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Xander Wehrens

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
DivisionMolecular Physiology & Biophysics
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Space Medicine
    DivisionCenter for Space Medicine

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Cardiology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Cardiology


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    R01HL089598     (WEHRENS, XANDER H.T.)Aug 1, 2007 - Jun 30, 2023
    NIH/NHLBI
    CaMKII Regulation of Cardiac Ryanodine Receptors in Atrial Fibrillation
    Role: Principal Investigator

    R01HL091947     (WEHRENS, XANDER H.T.)Apr 1, 2008 - Feb 28, 2020
    NIH/NHLBI
    Regulation of Sarcoplasmic Reticulum Calcium Release in Heart Failure
    Role: Principal Investigator

    R01HL117641     (WEHRENS, XANDER H.T.)Apr 1, 2014 - Mar 31, 2018
    NIH/NHLBI
    Determining the Role of Junctophilin-2 in Cardiac Disease
    Role: Principal Investigator

    R41HL129570     (WEHRENS, XANDER H.T.)Aug 1, 2015 - Jul 31, 2016
    NIH/NHLBI
    Development of novel compounds for the treatment of atrial fibrillation
    Role: Principal Investigator

    R01HL147108     (WEHRENS, XANDER H.T.)Apr 15, 2019 - Feb 28, 2023
    NIH/NHLBI
    Mechanisms underlying atrial fibrillation associated with chronic kidney disease
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Greer-Short A, Musa H, Alsina KM, Ni L, Word TA, Reynolds JO, Gratz D, Lane C, El-Refaey M, Unudurthi S, Skaf M, Li N, Fedorov VV, Wehrens XHT, Mohler PJ, Hund TJ. Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2019 Oct 14. PMID: 31622781.
      View in: PubMed
    2. Siebert V, Allencherril J, Ye Y, Wehrens XHT, Birnbaum Y. The Role of Non-coding RNAs in Ischemic Myocardial Reperfusion Injury. Cardiovasc Drugs Ther. 2019 Aug; 33(4):489-498. PMID: 31332654.
      View in: PubMed
    3. Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 Jul 30; 140(5):440-442. PMID: 31356139.
      View in: PubMed
    4. Cheedipudi SM, Hu J, Fan S, Yuan P, Karmouch J, Czernuszewicz G, Robertson MJ, Coarfa C, Hong K, Yao Y, Moore HC, Wehrens X, Gurha P, Marian AJ. Exercise Restores Dysregulated Gene Expression in a Mouse Model of Arrhythmogenic Cardiomyopathy. Cardiovasc Res. 2019 Jul 26. PMID: 31350552.
      View in: PubMed
    5. Jones EG, Mazaheri N, Maroofian R, Zamani M, Seifi T, Sedaghat A, Shariati G, Jamshidi Y, Allen HD, Wehrens XHT, Galehdari H, Landstrom AP. Analysis of enriched rare variants in JPH2-encoded junctophilin-2 among Greater Middle Eastern individuals reveals a novel homozygous variant associated with neonatal dilated cardiomyopathy. Sci Rep. 2019 Jun 21; 9(1):9038. PMID: 31227780.
      View in: PubMed
    6. Brandenburg S, Pawlowitz J, Eikenbusch B, Peper J, Kohl T, Mitronova GY, Sossalla S, Hasenfuss G, Wehrens XH, Kohl P, Rog-Zielinska EA, Lehnart SE. Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis. JCI Insight. 2019 Jun 20; 4(12). PMID: 31217359.
      View in: PubMed
    7. Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 Aug 20; 140(8):681-693. PMID: 31185731.
      View in: PubMed
    8. Donelson J, Wang Q, Monroe TO, Jiang X, Zhou J, Yu H, Mo Q, Sun Q, Marini JC, Wang X, Nakata PA, Hirschi KD, Wang J, Rodney GG, Wehrens XHT, Cheng N. Cardiac-specific ablation of glutaredoxin 3 leads to cardiac hypertrophy and heart failure. Physiol Rep. 2019 Apr; 7(8):e14071. PMID: 31033205.
