M, Ling H, Valverde CA, De Giusti VC, Sommese L, Palomeque J, Aiello EA, Skapura DG, Rinaldi G, Respress JL, Brown JH, Wehrens XH, Salas MA, Mattiazzi A. CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury. J Mol Cell Cardiol. 2014 Sep; 74:274-83. PMID: 24949568.
      Citations: 14     Fields:    Translation:AnimalsCells
    94. Beavers DL, Landstrom AP, Chiang DY, Wehrens XH. Emerging roles of junctophilin-2 in the heart and implications for cardiac diseases. Cardiovasc Res. 2014 Jul 15; 103(2):198-205. PMID: 24935431.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    95. Wang J, Bai Y, Li N, Ye W, Zhang M, Greene SB, Tao Y, Chen Y, Wehrens XH, Martin JF. Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9181-6. PMID: 24927531.
      Citations: 34     Fields:    Translation:HumansAnimals
    96. Chiang DY, Li N, Wang Q, Alsina KM, Quick AP, Reynolds JO, Wang G, Skapura D, Voigt N, Dobrev D, Wehrens XH. Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 01; 103(1):178-87. PMID: 24812280.
      Citations: 24     Fields:    Translation:AnimalsCells
    97. Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA. Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development. Nat Commun. 2014 Apr 22; 5:3603. PMID: 24752171.
      Citations: 52     Fields:    Translation:AnimalsCells
    98. Dobrev D, Wehrens XH. Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res. 2014 Apr 11; 114(8):1311-9; discussion 1319. PMID: 24723656.
      Citations: 48     Fields:    Translation:HumansAnimals
    99. Landstrom AP, Beavers DL, Wehrens XH. The junctophilin family of proteins: from bench to bedside. Trends Mol Med. 2014 Jun; 20(6):353-62. PMID: 24636942.
      Citations: 12     Fields:    Translation:HumansCells
    100. Heijman J, Voigt N, Wehrens XH, Dobrev D. Calcium dysregulation in atrial fibrillation: the role of CaMKII. Front Pharmacol. 2014; 5:30. PMID: 24624086.
      Citations:    
    101. Zhang C, Chen B, Guo A, Zhu Y, Miller JD, Gao S, Yuan C, Kutschke W, Zimmerman K, Weiss RM, Wehrens XH, Hong J, Johnson FL, Santana LF, Anderson ME, Song LS. Microtubule-mediated defects in junctophilin-2 trafficking contribute to myocyte transverse-tubule remodeling and Ca2+ handling dysfunction in heart failure. Circulation. 2014 Apr 29; 129(17):1742-50. PMID: 24519927.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    102. Li N, Chiang DY, Wang S, Wang Q, Sun L, Voigt N, Respress JL, Ather S, Skapura DG, Jordan VK, Horrigan FT, Schmitz W, Müller FU, Valderrabano M, Nattel S, Dobrev D, Wehrens XHT. Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model. Circulation. 2014 Mar 25; 129(12):1276-1285. PMID: 24398018.
      Citations: 50     Fields:    Translation:AnimalsCells
    103. Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XHT, Nattel S, Dobrev D. Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. Circulation. 2014 Jan 14; 129(2):145-156. PMID: 24249718.
      Citations: 112     Fields:    Translation:HumansCells
    104. Ho HT, Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Györke S. Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides. Cardiovasc Res. 2014 Jan 01; 101(1):165-74. PMID: 24104877.
      Citations: 19     Fields:    Translation:AnimalsCells
    105. Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One. 2013; 8(9):e75882. PMID: 24086656.
      Citations: 17     Fields:    Translation:AnimalsCells
    106. Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57. PMID: 24030498.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    107. Beavers DL, Wang W, Ather S, Voigt N, Garbino A, Dixit SS, Landstrom AP, Li N, Wang Q, Olivotto I, Dobrev D, Ackerman MJ, Wehrens XHT. Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization. J Am Coll Cardiol. 2013 Nov 19; 62(21):2010-9. PMID: 23973696.
