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BELLEN, HUGO
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overview Investigator, Howard Hughes Medical Institute, Baylor College of Medicine Professor, Departments of Molecular and Human Genetics and Neuroscience Director, Program in Developmental Biology I am interested in (1) providing a better fundamental understanding of the biology that governs the proper function and maintenance of neurons in aging adults (2) developing tools that can be applied to most genes to control transcript and protein levels in adult neurons to assess which proteins are required for neuronal survival and proper function (3) creating genome wide libraries to manipulate most genes in vivo. My lab uses the fruit fly Drosophila melanogaster as a model system because most biological processes are evolutionarily conserved and studies in fruit flies provide many important clues about the aging process in animals and human diseases.
One or more keywords matched the following items that are connected to BELLEN, HUGO
Item TypeName
Academic Article Enhancement of presynaptic calcium current by cysteine string protein.
Academic Article Senseless acts as a binary switch during sensory organ precursor selection.
Academic Article Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner.
Academic Article Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila.
Academic Article The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila.
Academic Article Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer.
Academic Article Sec15 interacts with Rab11 via a novel domain and affects Rab11 localization in vivo.
Academic Article Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation.
Academic Article Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development.
Academic Article straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit.
Academic Article Growth factor independence-1 is expressed in primary human neuroendocrine lung carcinomas and mediates the differentiation of murine pulmonary neuroendocrine cells.
Academic Article Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster.
Academic Article 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future.
Academic Article Synaptic mitochondria are critical for mobilization of reserve pool vesicles at Drosophila neuromuscular junctions.
Academic Article The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.
Academic Article Internalization is required for proper Wingless signaling in Drosophila melanogaster.
Academic Article Mutations in Drosophila sec15 reveal a function in neuronal targeting for a subset of exocyst components.
Academic Article The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins.
Academic Article Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors.
Academic Article Spectraplakins promote microtubule-mediated axonal growth by functioning as structural microtubule-associated proteins and EB1-dependent +TIPs (tip interacting proteins).
Academic Article Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity.
Academic Article Drosophila neuroligin 2 is required presynaptically and postsynaptically for proper synaptic differentiation and synaptic transmission.
Academic Article The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses.
Academic Article The nicotinic acetylcholine receptor Dalpha7 is required for an escape behavior in Drosophila.
Academic Article Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator.
Academic Article Thirty-one flavors of Drosophila rab proteins.
Academic Article NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration.
Academic Article Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles.
Academic Article Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.
Academic Article The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.
Academic Article A novel neuronal pathway for visually guided escape in Drosophila melanogaster.
Academic Article A Notch updated.
Academic Article The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy.
Academic Article Sequoia regulates cell fate decisions in the external sensory organs of adult Drosophila.
Academic Article The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors.
Academic Article Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling.
Academic Article Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.
Academic Article Rab3 GTPase lands Bruchpilot.
Academic Article The Drosophila gene disruption project: progress using transposons with distinctive site specificities.
Academic Article Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients.
Academic Article Drosophila Ten-m and filamin affect motor neuron growth cone guidance.
Academic Article A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene.
Academic Article An assay to detect in vivo Y chromosome loss in Drosophila wing disc cells.
Academic Article A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.
Academic Article Rich regulates target specificity of photoreceptor cells and N-cadherin trafficking in the Drosophila visual system via Rab6.
Academic Article MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes.
Academic Article The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit.
Academic Article Stringent analysis of gene function and protein-protein interactions using fluorescently tagged genes.
Academic Article dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions.
Academic Article Crag is a GEF for Rab11 required for rhodopsin trafficking and maintenance of adult photoreceptor cells.
Academic Article Synaptotagmin I, a Ca2+ sensor for neurotransmitter release.
Academic Article Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating.
Academic Article Endophilin promotes a late step in endocytosis at glial invaginations in Drosophila photoreceptor terminals.
Academic Article The ins and outs of Wingless signaling.
Academic Article Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress.
Academic Article Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis.
Academic Article Gfi/Pag-3/senseless zinc finger proteins: a unifying theme?
Academic Article Hauling t-SNAREs on the microtubule highway.
Academic Article Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin.
Academic Article Transgenesis upgrades for Drosophila melanogaster.
Academic Article V-ATPase V0 sector subunit a1 in neurons is a target of calmodulin.
Academic Article Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.
Academic Article Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction.
Academic Article A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.
Academic Article Drosophila P elements preferentially transpose to replication origins.
Academic Article Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.
Academic Article Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans.