      View in: PubMed
    9. Valverde CA, Mazzocchi G, Di Carlo MN, Ciocci Pardo A, Salas N, Ragone MI, Felice JI, Cely-Ortiz A, Consolini AE, Portiansky E, Mosca S, Kranias EG, Wehrens XHT, Mattiazzi A. Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors. Cardiovasc Res. 2019 Mar 01; 115(3):556-569. PMID: 30169578.
      View in: PubMed
    10. El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ. Protein Phosphatase 2A Regulates Cardiac Na+ Channels. Circ Res. 2019 Mar; 124(5):737-746. PMID: 30602331.
      View in: PubMed
    11. Monroe TO, Hill MC, Morikawa Y, Leach JP, Heallen T, Cao S, Krijger PHL, de Laat W, Wehrens XHT, Rodney GG, Martin JF. YAP Partially Reprograms Chromatin Accessibility to Directly Induce Adult Cardiogenesis In Vivo. Dev Cell. 2019 03 25; 48(6):765-779.e7. PMID: 30773489.
      View in: PubMed
    12. Ni L, Scott L, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHT. Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262. PMID: 30582449.
      View in: PubMed
    13. Nie J, Duan Q, He M, Li X, Wang B, Zhou C, Wu L, Wen Z, Chen C, Wang DW, Alsina KM, Wehrens XHT, Wang DW, Ni L. Ranolazine prevents pressure overload-induced cardiac hypertrophy and heart failure by restoring aberrant Na+ and Ca2+ handling. J Cell Physiol. 2019 Jul; 234(7):11587-11601. PMID: 30488495.
      View in: PubMed
    14. Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 11 13; 138(20):2227-2242. PMID: 29802206.
      View in: PubMed
    15. Hulsurkar M, Quick AP, Wehrens XH. STAT3: a link between CaMKII-ßIV-spectrin and maladaptive remodeling? J Clin Invest. 2018 12 03; 128(12):5219-5221. PMID: 30418170.
      View in: PubMed
    16. Ni L, Wehrens XHT. Cardiac troponin I-more than a biomarker for myocardial ischemia? Ann Transl Med. 2018 Nov; 6(Suppl 1):S17. PMID: 30613592.
      View in: PubMed
    17. Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D. Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Front Physiol. 2018; 9:1383. PMID: 30356673.
      View in: PubMed
    18. Chiang DY, Alsina KM, Corradini E, Fitzpatrick M, Ni L, Lahiri SK, Reynolds JO, Pan X, Scott L, Heck AJR, Wehrens XHT. Rearrangement of the Protein Phosphatase 1 Interactome During Heart Failure Progression. Circulation. 2018 10 09; 138(15):1569-1581. PMID: 29669786.
      View in: PubMed
    19. Pang PD, Alsina KM, Cao S, Koushik AB, Wehrens XHT, Cooper TA. CRISPR -Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias. J Am Heart Assoc. 2018 10 02; 7(19):e010393. PMID: 30371314.
      View in: PubMed
    20. Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 09 28; 123(8):953-963. PMID: 30355031.
      View in: PubMed
    21. Dobrev D, Fender AC, Wehrens XHT. Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter? Cardiovasc Res. 2018 09 01; 114(11):1428-1429. PMID: 29982290.
      View in: PubMed
    22. Wehrens XHT. Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development. JACC Basic Transl Sci. 2018 Aug; 3(4):518-520. PMID: 30175275.
      View in: PubMed
    23. Dobrev D, Wehrens XHT. Mouse Models of Cardiac Arrhythmias. Circ Res. 2018 07 20; 123(3):332-334. PMID: 30026380.
      View in: PubMed
    24. Campbell HM, Wehrens XHT. Genetics of atrial fibrillation: an update. Curr Opin Cardiol. 2018 05; 33(3):304-310. PMID: 29461262.
      View in: PubMed
    25. Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHT. Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682. PMID: 29654126.
      View in: PubMed
    26. Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt DM, Pautler RG, Valderrábano M, Wehrens XH, Anderson AE. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018 Jun; 3(2):213-223. PMID: 29881800.
