WILLIAM LAGOR

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston, TX 77030
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    R01HL132840     (LAGOR, WILLIAM RAYMOND)Dec 20, 2016 - Nov 30, 2021
    NIH/NHLBI
    Genetic Repair of Familial Hypercholesterolemia
    Role: Principal Investigator

    U42OD026645     (HEANEY, JASON D)Sep 18, 2018 - Jul 31, 2023
    NIH
    BCM-Rice resource for the analysis of somatic gene editing in mice
    Role: Co-Principal Investigator

    UG3HL151545     (BAO, GANG)Sep 1, 2019 - Jun 30, 2022
    NIH/NHLBI
    Velcro AAV Vector for tissue-specific delivery of genome editing reagents with enhanced cargo capacity
    Role: Co-Principal Investigator

    R01DK124477     (LAGOR, WILLIAM RAYMOND)Apr 6, 2020 - Feb 29, 2024
    NIH/NIDDK
    Physiological Dissection of the Mevalonate Pathway
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. De Giorgi M, Jarrett KE, Burton JC, Doerfler AM, Hurley A, Li A, Hsu RH, Furgurson M, Patel KR, Han J, Borchers CH, Lagor WR. Depletion of essential isoprenoids and ER stress induction following acute liver-specific deletion of HMG-CoA Reductase. J Lipid Res. 2020 Oct 27. PMID: 33109681.
      Citations:    Fields:    
    2. Pastore N, Huynh T, Herz NJ, Calcagni' A, Klisch TJ, Brunetti L, Kim KH, De Giorgi M, Hurley A, Carissimo A, Mutarelli M, Aleksieva N, D'Orsi L, Lagor WR, Moore DD, Settembre C, Finegold MJ, Forbes SJ, Ballabio A. TFEB regulates murine liver cell fate during development and regeneration. Nat Commun. 2020 05 18; 11(1):2461. PMID: 32424153.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Doerfler AM, Walkey CJ, Lagor WR. Recent advances in genome editing for cardiovascular disease. Curr Opin Cardiol. 2020 05; 35(3):242-248. PMID: 32073405.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Li A, Tanner MR, Lee CM, Hurley AE, De Giorgi M, Jarrett KE, Davis TH, Doerfler AM, Bao G, Beeton C, Lagor WR. AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9. Mol Ther. 2020 06 03; 28(6):1432-1441. PMID: 32348718.
      Citations: 4     Fields:    
    5. Li Z, Votava JA, Zajac GJM, Nguyen JN, Leyva Jaimes FB, Ly SM, Brinkman JA, De Giorgi M, Kaul S, Green CL, St Clair SL, Belisle SL, Rios JM, Nelson DW, Sorci-Thomas MG, Lagor WR, Lamming DW, Eric Yen CL, Parks BW. Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism. Cell Metab. 2020 Apr 07; 31(4):741-754.e5. PMID: 32197071.
      Citations:    Fields:    
    6. Lian Z, Perrard XD, Peng X, Raya JL, Hernandez AA, Johnson CG, Lagor WR, Pownall HJ, Hoogeveen RC, Simon SI, Sacks FM, Ballantyne CM, Wu H. Replacing Saturated Fat With Unsaturated Fat in Western Diet Reduces Foamy Monocytes and Atherosclerosis in Male Ldlr-/- Mice. Arterioscler Thromb Vasc Biol. 2020 01; 40(1):72-85. PMID: 31619061.
      Citations:    Fields:    Translation:AnimalsCells
    7. Fan Q, Mao H, Angelini A, Coarfa C, Robertson MJ, Lagor WR, Wehrens XHT, Martin JF, Pi X, Xie L. Depletion of Endothelial Prolyl Hydroxylase Domain Protein 2 and 3 Promotes Cardiomyocyte Proliferation and Prevents Ventricular Failure Induced by Myocardial Infarction. Circulation. 2019 07 30; 140(5):440-442. PMID: 31356139.
      Citations: 3     Fields:    Translation:AnimalsCells
    8. Furgurson M, Lagor WR. CRISPR: a promising tool for lipid physiology and therapeutics. Curr Opin Lipidol. 2019 06; 30(3):172-176. PMID: 30893109.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Ni L, Scott L, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHT. Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262. PMID: 30582449.
