"ras Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 3.6.1.47.
| Descriptor ID |
D018631
|
| MeSH Number(s) |
D08.811.277.040.330.300.400.500 D12.644.360.525.500 D12.776.157.325.515.500 D12.776.476.525.500
|
| Concept/Terms |
ras Proteins- ras Proteins
- ras GTPases
- GTPases, ras
- Gene Products, ras
- ras Gene Products
|
Below are MeSH descriptors whose meaning is more general than "ras Proteins".
Below are MeSH descriptors whose meaning is more specific than "ras Proteins".
This graph shows the total number of publications written about "ras Proteins" by people in this website by year, and whether "ras Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 4 | 1 | 5 |
| 1996 | 2 | 1 | 3 |
| 1998 | 1 | 2 | 3 |
| 1999 | 5 | 2 | 7 |
| 2000 | 3 | 3 | 6 |
| 2001 | 5 | 4 | 9 |
| 2002 | 3 | 5 | 8 |
| 2003 | 3 | 6 | 9 |
| 2004 | 3 | 4 | 7 |
| 2005 | 1 | 10 | 11 |
| 2006 | 3 | 10 | 13 |
| 2007 | 6 | 8 | 14 |
| 2008 | 8 | 9 | 17 |
| 2009 | 15 | 10 | 25 |
| 2010 | 6 | 12 | 18 |
| 2011 | 17 | 18 | 35 |
| 2012 | 14 | 15 | 29 |
| 2013 | 18 | 12 | 30 |
| 2014 | 18 | 12 | 30 |
| 2015 | 14 | 10 | 24 |
| 2016 | 7 | 4 | 11 |
| 2017 | 2 | 9 | 11 |
| 2018 | 5 | 4 | 9 |
| 2019 | 5 | 5 | 10 |
| 2020 | 7 | 4 | 11 |
| 2021 | 3 | 3 | 6 |
| 2022 | 1 | 3 | 4 |
| 2023 | 1 | 1 | 2 |
| 2024 | 1 | 4 | 5 |
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Below are the most recent publications written about "ras Proteins" by people in Profiles.
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Update on Pediatric Cancer Surveillance Recommendations for Patients with Neurofibromatosis Type 1, Noonan Syndrome, CBL Syndrome, Costello Syndrome, and Related RASopathies. Clin Cancer Res. 2024 Nov 01; 30(21):4834-4843.
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Germline mutations in a G protein identify signaling cross-talk in T cells. Science. 2024 Sep 20; 385(6715):eadd8947.
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Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket. Cell. 2024 Oct 31; 187(22):6379-6392.e17.
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Clinical and Genomic Landscape of RAS Mutations in Gynecologic Cancers. Clin Cancer Res. 2024 Jul 15; 30(14):2986-2995.
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Early elevations of RAS protein level and activity are critical for the development of PDAC in the context of inflammation. Cancer Lett. 2024 Apr 01; 586:216694.
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The 8th International RASopathies Symposium: Expanding research and care practice through global collaboration and advocacy. Am J Med Genet A. 2024 04; 194(4):e63477.
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Toll-like receptor 2 selectively modulates Ras isoforms expression in Leishmania major infection. Cytokine. 2023 09; 169:156301.
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Implications of RAS mutational status in subsets of patients with newly diagnosed acute myeloid leukemia across therapy subtypes. Am J Hematol. 2022 12; 97(12):1599-1606.
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The seventh international RASopathies symposium: Pathways to a cure-expanding knowledge, enhancing research, and therapeutic discovery. Am J Med Genet A. 2022 06; 188(6):1915-1927.
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Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia. Signal Transduct Target Ther. 2022 02 21; 7(1):51.