Nuclear Receptor Coactivator 3

"Nuclear Receptor Coactivator 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.

Descriptor ID	D056921
MeSH Number(s)	D08.811.913.050.134.415.500.150 D12.644.360.024.314.300 D12.776.157.057.080.300 D12.776.476.024.394.300 D12.776.660.675.300 D12.776.930.617.300
Concept/Terms	Nuclear Receptor Coactivator 3 Nuclear Receptor Coactivator 3 Thyroid Hormone Receptor Activator Molecule 1 Amplified in Breast Cancer-1 Protein Amplified in Breast Cancer 1 Protein Steroid Receptor Coactivator 3 Nuclear Receptor Coactivator-3 Receptor-Associated Coactivator 3 Receptor Associated Coactivator 3

Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Coactivator 3".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Acyltransferases [D08.811.913.050]
Acetyltransferases [D08.811.913.050.134]
Lysine Acetyltransferases [D08.811.913.050.134.415]
Histone Acetyltransferases [D08.811.913.050.134.415.500]
Nuclear Receptor Coactivator 3 [D08.811.913.050.134.415.500.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Nuclear Receptor Coactivators [D12.644.360.024.314]
Nuclear Receptor Coactivator 3 [D12.644.360.024.314.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Nuclear Receptor Coactivators [D12.776.157.057.080]
Nuclear Receptor Coactivator 3 [D12.776.157.057.080.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Nuclear Receptor Coactivators [D12.776.476.024.394]
Nuclear Receptor Coactivator 3 [D12.776.476.024.394.300]
Nuclear Proteins [D12.776.660]
Nuclear Receptor Coactivators [D12.776.660.675]
Nuclear Receptor Coactivator 3 [D12.776.660.675.300]
Transcription Factors [D12.776.930]
Nuclear Receptor Coactivators [D12.776.930.617]
Nuclear Receptor Coactivator 3 [D12.776.930.617.300]

Below are MeSH descriptors whose meaning is related to "Nuclear Receptor Coactivator 3".

Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Coactivator 3".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nuclear Receptor Coactivator 3" by people in this website by year, and whether "Nuclear Receptor Coactivator 3" was a major or minor topic of these publications.

Bar chart showing 135 publications over 23 distinct years, with a maximum of 15 publications in 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	2	2
2000	0	1	1
2001	0	1	1
2002	0	7	7
2003	0	9	9
2004	0	6	6
2005	0	9	9
2006	0	14	14
2007	0	7	7
2008	0	13	13
2009	1	7	8
2010	13	2	15
2011	4	1	5
2012	5	0	5
2013	3	3	6
2014	5	1	6
2015	7	0	7
2016	2	0	2
2017	3	2	5
2018	4	0	4
2019	0	1	1
2020	1	0	1

Below are the most recent publications written about "Nuclear Receptor Coactivator 3" by people in Profiles.

Yu X, Yi P, Hamilton RA, Shen H, Chen M, Foulds CE, Mancini MA, Ludtke SJ, Wang Z, O'Malley BW. Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes. Mol Cell. 2020 09 03; 79(5):812-823.e4.

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Blundon MA, Dasgupta S. Metabolic Dysregulation Controls Endocrine Therapy-Resistant Cancer Recurrence and Metastasis. Endocrinology. 2019 08 01; 160(8):1811-1820.

View in: PubMed
Song X, Chen H, Zhang C, Yu Y, Chen Z, Liang H, Van Buren G, McElhany AL, Fisher WE, Lonard DM, O'Malley BW, Wang J. SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319.

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Tanaka K, Martinez GJ, Yan X, Long W, Ichiyama K, Chi X, Kim BS, Reynolds JM, Chung Y, Tanaka S, Liao L, Nakanishi Y, Yoshimura A, Zheng P, Wang X, Tian Q, Xu J, O'Malley BW, Dong C. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3. Cell Rep. 2018 05 22; 23(8):2318-2329.

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Panigrahi AK, Foulds CE, Lanz RB, Hamilton RA, Yi P, Lonard DM, Tsai MJ, Tsai SY, O'Malley BW. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7.

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Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254.

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Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4.

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Kashani-Sabet M, Nosrati M, Miller JR, Sagebiel RW, Leong SPL, Lesniak A, Tong S, Lee SJ, Kirkwood JM. Prospective Validation of Molecular Prognostic Markers in Cutaneous Melanoma: A Correlative Analysis of E1690. Clin Cancer Res. 2017 Nov 15; 23(22):6888-6892.

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Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BW. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304.

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Rohira AD, Lonard DM. Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers. Biochem Pharmacol. 2017 09 15; 140:1-7.

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