      Citations: 3     Fields:    Translation:AnimalsCells
    10. De Giorgi M, Lagor WR. Gene Delivery in Lipid Research and Therapies. Methodist Debakey Cardiovasc J. 2019 Jan-Mar; 15(1):62-69. PMID: 31049151.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Li A, Lee CM, Hurley AE, Jarrett KE, De Giorgi M, Lu W, Balderrama KS, Doerfler AM, Deshmukh H, Ray A, Bao G, Lagor WR. A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing. Mol Ther Methods Clin Dev. 2019 Mar 15; 12:111-122. PMID: 30619914.
      Citations:    
    12. Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHT. In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 09 28; 123(8):953-963. PMID: 30355031.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Jarrett KE, Lee C, De Giorgi M, Hurley A, Gillard BK, Doerfler AM, Li A, Pownall HJ, Bao G, Lagor WR. Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. Arterioscler Thromb Vasc Biol. 2018 09; 38(9):1997-2006. PMID: 30026278.
      Citations: 14     Fields:    Translation:AnimalsCells
    14. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115.
      Citations: 4     Fields:    Translation:AnimalsCells
    15. Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 04 18; 9(1):1544. PMID: 29670083.
      Citations: 2     Fields:    Translation:AnimalsCells
    16. Musunuru K, Lagor WR, Miano JM. What Do We Really Think About Human Germline Genome Editing, and What Does It Mean for Medicine? Circ Cardiovasc Genet. 2017 10; 10(5). PMID: 28974517.
      Citations: 2     Fields:    Translation:Humans
    17. Pankowicz FP, Jarrett KE, Lagor WR, Bissig KD. CRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 07; 66(7):1329-1340. PMID: 28487442.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    18. Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659. PMID: 28337975.
      Citations: 13     Fields:    Translation:AnimalsCells
    19. Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WR. Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep. 2017 03 16; 7:44624. PMID: 28300165.
      Citations: 24     Fields:    Translation:AnimalsCells
    20. Kuwano T, Bi X, Cipollari E, Yasuda T, Lagor WR, Szapary HJ, Tohyama J, Millar JS, Billheimer JT, Lyssenko NN, Rader DJ. Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport. J Lipid Res. 2017 04; 58(4):731-741. PMID: 28137768.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    21. Palmer EE, Jarrett KE, Sachdev RK, Al Zahrani F, Hashem MO, Ibrahim N, Sampaio H, Kandula T, Macintosh R, Gupta R, Conlon DM, Billheimer JT, Rader DJ, Funato K, Walkey CJ, Lee CS, Loo C, Brammah S, Elakis G, Zhu Y, Buckley M, Kirk EP, Bye A, Alkuraya FS, Roscioli T, Lagor WR. Neuronal deficiency of ARV1 causes an autosomal recessive epileptic encephalopathy. Hum Mol Genet. 2016 07 15; 25(14):3042-3054. PMID: 27270415.
      Citations: 4     Fields:    Translation:HumansCells
    22. Gillard BK, Rodriguez PJ, Fields DW, Raya JL, Lagor WR, Rosales C, Courtney HS, Gotto AM, Pownall HJ. Streptococcal serum opacity factor promotes cholesterol ester metabolism and bile acid secretion in vitro and in vivo. Biochim Biophys Acta. 2016 Mar; 1861(3):196-204. PMID: 26709142.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    23. Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J Biol Chem. 2015 Sep 25; 290(39):23751-65. PMID: 26245899.
      Citations: 14     Fields:    Translation:AnimalsCells
    24. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339. PMID: 26081744.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    25. Yang Y, Kuwano T, Lagor WR, Albert CJ, Brenton S, Rader DJ, Ford DA, Brown RJ. Lipidomic analyses of female mice lacking hepatic lipase and endothelial lipase indicate selective modulation of plasma lipid species. Lipids. 2014 Jun; 49(6):505-15. PMID: 24777581.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    26. Lagor WR, Fields DW, Bauer RC, Crawford A, Abt MC, Artis D, Wherry EJ, Rader DJ. Genetic manipulation of the ApoF/Stat2 locus supports an important role for type I interferon signaling in atherosclerosis. Atherosclerosis. 2014 Mar; 233(1):234-41. PMID: 24529150.