      Citations: 56     Fields:    Translation:AnimalsCells
    108. Chen B, Guo A, Zhang C, Chen R, Zhu Y, Hong J, Kutschke W, Zimmerman K, Weiss RM, Zingman L, Anderson ME, Wehrens XH, Song LS. Critical roles of junctophilin-2 in T-tubule and excitation-contraction coupling maturation during postnatal development. Cardiovasc Res. 2013 Oct 01; 100(1):54-62. PMID: 23860812.
      Citations: 37     Fields:    Translation:AnimalsCells
    109. Ather S, Respress JL, Li N, Wehrens XH. Alterations in ryanodine receptors and related proteins in heart failure. Biochim Biophys Acta. 2013 Dec; 1832(12):2425-31. PMID: 23770282.
      Citations: 19     Fields:    Translation:HumansAnimals
    110. Wu SP, Cheng CM, Lanz RB, Wang T, Respress JL, Ather S, Chen W, Tsai SJ, Wehrens XH, Tsai MJ, Tsai SY. Atrial identity is determined by a COUP-TFII regulatory network. Dev Cell. 2013 May 28; 25(4):417-26. PMID: 23725765.
      Citations: 41     Fields:    Translation:AnimalsCells
    111. Reynolds JO, Chiang DY, Wang W, Beavers DL, Dixit SS, Skapura DG, Landstrom AP, Song LS, Ackerman MJ, Wehrens XH. Junctophilin-2 is necessary for T-tubule maturation during mouse heart development. Cardiovasc Res. 2013 Oct 01; 100(1):44-53. PMID: 23715556.
      Citations: 42     Fields:    Translation:AnimalsCells
    112. Wehrens XH, Chiang DY, Li N. Chronic exercise: a contributing factor to atrial fibrillation? J Am Coll Cardiol. 2013 Jul 02; 62(1):78-80. PMID: 23583764.
      Citations:    Fields:    Translation:Animals
    113. Dixit SS, Wang T, Manzano EJ, Yoo S, Lee J, Chiang DY, Ryan N, Respress JL, Yechoor VK, Wehrens XH. Effects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose tolerance. PLoS One. 2013; 8(3):e58655. PMID: 23516528.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    114. Heijman J, Wehrens XH, Dobrev D. Atrial arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia--is there a mechanistic link between sarcoplasmic reticulum Ca(2+) leak and re-entry? Acta Physiol (Oxf). 2013 Feb; 207(2):208-11. PMID: 23157571.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    115. Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM. Epac2 mediates cardiac ß1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22. PMID: 23363625.
      Citations: 56     Fields:    Translation:AnimalsCells
    116. Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr; 10(4):592-9. PMID: 23246599.
      Citations: 24     Fields:    Translation:AnimalsCells
    117. Li N, Wehrens XH. Extinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm. 2013 Jan; 10(1):108-9. PMID: 23085093.
      Citations: 1     Fields:    Translation:Animals
    118. DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJ. CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec; 9(12):2034-41. PMID: 23059182.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    119. Wu Y, Luczak ED, Lee EJ, Hidalgo C, Yang J, Gao Z, Li J, Wehrens XH, Granzier H, Anderson ME. CaMKII effects on inotropic but not lusitropic force frequency responses require phospholamban. J Mol Cell Cardiol. 2012 Sep; 53(3):429-36. PMID: 22796260.
      Citations: 10     Fields:    Translation:AnimalsCells
    120. Liu D, Huang L, Wang Y, Wang W, Wehrens XH, Belousova T, Abdelrahim M, DiMattia G, Sheikh-Hamad D. Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS One. 2012; 7(5):e36994. PMID: 22693564.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    121. Ather S, Bavishi C, McCauley MD, Dhaliwal A, Deswal A, Johnson S, Chan W, Aguilar D, Pritchett AM, Ramasubbu K, Wehrens XH, Bozkurt B. Worsening renal function is not associated with response to treatment in acute heart failure. Int J Cardiol. 2013 Sep 01; 167(5):1912-7. PMID: 22633437.
