Receptor, Anaphylatoxin C5a
"Receptor, Anaphylatoxin C5a" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A G-protein-coupled receptor that signals an increase in intracellular calcium in response to the potent ANAPHYLATOXIN peptide COMPLEMENT C5A.
| Descriptor ID |
D044087
|
| MeSH Number(s) |
D12.776.543.750.695.024 D12.776.543.750.705.833.550
|
| Concept/Terms |
Receptor, Anaphylatoxin C5a- Receptor, Anaphylatoxin C5a
- CD88 Antigen
- Antigen, CD88
- Receptor, Complement 5a
- CD88 Antigens
- Anaphylatoxin C5a Receptor
- Antigens, CD88
- C5a Receptors
- Receptors, C5a
- Complement 5a Receptor
|
Below are MeSH descriptors whose meaning is more general than "Receptor, Anaphylatoxin C5a".
Below are MeSH descriptors whose meaning is more specific than "Receptor, Anaphylatoxin C5a".
This graph shows the total number of publications written about "Receptor, Anaphylatoxin C5a" by people in this website by year, and whether "Receptor, Anaphylatoxin C5a" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1998 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 2 | 2 |
| 2005 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 0 | 1 | 1 |
| 2018 | 0 | 1 | 1 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, Anaphylatoxin C5a" by people in Profiles.
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C5aR1 inhibition reprograms tumor associated macrophages and reverses PARP inhibitor resistance in breast cancer. Nat Commun. 2024 May 27; 15(1):4485.
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Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells. J Biol Chem. 2018 05 11; 293(19):7195-7208.
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The C5a anaphylatoxin receptor (C5aR1) protects against Listeria monocytogenes infection by inhibiting type 1 IFN expression. J Immunol. 2014 Nov 15; 193(10):5099-107.
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C5a receptor signaling prevents folate deficiency-induced neural tube defects in mice. J Immunol. 2013 Apr 01; 190(7):3493-9.
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Inhibition of complement C5a prevents breakdown of the blood-brain barrier and pituitary dysfunction in experimental sepsis. Crit Care. 2009; 13(1):R12.
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IFN-gamma and IL-17 production in experimental autoimmune encephalomyelitis depends on local APC-T cell complement production. J Immunol. 2008 May 01; 180(9):5882-9.
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Disruption of the C5a receptor gene increases resistance to acute Gram-negative bacteremia and endotoxic shock: opposing roles of C3a and C5a. Mol Immunol. 2008 Apr; 45(7):1907-15.
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C5a receptor deficiency attenuates T cell function and renal disease in MRLlpr mice. J Am Soc Nephrol. 2005 Dec; 16(12):3572-82.
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Upregulation of fibronectin but not of entactin, collagen IV and smooth muscle actin by anaphylatoxin C5a in rat hepatic stellate cells. Histol Histopathol. 2004 10; 19(4):1165-74.
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Genetic mapping of the human C5a receptor. Identification of transmembrane amino acids critical for receptor function. J Biol Chem. 2000 Nov 10; 275(45):35393-401.