Sterol Regulatory Element Binding Proteins
"Sterol Regulatory Element Binding Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Sterol regulatory element binding proteins are basic helix-loop-helix leucine zipper transcription factors that bind the sterol regulatory element TCACNCCAC. They are synthesized as precursors that are threaded into the MEMBRANES of the ENDOPLASMIC RETICULUM.
| Descriptor ID |
D051779
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| MeSH Number(s) |
D12.776.260.103.500.750 D12.776.260.108.092.750 D12.776.930.125.500.750 D12.776.930.127.092.750
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| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Sterol Regulatory Element Binding Proteins".
Below are MeSH descriptors whose meaning is more specific than "Sterol Regulatory Element Binding Proteins".
This graph shows the total number of publications written about "Sterol Regulatory Element Binding Proteins" by people in this website by year, and whether "Sterol Regulatory Element Binding Proteins" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2014 | 1 | 0 | 1 |
| 2015 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sterol Regulatory Element Binding Proteins" by people in Profiles.
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Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo. J Med Chem. 2021 05 13; 64(9):5689-5709.
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Synthetic Chemical Probes That Dissect Vitamin D Activities. ACS Chem Biol. 2019 12 20; 14(12):2851-2858.
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Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. ACS Chem Biol. 2019 09 20; 14(9):1860-1865.
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Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell Chem Biol. 2017 Feb 16; 24(2):207-217.
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Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration. Cell. 2015 Jan 15; 160(1-2):177-90.
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ChIP-seq and in vivo transcriptome analyses of the Aspergillus fumigatus SREBP SrbA reveals a new regulator of the fungal hypoxia response and virulence. PLoS Pathog. 2014 Nov; 10(11):e1004487.
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Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14; 54(13):4923-7.
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A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28; 16(8):882-92.