      Citations: 7     Fields:    Translation:Humans
    122. Gurha P, Abreu-Goodger C, Wang T, Ramirez MO, Drumond AL, van Dongen S, Chen Y, Bartonicek N, Enright AJ, Lee B, Kelm RJ, Reddy AK, Taffet GE, Bradley A, Wehrens XH, Entman ML, Rodriguez A. Targeted deletion of microRNA-22 promotes stress-induced cardiac dilation and contractile dysfunction. Circulation. 2012 Jun 05; 125(22):2751-61. PMID: 22570371.
      Citations: 58     Fields:    Translation:AnimalsCells
    123. Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Skårdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83. PMID: 22511749.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    124. Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70. PMID: 22456474.
      Citations: 169     Fields:    Translation:HumansAnimalsCells
    125. Ather S, Chan W, Bozkurt B, Aguilar D, Ramasubbu K, Zachariah AA, Wehrens XH, Deswal A. Impact of noncardiac comorbidities on morbidity and mortality in a predominantly male population with heart failure and preserved versus reduced ejection fraction. J Am Coll Cardiol. 2012 Mar 13; 59(11):998-1005. PMID: 22402071.
      Citations: 134     Fields:    Translation:Humans
    126. Jayasinghe ID, Baddeley D, Kong CH, Wehrens XH, Cannell MB, Soeller C. Nanoscale organization of junctophilin-2 and ryanodine receptors within peripheral couplings of rat ventricular cardiomyocytes. Biophys J. 2012 Mar 07; 102(5):L19-21. PMID: 22404946.
      Citations: 19     Fields:    Translation:AnimalsCells
    127. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature. 2012 Feb 22; 483(7387):96-9. PMID: 22367544.
      Citations: 116     Fields:    Translation:AnimalsCells
    128. McCauley MD, Wang T, Mike E, Herrera J, Beavers DL, Huang TW, Ward CS, Skinner S, Percy AK, Glaze DG, Wehrens XH, Neul JL. Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome. Sci Transl Med. 2011 Dec 14; 3(113):113ra125. PMID: 22174313.
      Citations: 31     Fields:    Translation:HumansAnimals
    129. Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 03; 110(3):465-70. PMID: 22158709.
      Citations: 50     Fields:    Translation:AnimalsCells
    130. Wang T, Wehrens XH. Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform. Heart Rhythm. 2012 Apr; 9(4):598-9. PMID: 22138134.
      Citations: 2     Fields:    Translation:Humans
    131. Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, Müller FU. Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20; 166(2):366-74. PMID: 22093963.
      Citations: 19     Fields:    Translation:Animals
    132. Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, Dobrev D, Wehrens XH, Mohler PJ. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22. PMID: 21859974.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    133. Said M, Becerra R, Valverde CA, Kaetzel MA, Dedman JR, Mundiña-Weilenmann C, Wehrens XH, Vittone L, Mattiazzi A. Calcium-calmodulin dependent protein kinase II (CaMKII): a main signal responsible for early reperfusion arrhythmias. J Mol Cell Cardiol. 2011 Dec; 51(6):936-44. PMID: 21888910.
      Citations: 32     Fields:    Translation:AnimalsCells
    134. McCauley MD, Wehrens XH. Targeting ryanodine receptors for anti-arrhythmic therapy. Acta Pharmacol Sin. 2011 Jun; 32(6):749-57. PMID: 21642946.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    135. Ather S, Chan W, Chillar A, Aguilar D, Pritchett AM, Ramasubbu K, Wehrens XH, Deswal A, Bozkurt B. Association of systolic blood pressure with mortality in patients with heart failure with reduced ejection fraction: a complex relationship. Am Heart J. 2011 Mar; 161(3):567-73. PMID: 21392613.
      Citations: 13     Fields:    Translation:Humans
    136. van Oort RJ, Garbino A, Wang W, Dixit SS, Landstrom AP, Gaur N, De Almeida AC, Skapura DG, Rudy Y, Burns AR, Ackerman MJ, Wehrens XH. Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. Circulation. 2011 Mar 08; 123(9):979-88. PMID: 21339484.
