"Transcription Factor 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that functions in neuronal CELL DIFFERENTIATION. It dimerizes with other bHLH transcription factors and activates transcription through binding to E-BOX ELEMENTS containing 5'-ACANNTGT-3' or 5'-CCANNTGG-3' sequences. Mutations in the TCF-4 gene are associated with Pitt-Hopkins Syndrome, a severe developmental disorder.
| Descriptor ID |
D000073940
|
| MeSH Number(s) |
D12.776.260.108.092.937 D12.776.930.125.500.937
|
| Concept/Terms |
Transcription Factor 4- Transcription Factor 4
- TCF4 Transcription Factor
- Transcription Factor, TCF4
- TCF-4 Transcription Factor
- TCF 4 Transcription Factor
- Transcription Factor, TCF-4
- TCF-4 Protein
- TCF 4 Protein
|
Below are MeSH descriptors whose meaning is more general than "Transcription Factor 4".
Below are MeSH descriptors whose meaning is more specific than "Transcription Factor 4".
This graph shows the total number of publications written about "Transcription Factor 4" by people in this website by year, and whether "Transcription Factor 4" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 2 | 2 |
| 2013 | 0 | 1 | 1 |
| 2016 | 0 | 2 | 2 |
| 2017 | 2 | 1 | 3 |
| 2018 | 0 | 1 | 1 |
| 2019 | 3 | 2 | 5 |
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Below are the most recent publications written about "Transcription Factor 4" by people in Profiles.
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Wnt-Induced Stabilization of KDM4C Is Required for Wnt/?-Catenin Target Gene Expression and Glioblastoma Tumorigenesis. Cancer Res. 2020 03 01; 80(5):1049-1063.
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Dual Expression of TCF4 and CD123 Is Highly Sensitive and Specific For Blastic Plasmacytoid Dendritic Cell Neoplasm. Am J Surg Pathol. 2019 10; 43(10):1429-1437.
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Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res. 2019 09 19; 47(16):8375-8387.
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Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma. Sci Transl Med. 2019 06 19; 11(497).
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Diagnosis and management in Pitt-Hopkins syndrome: First international consensus statement. Clin Genet. 2019 04; 95(4):462-478.
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Estrogen-related receptor gamma functions as a tumor suppressor in gastric cancer. Nat Commun. 2018 05 15; 9(1):1920.
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Common Pathophysiology in Multiple Mouse Models of Pitt-Hopkins Syndrome. J Neurosci. 2018 01 24; 38(4):918-936.
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A transcriptional coregulator, SPIN?DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem. 2017 12 22; 292(51):20808-20817.
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Dual molecular diagnosis contributes to atypical Prader-Willi phenotype in monozygotic twins. Am J Med Genet A. 2017 Sep; 173(9):2451-2455.
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A regulatory circuit of miR-125b/miR-20b and Wnt signalling controls glioblastoma phenotypes through FZD6-modulated pathways. Nat Commun. 2016 10 04; 7:12885.