      View in: PubMed
    27. Klipp RC, Li N, Wang Q, Word TA, Sibrian-Vazquez M, Strongin RM, Wehrens XHT, Abramson JJ. EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586. PMID: 29248564.
      View in: PubMed
    28. Kitagawa MG, Reynolds JO, Wehrens XHT, Bryan RM, Pandit LM. Hemodynamic and Pathologic Characterization of the TASK-1-/- Mouse Does Not Demonstrate Pulmonary Hypertension. Front Med (Lausanne). 2017; 4:177. PMID: 29109948.
      View in: PubMed
    29. Karmouch J, Zhou QQ, Miyake CY, Lombardi R, Kretzschmar K, Bannier-Hélaouët M, Clevers H, Wehrens XHT, Willerson JT, Marian AJ. Distinct Cellular Basis for Early Cardiac Arrhythmias, the Cardinal Manifestation of Arrhythmogenic Cardiomyopathy, and the Skin Phenotype of Cardiocutaneous Syndromes. Circ Res. 2017 Dec 08; 121(12):1346-1359. PMID: 29018034.
      View in: PubMed
    30. Liu R, Lee J, Kim BS, Wang Q, Buxton SK, Balasubramanyam N, Kim JJ, Dong J, Zhang A, Li S, Gupte AA, Hamilton DJ, Martin JF, Rodney GG, Coarfa C, Wehrens XH, Yechoor VK, Moulik M. Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017 09 07; 2(17). PMID: 28878117.
      View in: PubMed
    31. Miyake CY, Asaki SY, Webster G, Czosek RJ, Atallah J, Avasarala K, Rao SO, Thomas PE, Kim JJ, Valdes SO, de la Uz C, Wang Y, Wehrens XHT, Abrams D. Circadian Variation of Ventricular Arrhythmias in Catecholaminergic Polymorphic Ventricular Tachycardia. JACC Clin Electrophysiol. 2017 11; 3(11):1308-1317. PMID: 29759629.
      View in: PubMed
    32. Landstrom AP, Dobrev D, Wehrens XHT. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993. PMID: 28596175.
      View in: PubMed
    33. Dobrev D, Wehrens XHT. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 06 15; 595(12):4001-4008. PMID: 28181690.
      View in: PubMed
    34. Federico M, Portiansky EL, Sommese L, Alvarado FJ, Blanco PG, Zanuzzi CN, Dedman J, Kaetzel M, Wehrens XHT, Mattiazzi A, Palomeque J. Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance. J Physiol. 2017 06 15; 595(12):4089-4108. PMID: 28105734.
      View in: PubMed
    35. Quick AP, Landstrom AP, Wang Q, Beavers DL, Reynolds JO, Barreto-Torres G, Tran V, Showell J, Philippen LE, Morris SA, Skapura D, Bos JM, Pedersen SE, Pautler RG, Ackerman MJ, Wehrens XH. Novel junctophilin-2 mutation A405S is associated with basal septal hypertrophy and diastolic dysfunction. JACC Basic Transl Sci. 2017 Feb; 2(1):56-67. PMID: 28393127.
      View in: PubMed
    36. Heijman J, Ghezelbash S, Wehrens XH, Dobrev D. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 02; 103:110-120. PMID: 28077320.
      View in: PubMed
    37. Hinton AO, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644. PMID: 28006821.
      View in: PubMed
    38. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063.
      View in: PubMed
    39. Herrera JA, Ward CS, Wehrens XH, Neul JL. Methyl-CpG binding-protein 2 function in cholinergic neurons mediates cardiac arrhythmogenesis. Hum Mol Genet. 2016 11 15; 25(22):4983-4995. PMID: 28159985.
      View in: PubMed
    40. Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. J Physiol. 2016 11 01; 594(21):6433-6435. PMID: 27800622.
      View in: PubMed
    41. Li N, Wang Q, Sibrian-Vazquez M, Klipp RC, Reynolds JO, Word TA, Scott L, Salama G, Strongin RM, Abramson JJ, Wehrens XHT. Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs. Int J Cardiol. 2017 Jan 15; 227:668-673. PMID: 27838126.
