Interferon Regulatory Factor-3
"Interferon Regulatory Factor-3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An interferon regulatory factor that is expressed constitutively and undergoes POST-TRANSLATIONAL MODIFICATION following viral infection. PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA, and activates transcription.
| Descriptor ID |
D050838
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| MeSH Number(s) |
D12.644.360.024.302.374 D12.776.157.057.050.374 D12.776.260.504.374 D12.776.476.024.385.374 D12.776.744.562 D12.776.930.332.374
|
| Concept/Terms |
Interferon Regulatory Factor-3- Interferon Regulatory Factor-3
- Interferon Regulatory Factor 3
- IRF-3 Transcription Factor
- IRF 3 Transcription Factor
- Transcription Factor, IRF-3
- IFN-Regulatory Factor 3
- IFN Regulatory Factor 3
|
Below are MeSH descriptors whose meaning is more general than "Interferon Regulatory Factor-3".
Below are MeSH descriptors whose meaning is more specific than "Interferon Regulatory Factor-3".
This graph shows the total number of publications written about "Interferon Regulatory Factor-3" by people in this website by year, and whether "Interferon Regulatory Factor-3" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2007 | 3 | 0 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 3 | 4 |
| 2012 | 0 | 3 | 3 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
| 2019 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interferon Regulatory Factor-3" by people in Profiles.
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Mitochondrial (mt)DNA-cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling promotes pyroptosis of macrophages via interferon regulatory factor (IRF)7/IRF3 activation to aggravate lung injury during severe acute pancreatitis. Cell Mol Biol Lett. 2024 Apr 27; 29(1):61.
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Targeting DNA Damage Response Promotes Antitumor Immunity through STING-Mediated T-cell Activation in Small Cell Lung Cancer. Cancer Discov. 2019 05; 9(5):646-661.
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The Effect of Lipopolysaccharide on Noxa Expression Is Mediated through IRF1, 3, and 7. J Microbiol Biotechnol. 2018 Mar 28; 28(3):491-497.
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STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity. Arterioscler Thromb Vasc Biol. 2017 05; 37(5):920-929.
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PPM1A silences cytosolic RNA sensing and antiviral defense through direct dephosphorylation of MAVS and TBK1. Sci Adv. 2016 07; 2(7):e1501889.
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CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection. Cell Rep. 2016 Mar 15; 14(10):2389-401.
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Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks. Nat Commun. 2014 Dec 15; 5:5811.
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USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. J Exp Med. 2014 Feb 10; 211(2):313-28.
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Regulation of interferon-? by MAGI-1 and its interaction with influenza A virus NS1 protein with ESEV PBM. PLoS One. 2012; 7(7):e41251.
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PPM1B negatively regulates antiviral response via dephosphorylating TBK1. Cell Signal. 2012 Nov; 24(11):2197-204.