      Citations: 105     Fields:    Translation:AnimalsCells
    137. McCauley MD, Wehrens XH. Ryanodine receptor phosphorylation, calcium/calmodulin-dependent protein kinase II, and life-threatening ventricular arrhythmias. Trends Cardiovasc Med. 2011 Feb; 21(2):48-51. PMID: 22578240.
      Citations: 8     Fields:    Translation:HumansCells
    138. Landstrom AP, Kellen CA, Dixit SS, van Oort RJ, Garbino A, Weisleder N, Ma J, Wehrens XH, Ackerman MJ. Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling. Circ Heart Fail. 2011 Mar; 4(2):214-23. PMID: 21216834.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    139. van Oort RJ, McCauley MD, Dixit SS, Pereira L, Yang Y, Respress JL, Wang Q, De Almeida AC, Skapura DG, Anderson ME, Bers DM, Wehrens XH. Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation. 2010 Dec 21; 122(25):2669-79. PMID: 21098440.
      Citations: 110     Fields:    Translation:AnimalsCells
    140. Dobrev D, Voigt N, Wehrens XH. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 01; 89(4):734-43. PMID: 20943673.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    141. Wehrens XH. CaMKII regulation of the cardiac ryanodine receptor and sarcoplasmic reticulum calcium release. Heart Rhythm. 2011 Feb; 8(2):323-5. PMID: 20887810.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    142. Garbino A, Wehrens XH. Emerging role of junctophilin-2 as a regulator of calcium handling in the heart. Acta Pharmacol Sin. 2010 Sep; 31(9):1019-21. PMID: 20694023.
      Citations: 12     Fields:    Translation:HumansAnimals
    143. Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XH. Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70. PMID: 20615971.
      Citations: 27     Fields:    Translation:AnimalsCells
    144. Respress JL, Wehrens XH. Transthoracic echocardiography in mice. J Vis Exp. 2010 May 28; (39). PMID: 20517201.
      Citations: 24     Fields:    Translation:Animals
    145. McCauley MD, Wehrens XH. Ambulatory ECG recording in mice. J Vis Exp. 2010 May 27; (39). PMID: 20517202.
      Citations: 7     Fields:    Translation:Animals
    146. Li N, Wehrens XH. Programmed electrical stimulation in mice. J Vis Exp. 2010 May 26; (39). PMID: 20512106.
      Citations: 19     Fields:    Translation:Animals
    147. Ather S, Peterson LE, Divakaran VG, Deswal A, Ramasubbu K, Giorgberidze I, Blaustein A, Wehrens XH, Mann DL, Bozkurt B. Digoxin treatment in heart failure--unveiling risk by cluster analysis of DIG data. Int J Cardiol. 2011 Aug 04; 150(3):264-9. PMID: 20471706.
      Citations: 3     Fields:    Translation:Humans
    148. Wang J, Klysik E, Sood S, Johnson RL, Wehrens XH, Martin JF. Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9753-8. PMID: 20457925.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    149. deAlmeida AC, van Oort RJ, Wehrens XH. Transverse aortic constriction in mice. J Vis Exp. 2010 Apr 21; (38). PMID: 20410870.
      Citations: 62     Fields:    Translation:HumansAnimals
    150. van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ, Wehrens XH. Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8. PMID: 20157052.
      Citations: 27     Fields:    Translation:AnimalsCells
    151. Wang W, Wehrens XH. Stress synchronizes calcium release and promotes SR calcium leak. J Physiol. 2010 Feb 01; 588(Pt 3):391-2. PMID: 20123791.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    152. Koshelev M, Sarma S, Price RE, Wehrens XH, Cooper TA. Heart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1. Hum Mol Genet. 2010 Mar 15; 19(6):1066-75. PMID: 20051426.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    153. Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4. PMID: 20685575.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    154. Mathur N, Sood S, Wang S, van Oort RJ, Sarma S, Li N, Skapura DG, Bayle JH, Valderrábano M, Wehrens XH. Sudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):677-85. PMID: 20009080.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    155. Wang GS, Kuyumcu-Martinez MN, Sarma S, Mathur N, Wehrens XH, Cooper TA. PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1. J Clin Invest. 2009 Dec; 119(12):3797-806. PMID: 19907076.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    156. McCauley MD, Wehrens XH. Animal models of arrhythmogenic cardiomyopathy. Dis Model Mech. 2009 Nov-Dec; 2(11-12):563-70. PMID: 19892887.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    157. Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51. PMID: 19603549.
