"Receptor, PAR-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including ENDOTHELIUM; LEUKOCYTES; and the GASTROINTESTINAL TRACT. The receptor is activated by TRYPSIN, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated THROMBIN RECEPTOR and by small synthetic peptides that contain the unmasked N-terminal sequence.
| Descriptor ID |
D044464
|
| MeSH Number(s) |
D12.776.543.750.695.035 D12.776.543.750.792.249
|
| Concept/Terms |
Receptor, PAR-2- Receptor, PAR-2
- Receptor, PAR 2
- Trypsin Receptors
- Receptors, Trypsin
- Trypsin Receptor
- PAR2 Receptor
- Receptor, PAR2
- Proteinase Activated Receptor 2
- Protease-Activated Receptor 2
- Protease Activated Receptor 2
- Receptor 2, Protease-Activated
- Receptor, Trypsin
- PAR-2 Receptor
- PAR 2 Receptor
|
Below are MeSH descriptors whose meaning is more general than "Receptor, PAR-2".
Below are MeSH descriptors whose meaning is more specific than "Receptor, PAR-2".
This graph shows the total number of publications written about "Receptor, PAR-2" by people in this website by year, and whether "Receptor, PAR-2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2017 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2020 | 1 | 0 | 1 |
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Below are the most recent publications written about "Receptor, PAR-2" by people in Profiles.
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Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2. J Neurosci. 2021 01 06; 41(1):193-210.
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Aspergillus fumigatus induction of IL-33 expression in chronic rhinosinusitis is PAR2-dependent. Laryngoscope. 2019 10; 129(10):2230-2235.
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Reply: Protease Plays a Role in Ragweed Pollen-Induced Neutrophil Recruitment and Epithelial Barrier Disruption. Am J Respir Cell Mol Biol. 2017 02; 56(2):272-273.
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Are testicular mast cells involved in the regulation of germ cells in man? Andrology. 2014 Jul; 2(4):615-22.
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Phenotypic changes in mouse pancreatic stellate cell Ca2+ signaling events following activation in culture and in a disease model of pancreatitis. Mol Biol Cell. 2011 Feb 01; 22(3):421-36.
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Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha. J Interferon Cytokine Res. 2001 Apr; 21(4):231-40.