      View in: PubMed
    42. Munro ML, Jayasinghe ID, Wang Q, Quick A, Wang W, Baddeley D, Wehrens XH, Soeller C. Junctophilin-2 in the nanoscale organisation and functional signalling of ryanodine receptor clusters in cardiomyocytes. J Cell Sci. 2016 12 01; 129(23):4388-4398. PMID: 27802169.
      View in: PubMed
    43. Quick AP, Wang Q, Philippen LE, Barreto-Torres G, Chiang DY, Beavers D, Wang G, Khalid M, Reynolds JO, Campbell HM, Showell J, McCauley MD, Scholten A, Wehrens XH. SPEG (Striated Muscle Preferentially Expressed Protein Kinase) Is Essential for Cardiac Function by Regulating Junctional Membrane Complex Activity. Circ Res. 2017 Jan 06; 120(1):110-119. PMID: 27729468.
      View in: PubMed
    44. Reynolds JO, Quick AP, Wang Q, Beavers DL, Philippen LE, Showell J, Barreto-Torres G, Thuerauf DJ, Doroudgar S, Glembotski CC, Wehrens XH. Junctophilin-2 gene therapy rescues heart failure by normalizing RyR2-mediated Ca2+ release. Int J Cardiol. 2016 Dec 15; 225:371-380. PMID: 27760414.
      View in: PubMed
    45. Wang Q, Wehrens XH. Connecting enterovirus infection to dystrophin dysfunction in dilated cardiomyopathy. Ann Transl Med. 2016 Oct; 4(Suppl 1):S23. PMID: 27867991.
      View in: PubMed
    46. Chiang DY, Heck AJ, Dobrev D, Wehrens XH. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172. PMID: 27663175.
      View in: PubMed
    47. Aiba I, Wehrens XH, Noebels JL. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903. PMID: 27482086.
      View in: PubMed
    48. Becerra R, Román B, Di Carlo MN, Mariangelo JI, Salas M, Sanchez G, Donoso P, Schinella GR, Vittone L, Wehrens XH, Mundiña-Weilenmann C, Said M. Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused heart. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H713-24. PMID: 27422983.
      View in: PubMed
    49. Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DM. CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72. PMID: 27318036.
      View in: PubMed
    50. Bal NC, Maurya SK, Singh S, Wehrens XH, Periasamy M. Increased Reliance on Muscle-based Thermogenesis upon Acute Minimization of Brown Adipose Tissue Function. J Biol Chem. 2016 08 12; 291(33):17247-57. PMID: 27298322.
      View in: PubMed
    51. Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, Garg NJ, Wehrens XHT, Yeo GW, Kuyumcu-Martinez MN. Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. Cell Rep. 2016 06 07; 15(10):2200-2213. PMID: 27239029.
      View in: PubMed
    52. Wu Y, Valdivia HH, Wehrens XH, Anderson ME. A Single Protein Kinase A or Calmodulin Kinase II Site Does Not Control the Cardiac Pacemaker Ca2+ Clock. Circ Arrhythm Electrophysiol. 2016 Feb; 9(2):e003180. PMID: 26857906.
      View in: PubMed
    53. Li N, Dobrev D, Wehrens XH. PITX2: a master regulator of cardiac channelopathy in atrial fibrillation? Cardiovasc Res. 2016 Mar 01; 109(3):345-7. PMID: 26782118.
      View in: PubMed
    54. Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov SY, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. J Physiol. 2016 Feb 01; 594(3):567-93. PMID: 26515697.
      View in: PubMed
    55. Heijman J, Algalarrondo V, Voigt N, Melka J, Wehrens XH, Dobrev D, Nattel S. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016 Apr 01; 109(4):467-79. PMID: 26705366.
      View in: PubMed
    56. Quick AP, Landstrom AP, Wehrens XH. Junctophilin-2 at the intersection of arrhythmia and pathologic cardiac remodeling. Heart Rhythm. 2016 Mar; 13(3):753-4. PMID: 26598319.