Concept 14-3-3 Proteins
Concept rab3 GTP-Binding Proteins
Concept Cytoskeletal Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Vesicular Transport Proteins
Concept Membrane Proteins
Concept LDL-Receptor Related Proteins
Concept DNA-Binding Proteins
Concept Muscle Proteins
Concept Qa-SNARE Proteins
Concept Luminescent Proteins
Concept Helminth Proteins
Concept Chromosomal Proteins, Non-Histone
Concept Carrier Proteins
Concept Cell Cycle Proteins
Concept Mitochondrial Proteins
Concept GTP-Binding Proteins
Concept Green Fluorescent Proteins
Concept ras Proteins
Concept Eye Proteins
Concept Recombinant Fusion Proteins
Concept Calcium-Binding Proteins
Concept SNARE Proteins
Concept Viral Nonstructural Proteins
Concept HSP40 Heat-Shock Proteins
Concept Mitochondrial Membrane Transport Proteins
Concept Sterol Regulatory Element Binding Proteins
Concept Contractile Proteins
Concept HSP70 Heat-Shock Proteins
Concept Hedgehog Proteins
Concept rho GTP-Binding Proteins
Concept Nuclear Proteins
Concept Recombinant Proteins
Concept Caenorhabditis elegans Proteins
Concept Drosophila Proteins
Concept Microfilament Proteins
Concept Microtubule Proteins
Concept Wnt Proteins
Concept rab5 GTP-Binding Proteins
Concept Fatty Acid Transport Proteins
Concept Insect Proteins
Concept Electron Transport Chain Complex Proteins
Concept rab1 GTP-Binding Proteins
Concept Mutant Proteins
Concept Iron-Binding Proteins
Concept Intracellular Signaling Peptides and Proteins
Concept Monomeric GTP-Binding Proteins
Concept tau Proteins
Concept Adaptor Proteins, Vesicular Transport
Concept R-SNARE Proteins
Concept Proto-Oncogene Proteins
Concept Nerve Tissue Proteins
Concept Tumor Suppressor Proteins
Concept RNA-Binding Proteins
Concept Intercellular Signaling Peptides and Proteins
Concept Repressor Proteins
Concept HSP90 Heat-Shock Proteins
Concept rab GTP-Binding Proteins
Concept T-Box Domain Proteins
Concept Bone Morphogenetic Proteins
Concept Proteins
Concept Zebrafish Proteins
Concept Microtubule-Associated Proteins
Academic Article Drosophila EHBP1 regulates Scabrous secretion during Notch-mediated lateral inhibition.
Academic Article Protein phosphatase 1? limits ring canal constriction during Drosophila germline cyst formation.
Academic Article VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.
Academic Article miR-9a minimizes the phenotypic impact of genomic diversity by buffering a transcription factor.
Academic Article A mitocentric view of Parkinson's disease.
Academic Article Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases.
Academic Article The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration.
Academic Article The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.
Academic Article Drosophila Tempura, a novel protein prenyltransferase a subunit, regulates notch signaling via Rab1 and Rab11.
Academic Article Mitochondrial fusion but not fission regulates larval growth and synaptic development through steroid hormone production.
Academic Article A TRPV channel in Drosophila motor neurons regulates presynaptic resting Ca2+ levels, synapse growth, and synaptic transmission.
Academic Article Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration.
Academic Article Huntingtin functions as a scaffold for selective macroautophagy.
Academic Article A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis.
Academic Article A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila.
Academic Article A genetic toolkit for tagging intronic MiMIC containing genes.
Academic Article Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.
Academic Article The retromer complex in development and disease.
Academic Article Increased COUP-TFII expression in adult hearts induces mitochondrial dysfunction resulting in heart failure.
Academic Article Ig Superfamily Ligand and Receptor Pairs Expressed in Synaptic Partners in Drosophila.
Academic Article Control of Synaptic Connectivity by a Network of Drosophila IgSF Cell Surface Proteins.
Academic Article WAC Regulates mTOR Activity by Acting as an Adaptor for the TTT and Pontin/Reptin Complexes.
Academic Article Ubr3, a Novel Modulator of Hh Signaling Affects the Degradation of Costal-2 and Kif7 through Poly-ubiquitination.
Academic Article NMNAT2:HSP90 Complex Mediates Proteostasis in Proteinopathies.
Academic Article Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.
Academic Article The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals.
Academic Article Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration.
Academic Article Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila.
Academic Article Recurrent De Novo and Biallelic Variation of ATAD3A, Encoding a Mitochondrial Membrane Protein, Results in Distinct Neurological Syndromes.
Academic Article Loss of Frataxin activates the iron/sphingolipid/PDK1/Mef2 pathway in mammals.
Academic Article Loss of Nardilysin, a Mitochondrial Co-chaperone for a-Ketoglutarate Dehydrogenase, Promotes mTORC1 Activation and Neurodegeneration.
Academic Article Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.
Academic Article Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.
Academic Article A cell cycle-independent, conditional gene inactivation strategy for differentially tagging wild-type and mutant cells.
Academic Article Peroxisomal biogenesis is genetically and biochemically linked to carbohydrate metabolism in Drosophila and mouse.
Academic Article The Glia-Neuron Lactate Shuttle and Elevated ROS Promote Lipid Synthesis in Neurons and Lipid Droplet Accumulation in Glia via APOE/D.
Academic Article The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.
Academic Article The expanding neurological phenotype of DNM1L-related disorders.