      Citations: 163     Fields:    Translation:HumansAnimalsCells
    158. Garbino A, van Oort RJ, Dixit SS, Landstrom AP, Ackerman MJ, Wehrens XH. Molecular evolution of the junctophilin gene family. Physiol Genomics. 2009 May 13; 37(3):175-86. PMID: 19318539.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    159. Wu Y, Gao Z, Chen B, Koval OM, Singh MV, Guan X, Hund TJ, Kutschke W, Sarma S, Grumbach IM, Wehrens XH, Mohler PJ, Song LS, Anderson ME. Calmodulin kinase II is required for fight or flight sinoatrial node physiology. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5972-7. PMID: 19276108.
      Citations: 76     Fields:    Translation:AnimalsCells
    160. Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (1985). 2009 Apr; 106(4):1280-92. PMID: 19131475.
      Citations: 35     Fields:    Translation:AnimalsCells
    161. Lalani SR, Thakuria JV, Cox GF, Wang X, Bi W, Bray MS, Shaw C, Cheung SW, Chinault AC, Boggs BA, Ou Z, Brundage EK, Lupski JR, Gentile J, Waisbren S, Pursley A, Ma L, Khajavi M, Zapata G, Friedman R, Kim JJ, Towbin JA, Stankiewicz P, Schnittger S, Hansmann I, Ai T, Sood S, Wehrens XH, Martin JF, Belmont JW, Potocki L. 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet. 2009 Mar; 46(3):168-75. PMID: 18812404.
      Citations: 15     Fields:    Translation:HumansAnimals
    162. van Oort RJ, Altamirano J, Lederer WJ, Wehrens XH. Alternative splicing: a key mechanism for ankyrin-B functional diversity? J Mol Cell Cardiol. 2008 Dec; 45(6):709-11. PMID: 18838078.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    163. Bourajjaj M, Armand AS, da Costa Martins PA, Weijts B, van der Nagel R, Heeneman S, Wehrens XH, De Windt LJ. NFATc2 is a necessary mediator of calcineurin-dependent cardiac hypertrophy and heart failure. J Biol Chem. 2008 Aug 08; 283(32):22295-303. PMID: 18477567.
      Citations: 48     Fields:    Translation:Animals
    164. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54. PMID: 18598963.
      Citations: 53     Fields:    Translation:AnimalsCells
    165. Chelu MG, Wehrens XH. Sarcoplasmic reticulum calcium leak and cardiac arrhythmias. Biochem Soc Trans. 2007 Nov; 35(Pt 5):952-6. PMID: 17956253.
      Citations: 22     Fields:    Translation:HumansCells
    166. Mohler PJ, Wehrens XH. Mechanisms of human arrhythmia syndromes: abnormal cardiac macromolecular interactions. Physiology (Bethesda). 2007 Oct; 22:342-50. PMID: 17928548.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    167. Wehrens XH. Istaroxime, a novel luso-inotropic agent for the treatment of acute heart failure. Curr Opin Investig Drugs. 2007 Sep; 8(9):769-77. PMID: 17729189.
      Citations:    Fields:    Translation:HumansAnimalsCells
    168. Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. Int J Cardiol. 2007 Oct 18; 121(3):249-52. PMID: 17761312.
      Citations:    Fields:    Translation:Humans
    169. Chen-Izu Y, Ward CW, Stark W, Banyasz T, Sumandea MP, Balke CW, Izu LT, Wehrens XH. Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. . 2007 Oct; 293(4):H2409-17. PMID: 17630346.
      Citations:    
    170. Santonastasi M, Wehrens XH. Ryanodine receptors as pharmacological targets for heart disease. Acta Pharmacol Sin. 2007 Jul; 28(7):937-44. PMID: 17588328.
