 Nuclear Receptor Coactivator 3
"Nuclear Receptor Coactivator 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.
| Descriptor ID |
D056921
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| MeSH Number(s) |
D08.811.913.050.134.415.500.150 D12.644.360.024.314.300 D12.776.157.057.080.300 D12.776.476.024.394.300 D12.776.660.675.300 D12.776.930.617.300
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| Concept/Terms |
Nuclear Receptor Coactivator 3- Nuclear Receptor Coactivator 3
- Thyroid Hormone Receptor Activator Molecule 1
- Amplified in Breast Cancer-1 Protein
- Amplified in Breast Cancer 1 Protein
- Steroid Receptor Coactivator 3
- Nuclear Receptor Coactivator-3
- Receptor-Associated Coactivator 3
- Receptor Associated Coactivator 3
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Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Coactivator 3".
Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Coactivator 3".
This graph shows the total number of publications written about "Nuclear Receptor Coactivator 3" by people in this website by year, and whether "Nuclear Receptor Coactivator 3" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 1998 | 0 | 1 | 1 | | 1999 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 7 | 7 | | 2003 | 0 | 9 | 9 | | 2004 | 0 | 7 | 7 | | 2005 | 0 | 9 | 9 | | 2006 | 0 | 14 | 14 | | 2007 | 0 | 7 | 7 | | 2008 | 0 | 13 | 13 | | 2009 | 1 | 7 | 8 | | 2010 | 13 | 2 | 15 | | 2011 | 4 | 1 | 5 | | 2012 | 5 | 0 | 5 | | 2013 | 3 | 3 | 6 | | 2014 | 5 | 1 | 6 | | 2015 | 7 | 0 | 7 | | 2016 | 2 | 0 | 2 | | 2017 | 3 | 1 | 4 | | 2018 | 2 | 0 | 2 |
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Below are the most recent publications written about "Nuclear Receptor Coactivator 3" by people in Profiles.
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Panigrahi AK, Foulds CE, Lanz RB, Hamilton RA, Yi P, Lonard DM, Tsai MJ, Tsai SY, O'Malley BW. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7.
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Dasgupta S, Rajapakshe K, Zhu B, Nikolai BC, Yi P, Putluri N, Choi JM, Jung SY, Coarfa C, Westbrook TF, Zhang XH, Foulds CE, Tsai SY, Tsai MJ, O'Malley BW. Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer. Nature. 2018 04; 556(7700):249-254.
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Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4.
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Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BW. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304.
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Rohira AD, Lonard DM. Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers. Biochem Pharmacol. 2017 09 15; 140:1-7.
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Blattner M, Liu D, Robinson BD, Huang D, Poliakov A, Gao D, Nataraj S, Deonarine LD, Augello MA, Sailer V, Ponnala L, Ittmann M, Chinnaiyan AM, Sboner A, Chen Y, Rubin MA, Barbieri CE. SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling. Cancer Cell. 2017 03 13; 31(3):436-451.
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Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5.
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Nikolai BC, Lanz RB, York B, Dasgupta S, Mitsiades N, Creighton CJ, Tsimelzon A, Hilsenbeck SG, Lonard DM, Smith CL, O'Malley BW. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75.
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Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang J. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011.
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Li L. Overdose the addiction--A new strategy to ablate cancer cells. Sci China Life Sci. 2015 Nov; 58(11):1169-70.
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