      View in: PubMed
    57. Wang Q, Wang W, Wang G, Rodney GG, Wehrens XH. Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):177-84. PMID: 26555638.
      View in: PubMed
    58. Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ. Protein phosphatase 2A regulatory subunit B56a limits phosphatase activity in the heart. Sci Signal. 2015 Jul 21; 8(386):ra72. PMID: 26198358.
      View in: PubMed
    59. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324.
      View in: PubMed
    60. Landstrom AP, Sun JJ, Ray RS, Wehrens XH. It's not the heart: autonomic nervous system predisposition to lethal ventricular arrhythmias. Heart Rhythm. 2015 Nov; 12(11):2294-5. PMID: 26164374.
      View in: PubMed
    61. Doroudgar S, Völkers M, Thuerauf DJ, Khan M, Mohsin S, Respress JL, Wang W, Gude N, Müller OJ, Wehrens XH, Sussman MA, Glembotski CC. Hrd1 and ER-Associated Protein Degradation, ERAD, are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes. Circ Res. 2015 Aug 28; 117(6):536-46. PMID: 26137860.
      View in: PubMed
    62. Chiang DY, Kim JJ, Valdes SO, de la Uz C, Fan Y, Orcutt J, Domino M, Smith M, Wehrens XH, Miyake CY. Loss-of-Function SCN5A Mutations Associated With Sinus Node Dysfunction, Atrial Arrhythmias, and Poor Pacemaker Capture. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1105-12. PMID: 26111534.
      View in: PubMed
    63. Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson C. PHD2/3-dependent hydroxylation tunes cardiac response to ß-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71. PMID: 26075818.
      View in: PubMed
    64. Grimm M, Ling H, Willeford A, Pereira L, Gray CB, Erickson JR, Sarma S, Respress JL, Wehrens XH, Bers DM, Brown JH. CaMKIId mediates ß-adrenergic effects on RyR2 phosphorylation and SR Ca(2+) leak and the pathophysiological response to chronic ß-adrenergic stimulation. J Mol Cell Cardiol. 2015 Aug; 85:282-91. PMID: 26080362.
      View in: PubMed
    65. Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. Corrigendum: The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jun 03; 6:7241. PMID: 26037243.
      View in: PubMed
    66. Xi Y, James Chao ZY, Yan W, Abbasi S, Yin X, Mathuria N, Patel M, Fan C, Sun J, Wu G, Wang S, Elayda M, Gao L, Wehrens XH, Lin SF, Cheng J. Neuronally released vasoactive intestinal polypeptide alters atrial electrophysiological properties and may promote atrial fibrillation. Heart Rhythm. 2015 Jun; 12(6):1352-61. PMID: 25748673.
      View in: PubMed
    67. Herrera JA, Ward CS, Pitcher MR, Percy AK, Skinner S, Kaufmann WE, Glaze DG, Wehrens XH, Neul JL. Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs. Dis Model Mech. 2015 Apr; 8(4):363-71. PMID: 25713300.
      View in: PubMed
    68. Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015 Apr 01; 184:190-7. PMID: 25706326.
      View in: PubMed
    69. Wu Y, Rasmussen TP, Koval OM, Joiner ML, Hall DD, Chen B, Luczak ED, Wang Q, Rokita AG, Wehrens XH, Song LS, Anderson ME. The mitochondrial uniporter controls fight or flight heart rate increases. Nat Commun. 2015 Jan 20; 6:6081. PMID: 25603276.
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    70. Chiang DY, Lebesgue N, Beavers DL, Alsina KM, Damen JM, Voigt N, Dobrev D, Wehrens XH, Scholten A. Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. J Am Coll Cardiol. 2015 Jan 20; 65(2):163-73. PMID: 25593058.
      View in: PubMed
    71. Aschar-Sobbi R, Izaddoustdar F, Korogyi AS, Wang Q, Farman GP, Yang F, Yang W, Dorian D, Simpson JA, Tuomi JM, Jones DL, Nanthakumar K, Cox B, Wehrens XH, Dorian P, Backx PH. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFa. Nat Commun. 2015 Jan 19; 6:6018. PMID: 25598495.