      Citations: 11     Fields:    Translation:HumansCells
    171. Wehrens XH. Leaky ryanodine receptors cause delayed afterdepolarizations and ventricular arrhythmias. Eur Heart J. 2007 May; 28(9):1054-6. PMID: 17459904.
      Citations: 1     Fields:    Translation:Humans
    172. van Oort RJ, Wehrens XH. Subcellular targeting of phosphatases: a novel function of ankyrins. . 2007 Jul; 293(1):H15-6. PMID: 17449551.
      Citations:    
    173. Landstrom AP, Weisleder N, Batalden KB, Bos JM, Tester DJ, Ommen SR, Wehrens XH, Claycomb WC, Ko JK, Hwang M, Pan Z, Ma J, Ackerman MJ. Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. J Mol Cell Cardiol. 2007 Jun; 42(6):1026-35. PMID: 17509612.
      Citations: 79     Fields:    Translation:HumansCells
    174. Durham WJ, Wehrens XH, Sood S, Hamilton SL. Diseases associated with altered ryanodine receptor activity. Subcell Biochem. 2007; 45:273-321. PMID: 18193641.
      Citations: 13     Fields:    Translation:Humans
    175. Wehrens XH. The molecular basis of catecholaminergic polymorphic ventricular tachycardia: what are the different hypotheses regarding mechanisms? Heart Rhythm. 2007 Jun; 4(6):794-7. PMID: 17556207.
      Citations: 9     Fields:    Translation:Humans
    176. Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12179-84. PMID: 16873551.
      Citations: 62     Fields:    Translation:Animals
    177. Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7906-10. PMID: 16672364.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    178. Huang F, Shan J, Reiken S, Wehrens XH, Marks AR. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3456-61. PMID: 16481613.
      Citations: 26     Fields:    Translation:AnimalsCells
    179. Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):511-8. PMID: 16407108.
      Citations: 125     Fields:    Translation:AnimalsCells
    180. Wehrens XH. Structural determinants of potassium channel blockade and drug-induced arrhythmias. Handb Exp Pharmacol. 2006; (171):123-57. PMID: 16610343.
      Citations: 2     Fields:    Translation:HumansAnimals
    181. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35. PMID: 16213210.
      Citations: 162     Fields:    Translation:AnimalsCells
    182. Lehnart SE, Wehrens XH, Marks AR. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 2005 Jun 28; 111(25):3342-6. PMID: 15983258.
      Citations: 12     Fields:    Translation:HumansCells
    183. Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9607-12. PMID: 15972811.
      Citations: 65     Fields:    Translation:Animals
    184. Wehrens XH, Lehnart SE, Marks AR. Ryanodine receptor-targeted anti-arrhythmic therapy. Ann N Y Acad Sci. 2005 Jun; 1047:366-75. PMID: 16093511.
      Citations: 21     Fields:    Translation:Humans
    185. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32. PMID: 15851612.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    186. Wehrens XH, Lehnart SE, Marks AR. Intracellular calcium release and cardiac disease. Annu Rev Physiol. 2005; 67:69-98. PMID: 15709953.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    187. Wehrens XH, Marks AR. Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations. Mayo Clin Proc. 2004 Nov; 79(11):1367-71. PMID: 15544013.
      Citations: 4     Fields:    Translation:Humans
    188. Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1267-79. PMID: 15336974.
      Citations: 18     Fields:    Translation:HumansAnimals
    189. Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73. PMID: 15232578.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    190. Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation. 2004 Jun 29; 109(25):3208-14. PMID: 15197150.
      Citations: 87     Fields:    Translation:HumansCells
    191. Wehrens XH, Doevendans PA. Cardiac rupture complicating myocardial infarction. Int J Cardiol. 2004 Jun; 95(2-3):285-92. PMID: 15193834.
      Citations: 12     Fields:    Translation:Humans
    192. Lehnart SE, Wehrens XH, Kushnir A, Marks AR. Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci. 2004 May; 1015:144-59. PMID: 15201156.
