Microphthalmia-Associated Transcription Factor
"Microphthalmia-Associated Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.
| Descriptor ID |
D051739
|
| MeSH Number(s) |
D12.776.260.103.500.500 D12.776.260.108.092.500 D12.776.930.125.500.500 D12.776.930.127.092.500
|
| Concept/Terms |
Microphthalmia-Associated Transcription Factor- Microphthalmia-Associated Transcription Factor
- Microphthalmia Associated Transcription Factor
- Transcription Factor, Microphthalmia-Associated
- MITF Transcription Factor
- Transcription Factor Microphthalmia
- Microphthalmia, Transcription Factor
- MITF Protein
|
Below are MeSH descriptors whose meaning is more general than "Microphthalmia-Associated Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Microphthalmia-Associated Transcription Factor".
This graph shows the total number of publications written about "Microphthalmia-Associated Transcription Factor" by people in this website by year, and whether "Microphthalmia-Associated Transcription Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 3 | 3 |
| 2005 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 1 | 0 | 1 |
| 2012 | 2 | 1 | 3 |
| 2013 | 1 | 2 | 3 |
| 2014 | 2 | 3 | 5 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 1 | 3 |
| 2018 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Microphthalmia-Associated Transcription Factor" by people in Profiles.
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Integrative clinical and molecular characterization of translocation renal cell carcinoma. Cell Rep. 2022 01 04; 38(1):110190.
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The clear cell sarcoma functional genomic landscape. J Clin Invest. 2021 08 02; 131(15).
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TFEB/Mitf links impaired nuclear import to autophagolysosomal dysfunction in C9-ALS. Elife. 2020 12 10; 9.
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Immune checkpoint inhibitors in MITF family translocation renal cell carcinomas and genetic correlates of exceptional responders. J Immunother Cancer. 2018 12 27; 6(1):159.
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A PAX3/BRN2 rheostat controls the dynamics of BRAF mediated MITF regulation in MITFhigh /AXLlow melanoma. Pigment Cell Melanoma Res. 2019 03; 32(2):280-291.
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Prognostic Implication of Lymphovascular Invasion Detected by Double Immunostaining for D2-40 and MITF1 in Primary Cutaneous Melanoma. Am J Dermatopathol. 2016 Jul; 38(7):484-91.
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sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance. Nature. 2016 Apr 14; 532(7598):250-4.
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Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway. Autophagy. 2016; 12(3):484-98.
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MITF Modulates Therapeutic Resistance through EGFR Signaling. J Invest Dermatol. 2015 Jul; 135(7):1863-1872.
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Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1a and oxidative phosphorylation in melanoma. Cancer Res. 2014 Dec 01; 74(23):7037-47.