Nuclear Receptor Coactivator 3

"Nuclear Receptor Coactivator 3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A nuclear receptor coactivator with specificity for ESTROGEN RECEPTORS and PROGESTERONE RECEPTORS. It contains a histone acetyltransferase activity that may play a role in CHROMATIN REMODELING during the process of nuclear receptor-induced transcription. The coactivator has been found at elevated levels in certain HORMONE-DEPENDENT NEOPLASMS such as those found in BREAST CANCER.

Descriptor ID	D056921
MeSH Number(s)	D08.811.913.050.134.415.500.150 D12.644.360.024.314.300 D12.776.157.057.080.300 D12.776.476.024.394.300 D12.776.660.675.300 D12.776.930.617.300
Concept/Terms	Nuclear Receptor Coactivator 3 Nuclear Receptor Coactivator 3 Thyroid Hormone Receptor Activator Molecule 1 Amplified in Breast Cancer-1 Protein Amplified in Breast Cancer 1 Protein Steroid Receptor Coactivator 3 Nuclear Receptor Coactivator-3 Receptor-Associated Coactivator 3 Receptor Associated Coactivator 3

Below are MeSH descriptors whose meaning is more general than "Nuclear Receptor Coactivator 3".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Acyltransferases [D08.811.913.050]
Acetyltransferases [D08.811.913.050.134]
Lysine Acetyltransferases [D08.811.913.050.134.415]
Histone Acetyltransferases [D08.811.913.050.134.415.500]
Nuclear Receptor Coactivator 3 [D08.811.913.050.134.415.500.150]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Adaptor Proteins, Signal Transducing [D12.644.360.024]
Nuclear Receptor Coactivators [D12.644.360.024.314]
Nuclear Receptor Coactivator 3 [D12.644.360.024.314.300]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Adaptor Proteins, Signal Transducing [D12.776.157.057]
Nuclear Receptor Coactivators [D12.776.157.057.080]
Nuclear Receptor Coactivator 3 [D12.776.157.057.080.300]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Adaptor Proteins, Signal Transducing [D12.776.476.024]
Nuclear Receptor Coactivators [D12.776.476.024.394]
Nuclear Receptor Coactivator 3 [D12.776.476.024.394.300]
Nuclear Proteins [D12.776.660]
Nuclear Receptor Coactivators [D12.776.660.675]
Nuclear Receptor Coactivator 3 [D12.776.660.675.300]
Transcription Factors [D12.776.930]
Nuclear Receptor Coactivators [D12.776.930.617]
Nuclear Receptor Coactivator 3 [D12.776.930.617.300]

Below are MeSH descriptors whose meaning is related to "Nuclear Receptor Coactivator 3".

Below are MeSH descriptors whose meaning is more specific than "Nuclear Receptor Coactivator 3".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nuclear Receptor Coactivator 3" by people in this website by year, and whether "Nuclear Receptor Coactivator 3" was a major or minor topic of these publications.

Bar chart showing 138 publications over 24 distinct years, with a maximum of 13 publications in 2006 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
1999	0	2	2
2000	0	1	1
2001	0	1	1
2002	0	7	7
2003	0	8	8
2004	0	7	7
2005	0	9	9
2006	0	13	13
2007	0	7	7
2008	0	12	12
2009	1	7	8
2010	12	1	13
2011	4	1	5
2012	5	0	5
2013	3	3	6
2014	5	1	6
2015	7	0	7
2016	2	0	2
2017	3	2	5
2018	4	0	4
2019	0	1	1
2020	2	1	3
2021	3	2	5

Below are the most recent publications written about "Nuclear Receptor Coactivator 3" by people in Profiles.

Qin L, Chen J, Lu D, Jain P, Yu Y, Cardenas D, Peng X, Yu X, Xu J, Wang J, O'Malley BW, Lonard DM. Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 08 13; 28(10):657-670.

View in: PubMed
Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021 03 25; 4(1):399.

View in: PubMed
Mullany LK, Lonard DM, O'Malley BW. Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3).

View in: PubMed
Liu J, Xie Y, Guo J, Li X, Wang J, Jiang H, Peng Z, Wang J, Wang S, Li Q, Ye L, Zhong Y, Zhang Q, Liu X, Lonard DM, Wang J, O'Malley BW, Liu Z. Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022.

View in: PubMed
Nikolai BC, Jain P, Cardenas DL, York B, Feng Q, McKenna NJ, Dasgupta S, Lonard DM, O'Malley BW. Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441.

View in: PubMed
Sawant Dessai A, Dominguez MP, Chen UI, Hasper J, Prechtl C, Yu C, Katsuta E, Dai T, Zhu B, Jung SY, Putluri N, Takabe K, Zhang XH, O'Malley BW, Dasgupta S. Transcriptional Repression of SIRT3 Potentiates Mitochondrial Aconitase Activation to Drive Aggressive Prostate Cancer to the Bone. Cancer Res. 2021 01 01; 81(1):50-63.

View in: PubMed
Yu X, Yi P, Hamilton RA, Shen H, Chen M, Foulds CE, Mancini MA, Ludtke SJ, Wang Z, O'Malley BW. Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes. Mol Cell. 2020 09 03; 79(5):812-823.e4.

View in: PubMed
Lee WK, Kim WG, Fozzatti L, Park S, Zhao L, Willingham MC, Lonard D, O'Malley BW, Cheng SY. Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer. Endocr Relat Cancer. 2020 04; 27(4):209-220.

View in: PubMed
Blundon MA, Dasgupta S. Metabolic Dysregulation Controls Endocrine Therapy-Resistant Cancer Recurrence and Metastasis. Endocrinology. 2019 08 01; 160(8):1811-1820.

View in: PubMed
Song X, Chen H, Zhang C, Yu Y, Chen Z, Liang H, Van Buren G, McElhany AL, Fisher WE, Lonard DM, O'Malley BW, Wang J. SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319.

View in: PubMed

People

Explore

Similar Concepts

Top Journals