      Citations: 27     Fields:    Translation:HumansCells
    193. Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004 Apr 09; 304(5668):292-6. PMID: 15073377.
      Citations: 139     Fields:    Translation:HumansAnimalsCells
    194. Wehrens XH, Doevendans PA. Congenital and drug-induced long-QT syndrome: an update. Neth Heart J. 2004 Apr; 12(4):165-172. PMID: 25696318.
      Citations:    
    195. Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 Apr 02; 94(6):e61-70. PMID: 15016728.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    196. Wehrens XH, Offermans JP, Snijders M, Peeters LL. Fetal cardiovascular response to large placental chorioangiomas. J Perinat Med. 2004; 32(2):107-12. PMID: 15085884.
      Citations: 4     Fields:    Translation:Humans
    197. Wehrens XH, Marks AR. Molecular determinants of altered contractility in heart failure. Ann Med. 2004; 36 Suppl 1:70-80. PMID: 15176427.
      Citations: 7     Fields:    Translation:HumansCells
    198. Wehrens XH, Marks AR. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci. 2003 Dec; 28(12):671-8. PMID: 14659699.
      Citations: 33     Fields:    Translation:HumansCells
    199. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 2003 Jun 27; 113(7):829-40. PMID: 12837242.
      Citations: 209     Fields:    Translation:AnimalsCells
    200. Wehrens XH, Doevendans PA. Cardiac rupture. N Engl J Med. 2003 May 29; 348(22):2264. PMID: 12773664.
      Citations:    Fields:    Translation:Humans
    201. Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, Marks AR. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20; 107(19):2459-66. PMID: 12743001.
      Citations: 75     Fields:    Translation:HumansCellsCTClinical Trials
    202. Wehrens XH, Rossenbacker T, Jongbloed RJ, Gewillig M, Heidbüchel H, Doevendans PA, Vos MA, Wellens HJ, Kass RS. A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating. Hum Mutat. 2003 May; 21(5):552. PMID: 12673799.
      Citations: 20     Fields:    Translation:HumansCells
    203. Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 2003 May 06; 107(17):2233-7. PMID: 12695286.
      Citations: 49     Fields:    Translation:HumansCells
    204. Wehrens XH, Vos MA, Doevendans PA, Wellens HJ. Novel insights in the congenital long QT syndrome. Ann Intern Med. 2002 Dec 17; 137(12):981-92. PMID: 12484714.
      Citations: 13     Fields:    Translation:Humans
    205. Buehler A, Martire A, Strohm C, Wolfram S, Fernandez B, Palmen M, Wehrens XH, Doevendans PA, Franz WM, Schaper W, Zimmermann R. Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovasc Res. 2002 Sep; 55(4):768-77. PMID: 12176126.
      Citations: 17     Fields:    Translation:AnimalsCells
    206. oude Egbrink MG, Janssen GH, Ookawa K, Slaaf DW, Reneman RS, Wehrens XH, Maaijwee KJ, Ohshima N, Struijker Boudier HA, Tangelder GJ. Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin. J Invest Dermatol. 2002 Feb; 118(2):323-6. PMID: 11841551.
      Citations: 5     Fields:    Translation:AnimalsCells
    207. Wehrens XH, Rouwet EV, oude Egbrink MG, Slaaf DW, Ramsay G. Effects of experimental lower-limb ischaemia-reperfusion injury on the mesenteric microcirculation. Br J Surg. 2002 Feb; 89(2):185-91. PMID: 11856131.
      Citations: 4     Fields:    Translation:AnimalsCells
    208. Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003; 43:441-61. PMID: 12540747.
      Citations: 19     Fields:    Translation:Humans
    209. Wehrens XH, Marks AR. Myocardial disease in failing hearts: defective excitation-contraction coupling. Cold Spring Harb Symp Quant Biol. 2002; 67:533-41. PMID: 12858580.
      Citations:    Fields:    Translation:HumansAnimalsCells
    210. Wehrens XH, Leiner T. Publications from extracurricular research. Lancet. 2001 Sep 08; 358(9284):846. PMID: 11582595.