Academic Article Pleiotropic neuropathological and biochemical alterations associated with Myo5a mutation in a rat Model.
Academic Article A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.
Academic Article A gene-specific T2A-GAL4 library for Drosophila.
Academic Article Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms.
Academic Article Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder.
Academic Article Gene Tagging Strategies To Assess Protein Expression, Localization, and Function in Drosophila.
Academic Article Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to a-Synuclein Gain.
Academic Article Visual impairment and progressive phthisis bulbi caused by recessive pathogenic variant in MARK3.
Academic Article Bi-allelic Loss-of-Function Variants in DNMBP Cause Infantile Cataracts.
Academic Article Sphingolipids in the Pathogenesis of Parkinson's Disease and Parkinsonism.
Academic Article VAMP associated proteins are required for autophagic and lysosomal degradation by promoting a PtdIns4P-mediated endosomal pathway.
Academic Article Interactions between the Ig-Superfamily Proteins DIP-a and Dpr6/10 Regulate Assembly of Neural Circuits.
Academic Article Neuron-Subtype-Specific Expression, Interaction Affinities, and Specificity Determinants of DIP/Dpr Cell Recognition Proteins.
Academic Article Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.
Grant A Comprehensive Resource for Manipulating the Drosophila Genome
Grant Hrs and Endocytic Regulation of Notch and Wingless
Grant A multi-species approach to find regulators of deafness genes
Academic Article Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification.
Academic Article Loss of proteins associated with amyotrophic lateral sclerosis affects lysosomal acidification via different routes.
Concept Serrate-Jagged Proteins
Concept Dishevelled Proteins
Concept Polycomb-Group Proteins
Concept Cdh1 Proteins
Academic Article De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia.
Academic Article cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Academic Article Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information.
Academic Article Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders.
Academic Article Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly.
Academic Article Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction.
Academic Article Use of the CRISPR-Cas9 System in Drosophila Cultured Cells to Introduce Fluorescent Tags into Endogenous Genes.
Academic Article Retromer subunit, VPS29, regulates synaptic transmission and is required for endolysosomal function in the aging brain.
Academic Article Novel role of dynamin-related-protein 1 in dynamics of ER-lipid droplets in adipose tissue.
Academic Article De Novo Variants in CDK19 Are Associated with a Syndrome Involving Intellectual Disability and Epileptic Encephalopathy.
Academic Article De novo mutations in TOMM70, a receptor of the mitochondrial import translocase, cause neurological impairment.
Academic Article The Daam2-VHL-Nedd4 axis governs developmental and regenerative oligodendrocyte differentiation.
Academic Article Drosophila Voltage-Gated Sodium Channels Are Only Expressed in Active Neurons and Are Localized to Distal Axonal Initial Segment-like Domains.
Academic Article BICRA, a SWI/SNF Complex Member, Is Associated with BAF-Disorder Related Phenotypes in Humans and Model Organisms.
Academic Article Rare deleterious de novo missense variants in Rnf2/Ring2 are associated with a neurodevelopmental disorder with unique clinical features.
Academic Article Heterozygous loss-of-function variants significantly expand the phenotypes associated with loss of GDF11.
Grant A Comprehensive Resource for Manipulating the Drosophila Genome
Academic Article TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila.
Academic Article De novo FZR1 loss-of-function variants cause developmental and epileptic encephalopathies.
Academic Article Daam2 Regulates Myelin Structure and the Oligodendrocyte Actin Cytoskeleton through Rac1 and Gelsolin.
Academic Article Novel dominant and recessive variants in human ROBO1 cause distinct neurodevelopmental defects through different mechanisms.
Academic Article De novo variants in EMC1 lead to neurodevelopmental delay and cerebellar degeneration and affect glial function in Drosophila.
Academic Article Loss of IRF2BPL impairs neuronal maintenance through excess Wnt signaling.
Academic Article Systematic expression profiling of Dpr and DIP genes reveals cell surface codes in Drosophila larval motor and sensory neurons.
Academic Article Loss of Activity-Induced Mitochondrial ATP Production Underlies the Synaptic Defects in a Drosophila Model of ALS.
Academic Article De novo variants in FRMD5 are associated with developmental delay, intellectual disability, ataxia, and abnormalities of eye movement.
Academic Article Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14).
Academic Article The recurrent de novo c.2011C>T missense variant in MTSS2 causes syndromic intellectual disability.
Academic Article Bi-allelic variants in INTS11 are associated with a complex neurological disorder.
Academic Article A comprehensive Drosophila resource to identify key functional interactions between SARS-CoV-2 factors and host proteins.
Academic Article Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies.
Academic Article Allelic strengths of encephalopathy-associated UBA5 variants correlate between in vivo and in vitro assays.
Academic Article OXR1 maintains the retromer to delay brain aging under dietary restriction.
Academic Article Loss of the endoplasmic reticulum protein Tmem208 affects cell polarity, development, and viability.
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