      Citations: 10     Fields:    Translation:AnimalsCells
    27. Lagor WR, Johnston JC, Lock M, Vandenberghe LH, Rader DJ. Adeno-associated viruses as liver-directed gene delivery vehicles: focus on lipoprotein metabolism. Methods Mol Biol. 2013; 1027:273-307. PMID: 23912992.
      Citations: 7     Fields:    Translation:AnimalsCells
    28. Kassim SH, Li H, Bell P, Somanathan S, Lagor W, Jacobs F, Billheimer J, Wilson JM, Rader DJ. Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia. Hum Gene Ther. 2013 Jan; 24(1):19-26. PMID: 22985273.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    29. Lagor WR, Fields DW, Khetarpal SA, Kumaravel A, Lin W, Weintraub N, Wu K, Hamm-Alvarez SF, Drazul-Schrader D, de la Llera-Moya M, Rothblat GH, Rader DJ. The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice. PLoS One. 2012; 7(2):e31616. PMID: 22363685.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    30. Boone LR, Lagor WR, Moya Mde L, Niesen MI, Rothblat GH, Ness GC. Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter. Atherosclerosis. 2011 Sep; 218(1):77-82. PMID: 21605865.
      Citations: 7     Fields:    Translation:AnimalsCells
    31. Nijstad N, de Boer JF, Lagor WR, Toelle M, Usher D, Annema W, der Giet Mv, Rader DJ, Tietge UJ. Overexpression of apolipoprotein O does not impact on plasma HDL levels or functionality in human apolipoprotein A-I transgenic mice. Biochim Biophys Acta. 2011 Apr; 1811(4):294-9. PMID: 21296681.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    32. Lagor WR, Rader DJ. Phospholipidation of HDL--how much is too much? Clin Chem. 2011 Jan; 57(1):4-6. PMID: 21078838.
      Citations: 2     Fields:    Translation:HumansAnimals
    33. Burkhardt R, Toh SA, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL, Rader DJ. Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice. J Clin Invest. 2010 Dec; 120(12):4410-4. PMID: 21084752.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    34. Brown RJ, Lagor WR, Sankaranaravanan S, Yasuda T, Quertermous T, Rothblat GH, Rader DJ. Impact of combined deficiency of hepatic lipase and endothelial lipase on the metabolism of both high-density lipoproteins and apolipoprotein B-containing lipoproteins. Circ Res. 2010 Aug 06; 107(3):357-64. PMID: 20558822.
      Citations: 26     Fields:    Translation:AnimalsCells
    35. Davidson WS, Silva RA, Chantepie S, Lagor WR, Chapman MJ, Kontush A. Proteomic analysis of defined HDL subpopulations reveals particle-specific protein clusters: relevance to antioxidative function. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):870-6. PMID: 19325143.
      Citations: 131     Fields:    Translation:HumansCells
    36. Niesen MI, Osborne AR, Lagor WR, Zhang H, Kazemfar K, Ness GC, Blanck G. Technological advances in the study of HLA-DRA promoter regulation: extending the functions of CIITA, Oct-1, Rb, and RFX. Acta Biochim Biophys Sin (Shanghai). 2009 Mar; 41(3):198-205. PMID: 19280058.
      Citations: 1     Fields:    Translation:AnimalsCells
    37. Lagor WR, Brown RJ, Toh SA, Millar JS, Fuki IV, de la Llera-Moya M, Yuen T, Rothblat G, Billheimer JT, Rader DJ. Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):40-6. PMID: 19008531.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    38. Lagor WR, Heller R, de Groh ED, Ness GC. Functional analysis of the hepatic HMG-CoA reductase promoter by in vivo electroporation. Exp Biol Med (Maywood). 2007 Mar; 232(3):353-61. PMID: 17327468.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Lagor WR, de Groh ED, Ness GC. Diabetes alters the occupancy of the hepatic 3-hydroxy-3-methylglutaryl-CoA reductase promoter. J Biol Chem. 2005 Nov 04; 280(44):36601-8. PMID: 16127173.
      Citations: 8     Fields:    Translation:AnimalsCells
    40. Osborne AR, Pollock VV, Lagor WR, Ness GC. Identification of insulin-responsive regions in the HMG-CoA reductase promoter. Biochem Biophys Res Commun. 2004 Jun 11; 318(4):814-8. PMID: 15147943.
      Citations: 9     Fields:    Translation:AnimalsCells
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