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    72. Shirokova N, Kang C, Fernandez-Tenorio M, Wang W, Wang Q, Wehrens XHT, Niggli E. Oxidative stress and ca(2+) release events in mouse cardiomyocytes. Biophys J. 2014 Dec 16; 107(12):2815-2827. PMID: 25517148.
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    73. Van Wagoner DR, Piccini JP, Albert CM, Anderson ME, Benjamin EJ, Brundel B, Califf RM, Calkins H, Chen PS, Chiamvimonvat N, Darbar D, Eckhardt LL, Ellinor PT, Exner DV, Fogel RI, Gillis AM, Healey J, Hohnloser SH, Kamel H, Lathrop DA, Lip GY, Mehra R, Narayan SM, Olgin J, Packer D, Peters NS, Roden DM, Ross HM, Sheldon R, Wehrens XH. Progress toward the prevention and treatment of atrial fibrillation: A summary of the Heart Rhythm Society Research Forum on the Treatment and Prevention of Atrial Fibrillation, Washington, DC, December 9-10, 2013. Heart Rhythm. 2015 Jan; 12(1):e5-e29. PMID: 25460864.
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    158. Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, Hamilton SL. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proc Natl Acad Sci U S A. 2006 Aug 08; 103(32):12179-84. PMID: 16873551.
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    159. Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, Mancarella S, Coromilas J, Lederer WJ, Kass RS, Marks AR. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7906-10. PMID: 16672364.
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    160. Huang F, Shan J, Reiken S, Wehrens XH, Marks AR. Analysis of calstabin2 (FKBP12.6)-ryanodine receptor interactions: rescue of heart failure by calstabin2 in mice. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3456-61. PMID: 16481613.
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    161. Wehrens XH, Lehnart SE, Reiken S, Vest JA, Wronska A, Marks AR. Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17; 103(3):511-8. PMID: 16407108.
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    162. Lehnart SE, Wehrens XH, Reiken S, Warrier S, Belevych AE, Harvey RD, Richter W, Jin SL, Conti M, Marks AR. Phosphodiesterase 4D deficiency in the ryanodine-receptor complex promotes heart failure and arrhythmias. Cell. 2005 Oct 07; 123(1):25-35. PMID: 16213210.
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    163. Lehnart SE, Wehrens XH, Marks AR. Defective ryanodine receptor interdomain interactions may contribute to intracellular Ca2+ leak: a novel therapeutic target in heart failure. Circulation. 2005 Jun 28; 111(25):3342-6. PMID: 15983258.
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    164. Wehrens XH, Lehnart SE, Reiken S, van der Nagel R, Morales R, Sun J, Cheng Z, Deng SX, de Windt LJ, Landry DW, Marks AR. Enhancing calstabin binding to ryanodine receptors improves cardiac and skeletal muscle function in heart failure. Proc Natl Acad Sci U S A. 2005 Jul 05; 102(27):9607-12. PMID: 15972811.
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    165. Wehrens XH, Lehnart SE, Marks AR. Ryanodine receptor-targeted anti-arrhythmic therapy. Ann N Y Acad Sci. 2005 Jun; 1047:366-75. PMID: 16093511.
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    166. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32. PMID: 15851612.
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    167. Wehrens XH, Lehnart SE, Marks AR. Intracellular calcium release and cardiac disease. Annu Rev Physiol. 2005; 67:69-98. PMID: 15709953.
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    168. Wehrens XH, Marks AR. Sudden unexplained death caused by cardiac ryanodine receptor (RyR2) mutations. Mayo Clin Proc. 2004 Nov; 79(11):1367-71. PMID: 15544013.
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    169. Lehnart SE, Wehrens XH, Marks AR. Calstabin deficiency, ryanodine receptors, and sudden cardiac death. Biochem Biophys Res Commun. 2004 Oct 01; 322(4):1267-79. PMID: 15336974.
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    170. Wehrens XH, Marks AR. Novel therapeutic approaches for heart failure by normalizing calcium cycling. Nat Rev Drug Discov. 2004 Jul; 3(7):565-73. PMID: 15232578.