      Citations: 1     Fields:    Translation:Humans
    211. Wehrens XH, Doevendans PA, Widdershoven JW, Dassen WR, Prenger K, Wellens HJ, Gorgels AP. Usefulness of sinus tachycardia and ST-segment elevation in V(5) to identify impending left ventricular free wall rupture in inferior wall myocardial infarction. Am J Cardiol. 2001 Aug 15; 88(4):414-7. PMID: 11545766.
      Citations: 1     Fields:    Translation:Humans
    212. Dammers R, Wehrens XH, oude Egbrink MG, Slaaf DW, Kurvers HA, Ramsay G. Microcirculatory effects of experimental acute limb ischaemia-reperfusion. Br J Surg. 2001 Jun; 88(6):816-24. PMID: 11412251.
      Citations: 2     Fields:    Translation:AnimalsCells
    213. Abriel H, Cabo C, Wehrens XH, Rivolta I, Motoike HK, Memmi M, Napolitano C, Priori SG, Kass RS. Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel. Circ Res. 2001 Apr 13; 88(7):740-5. PMID: 11304498.
      Citations: 40     Fields:    Translation:HumansCells
    214. Wehrens XH, Doevendans PA. [Primary osteomyelitis of sternum]. Ned Tijdschr Geneeskd. 2001 Feb 03; 145(5):245-6. PMID: 11219160.
      Citations:    Fields:    Translation:Humans
    215. Wehrens XH, van Breda E, van Velzen JS, oude Egbrink MG, Slaaf DW. Use of an intact mouse skeletal muscle preparation for endocrine vascular studies: evaluation of the model. Horm Metab Res. 2000 Sep; 32(9):378-80. PMID: 11014388.
      Citations:    Fields:    Translation:Animals
    216. Abriel H, Wehrens XH, Benhorin J, Kerem B, Kass RS. Molecular pharmacology of the sodium channel mutation D1790G linked to the long-QT syndrome. Circulation. 2000 Aug 22; 102(8):921-5. PMID: 10952963.
      Citations: 22     Fields:    Translation:HumansCells
    217. Wehrens XH, Abriel H, Cabo C, Benhorin J, Kass RS. Arrhythmogenic mechanism of an LQT-3 mutation of the human heart Na(+) channel alpha-subunit: A computational analysis. Circulation. 2000 Aug 01; 102(5):584-90. PMID: 10920073.
      Citations: 27     Fields:    Translation:HumansCells
    218. Wehrens XH, Doevendans PA, Ophuis TJ, Wellens HJ. A comparison of electrocardiographic changes during reperfusion of acute myocardial infarction by thrombolysis or percutaneous transluminal coronary angioplasty. Am Heart J. 2000 Mar; 139(3):430-6. PMID: 10689257.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    219. Wehrens XH, Kirchhoff S, Doevendans PA. Mouse electrocardiography: an interval of thirty years. Cardiovasc Res. 2000 Jan 01; 45(1):231-7. PMID: 10728340.
      Citations: 24     Fields:    Translation:HumansAnimals
    220. Wehrens XH, Mies B, Gimona M, Ramaekers FC, Van Eys GJ, Small JV. Localization of smoothelin in avian smooth muscle and identification of a vascular-specific isoform. FEBS Lett. 1997 Apr 01; 405(3):315-20. PMID: 9108311.
      Citations: 3     Fields:    Translation:AnimalsCells
    221. van Eys GJ, Völler MC, Timmer ED, Wehrens XH, Small JV, Schalken JA, Ramaekers FC, van der Loop FT. Smoothelin expression characteristics: development of a smooth muscle cell in vitro system and identification of a vascular variant. Cell Struct Funct. 1997 Feb; 22(1):65-72. PMID: 9113392.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    222. Wehrens XH, Doevendans PA, van Dantzig JM, Snoep G, Wellens HJ. Infected sternal fracture hematoma after cardiopulmonary resuscitation initially seen as pericarditis. Am Heart J. 1996 Sep; 132(3):685-6. PMID: 8800042.
      Citations:    Fields:    Translation:Humans
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