Sterol Regulatory Element Binding Protein 1
"Sterol Regulatory Element Binding Protein 1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A sterol regulatory element binding protein that regulates expression of GENES involved in FATTY ACIDS metabolism and LIPOGENESIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING.
| Descriptor ID |
D051780
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| MeSH Number(s) |
D12.776.260.103.500.750.500 D12.776.260.108.092.750.500 D12.776.930.125.500.750.500 D12.776.930.127.092.750.500
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Sterol Regulatory Element Binding Protein 1".
Below are MeSH descriptors whose meaning is more specific than "Sterol Regulatory Element Binding Protein 1".
This graph shows the total number of publications written about "Sterol Regulatory Element Binding Protein 1" by people in this website by year, and whether "Sterol Regulatory Element Binding Protein 1" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 2 | 2 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2008 | 2 | 0 | 2 |
| 2009 | 2 | 0 | 2 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2016 | 1 | 1 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 1 | 2 |
| 2020 | 1 | 1 | 2 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sterol Regulatory Element Binding Protein 1" by people in Profiles.
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PAK3 Exacerbates Cardiac Lipotoxicity via SREBP1c in Obesity Cardiomyopathy. Diabetes. 2024 Nov 01; 73(11):1805-1820.
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Hepatocyte SREBP signaling mediates clock communication within the liver. J Clin Invest. 2023 04 17; 133(8).
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Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice. J Biol Chem. 2022 10; 298(10):102401.
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Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. J Clin Invest. 2022 06 01; 132(11).
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A complementary study approach unravels novel players in the pathoetiology of Hirschsprung disease. PLoS Genet. 2020 11; 16(11):e1009106.
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The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020 04; 580(7804):530-535.
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The Absence of HIF-1a Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Rep. 2020 03 24; 30(12):4052-4064.e7.
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Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes. Cell. 2018 08 09; 174(4):831-842.e12.
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Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol. 2018 03; 58(3):391-401.
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Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications. Mol Cell Endocrinol. 2017 Nov 05; 455:75-82.