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    171. Lehnart SE, Wehrens XH, Laitinen PJ, Reiken SR, Deng SX, Cheng Z, Landry DW, Kontula K, Swan H, Marks AR. Sudden death in familial polymorphic ventricular tachycardia associated with calcium release channel (ryanodine receptor) leak. Circulation. 2004 Jun 29; 109(25):3208-14. PMID: 15197150.
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    172. Wehrens XH, Doevendans PA. Cardiac rupture complicating myocardial infarction. Int J Cardiol. 2004 Jun; 95(2-3):285-92. PMID: 15193834.
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    173. Lehnart SE, Wehrens XH, Kushnir A, Marks AR. Cardiac ryanodine receptor function and regulation in heart disease. Ann N Y Acad Sci. 2004 May; 1015:144-59. PMID: 15201156.
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    174. Wehrens XH, Lehnart SE, Reiken SR, Deng SX, Vest JA, Cervantes D, Coromilas J, Landry DW, Marks AR. Protection from cardiac arrhythmia through ryanodine receptor-stabilizing protein calstabin2. Science. 2004 Apr 09; 304(5668):292-6. PMID: 15073377.
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    175. Wehrens XH, Lehnart SE, Reiken SR, Marks AR. Ca2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res. 2004 Apr 02; 94(6):e61-70. PMID: 15016728.
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    176. Wehrens XH, Offermans JP, Snijders M, Peeters LL. Fetal cardiovascular response to large placental chorioangiomas. J Perinat Med. 2004; 32(2):107-12. PMID: 15085884.
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    177. Wehrens XH, Marks AR. Molecular determinants of altered contractility in heart failure. Ann Med. 2004; 36 Suppl 1:70-80. PMID: 15176427.
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    178. Wehrens XH, Marks AR. Altered function and regulation of cardiac ryanodine receptors in cardiac disease. Trends Biochem Sci. 2003 Dec; 28(12):671-8. PMID: 14659699.
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    179. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, Sun J, Guatimosim S, Song LS, Rosemblit N, D'Armiento JM, Napolitano C, Memmi M, Priori SG, Lederer WJ, Marks AR. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell. 2003 Jun 27; 113(7):829-40. PMID: 12837242.
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    180. Wehrens XH, Doevendans PA. Cardiac rupture. N Engl J Med. 2003 May 29; 348(22):2264. PMID: 12773664.
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    181. Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, Burkhoff D, Marks AR. Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20; 107(19):2459-66. PMID: 12743001.
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    182. Wehrens XH, Rossenbacker T, Jongbloed RJ, Gewillig M, Heidbüchel H, Doevendans PA, Vos MA, Wellens HJ, Kass RS. A novel mutation L619F in the cardiac Na+ channel SCN5A associated with long-QT syndrome (LQT3): a role for the I-II linker in inactivation gating. Hum Mutat. 2003 May; 21(5):552. PMID: 12673799.
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    183. Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 2003 May 06; 107(17):2233-7. PMID: 12695286.
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    184. Wehrens XH, Vos MA, Doevendans PA, Wellens HJ. Novel insights in the congenital long QT syndrome. Ann Intern Med. 2002 Dec 17; 137(12):981-92. PMID: 12484714.
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    185. Buehler A, Martire A, Strohm C, Wolfram S, Fernandez B, Palmen M, Wehrens XH, Doevendans PA, Franz WM, Schaper W, Zimmermann R. Angiogenesis-independent cardioprotection in FGF-1 transgenic mice. Cardiovasc Res. 2002 Sep; 55(4):768-77. PMID: 12176126.
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    186. oude Egbrink MG, Janssen GH, Ookawa K, Slaaf DW, Reneman RS, Wehrens XH, Maaijwee KJ, Ohshima N, Struijker Boudier HA, Tangelder GJ. Especially polymorphonuclear leukocytes, but also monomorphonuclear leukocytes, roll spontaneously in venules of intact rat skin: involvement of E-selectin. J Invest Dermatol. 2002 Feb; 118(2):323-6. PMID: 11841551.
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    187. Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003; 43:441-61. PMID: 12540747.
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